Ribosome biogenesis protein NSA1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q502_LEIMA

TriTrypDb:

LmjF.32.2730 , LMJLV39_320034700 , LMJSD75_320035000

Length:

1039

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q502

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q502

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1021	1025	PF00656	0.508
CLV_NRD_NRD_1	458	460	PF00675	0.552
CLV_NRD_NRD_1	525	527	PF00675	0.346
CLV_PCSK_KEX2_1	110	112	PF00082	0.412
CLV_PCSK_KEX2_1	177	179	PF00082	0.572
CLV_PCSK_KEX2_1	458	460	PF00082	0.552
CLV_PCSK_KEX2_1	796	798	PF00082	0.427
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.446
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.549
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.427
CLV_PCSK_PC7_1	454	460	PF00082	0.454
CLV_PCSK_SKI1_1	138	142	PF00082	0.451
CLV_PCSK_SKI1_1	156	160	PF00082	0.373
CLV_PCSK_SKI1_1	485	489	PF00082	0.485
CLV_PCSK_SKI1_1	527	531	PF00082	0.329
CLV_PCSK_SKI1_1	601	605	PF00082	0.485
CLV_PCSK_SKI1_1	651	655	PF00082	0.397
CLV_PCSK_SKI1_1	770	774	PF00082	0.474
CLV_PCSK_SKI1_1	797	801	PF00082	0.431
CLV_PCSK_SKI1_1	906	910	PF00082	0.570
CLV_PCSK_SKI1_1	942	946	PF00082	0.355
DEG_APCC_DBOX_1	769	777	PF00400	0.444
DEG_SCF_FBW7_1	732	737	PF00400	0.442
DOC_ANK_TNKS_1	403	410	PF00023	0.440
DOC_CKS1_1	669	674	PF01111	0.517
DOC_CYCLIN_RxL_1	637	647	PF00134	0.461
DOC_MAPK_DCC_7	456	465	PF00069	0.546
DOC_MAPK_gen_1	150	159	PF00069	0.380
DOC_MAPK_gen_1	456	465	PF00069	0.473
DOC_MAPK_gen_1	710	719	PF00069	0.502
DOC_MAPK_gen_1	767	776	PF00069	0.448
DOC_MAPK_gen_1	909	918	PF00069	0.459
DOC_MAPK_MEF2A_6	456	465	PF00069	0.452
DOC_MAPK_MEF2A_6	767	776	PF00069	0.451
DOC_MAPK_MEF2A_6	866	873	PF00069	0.415
DOC_MAPK_MEF2A_6	987	995	PF00069	0.443
DOC_MIT_MIM_1	151	160	PF04212	0.371
DOC_PP1_RVXF_1	1013	1020	PF00149	0.441
DOC_PP1_RVXF_1	258	264	PF00149	0.371
DOC_PP1_RVXF_1	940	946	PF00149	0.403
DOC_PP2B_LxvP_1	732	735	PF13499	0.358
DOC_PP4_FxxP_1	575	578	PF00568	0.387
DOC_PP4_MxPP_1	847	850	PF00568	0.435
DOC_USP7_MATH_1	129	133	PF00917	0.406
DOC_USP7_MATH_1	333	337	PF00917	0.725
DOC_USP7_MATH_1	351	355	PF00917	0.666
DOC_USP7_MATH_1	357	361	PF00917	0.598
DOC_USP7_MATH_1	379	383	PF00917	0.713
DOC_USP7_MATH_1	436	440	PF00917	0.576
DOC_USP7_MATH_1	498	502	PF00917	0.520
DOC_USP7_MATH_1	591	595	PF00917	0.421
DOC_USP7_MATH_1	890	894	PF00917	0.709
DOC_USP7_MATH_1	980	984	PF00917	0.576
DOC_USP7_MATH_2	890	896	PF00917	0.590
DOC_WW_Pin1_4	276	281	PF00397	0.466
DOC_WW_Pin1_4	51	56	PF00397	0.579
DOC_WW_Pin1_4	609	614	PF00397	0.456
DOC_WW_Pin1_4	668	673	PF00397	0.510
DOC_WW_Pin1_4	730	735	PF00397	0.469
DOC_WW_Pin1_4	886	891	PF00397	0.705
LIG_14-3-3_CanoR_1	215	220	PF00244	0.490
