Putative amino acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-Lysine transport protein, putative

Species:

Leishmania major

UniProt:

Q4Q509_LEIMA

TriTrypDb:

LmjF.32.2660 , LMJLV39_320034000 , LMJSD75_320034300

Length:

488

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 69

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 189
NetGPI	no	yes: 0, no: 190

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	172
GO:0020016	ciliary pocket	2	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

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Expansion

Sequence features

Q4Q509

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q509

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	20
GO:0006810	transport	3	20
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006820	monoatomic anion transport	5	2
GO:0006865	amino acid transport	5	20
GO:0009987	cellular process	1	20
GO:0015711	organic anion transport	5	2
GO:0015802	basic amino acid transport	6	2
GO:0015819	lysine transport	6	2

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0005215	transporter activity	1	20
GO:0005342	organic acid transmembrane transporter activity	3	20
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	20
GO:0015174	basic amino acid transmembrane transporter activity	6	2
GO:0015179	L-amino acid transmembrane transporter activity	6	20

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.772
CLV_C14_Caspase3-7	34	38	PF00656	0.658
CLV_C14_Caspase3-7	61	65	PF00656	0.704
CLV_NRD_NRD_1	266	268	PF00675	0.525
CLV_PCSK_SKI1_1	158	162	PF00082	0.272
CLV_PCSK_SKI1_1	313	317	PF00082	0.272
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.303
DOC_MAPK_FxFP_2	438	441	PF00069	0.342
DOC_MAPK_gen_1	267	273	PF00069	0.273
DOC_MAPK_MEF2A_6	236	245	PF00069	0.462

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P285	Leptomonas seymouri	42%	99%
A0A0N0P5D2	Leptomonas seymouri	47%	100%
A0A0N0P613	Leptomonas seymouri	28%	100%
A0A0N0P6F5	Leptomonas seymouri	27%	100%
A0A0N0P6F6	Leptomonas seymouri	41%	100%
A0A0N0P8T9	Leptomonas seymouri	39%	98%
A0A0N0P955	Leptomonas seymouri	43%	100%
A0A0N1I2L5	Leptomonas seymouri	42%	100%
A0A0N1I3F8	Leptomonas seymouri	45%	92%
A0A0N1I3H4	Leptomonas seymouri	41%	89%

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