LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
kinteoplast poly(A) polymerase complex 1 subunit, putative
Species:
Leishmania major
UniProt:
Q4Q508_LEIMA
TriTrypDb:
LmjF.32.2670 * , LMJLV39_320034100 * , LMJSD75_320034400 *
Length:
790

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 1

Expansion

Sequence features

Q4Q508
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q508

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009892 negative regulation of metabolic process 4 2
GO:0009893 positive regulation of metabolic process 4 2
GO:0009894 regulation of catabolic process 4 2
GO:0009895 negative regulation of catabolic process 5 2
GO:0009987 cellular process 1 2
GO:0010468 regulation of gene expression 5 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0010628 positive regulation of gene expression 6 2
GO:0016070 RNA metabolic process 5 2
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031324 negative regulation of cellular metabolic process 5 2
GO:0031329 regulation of cellular catabolic process 5 2
GO:0031330 negative regulation of cellular catabolic process 6 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043487 regulation of RNA stability 3 2
GO:0043488 regulation of mRNA stability 4 2
GO:0043489 RNA stabilization 4 2
GO:0043631 RNA polyadenylation 6 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 2
GO:0046483 heterocycle metabolic process 3 2
GO:0048255 mRNA stabilization 5 2
GO:0048518 positive regulation of biological process 3 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051252 regulation of RNA metabolic process 5 2
GO:0051253 negative regulation of RNA metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0061013 regulation of mRNA catabolic process 6 2
GO:0065007 biological regulation 1 2
GO:0065008 regulation of biological quality 2 2
GO:0071704 organic substance metabolic process 2 2
GO:0080090 regulation of primary metabolic process 4 2
GO:0090304 nucleic acid metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1902369 negative regulation of RNA catabolic process 7 2
GO:1902373 negative regulation of mRNA catabolic process 7 2
GO:1903311 regulation of mRNA metabolic process 6 2
GO:1903312 negative regulation of mRNA metabolic process 7 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.491
CLV_C14_Caspase3-7 147 151 PF00656 0.433
CLV_C14_Caspase3-7 268 272 PF00656 0.680
CLV_C14_Caspase3-7 348 352 PF00656 0.447
CLV_C14_Caspase3-7 50 54 PF00656 0.473