LIG_14-3-3_CanoR_1	476	480	PF00244	0.437
LIG_14-3-3_CanoR_1	710	715	PF00244	0.533
LIG_14-3-3_CanoR_1	73	82	PF00244	0.498
LIG_14-3-3_CanoR_1	797	806	PF00244	0.453
LIG_14-3-3_CanoR_1	839	847	PF00244	0.463
LIG_14-3-3_CanoR_1	880	886	PF00244	0.490
LIG_14-3-3_CanoR_1	955	964	PF00244	0.369
LIG_14-3-3_CanoR_1	987	995	PF00244	0.443
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BRCT_BRCA1_1	571	575	PF00533	0.485
LIG_CSL_BTD_1	950	953	PF09270	0.427
LIG_deltaCOP1_diTrp_1	634	638	PF00928	0.406
LIG_DLG_GKlike_1	830	838	PF00625	0.382
LIG_FHA_1	1003	1009	PF00498	0.455
LIG_FHA_1	1024	1030	PF00498	0.355
LIG_FHA_1	170	176	PF00498	0.513
LIG_FHA_1	220	226	PF00498	0.505
LIG_FHA_1	267	273	PF00498	0.611
LIG_FHA_1	414	420	PF00498	0.548
LIG_FHA_1	509	515	PF00498	0.394
LIG_FHA_1	731	737	PF00498	0.457
LIG_FHA_1	75	81	PF00498	0.439
LIG_FHA_1	752	758	PF00498	0.499
LIG_FHA_1	798	804	PF00498	0.419
LIG_FHA_1	83	89	PF00498	0.398
LIG_FHA_1	927	933	PF00498	0.371
LIG_FHA_1	986	992	PF00498	0.437
LIG_FHA_2	14	20	PF00498	0.489
LIG_FHA_2	243	249	PF00498	0.618
LIG_FHA_2	486	492	PF00498	0.487
LIG_FHA_2	645	651	PF00498	0.395
LIG_FHA_2	882	888	PF00498	0.586
LIG_IRF3_LxIS_1	605	612	PF10401	0.462
LIG_LIR_Apic_2	572	578	PF02991	0.377
LIG_LIR_Apic_2	579	583	PF02991	0.373
LIG_LIR_Gen_1	228	237	PF02991	0.373
LIG_LIR_Gen_1	604	614	PF02991	0.381
LIG_LIR_Gen_1	630	641	PF02991	0.402
LIG_LIR_Gen_1	718	728	PF02991	0.440
LIG_LIR_Gen_1	958	967	PF02991	0.465
LIG_LIR_Nem_3	228	233	PF02991	0.377
LIG_LIR_Nem_3	604	609	PF02991	0.375
LIG_LIR_Nem_3	630	636	PF02991	0.454
LIG_LIR_Nem_3	718	723	PF02991	0.432
LIG_LIR_Nem_3	958	964	PF02991	0.444
LIG_MYND_1	276	280	PF01753	0.531
LIG_NRBOX	830	836	PF00104	0.454
LIG_Pex14_1	1028	1032	PF04695	0.505
LIG_SH2_CRK	1032	1036	PF00017	0.478
LIG_SH2_CRK	253	257	PF00017	0.525
LIG_SH2_CRK	34	38	PF00017	0.465
LIG_SH2_CRK	518	522	PF00017	0.315
LIG_SH2_CRK	606	610	PF00017	0.440
LIG_SH2_CRK	670	674	PF00017	0.497
LIG_SH2_GRB2like	508	511	PF00017	0.351
LIG_SH2_NCK_1	286	290	PF00017	0.563
LIG_SH2_NCK_1	330	334	PF00017	0.643
LIG_SH2_PTP2	139	142	PF00017	0.434
LIG_SH2_PTP2	720	723	PF00017	0.409
LIG_SH2_SRC	286	289	PF00017	0.551
LIG_SH2_SRC	330	333	PF00017	0.643
LIG_SH2_SRC	580	583	PF00017	0.419
LIG_SH2_SRC	720	723	PF00017	0.409
LIG_SH2_SRC	963	966	PF00017	0.362
LIG_SH2_STAP1	286	290	PF00017	0.611
LIG_SH2_STAP1	606	610	PF00017	0.440
LIG_SH2_STAP1	875	879	PF00017	0.359
LIG_SH2_STAT5	139	142	PF00017	0.452
LIG_SH2_STAT5	543	546	PF00017	0.301
LIG_SH2_STAT5	580	583	PF00017	0.383
LIG_SH2_STAT5	606	609	PF00017	0.338
LIG_SH2_STAT5	670	673	PF00017	0.409
LIG_SH2_STAT5	720	723	PF00017	0.431
LIG_SH2_STAT5	792	795	PF00017	0.579
LIG_SH2_STAT5	81	84	PF00017	0.370
