Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4Z9_LEIMA

TriTrypDb:

LmjF.32.2760 , LMJLV39_320035000 , LMJSD75_320035300

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.485
CLV_C14_Caspase3-7	394	398	PF00656	0.681
CLV_C14_Caspase3-7	42	46	PF00656	0.698
CLV_C14_Caspase3-7	641	645	PF00656	0.730
CLV_C14_Caspase3-7	762	766	PF00656	0.672
CLV_NRD_NRD_1	138	140	PF00675	0.632
CLV_NRD_NRD_1	207	209	PF00675	0.635
CLV_NRD_NRD_1	279	281	PF00675	0.678
CLV_NRD_NRD_1	28	30	PF00675	0.802
CLV_NRD_NRD_1	423	425	PF00675	0.518
CLV_NRD_NRD_1	48	50	PF00675	0.412
CLV_NRD_NRD_1	492	494	PF00675	0.501
CLV_NRD_NRD_1	7	9	PF00675	0.651
CLV_NRD_NRD_1	847	849	PF00675	0.649
CLV_PCSK_FUR_1	87	91	PF00082	0.580
CLV_PCSK_KEX2_1	137	139	PF00082	0.645
CLV_PCSK_KEX2_1	207	209	PF00082	0.635
CLV_PCSK_KEX2_1	27	29	PF00082	0.863
CLV_PCSK_KEX2_1	279	281	PF00082	0.678
CLV_PCSK_KEX2_1	423	425	PF00082	0.518
CLV_PCSK_KEX2_1	48	50	PF00082	0.676
CLV_PCSK_KEX2_1	492	494	PF00082	0.513
CLV_PCSK_KEX2_1	499	501	PF00082	0.501
CLV_PCSK_KEX2_1	847	849	PF00082	0.531
CLV_PCSK_KEX2_1	89	91	PF00082	0.618
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.604
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.618
CLV_PCSK_SKI1_1	170	174	PF00082	0.579
CLV_PCSK_SKI1_1	207	211	PF00082	0.594
CLV_PCSK_SKI1_1	508	512	PF00082	0.567
CLV_PCSK_SKI1_1	9	13	PF00082	0.652
CLV_Separin_Metazoa	111	115	PF03568	0.656
CLV_Separin_Metazoa	404	408	PF03568	0.642
CLV_Separin_Metazoa	689	693	PF03568	0.504
CLV_Separin_Metazoa	772	776	PF03568	0.546
DEG_APCC_DBOX_1	169	177	PF00400	0.609
DEG_COP1_1	333	343	PF00400	0.493
DEG_SCF_FBW7_1	11	18	PF00400	0.772
DEG_SCF_FBW7_1	176	182	PF00400	0.560
DEG_SIAH_1	139	147	PF03145	0.616
DEG_SPOP_SBC_1	15	19	PF00917	0.712
DOC_CKS1_1	102	107	PF01111	0.692
DOC_CKS1_1	12	17	PF01111	0.773
DOC_CKS1_1	176	181	PF01111	0.685
DOC_CKS1_1	189	194	PF01111	0.661
DOC_CKS1_1	446	451	PF01111	0.591
DOC_CYCLIN_RxL_1	111	120	PF00134	0.542
DOC_CYCLIN_RxL_1	3	14	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.650
DOC_MAPK_gen_1	483	491	PF00069	0.459
DOC_PP4_FxxP_1	109	112	PF00568	0.683
DOC_USP7_MATH_1	15	19	PF00917	0.736
DOC_USP7_MATH_1	161	165	PF00917	0.690
DOC_USP7_MATH_1	179	183	PF00917	0.561
DOC_USP7_MATH_1	224	228	PF00917	0.480
DOC_USP7_MATH_1	36	40	PF00917	0.594
DOC_USP7_MATH_1	523	527	PF00917	0.665
