As/Sb Reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

As/Sb Reductase

Gene product:

As/Sb Reductase

Species:

Leishmania major

UniProt:

Q4Q501_LEIMA

TriTrypDb:

LmjF.32.2740 , LMJLV39_320034800 , LMJSD75_320035100

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q501

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q501

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004725	protein tyrosine phosphatase activity	4	2
GO:0008794	arsenate reductase (glutaredoxin) activity	4	2
GO:0016491	oxidoreductase activity	2	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0030611	arsenate reductase activity	3	2
GO:0030613	oxidoreductase activity, acting on phosphorus or arsenic in donors	3	2
GO:0030614	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor	4	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.400
CLV_C14_Caspase3-7	131	135	PF00656	0.400
CLV_C14_Caspase3-7	37	41	PF00656	0.314
CLV_NRD_NRD_1	42	44	PF00675	0.513
CLV_NRD_NRD_1	50	52	PF00675	0.519
CLV_PCSK_KEX2_1	42	44	PF00082	0.513
CLV_PCSK_KEX2_1	50	52	PF00082	0.519
CLV_PCSK_SKI1_1	16	20	PF00082	0.199
CLV_PCSK_SKI1_1	160	164	PF00082	0.199
CLV_PCSK_SKI1_1	190	194	PF00082	0.199
CLV_PCSK_SKI1_1	42	46	PF00082	0.503
DEG_APCC_DBOX_1	15	23	PF00400	0.199
DOC_CDC14_PxL_1	92	100	PF14671	0.199
DOC_CYCLIN_RxL_1	13	23	PF00134	0.199
DOC_CYCLIN_RxL_1	160	168	PF00134	0.400
DOC_MAPK_DCC_7	197	207	PF00069	0.400
DOC_MAPK_gen_1	75	83	PF00069	0.323
DOC_PP1_RVXF_1	41	48	PF00149	0.300
DOC_WW_Pin1_4	1	6	PF00397	0.549
LIG_14-3-3_CanoR_1	3	13	PF00244	0.523
LIG_14-3-3_CanoR_1	51	57	PF00244	0.327
LIG_Actin_WH2_2	194	211	PF00022	0.400
LIG_CtBP_PxDLS_1	111	115	PF00389	0.400
LIG_FHA_1	30	36	PF00498	0.199
LIG_FHA_1	69	75	PF00498	0.308
LIG_FHA_1	89	95	PF00498	0.199
LIG_FHA_2	162	168	PF00498	0.400
LIG_GBD_Chelix_1	14	22	PF00786	0.199
LIG_LIR_Apic_2	107	111	PF02991	0.437
LIG_LIR_Gen_1	104	114	PF02991	0.261
LIG_LIR_Gen_1	155	166	PF02991	0.400
LIG_LIR_Gen_1	71	81	PF02991	0.313
LIG_LIR_Gen_1	88	97	PF02991	0.199
LIG_LIR_Nem_3	104	109	PF02991	0.268
LIG_LIR_Nem_3	155	161	PF02991	0.400
LIG_LIR_Nem_3	213	219	PF02991	0.400
LIG_LIR_Nem_3	23	29	PF02991	0.199
LIG_LIR_Nem_3	71	76	PF02991	0.307
LIG_LIR_Nem_3	88	92	PF02991	0.199
LIG_LYPXL_S_1	94	98	PF13949	0.199
LIG_LYPXL_yS_3	95	98	PF13949	0.199
LIG_NRBOX	113	119	PF00104	0.400
LIG_NRBOX	30	36	PF00104	0.199
LIG_Pex14_1	212	216	PF04695	0.400
LIG_PTB_Apo_2	102	109	PF02174	0.199
LIG_PTB_Phospho_1	102	108	PF10480	0.199
LIG_Rb_LxCxE_1	150	167	PF01857	0.400
LIG_SH2_CRK	106	110	PF00017	0.252
LIG_SH2_CRK	89	93	PF00017	0.199
LIG_SH2_PTP2	108	111	PF00017	0.433
LIG_SH2_PTP2	200	203	PF00017	0.400
LIG_SH2_STAP1	158	162	PF00017	0.400
LIG_SH2_STAP1	89	93	PF00017	0.199
LIG_SH2_STAT5	106	109	PF00017	0.245
LIG_SH2_STAT5	200	203	PF00017	0.400
LIG_SH2_STAT5	206	209	PF00017	0.400
LIG_SH2_STAT5	46	49	PF00017	0.300
LIG_SH3_3	179	185	PF00018	0.400
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.400
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.400
LIG_SUMO_SIM_par_1	112	119	PF11976	0.400
LIG_SUMO_SIM_par_1	31	37	PF11976	0.199
LIG_TYR_ITIM	93	98	PF00017	0.199
LIG_TYR_ITSM	102	109	PF00017	0.199
MOD_CK1_1	4	10	PF00069	0.525
MOD_CK1_1	88	94	PF00069	0.199
MOD_CK2_1	149	155	PF00069	0.400
MOD_CK2_1	161	167	PF00069	0.400
MOD_Cter_Amidation	40	43	PF01082	0.506
MOD_GlcNHglycan	52	55	PF01048	0.518
MOD_GSK3_1	147	154	PF00069	0.400
MOD_GSK3_1	81	88	PF00069	0.337
MOD_N-GLC_1	104	109	PF02516	0.268
MOD_NEK2_1	161	166	PF00069	0.400
MOD_NEK2_1	52	57	PF00069	0.327
MOD_PKA_1	50	56	PF00069	0.322
MOD_PKA_2	132	138	PF00069	0.400
MOD_PKA_2	50	56	PF00069	0.322
MOD_Plk_1	104	110	PF00069	0.270
MOD_Plk_4	104	110	PF00069	0.270
MOD_Plk_4	120	126	PF00069	0.400
MOD_Plk_4	161	167	PF00069	0.400
MOD_Plk_4	177	183	PF00069	0.400
MOD_Plk_4	29	35	PF00069	0.199
MOD_Plk_4	68	74	PF00069	0.304
MOD_Plk_4	88	94	PF00069	0.199
MOD_ProDKin_1	1	7	PF00069	0.544
MOD_SUMO_for_1	109	112	PF00179	0.435
MOD_SUMO_rev_2	167	172	PF00179	0.400
TRG_DiLeu_BaEn_1	113	118	PF01217	0.400
TRG_DiLeu_BaEn_4	167	173	PF01217	0.400
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.199
TRG_ENDOCYTIC_2	106	109	PF00928	0.245
TRG_ENDOCYTIC_2	158	161	PF00928	0.400
TRG_ENDOCYTIC_2	219	222	PF00928	0.444
TRG_ENDOCYTIC_2	46	49	PF00928	0.300
TRG_ENDOCYTIC_2	89	92	PF00928	0.199
TRG_ENDOCYTIC_2	95	98	PF00928	0.199
TRG_ER_diArg_1	49	51	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q8WZK3	SCHPO	29%	100%