LIG_SH2_STAT5	963	966	PF00017	0.451
LIG_SH3_3	173	179	PF00018	0.520
LIG_SH3_3	34	40	PF00018	0.457
LIG_SH3_3	52	58	PF00018	0.539
LIG_SH3_3	542	548	PF00018	0.462
LIG_SH3_3	582	588	PF00018	0.396
LIG_SH3_3	626	632	PF00018	0.481
LIG_SH3_3	803	809	PF00018	0.415
LIG_SH3_3	914	920	PF00018	0.363
LIG_SH3_3	947	953	PF00018	0.437
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.447
LIG_SUMO_SIM_par_1	188	195	PF11976	0.363
LIG_SUMO_SIM_par_1	410	416	PF11976	0.465
LIG_SUMO_SIM_par_1	43	49	PF11976	0.366
LIG_TRAF2_1	336	339	PF00917	0.618
LIG_TRAF2_1	501	504	PF00917	0.553
LIG_TRAF2_1	653	656	PF00917	0.511
LIG_TYR_ITIM	1030	1035	PF00017	0.479
LIG_UBA3_1	44	50	PF00899	0.417
LIG_UBA3_1	844	851	PF00899	0.468
LIG_WRC_WIRS_1	216	221	PF05994	0.454
LIG_WW_3	613	617	PF00397	0.503
MOD_CDK_SPxK_1	668	674	PF00069	0.499
MOD_CDK_SPxxK_3	609	616	PF00069	0.538
MOD_CK1_1	166	172	PF00069	0.546
MOD_CK1_1	17	23	PF00069	0.513
MOD_CK1_1	266	272	PF00069	0.515
MOD_CK1_1	384	390	PF00069	0.672
MOD_CK1_1	439	445	PF00069	0.367
MOD_CK1_1	49	55	PF00069	0.583
MOD_CK1_1	833	839	PF00069	0.380
MOD_CK1_1	90	96	PF00069	0.605
MOD_CK1_1	989	995	PF00069	0.465
MOD_CK2_1	332	338	PF00069	0.755
MOD_CK2_1	485	491	PF00069	0.508
MOD_CK2_1	497	503	PF00069	0.544
MOD_CK2_1	547	553	PF00069	0.429
MOD_CK2_1	644	650	PF00069	0.428
MOD_CK2_1	712	718	PF00069	0.329
MOD_CK2_1	752	758	PF00069	0.569
MOD_CK2_1	811	817	PF00069	0.452
MOD_CK2_1	822	828	PF00069	0.433
MOD_CK2_1	851	857	PF00069	0.495
MOD_CK2_1	886	892	PF00069	0.566
MOD_CMANNOS	202	205	PF00535	0.364
MOD_Cter_Amidation	524	527	PF01082	0.349
MOD_GlcNHglycan	131	134	PF01048	0.374
MOD_GlcNHglycan	165	168	PF01048	0.429
MOD_GlcNHglycan	202	205	PF01048	0.504
MOD_GlcNHglycan	353	356	PF01048	0.734
MOD_GlcNHglycan	383	386	PF01048	0.718
MOD_GlcNHglycan	390	393	PF01048	0.512
MOD_GlcNHglycan	51	54	PF01048	0.532
MOD_GlcNHglycan	593	596	PF01048	0.462
MOD_GlcNHglycan	686	689	PF01048	0.687
MOD_GlcNHglycan	714	717	PF01048	0.349
MOD_GlcNHglycan	835	838	PF01048	0.436
MOD_GlcNHglycan	892	895	PF01048	0.640
MOD_GSK3_1	110	117	PF00069	0.479
MOD_GSK3_1	13	20	PF00069	0.589
MOD_GSK3_1	200	207	PF00069	0.453
MOD_GSK3_1	215	222	PF00069	0.358
MOD_GSK3_1	276	283	PF00069	0.456
MOD_GSK3_1	333	340	PF00069	0.747
MOD_GSK3_1	384	391	PF00069	0.589
MOD_GSK3_1	494	501	PF00069	0.478
MOD_GSK3_1	730	737	PF00069	0.499
MOD_GSK3_1	749	756	PF00069	0.431
MOD_GSK3_1	82	89	PF00069	0.493
MOD_GSK3_1	886	893	PF00069	0.647
MOD_GSK3_1	951	958	PF00069	0.437
MOD_GSK3_1	978	985	PF00069	0.624
MOD_LATS_1	213	219	PF00433	0.456
MOD_LATS_1	445	451	PF00433	0.565
MOD_N-GLC_1	122	127	PF02516	0.401
MOD_N-GLC_1	509	514	PF02516	0.381
MOD_N-GLC_1	74	79	PF02516	0.479
MOD_N-GLC_1	86	91	PF02516	0.502