CLV_C14_Caspase3-7 550 554 PF00656 0.631
CLV_C14_Caspase3-7 628 632 PF00656 0.641
CLV_C14_Caspase3-7 669 673 PF00656 0.484
CLV_C14_Caspase3-7 702 706 PF00656 0.518
CLV_NRD_NRD_1 170 172 PF00675 0.444
CLV_NRD_NRD_1 180 182 PF00675 0.393
CLV_NRD_NRD_1 216 218 PF00675 0.533
CLV_NRD_NRD_1 228 230 PF00675 0.416
CLV_NRD_NRD_1 237 239 PF00675 0.587
CLV_NRD_NRD_1 27 29 PF00675 0.558
CLV_NRD_NRD_1 31 33 PF00675 0.512
CLV_NRD_NRD_1 358 360 PF00675 0.398
CLV_NRD_NRD_1 479 481 PF00675 0.447
CLV_NRD_NRD_1 515 517 PF00675 0.426
CLV_NRD_NRD_1 524 526 PF00675 0.349
CLV_NRD_NRD_1 607 609 PF00675 0.472
CLV_NRD_NRD_1 715 717 PF00675 0.458
CLV_NRD_NRD_1 763 765 PF00675 0.461
CLV_NRD_NRD_1 88 90 PF00675 0.419
CLV_PCSK_FUR_1 168 172 PF00082 0.493
CLV_PCSK_FUR_1 226 230 PF00082 0.499
CLV_PCSK_FUR_1 761 765 PF00082 0.463
CLV_PCSK_KEX2_1 170 172 PF00082 0.421
CLV_PCSK_KEX2_1 180 182 PF00082 0.406
CLV_PCSK_KEX2_1 218 220 PF00082 0.517
CLV_PCSK_KEX2_1 228 230 PF00082 0.435
CLV_PCSK_KEX2_1 236 238 PF00082 0.461
CLV_PCSK_KEX2_1 293 295 PF00082 0.481
CLV_PCSK_KEX2_1 298 300 PF00082 0.422
CLV_PCSK_KEX2_1 31 33 PF00082 0.551
CLV_PCSK_KEX2_1 358 360 PF00082 0.533
CLV_PCSK_KEX2_1 390 392 PF00082 0.321
CLV_PCSK_KEX2_1 408 410 PF00082 0.395
CLV_PCSK_KEX2_1 479 481 PF00082 0.395
CLV_PCSK_KEX2_1 606 608 PF00082 0.514
CLV_PCSK_KEX2_1 720 722 PF00082 0.519
CLV_PCSK_KEX2_1 761 763 PF00082 0.436
CLV_PCSK_KEX2_1 87 89 PF00082 0.430
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.509
CLV_PCSK_PC1ET2_1 293 295 PF00082 0.481
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.422
CLV_PCSK_PC1ET2_1 390 392 PF00082 0.321
CLV_PCSK_PC1ET2_1 408 410 PF00082 0.395
CLV_PCSK_PC1ET2_1 720 722 PF00082 0.413
CLV_PCSK_PC7_1 214 220 PF00082 0.597
CLV_PCSK_PC7_1 294 300 PF00082 0.429
CLV_PCSK_PC7_1 603 609 PF00082 0.476
CLV_PCSK_PC7_1 716 722 PF00082 0.431
CLV_PCSK_SKI1_1 160 164 PF00082 0.357
CLV_PCSK_SKI1_1 23 27 PF00082 0.745
CLV_PCSK_SKI1_1 294 298 PF00082 0.557
CLV_PCSK_SKI1_1 49 53 PF00082 0.445
CLV_PCSK_SKI1_1 64 68 PF00082 0.390
CLV_PCSK_SKI1_1 736 740 PF00082 0.385
CLV_PCSK_SKI1_1 782 786 PF00082 0.424
CLV_Separin_Metazoa 73 77 PF03568 0.531
DEG_APCC_DBOX_1 179 187 PF00400 0.399
DEG_APCC_DBOX_1 678 686 PF00400 0.427
DEG_Nend_Nbox_1 1 3 PF02207 0.564
DOC_CYCLIN_RxL_1 298 310 PF00134 0.568
DOC_MAPK_gen_1 113 122 PF00069 0.481
DOC_MAPK_MEF2A_6 113 122 PF00069 0.481
DOC_MAPK_MEF2A_6 303 311 PF00069 0.485
DOC_MAPK_NFAT4_5 113 121 PF00069 0.477
DOC_MAPK_RevD_3 157 171 PF00069 0.391