DOC_USP7_MATH_1	529	533	PF00917	0.677
DOC_USP7_MATH_1	598	602	PF00917	0.847
DOC_USP7_MATH_1	627	631	PF00917	0.697
DOC_USP7_MATH_1	75	79	PF00917	0.770
DOC_USP7_MATH_1	795	799	PF00917	0.588
DOC_USP7_MATH_1	817	821	PF00917	0.799
DOC_WW_Pin1_4	101	106	PF00397	0.737
DOC_WW_Pin1_4	11	16	PF00397	0.658
DOC_WW_Pin1_4	129	134	PF00397	0.667
DOC_WW_Pin1_4	175	180	PF00397	0.665
DOC_WW_Pin1_4	188	193	PF00397	0.654
DOC_WW_Pin1_4	22	27	PF00397	0.662
DOC_WW_Pin1_4	287	292	PF00397	0.725
DOC_WW_Pin1_4	294	299	PF00397	0.619
DOC_WW_Pin1_4	318	323	PF00397	0.453
DOC_WW_Pin1_4	43	48	PF00397	0.585
DOC_WW_Pin1_4	445	450	PF00397	0.664
DOC_WW_Pin1_4	554	559	PF00397	0.681
DOC_WW_Pin1_4	564	569	PF00397	0.763
DOC_WW_Pin1_4	575	580	PF00397	0.635
DOC_WW_Pin1_4	586	591	PF00397	0.702
DOC_WW_Pin1_4	615	620	PF00397	0.667
DOC_WW_Pin1_4	656	661	PF00397	0.769
LIG_14-3-3_CanoR_1	139	145	PF00244	0.801
LIG_14-3-3_CanoR_1	21	26	PF00244	0.786
LIG_14-3-3_CanoR_1	37	47	PF00244	0.559
LIG_14-3-3_CanoR_1	423	427	PF00244	0.647
LIG_14-3-3_CanoR_1	472	481	PF00244	0.485
LIG_14-3-3_CanoR_1	48	54	PF00244	0.503
LIG_14-3-3_CanoR_1	492	496	PF00244	0.645
LIG_14-3-3_CanoR_1	599	606	PF00244	0.726
LIG_14-3-3_CanoR_1	621	627	PF00244	0.592
LIG_14-3-3_CanoR_1	655	660	PF00244	0.638
LIG_14-3-3_CanoR_1	692	696	PF00244	0.586
LIG_14-3-3_CanoR_1	775	779	PF00244	0.597
LIG_14-3-3_CanoR_1	797	804	PF00244	0.718
LIG_Actin_WH2_2	408	425	PF00022	0.622
LIG_Actin_WH2_2	677	694	PF00022	0.509
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_4	585	589	PF00653	0.746
LIG_BRCT_BRCA1_1	446	450	PF00533	0.551
LIG_BRCT_BRCA1_1	766	770	PF00533	0.614
LIG_CSL_BTD_1	186	189	PF09270	0.577
LIG_CtBP_PxDLS_1	623	627	PF00389	0.653
LIG_EVH1_2	105	109	PF00568	0.653
LIG_FHA_1	139	145	PF00498	0.677
LIG_FHA_1	191	197	PF00498	0.744
LIG_FHA_1	322	328	PF00498	0.475
LIG_FHA_1	439	445	PF00498	0.705
LIG_FHA_1	446	452	PF00498	0.657
LIG_FHA_1	511	517	PF00498	0.732
LIG_FHA_1	799	805	PF00498	0.782
LIG_FHA_2	237	243	PF00498	0.478
LIG_FHA_2	392	398	PF00498	0.678
LIG_FHA_2	40	46	PF00498	0.714
LIG_FHA_2	60	66	PF00498	0.465
LIG_FHA_2	698	704	PF00498	0.696
LIG_FHA_2	830	836	PF00498	0.562
LIG_GBD_Chelix_1	465	473	PF00786	0.623
LIG_Integrin_RGD_1	68	70	PF01839	0.670
LIG_LIR_Apic_2	107	112	PF02991	0.703
LIG_LIR_Gen_1	349	360	PF02991	0.457
LIG_LIR_Nem_3	349	355	PF02991	0.455
LIG_LIR_Nem_3	767	773	PF02991	0.536
LIG_LIR_Nem_3	826	830	PF02991	0.597
LIG_PCNA_PIPBox_1	345	354	PF02747	0.543
LIG_PCNA_yPIPBox_3	345	357	PF02747	0.544
LIG_PDZ_Class_1	858	863	PF00595	0.665
LIG_RPA_C_Fungi	480	492	PF08784	0.517
LIG_SH2_NCK_1	13	17	PF00017	0.655
LIG_SH2_STAP1	845	849	PF00017	0.654
LIG_SH2_STAT3	467	470	PF00017	0.626
LIG_SH2_STAT5	108	111	PF00017	0.653
LIG_SH2_STAT5	13	16	PF00017	0.830
LIG_SH2_STAT5	202	205	PF00017	0.613
LIG_SH2_STAT5	54	57	PF00017	0.541
LIG_SH3_2	133	138	PF14604	0.631
LIG_SH3_2	515	520	PF14604	0.773
LIG_SH3_3	109	115	PF00018	0.592
LIG_SH3_3	130	136	PF00018	0.714
LIG_SH3_3	186	192	PF00018	0.749
LIG_SH3_3	193	199	PF00018	0.669
LIG_SH3_3	30	36	PF00018	0.601
LIG_SH3_3	443	449	PF00018	0.620
LIG_SH3_3	509	515	PF00018	0.770
LIG_SH3_3	576	582	PF00018	0.635
LIG_SH3_3	617	623	PF00018	0.751
LIG_SH3_3	648	654	PF00018	0.757
LIG_SH3_3	701	707	PF00018	0.651
LIG_SH3_3	835	841	PF00018	0.729
LIG_SUMO_SIM_par_1	622	628	PF11976	0.653
LIG_TRAF2_1	414	417	PF00917	0.612
LIG_TRAF2_1	460	463	PF00917	0.618
LIG_TRAF2_1	494	497	PF00917	0.541
LIG_Vh1_VBS_1	301	319	PF01044	0.529
LIG_WW_1	105	108	PF00397	0.716
LIG_WW_3	752	756	PF00397	0.759
MOD_CDC14_SPxK_1	135	138	PF00782	0.678
MOD_CDC14_SPxK_1	25	28	PF00782	0.737
MOD_CDC14_SPxK_1	46	49	PF00782	0.567
MOD_CDK_SPK_2	132	137	PF00069	0.706
MOD_CDK_SPK_2	22	27	PF00069	0.789
MOD_CDK_SPK_2	294	299	PF00069	0.615
MOD_CDK_SPK_2	43	48	PF00069	0.585
MOD_CDK_SPxK_1	132	138	PF00069	0.675
MOD_CDK_SPxK_1	22	28	PF00069	0.734
MOD_CDK_SPxK_1	43	49	PF00069	0.583
MOD_CDK_SPxK_1	615	621	PF00069	0.691
MOD_CDK_SPxxK_3	132	139	PF00069	0.709
MOD_CDK_SPxxK_3	22	29	PF00069	0.792
MOD_CK1_1	107	113	PF00069	0.649
MOD_CK1_1	132	138	PF00069	0.746
MOD_CK1_1	153	159	PF00069	0.618
MOD_CK1_1	194	200	PF00069	0.723
MOD_CK1_1	2	8	PF00069	0.692
MOD_CK1_1	297	303	PF00069	0.595
MOD_CK1_1	39	45	PF00069	0.664
MOD_CK1_1	428	434	PF00069	0.675
MOD_CK1_1	557	563	PF00069	0.711
MOD_CK1_1	564	570	PF00069	0.794
MOD_CK1_1	573	579	PF00069	0.648
MOD_CK1_1	589	595	PF00069	0.648
MOD_CK1_1	622	628	PF00069	0.660
MOD_CK1_1	658	664	PF00069	0.717
MOD_CK1_1	679	685	PF00069	0.698
MOD_CK1_1	760	766	PF00069	0.679
MOD_CK1_1	780	786	PF00069	0.580
MOD_CK1_1	796	802	PF00069	0.773
MOD_CK1_1	809	815	PF00069	0.639
MOD_CK2_1	236	242	PF00069	0.529
MOD_CK2_1	481	487	PF00069	0.490
MOD_CK2_1	491	497	PF00069	0.495
MOD_CK2_1	59	65	PF00069	0.710
MOD_CK2_1	697	703	PF00069	0.626
MOD_CK2_1	766	772	PF00069	0.606
MOD_CK2_1	829	835	PF00069	0.684
MOD_GlcNHglycan	181	184	PF01048	0.562
MOD_GlcNHglycan	258	261	PF01048	0.475
MOD_GlcNHglycan	265	268	PF01048	0.588
MOD_GlcNHglycan	284	287	PF01048	0.516
MOD_GlcNHglycan	38	41	PF01048	0.643
MOD_GlcNHglycan	388	391	PF01048	0.567
MOD_GlcNHglycan	4	7	PF01048	0.654
MOD_GlcNHglycan	521	524	PF01048	0.660
MOD_GlcNHglycan	531	534	PF01048	0.632
MOD_GlcNHglycan	550	553	PF01048	0.762
MOD_GlcNHglycan	561	564	PF01048	0.692
MOD_GlcNHglycan	573	576	PF01048	0.595
MOD_GlcNHglycan	600	603	PF01048	0.794
MOD_GlcNHglycan	606	609	PF01048	0.683
MOD_GlcNHglycan	629	632	PF01048	0.684
MOD_GlcNHglycan	725	728	PF01048	0.738
MOD_GlcNHglycan	729	732	PF01048	0.815
MOD_GlcNHglycan	73	76	PF01048	0.698
MOD_GlcNHglycan	841	844	PF01048	0.513
MOD_GSK3_1	11	18	PF00069	0.658
MOD_GSK3_1	125	132	PF00069	0.628
MOD_GSK3_1	140	147	PF00069	0.702
MOD_GSK3_1	150	157	PF00069	0.620
MOD_GSK3_1	161	168	PF00069	0.699
MOD_GSK3_1	175	182	PF00069	0.601
MOD_GSK3_1	190	197	PF00069	0.642
MOD_GSK3_1	297	304	PF00069	0.646
MOD_GSK3_1	39	46	PF00069	0.645
MOD_GSK3_1	428	435	PF00069	0.726
MOD_GSK3_1	49	56	PF00069	0.623
MOD_GSK3_1	519	526	PF00069	0.743
MOD_GSK3_1	557	564	PF00069	0.804
MOD_GSK3_1	571	578	PF00069	0.684
MOD_GSK3_1	594	601	PF00069	0.857
MOD_GSK3_1	604	611	PF00069	0.632
MOD_GSK3_1	615	622	PF00069	0.641
MOD_GSK3_1	655	662	PF00069	0.822
MOD_GSK3_1	663	670	PF00069	0.787
MOD_GSK3_1	691	698	PF00069	0.691
MOD_GSK3_1	71	78	PF00069	0.731
MOD_GSK3_1	723	730	PF00069	0.753
MOD_GSK3_1	759	766	PF00069	0.786
MOD_GSK3_1	780	787	PF00069	0.655
MOD_GSK3_1	793	800	PF00069	0.571
MOD_GSK3_1	806	813	PF00069	0.720
MOD_GSK3_1	819	826	PF00069	0.637
MOD_N-GLC_1	122	127	PF02516	0.583
MOD_N-GLC_1	809	814	PF02516	0.775
MOD_NEK2_1	154	159	PF00069	0.685
MOD_NEK2_1	310	315	PF00069	0.584
MOD_NEK2_1	422	427	PF00069	0.565
MOD_NEK2_1	481	486	PF00069	0.491
MOD_NEK2_1	548	553	PF00069	0.700
MOD_NEK2_1	570	575	PF00069	0.793
MOD_NEK2_1	664	669	PF00069	0.663
MOD_NEK2_1	691	696	PF00069	0.605
MOD_NEK2_1	782	787	PF00069	0.608
MOD_PIKK_1	194	200	PF00454	0.794
MOD_PIKK_1	365	371	PF00454	0.502
MOD_PIKK_1	458	464	PF00454	0.726
MOD_PIKK_1	589	595	PF00454	0.794
MOD_PIKK_1	659	665	PF00454	0.793
MOD_PK_1	148	154	PF00069	0.580
MOD_PK_1	757	763	PF00069	0.688
MOD_PKA_1	138	144	PF00069	0.688
MOD_PKA_2	138	144	PF00069	0.647
MOD_PKA_2	2	8	PF00069	0.639
MOD_PKA_2	236	242	PF00069	0.480
MOD_PKA_2	36	42	PF00069	0.611
MOD_PKA_2	386	392	PF00069	0.522
MOD_PKA_2	422	428	PF00069	0.647
MOD_PKA_2	491	497	PF00069	0.651
MOD_PKA_2	519	525	PF00069	0.719
MOD_PKA_2	598	604	PF00069	0.791
MOD_PKA_2	691	697	PF00069	0.550
MOD_PKA_2	774	780	PF00069	0.788
MOD_PKA_2	796	802	PF00069	0.716
MOD_PKB_1	755	763	PF00069	0.658
MOD_Plk_1	310	316	PF00069	0.574
MOD_Plk_1	757	763	PF00069	0.688
MOD_Plk_2-3	432	438	PF00069	0.529
MOD_Plk_4	104	110	PF00069	0.669
MOD_Plk_4	140	146	PF00069	0.644
MOD_Plk_4	339	345	PF00069	0.469
MOD_Plk_4	777	783	PF00069	0.612
MOD_ProDKin_1	101	107	PF00069	0.736
MOD_ProDKin_1	11	17	PF00069	0.659
MOD_ProDKin_1	129	135	PF00069	0.669
MOD_ProDKin_1	175	181	PF00069	0.660
MOD_ProDKin_1	188	194	PF00069	0.652
MOD_ProDKin_1	22	28	PF00069	0.665
MOD_ProDKin_1	287	293	PF00069	0.723
MOD_ProDKin_1	294	300	PF00069	0.607
MOD_ProDKin_1	318	324	PF00069	0.453
MOD_ProDKin_1	43	49	PF00069	0.583
MOD_ProDKin_1	445	451	PF00069	0.669
MOD_ProDKin_1	554	560	PF00069	0.682
MOD_ProDKin_1	564	570	PF00069	0.764
MOD_ProDKin_1	575	581	PF00069	0.634
MOD_ProDKin_1	586	592	PF00069	0.699
MOD_ProDKin_1	615	621	PF00069	0.669
MOD_ProDKin_1	656	662	PF00069	0.768
TRG_DiLeu_BaEn_4	417	423	PF01217	0.504
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.557
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.542
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.534
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.724
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.648
TRG_ENDOCYTIC_2	352	355	PF00928	0.454
TRG_ER_diArg_1	136	139	PF00400	0.728
TRG_ER_diArg_1	207	209	PF00400	0.635
TRG_ER_diArg_1	26	29	PF00400	0.852
TRG_ER_diArg_1	422	424	PF00400	0.518
TRG_ER_diArg_1	47	49	PF00400	0.574
TRG_ER_diArg_1	491	493	PF00400	0.509
TRG_ER_diArg_1	506	509	PF00400	0.583
TRG_ER_diArg_1	754	757	PF00400	0.768
TRG_ER_diArg_1	847	849	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	493	497	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L2	Leptomonas seymouri	37%	100%
A0A3S5H7S7	Leishmania donovani	86%	99%
A4HKR7	Leishmania braziliensis	66%	99%
A4I897	Leishmania infantum	87%	98%
E9B355	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%