MOD_N-GLC_2	398	400	PF02516	0.421
MOD_NEK2_1	263	268	PF00069	0.489
MOD_NEK2_1	27	32	PF00069	0.406
MOD_NEK2_1	388	393	PF00069	0.481
MOD_NEK2_1	644	649	PF00069	0.380
MOD_NEK2_1	740	745	PF00069	0.486
MOD_NEK2_1	926	931	PF00069	0.393
MOD_NEK2_2	475	480	PF00069	0.492
MOD_PIKK_1	644	650	PF00454	0.322
MOD_PIKK_1	734	740	PF00454	0.527
MOD_PIKK_1	955	961	PF00454	0.462
MOD_PK_1	18	24	PF00069	0.530
MOD_PKA_1	110	116	PF00069	0.487
MOD_PKA_2	110	116	PF00069	0.487
MOD_PKA_2	17	23	PF00069	0.538
MOD_PKA_2	214	220	PF00069	0.471
MOD_PKA_2	475	481	PF00069	0.474
MOD_PKA_2	838	844	PF00069	0.473
MOD_PKA_2	954	960	PF00069	0.464
MOD_PKA_2	986	992	PF00069	0.463
MOD_Plk_1	122	128	PF00069	0.364
MOD_Plk_1	143	149	PF00069	0.516
MOD_Plk_1	18	24	PF00069	0.470
MOD_Plk_1	437	443	PF00069	0.521
MOD_Plk_1	509	515	PF00069	0.374
MOD_Plk_1	552	558	PF00069	0.370
MOD_Plk_1	86	92	PF00069	0.503
MOD_Plk_1	989	995	PF00069	0.405
MOD_Plk_2-3	337	343	PF00069	0.682
MOD_Plk_2-3	978	984	PF00069	0.534
MOD_Plk_4	122	128	PF00069	0.398
MOD_Plk_4	225	231	PF00069	0.391
MOD_Plk_4	242	248	PF00069	0.596
MOD_Plk_4	384	390	PF00069	0.602
MOD_Plk_4	576	582	PF00069	0.484
MOD_Plk_4	601	607	PF00069	0.350
MOD_Plk_4	64	70	PF00069	0.474
MOD_Plk_4	742	748	PF00069	0.403
MOD_Plk_4	830	836	PF00069	0.436
MOD_Plk_4	989	995	PF00069	0.434
MOD_ProDKin_1	276	282	PF00069	0.475
MOD_ProDKin_1	51	57	PF00069	0.563
MOD_ProDKin_1	609	615	PF00069	0.466
MOD_ProDKin_1	668	674	PF00069	0.517
MOD_ProDKin_1	730	736	PF00069	0.460
MOD_ProDKin_1	886	892	PF00069	0.711
TRG_DiLeu_BaEn_1	188	193	PF01217	0.405
TRG_DiLeu_BaEn_1	769	774	PF01217	0.463
TRG_DiLeu_BaEn_2	989	995	PF01217	0.270
TRG_DiLeu_BaEn_4	482	488	PF01217	0.517
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.516
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.426
TRG_DiLeu_BaLyEn_6	939	944	PF01217	0.440
TRG_ENDOCYTIC_2	1032	1035	PF00928	0.470
TRG_ENDOCYTIC_2	139	142	PF00928	0.411
TRG_ENDOCYTIC_2	34	37	PF00928	0.482
TRG_ENDOCYTIC_2	518	521	PF00928	0.336
TRG_ENDOCYTIC_2	543	546	PF00928	0.307
TRG_ENDOCYTIC_2	606	609	PF00928	0.350
TRG_ENDOCYTIC_2	633	636	PF00928	0.414
TRG_ENDOCYTIC_2	670	673	PF00928	0.443
TRG_ENDOCYTIC_2	720	723	PF00928	0.409
TRG_ENDOCYTIC_2	963	966	PF00928	0.451
TRG_ER_diArg_1	458	460	PF00400	0.573
TRG_ER_diArg_1	523	526	PF00400	0.346
TRG_ER_diArg_1	910	913	PF00400	0.324
TRG_ER_FFAT_1	326	336	PF00635	0.634
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z6	Leptomonas seymouri	62%	98%
A0A1X0NRM5	Trypanosomatidae	38%	100%
A0A3S7X5X2	Leishmania donovani	93%	100%
A0A422NZR3	Trypanosoma rangeli	38%	100%
A4HKR4	Leishmania braziliensis	78%	100%
A4I894	Leishmania infantum	93%	100%
E9B352	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%