DOC_PP1_RVXF_1 734 741 PF00149 0.384
DOC_PP2B_LxvP_1 683 686 PF13499 0.431
DOC_PP2B_LxvP_1 768 771 PF13499 0.445
DOC_PP4_FxxP_1 465 468 PF00568 0.422
DOC_USP7_MATH_1 125 129 PF00917 0.557
DOC_USP7_MATH_1 19 23 PF00917 0.594
DOC_USP7_MATH_1 239 243 PF00917 0.708
DOC_USP7_MATH_1 248 252 PF00917 0.785
DOC_USP7_MATH_1 557 561 PF00917 0.714
DOC_USP7_UBL2_3 610 614 PF12436 0.553
DOC_WW_Pin1_4 12 17 PF00397 0.650
DOC_WW_Pin1_4 237 242 PF00397 0.712
DOC_WW_Pin1_4 246 251 PF00397 0.779
DOC_WW_Pin1_4 279 284 PF00397 0.690
DOC_WW_Pin1_4 630 635 PF00397 0.571
LIG_14-3-3_CanoR_1 196 204 PF00244 0.524
LIG_14-3-3_CanoR_1 219 227 PF00244 0.522
LIG_14-3-3_CanoR_1 334 338 PF00244 0.329
LIG_14-3-3_CanoR_1 358 364 PF00244 0.403
LIG_14-3-3_CanoR_1 47 52 PF00244 0.469
LIG_14-3-3_CanoR_1 472 477 PF00244 0.506
LIG_14-3-3_CanoR_1 592 598 PF00244 0.512
LIG_Actin_WH2_2 469 484 PF00022 0.526
LIG_ActinCP_TwfCPI_2 465 474 PF01115 0.507
LIG_AP2alpha_2 713 715 PF02296 0.563
LIG_BIR_III_4 629 633 PF00653 0.463
LIG_BRCT_BRCA1_1 198 202 PF00533 0.570
LIG_BRCT_BRCA1_1 337 341 PF00533 0.424
LIG_deltaCOP1_diTrp_1 387 392 PF00928 0.314
LIG_deltaCOP1_diTrp_1 776 781 PF00928 0.408
LIG_FHA_1 162 168 PF00498 0.503
LIG_FHA_1 352 358 PF00498 0.452
LIG_FHA_1 368 374 PF00498 0.291
LIG_FHA_1 416 422 PF00498 0.479
LIG_FHA_1 592 598 PF00498 0.398
LIG_FHA_1 743 749 PF00498 0.512
LIG_FHA_2 104 110 PF00498 0.484
LIG_FHA_2 315 321 PF00498 0.497
LIG_FHA_2 50 56 PF00498 0.414
LIG_FHA_2 557 563 PF00498 0.640
LIG_FHA_2 626 632 PF00498 0.566
LIG_FHA_2 92 98 PF00498 0.454
LIG_GBD_Chelix_1 311 319 PF00786 0.498
LIG_GBD_Chelix_1 652 660 PF00786 0.508
LIG_LIR_Apic_2 462 468 PF02991 0.431
LIG_LIR_Gen_1 109 119 PF02991 0.472
LIG_LIR_Gen_1 323 333 PF02991 0.305
LIG_LIR_Gen_1 53 62 PF02991 0.445
LIG_LIR_Gen_1 616 625 PF02991 0.434
LIG_LIR_Nem_3 109 114 PF02991 0.466
LIG_LIR_Nem_3 323 328 PF02991 0.321
LIG_LIR_Nem_3 330 335 PF02991 0.315
LIG_LIR_Nem_3 404 410 PF02991 0.376
LIG_LIR_Nem_3 53 59 PF02991 0.429
LIG_LIR_Nem_3 616 621 PF02991 0.422
LIG_MYND_1 680 684 PF01753 0.428
LIG_NRBOX 640 646 PF00104 0.571
LIG_Pex14_2 328 332 PF04695 0.312
LIG_Pex14_2 727 731 PF04695 0.500
LIG_SH2_CRK 519 523 PF00017 0.366
LIG_SH2_STAP1 353 357 PF00017 0.387
LIG_SH2_STAP1 361 365 PF00017 0.376
LIG_SH2_STAP1 393 397 PF00017 0.329
LIG_SH2_STAP1 519 523 PF00017 0.451
LIG_SH2_STAT3 166 169 PF00017 0.506
LIG_SH2_STAT5 166 169 PF00017 0.361
LIG_SH2_STAT5 353 356 PF00017 0.341
LIG_SH2_STAT5 376 379 PF00017 0.495
