Trafficking protein particle complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sybindin-like family, putative

Species:

Leishmania major

UniProt:

Q4Q503_LEIMA

TriTrypDb:

LmjF.32.2720 , LMJLV39_320034600 , LMJSD75_320034900

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0005794	Golgi apparatus	5	11
GO:0030008	TRAPP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

Q4Q503

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q503

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.411
CLV_NRD_NRD_1	140	142	PF00675	0.261
CLV_PCSK_KEX2_1	140	142	PF00082	0.298
CLV_PCSK_SKI1_1	141	145	PF00082	0.220
CLV_PCSK_SKI1_1	18	22	PF00082	0.405
CLV_PCSK_SKI1_1	86	90	PF00082	0.324
DOC_CKS1_1	53	58	PF01111	0.358
DOC_CKS1_1	79	84	PF01111	0.298
DOC_CYCLIN_yClb5_NLxxxL_5	96	105	PF00134	0.334
DOC_PP1_RVXF_1	84	91	PF00149	0.389
DOC_PP4_FxxP_1	21	24	PF00568	0.324
DOC_USP7_MATH_1	60	64	PF00917	0.285
DOC_WW_Pin1_4	20	25	PF00397	0.398
DOC_WW_Pin1_4	52	57	PF00397	0.292
DOC_WW_Pin1_4	78	83	PF00397	0.298
LIG_14-3-3_CanoR_1	140	144	PF00244	0.414
LIG_APCC_ABBA_1	87	92	PF00400	0.389
LIG_APCC_ABBAyCdc20_2	86	92	PF00400	0.389
LIG_BRCT_BRCA1_1	41	45	PF00533	0.280
LIG_BRCT_BRCA1_1	83	87	PF00533	0.398
LIG_EH_1	115	119	PF12763	0.280
LIG_FHA_1	134	140	PF00498	0.324
LIG_FHA_2	118	124	PF00498	0.415
LIG_FHA_2	20	26	PF00498	0.299
LIG_FHA_2	65	71	PF00498	0.358
LIG_LIR_Apic_2	19	24	PF02991	0.326
LIG_LIR_Gen_1	144	149	PF02991	0.327
LIG_LIR_Gen_1	84	92	PF02991	0.398
LIG_LIR_Nem_3	84	90	PF02991	0.398
LIG_LIR_Nem_3	99	105	PF02991	0.311
LIG_OCRL_FandH_1	101	113	PF00620	0.299
LIG_SH2_NCK_1	79	83	PF00017	0.280
LIG_SH2_STAP1	109	113	PF00017	0.400
MOD_CK2_1	64	70	PF00069	0.339
MOD_GlcNHglycan	11	14	PF01048	0.317
MOD_GlcNHglycan	62	65	PF01048	0.310
MOD_GSK3_1	16	23	PF00069	0.398
MOD_GSK3_1	39	46	PF00069	0.299
MOD_GSK3_1	48	55	PF00069	0.294
MOD_GSK3_1	60	67	PF00069	0.320
MOD_GSK3_1	88	95	PF00069	0.294
MOD_N-GLC_1	9	14	PF02516	0.303
MOD_N-GLC_1	92	97	PF02516	0.405
MOD_NEK2_1	36	41	PF00069	0.303
MOD_NEK2_1	44	49	PF00069	0.301
MOD_NEK2_1	96	101	PF00069	0.389
MOD_PIKK_1	48	54	PF00454	0.293
MOD_PKA_2	139	145	PF00069	0.434
MOD_Plk_1	92	98	PF00069	0.379
MOD_Plk_2-3	92	98	PF00069	0.358
MOD_Plk_4	39	45	PF00069	0.280
MOD_Plk_4	64	70	PF00069	0.319
MOD_ProDKin_1	20	26	PF00069	0.398
MOD_ProDKin_1	52	58	PF00069	0.292
MOD_ProDKin_1	78	84	PF00069	0.298
TRG_ENDOCYTIC_2	109	112	PF00928	0.405
TRG_ENDOCYTIC_2	146	149	PF00928	0.529
TRG_ER_diArg_1	139	141	PF00400	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M0	Leptomonas seymouri	86%	100%
A0A0S4JPM9	Bodo saltans	56%	85%
A0A1X0NRN0	Trypanosomatidae	71%	95%
A0A3Q8IH79	Leishmania donovani	99%	100%
A0A3R7NSI3	Trypanosoma rangeli	73%	95%
A4HKR3	Leishmania braziliensis	94%	100%
A4I893	Leishmania infantum	99%	100%
D0AAG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	95%
E9B351	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O43041	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q2TBL9	Bos taurus	28%	68%
Q54UU1	Dictyostelium discoideum	22%	100%
Q5R9J9	Pongo abelii	29%	68%
Q69BT7	Rattus norvegicus	28%	68%
Q9ES56	Mus musculus	28%	68%
Q9Y296	Homo sapiens	29%	68%