LIG_SH2_STAT5 483 486 PF00017 0.396
LIG_SH2_STAT5 691 694 PF00017 0.410
LIG_SH2_STAT5 90 93 PF00017 0.465
LIG_SH3_1 764 770 PF00018 0.465
LIG_SH3_1 772 778 PF00018 0.407
LIG_SH3_3 13 19 PF00018 0.671
LIG_SH3_3 394 400 PF00018 0.498
LIG_SH3_3 465 471 PF00018 0.563
LIG_SH3_3 678 684 PF00018 0.426
LIG_SH3_3 731 737 PF00018 0.371
LIG_SH3_3 764 770 PF00018 0.445
LIG_SH3_3 772 778 PF00018 0.399
LIG_SUMO_SIM_anti_2 308 314 PF11976 0.511
LIG_SUMO_SIM_anti_2 369 375 PF11976 0.393
LIG_TRAF2_1 213 216 PF00917 0.516
LIG_TRAF2_1 379 382 PF00917 0.467
LIG_TRAF2_1 673 676 PF00917 0.334
LIG_TRAF2_2 119 124 PF00917 0.634
LIG_UBA3_1 315 324 PF00899 0.542
LIG_UBA3_1 656 665 PF00899 0.414
MOD_CDK_SPxxK_3 630 637 PF00069 0.437
MOD_CK1_1 175 181 PF00069 0.466
MOD_CK1_1 21 27 PF00069 0.719
MOD_CK1_1 240 246 PF00069 0.632
MOD_CK1_1 251 257 PF00069 0.660
MOD_CK1_1 314 320 PF00069 0.455
MOD_CK1_1 535 541 PF00069 0.628
MOD_CK1_1 602 608 PF00069 0.654
MOD_CK1_1 690 696 PF00069 0.375
MOD_CK2_1 252 258 PF00069 0.777
MOD_CK2_1 307 313 PF00069 0.535
MOD_CK2_1 314 320 PF00069 0.463
MOD_CK2_1 472 478 PF00069 0.382
MOD_CK2_1 49 55 PF00069 0.419
MOD_CK2_1 663 669 PF00069 0.384
MOD_GlcNHglycan 244 248 PF01048 0.649
MOD_GlcNHglycan 267 270 PF01048 0.652
MOD_GlcNHglycan 435 438 PF01048 0.638
MOD_GlcNHglycan 537 540 PF01048 0.639
MOD_GlcNHglycan 553 557 PF01048 0.682
MOD_GlcNHglycan 559 562 PF01048 0.713
MOD_GlcNHglycan 692 695 PF01048 0.367
MOD_GlcNHglycan 710 713 PF01048 0.548
MOD_GSK3_1 125 132 PF00069 0.558
MOD_GSK3_1 17 24 PF00069 0.607
MOD_GSK3_1 239 246 PF00069 0.744
MOD_GSK3_1 248 255 PF00069 0.794
MOD_GSK3_1 261 268 PF00069 0.733
MOD_GSK3_1 277 284 PF00069 0.634
MOD_GSK3_1 307 314 PF00069 0.391
MOD_GSK3_1 548 555 PF00069 0.687
MOD_GSK3_1 593 600 PF00069 0.501
MOD_GSK3_1 602 609 PF00069 0.542
MOD_GSK3_1 65 72 PF00069 0.413
MOD_GSK3_1 8 15 PF00069 0.691
MOD_NEK2_1 129 134 PF00069 0.516
MOD_NEK2_1 152 157 PF00069 0.316
MOD_NEK2_1 230 235 PF00069 0.565
MOD_NEK2_1 263 268 PF00069 0.584
MOD_NEK2_1 288 293 PF00069 0.641
MOD_NEK2_1 297 302 PF00069 0.570
MOD_NEK2_1 307 312 PF00069 0.532
MOD_NEK2_1 335 340 PF00069 0.405
MOD_NEK2_1 532 537 PF00069 0.529
MOD_NEK2_1 552 557 PF00069 0.473
MOD_NEK2_1 593 598 PF00069 0.337
MOD_NEK2_1 740 745 PF00069 0.420
MOD_NEK2_1 91 96 PF00069 0.451
MOD_NEK2_2 103 108 PF00069 0.500
MOD_NEK2_2 139 144 PF00069 0.432
MOD_NEK2_2 353 358 PF00069 0.434
MOD_OFUCOSY 262 267 PF10250 0.566
MOD_PIKK_1 129 135 PF00454 0.514
MOD_PIKK_1 191 197 PF00454 0.386
MOD_PIKK_1 335 341 PF00454 0.389
MOD_PIKK_1 451 457 PF00454 0.538
MOD_PIKK_1 591 597 PF00454 0.499
MOD_PK_1 359 365 PF00069 0.540
MOD_PKA_1 606 612 PF00069 0.579
MOD_PKA_2 333 339 PF00069 0.333
MOD_PKA_2 591 597 PF00069 0.557
MOD_PKA_2 602 608 PF00069 0.616
MOD_PKB_1 217 225 PF00069 0.529
MOD_Plk_1 139 145 PF00069 0.425
MOD_Plk_1 152 158 PF00069 0.399
MOD_Plk_1 307 313 PF00069 0.392
MOD_Plk_1 91 97 PF00069 0.453
MOD_Plk_2-3 663 669 PF00069 0.384
MOD_Plk_4 139 145 PF00069 0.425
MOD_Plk_4 152 158 PF00069 0.399
MOD_Plk_4 307 313 PF00069 0.434
MOD_Plk_4 593 599 PF00069 0.477
MOD_Plk_4 687 693 PF00069 0.427
MOD_ProDKin_1 12 18 PF00069 0.650
MOD_ProDKin_1 237 243 PF00069 0.717
MOD_ProDKin_1 246 252 PF00069 0.779
MOD_ProDKin_1 279 285 PF00069 0.685
MOD_ProDKin_1 630 636 PF00069 0.562
MOD_SUMO_for_1 379 382 PF00179 0.517
MOD_SUMO_for_1 613 616 PF00179 0.546
MOD_SUMO_rev_2 402 410 PF00179 0.507
MOD_SUMO_rev_2 661 666 PF00179 0.376
TRG_DiLeu_BaEn_1 640 645 PF01217 0.637
TRG_DiLeu_BaLyEn_6 652 657 PF01217 0.388
TRG_DiLeu_BaLyEn_6 734 739 PF01217 0.391
TRG_DiLeu_LyEn_5 640 645 PF01217 0.495
TRG_DiLeu_LyEn_5 678 683 PF01217 0.440
TRG_ENDOCYTIC_2 393 396 PF00928 0.408
TRG_ENDOCYTIC_2 407 410 PF00928 0.313
TRG_ENDOCYTIC_2 486 489 PF00928 0.448
TRG_ENDOCYTIC_2 519 522 PF00928 0.372
TRG_ER_diArg_1 167 170 PF00400 0.503
TRG_ER_diArg_1 226 229 PF00400 0.512
TRG_ER_diArg_1 235 238 PF00400 0.564
TRG_ER_diArg_1 357 359 PF00400 0.507
TRG_ER_diArg_1 479 482 PF00400 0.379
TRG_ER_diArg_1 606 608 PF00400 0.518
TRG_ER_diArg_1 761 764 PF00400 0.469
TRG_ER_diArg_1 87 89 PF00400 0.430
TRG_NLS_MonoExtC_3 27 32 PF00514 0.662
TRG_NLS_MonoExtC_3 715 720 PF00514 0.561
TRG_NLS_MonoExtN_4 26 32 PF00514 0.669
TRG_NLS_MonoExtN_4 290 296 PF00514 0.514
TRG_NLS_MonoExtN_4 714 720 PF00514 0.457
TRG_Pf-PMV_PEXEL_1 219 223 PF00026 0.516
TRG_Pf-PMV_PEXEL_1 474 478 PF00026 0.530
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 516 521 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I355 Leptomonas seymouri 72% 93%
A0A0S4JPP8 Bodo saltans 42% 100%
A0A1X0NS88 Trypanosomatidae 49% 99%
A0A3R7LBC9 Trypanosoma rangeli 52% 100%
A0A3S7X5U8 Leishmania donovani 96% 100%
A4HKQ8 Leishmania braziliensis 85% 100%
A4I888 Leishmania infantum 96% 100%
D0AAF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9B346 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5AUT0 Trypanosoma cruzi 53% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS