Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP109

Species:

Leishmania major

UniProt:

Q4Q4Z7_LEIMA

TriTrypDb:

LmjF.32.2780 , LMJLV39_320035300 , LMJSD75_320035500

Length:

1094

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0031080	nuclear pore outer ring	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q4Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.614
CLV_C14_Caspase3-7	507	511	PF00656	0.362
CLV_NRD_NRD_1	2	4	PF00675	0.641
CLV_NRD_NRD_1	5	7	PF00675	0.569
CLV_NRD_NRD_1	620	622	PF00675	0.685
CLV_PCSK_FUR_1	3	7	PF00082	0.662
CLV_PCSK_KEX2_1	4	6	PF00082	0.602
CLV_PCSK_KEX2_1	620	622	PF00082	0.685
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.681
CLV_PCSK_SKI1_1	115	119	PF00082	0.570
CLV_PCSK_SKI1_1	5	9	PF00082	0.562
CLV_PCSK_SKI1_1	519	523	PF00082	0.492
CLV_PCSK_SKI1_1	589	593	PF00082	0.459
CLV_PCSK_SKI1_1	612	616	PF00082	0.534
CLV_PCSK_SKI1_1	751	755	PF00082	0.572
CLV_PCSK_SKI1_1	932	936	PF00082	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.716
DEG_SPOP_SBC_1	1074	1078	PF00917	0.813
DOC_ANK_TNKS_1	1039	1046	PF00023	0.683
DOC_CYCLIN_RxL_1	609	618	PF00134	0.538
DOC_CYCLIN_RxL_1	929	939	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.555
DOC_MAPK_gen_1	3	9	PF00069	0.646
DOC_MAPK_gen_1	589	597	PF00069	0.522
DOC_MAPK_gen_1	709	719	PF00069	0.536
DOC_MAPK_MEF2A_6	161	168	PF00069	0.688
DOC_MAPK_MEF2A_6	367	375	PF00069	0.565
DOC_MAPK_MEF2A_6	889	896	PF00069	0.496
DOC_PP1_RVXF_1	113	120	PF00149	0.579
DOC_PP1_RVXF_1	284	290	PF00149	0.520
DOC_PP2B_LxvP_1	272	275	PF13499	0.582
DOC_PP2B_LxvP_1	49	52	PF13499	0.732
DOC_PP2B_LxvP_1	650	653	PF13499	0.499
DOC_PP2B_LxvP_1	764	767	PF13499	0.542
DOC_PP2B_LxvP_1	772	775	PF13499	0.477
DOC_PP2B_LxvP_1	973	976	PF13499	0.684
DOC_PP4_FxxP_1	719	722	PF00568	0.476
DOC_USP7_MATH_1	1070	1074	PF00917	0.799
DOC_USP7_MATH_1	1075	1079	PF00917	0.819
DOC_USP7_MATH_1	1083	1087	PF00917	0.555
DOC_USP7_MATH_1	24	28	PF00917	0.652
DOC_USP7_MATH_1	245	249	PF00917	0.716
DOC_USP7_MATH_1	278	282	PF00917	0.699
DOC_USP7_MATH_1	333	337	PF00917	0.771
DOC_USP7_MATH_1	341	345	PF00917	0.645
DOC_USP7_MATH_1	393	397	PF00917	0.686
DOC_USP7_MATH_1	466	470	PF00917	0.749
DOC_USP7_MATH_1	50	54	PF00917	0.652
DOC_USP7_MATH_1	553	557	PF00917	0.550
DOC_USP7_MATH_1	566	570	PF00917	0.470
DOC_USP7_MATH_1	655	659	PF00917	0.527
DOC_USP7_MATH_1	664	668	PF00917	0.366
DOC_USP7_MATH_1	691	695	PF00917	0.677
DOC_USP7_MATH_1	698	702	PF00917	0.545
DOC_USP7_MATH_1	81	85	PF00917	0.573
DOC_USP7_MATH_1	822	826	PF00917	0.587
DOC_WW_Pin1_4	1077	1082	PF00397	0.767
DOC_WW_Pin1_4	136	141	PF00397	0.757
DOC_WW_Pin1_4	179	184	PF00397	0.623
DOC_WW_Pin1_4	276	281	PF00397	0.655
DOC_WW_Pin1_4	412	417	PF00397	0.573
DOC_WW_Pin1_4	636	641	PF00397	0.503
DOC_WW_Pin1_4	669	674	PF00397	0.570
DOC_WW_Pin1_4	867	872	PF00397	0.480
DOC_WW_Pin1_4	90	95	PF00397	0.639
DOC_WW_Pin1_4	911	916	PF00397	0.657
LIG_14-3-3_CanoR_1	1056	1061	PF00244	0.660
LIG_14-3-3_CanoR_1	234	240	PF00244	0.657
LIG_14-3-3_CanoR_1	254	258	PF00244	0.728
LIG_14-3-3_CanoR_1	286	296	PF00244	0.357
LIG_14-3-3_CanoR_1	342	347	PF00244	0.662
LIG_14-3-3_CanoR_1	5	10	PF00244	0.565
LIG_14-3-3_CanoR_1	541	551	PF00244	0.600
LIG_14-3-3_CanoR_1	596	604	PF00244	0.499
LIG_14-3-3_CanoR_1	620	625	PF00244	0.584
LIG_14-3-3_CanoR_1	932	942	PF00244	0.637
LIG_14-3-3_CanoR_1	99	107	PF00244	0.714
LIG_Actin_WH2_2	576	594	PF00022	0.557
LIG_Actin_WH2_2	776	793	PF00022	0.552
LIG_Actin_WH2_2	806	823	PF00022	0.413
LIG_APCC_ABBA_1	373	378	PF00400	0.620
LIG_BIR_III_4	392	396	PF00653	0.621
LIG_BIR_III_4	692	696	PF00653	0.616
LIG_Clathr_ClatBox_1	163	167	PF01394	0.611
LIG_FHA_1	112	118	PF00498	0.600
LIG_FHA_1	180	186	PF00498	0.570
LIG_FHA_1	210	216	PF00498	0.542
LIG_FHA_1	269	275	PF00498	0.598
LIG_FHA_1	345	351	PF00498	0.694
LIG_FHA_1	406	412	PF00498	0.566
LIG_FHA_1	520	526	PF00498	0.467
LIG_FHA_1	599	605	PF00498	0.558
LIG_FHA_2	387	393	PF00498	0.636
LIG_FHA_2	42	48	PF00498	0.620
LIG_FHA_2	70	76	PF00498	0.633
LIG_FHA_2	912	918	PF00498	0.602
LIG_GBD_Chelix_1	573	581	PF00786	0.302
LIG_GBD_Chelix_1	872	880	PF00786	0.486
LIG_LIR_Gen_1	238	247	PF02991	0.650
LIG_LIR_Gen_1	713	723	PF02991	0.528
LIG_LIR_Gen_1	829	839	PF02991	0.538
LIG_LIR_Nem_3	238	243	PF02991	0.657
LIG_LIR_Nem_3	293	299	PF02991	0.487
LIG_LIR_Nem_3	556	562	PF02991	0.484
LIG_LIR_Nem_3	683	687	PF02991	0.542
LIG_LIR_Nem_3	713	718	PF02991	0.524
LIG_LIR_Nem_3	727	733	PF02991	0.362
LIG_NRBOX	534	540	PF00104	0.545
LIG_NRBOX	785	791	PF00104	0.514
LIG_NRBOX	930	936	PF00104	0.615
LIG_PCNA_yPIPBox_3	16	29	PF02747	0.691
LIG_PCNA_yPIPBox_3	532	541	PF02747	0.550
LIG_Pex14_1	711	715	PF04695	0.516
LIG_Pex14_2	715	719	PF04695	0.463
LIG_Rb_pABgroove_1	826	834	PF01858	0.339
LIG_RPA_C_Fungi	565	577	PF08784	0.433
LIG_SH2_CRK	406	410	PF00017	0.586
LIG_SH2_CRK	536	540	PF00017	0.543
LIG_SH2_CRK	559	563	PF00017	0.474
LIG_SH2_CRK	682	686	PF00017	0.542
LIG_SH2_CRK	851	855	PF00017	0.562
LIG_SH2_NCK_1	240	244	PF00017	0.653
LIG_SH2_NCK_1	800	804	PF00017	0.495
LIG_SH2_PTP2	684	687	PF00017	0.572
LIG_SH2_PTP2	897	900	PF00017	0.492
LIG_SH2_SRC	240	243	PF00017	0.734
LIG_SH2_SRC	903	906	PF00017	0.432
LIG_SH2_STAP1	240	244	PF00017	0.731
LIG_SH2_STAP1	429	433	PF00017	0.507
LIG_SH2_STAP1	575	579	PF00017	0.485
LIG_SH2_STAP1	903	907	PF00017	0.428
LIG_SH2_STAT3	429	432	PF00017	0.556
LIG_SH2_STAT5	457	460	PF00017	0.610
LIG_SH2_STAT5	684	687	PF00017	0.482
LIG_SH2_STAT5	800	803	PF00017	0.516
LIG_SH2_STAT5	897	900	PF00017	0.410
LIG_SH2_STAT5	930	933	PF00017	0.540
LIG_SH3_3	142	148	PF00018	0.682
LIG_SH3_3	34	40	PF00018	0.674
LIG_SH3_3	376	382	PF00018	0.581
LIG_SH3_3	842	848	PF00018	0.334
LIG_SH3_3	865	871	PF00018	0.478
LIG_SH3_3	952	958	PF00018	0.685
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.475
LIG_SUMO_SIM_par_1	162	167	PF11976	0.691
LIG_SUMO_SIM_par_1	721	727	PF11976	0.504
LIG_SUMO_SIM_par_1	946	952	PF11976	0.543
LIG_TRAF2_1	511	514	PF00917	0.501
LIG_TRAF2_1	72	75	PF00917	0.688
LIG_TYR_ITIM	404	409	PF00017	0.592
LIG_TYR_ITIM	557	562	PF00017	0.484
LIG_TYR_ITIM	680	685	PF00017	0.518
LIG_TYR_ITIM	849	854	PF00017	0.542
LIG_UBA3_1	583	592	PF00899	0.443
LIG_WRC_WIRS_1	25	30	PF05994	0.616
MOD_CDK_SPxK_1	90	96	PF00069	0.610
MOD_CK1_1	1073	1079	PF00069	0.735
MOD_CK1_1	1086	1092	PF00069	0.676
MOD_CK1_1	300	306	PF00069	0.548
MOD_CK1_1	336	342	PF00069	0.775
MOD_CK1_1	344	350	PF00069	0.659
MOD_CK1_1	492	498	PF00069	0.543
MOD_CK1_1	598	604	PF00069	0.596
MOD_CK1_1	911	917	PF00069	0.616
MOD_CK1_1	933	939	PF00069	0.661
MOD_CK1_1	98	104	PF00069	0.629
MOD_CK2_1	1059	1065	PF00069	0.803
MOD_CK2_1	314	320	PF00069	0.748
MOD_CK2_1	41	47	PF00069	0.660
MOD_CK2_1	508	514	PF00069	0.516
MOD_CK2_1	625	631	PF00069	0.670
MOD_CK2_1	69	75	PF00069	0.630
MOD_CK2_1	698	704	PF00069	0.622
MOD_CK2_1	799	805	PF00069	0.514
MOD_CK2_1	992	998	PF00069	0.761
MOD_GlcNHglycan	1002	1005	PF01048	0.723
MOD_GlcNHglycan	1014	1017	PF01048	0.794
MOD_GlcNHglycan	1024	1027	PF01048	0.710
MOD_GlcNHglycan	1072	1075	PF01048	0.741
MOD_GlcNHglycan	1085	1088	PF01048	0.755
MOD_GlcNHglycan	119	122	PF01048	0.519
MOD_GlcNHglycan	247	250	PF01048	0.670
MOD_GlcNHglycan	280	283	PF01048	0.654
MOD_GlcNHglycan	316	319	PF01048	0.711
MOD_GlcNHglycan	336	339	PF01048	0.474
MOD_GlcNHglycan	448	451	PF01048	0.680
MOD_GlcNHglycan	469	472	PF01048	0.761
MOD_GlcNHglycan	510	513	PF01048	0.523
MOD_GlcNHglycan	544	547	PF01048	0.594
MOD_GlcNHglycan	636	639	PF01048	0.621
MOD_GlcNHglycan	662	665	PF01048	0.540
MOD_GlcNHglycan	688	692	PF01048	0.572
MOD_GlcNHglycan	693	696	PF01048	0.611
MOD_GlcNHglycan	801	804	PF01048	0.624
MOD_GlcNHglycan	83	86	PF01048	0.611
MOD_GlcNHglycan	859	862	PF01048	0.455
MOD_GlcNHglycan	911	914	PF01048	0.598
MOD_GlcNHglycan	935	938	PF01048	0.585
MOD_GlcNHglycan	960	965	PF01048	0.752
MOD_GlcNHglycan	973	976	PF01048	0.604
MOD_GlcNHglycan	981	984	PF01048	0.688
MOD_GlcNHglycan	994	997	PF01048	0.670
MOD_GSK3_1	1018	1025	PF00069	0.687
MOD_GSK3_1	1035	1042	PF00069	0.548
MOD_GSK3_1	1055	1062	PF00069	0.630
MOD_GSK3_1	1065	1072	PF00069	0.679
MOD_GSK3_1	107	114	PF00069	0.567
MOD_GSK3_1	1073	1080	PF00069	0.581
MOD_GSK3_1	1083	1090	PF00069	0.464
MOD_GSK3_1	341	348	PF00069	0.670
MOD_GSK3_1	362	369	PF00069	0.705
MOD_GSK3_1	474	481	PF00069	0.706
MOD_GSK3_1	489	496	PF00069	0.381
MOD_GSK3_1	542	549	PF00069	0.570
MOD_GSK3_1	620	627	PF00069	0.546
MOD_GSK3_1	660	667	PF00069	0.485
MOD_GSK3_1	687	694	PF00069	0.553
MOD_GSK3_1	724	731	PF00069	0.497
MOD_GSK3_1	872	879	PF00069	0.464
MOD_GSK3_1	926	933	PF00069	0.536
MOD_GSK3_1	95	102	PF00069	0.598
MOD_NEK2_1	193	198	PF00069	0.632
MOD_NEK2_1	355	360	PF00069	0.530
MOD_NEK2_1	386	391	PF00069	0.493
MOD_NEK2_1	446	451	PF00069	0.669
MOD_NEK2_1	482	487	PF00069	0.576
MOD_NEK2_1	508	513	PF00069	0.520
MOD_NEK2_1	615	620	PF00069	0.560
MOD_NEK2_1	634	639	PF00069	0.561
MOD_NEK2_1	680	685	PF00069	0.383
MOD_NEK2_1	935	940	PF00069	0.666
MOD_NEK2_1	95	100	PF00069	0.658
MOD_NEK2_1	978	983	PF00069	0.687
MOD_NEK2_2	728	733	PF00069	0.470
MOD_PIKK_1	336	342	PF00454	0.799
MOD_PIKK_1	345	351	PF00454	0.517
MOD_PIKK_1	444	450	PF00454	0.585
MOD_PIKK_1	916	922	PF00454	0.585
MOD_PK_1	620	626	PF00069	0.622
MOD_PKA_1	5	11	PF00069	0.566
MOD_PKA_1	620	626	PF00069	0.676
MOD_PKA_2	1039	1045	PF00069	0.743
MOD_PKA_2	1055	1061	PF00069	0.606
MOD_PKA_2	1065	1071	PF00069	0.702
MOD_PKA_2	233	239	PF00069	0.728
MOD_PKA_2	253	259	PF00069	0.674
MOD_PKA_2	341	347	PF00069	0.724
MOD_PKA_2	5	11	PF00069	0.566
MOD_PKA_2	508	514	PF00069	0.522
MOD_PKA_2	595	601	PF00069	0.491
MOD_PKA_2	620	626	PF00069	0.634
MOD_PKA_2	711	717	PF00069	0.525
MOD_PKA_2	835	841	PF00069	0.502
MOD_PKA_2	95	101	PF00069	0.701
MOD_PKB_1	3	11	PF00069	0.645
MOD_Plk_1	193	199	PF00069	0.687
MOD_Plk_1	209	215	PF00069	0.483
MOD_Plk_1	290	296	PF00069	0.407
MOD_Plk_1	519	525	PF00069	0.608
MOD_Plk_1	655	661	PF00069	0.584
MOD_Plk_1	876	882	PF00069	0.486
MOD_Plk_1	960	966	PF00069	0.682
MOD_Plk_4	1056	1062	PF00069	0.702
MOD_Plk_4	209	215	PF00069	0.543
MOD_Plk_4	24	30	PF00069	0.627
MOD_Plk_4	253	259	PF00069	0.725
MOD_Plk_4	290	296	PF00069	0.437
MOD_Plk_4	300	306	PF00069	0.402
MOD_Plk_4	366	372	PF00069	0.617
MOD_Plk_4	457	463	PF00069	0.566
MOD_Plk_4	482	488	PF00069	0.632
MOD_Plk_4	519	525	PF00069	0.544
MOD_Plk_4	610	616	PF00069	0.557
MOD_Plk_4	620	626	PF00069	0.540
MOD_Plk_4	680	686	PF00069	0.519
MOD_Plk_4	711	717	PF00069	0.525
MOD_Plk_4	749	755	PF00069	0.661
MOD_Plk_4	926	932	PF00069	0.545
MOD_ProDKin_1	1077	1083	PF00069	0.767
MOD_ProDKin_1	136	142	PF00069	0.756
MOD_ProDKin_1	179	185	PF00069	0.632
MOD_ProDKin_1	276	282	PF00069	0.644
MOD_ProDKin_1	412	418	PF00069	0.561
MOD_ProDKin_1	636	642	PF00069	0.490
MOD_ProDKin_1	669	675	PF00069	0.562
MOD_ProDKin_1	867	873	PF00069	0.471
MOD_ProDKin_1	90	96	PF00069	0.649
MOD_ProDKin_1	911	917	PF00069	0.658
MOD_SUMO_rev_2	743	752	PF00179	0.617
MOD_SUMO_rev_2	938	948	PF00179	0.629
TRG_DiLeu_BaEn_1	713	718	PF01217	0.542
TRG_DiLeu_BaEn_1	840	845	PF01217	0.539
TRG_DiLeu_BaEn_2	673	679	PF01217	0.451
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.542
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.455
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.256
TRG_DiLeu_BaLyEn_6	811	816	PF01217	0.534
TRG_DiLeu_BaLyEn_6	973	978	PF01217	0.694
TRG_ENDOCYTIC_2	240	243	PF00928	0.656
TRG_ENDOCYTIC_2	406	409	PF00928	0.586
TRG_ENDOCYTIC_2	536	539	PF00928	0.546
TRG_ENDOCYTIC_2	559	562	PF00928	0.474
TRG_ENDOCYTIC_2	575	578	PF00928	0.361
TRG_ENDOCYTIC_2	682	685	PF00928	0.439
TRG_ENDOCYTIC_2	832	835	PF00928	0.520
TRG_ENDOCYTIC_2	851	854	PF00928	0.492
TRG_ENDOCYTIC_2	897	900	PF00928	0.412
TRG_ER_diArg_1	3	6	PF00400	0.614
TRG_ER_diArg_1	619	621	PF00400	0.638
TRG_ER_diArg_1	70	73	PF00400	0.677
TRG_NLS_MonoCore_2	2	7	PF00514	0.670
TRG_NLS_MonoExtN_4	3	8	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML2	Leptomonas seymouri	52%	100%
A0A1X0NRY7	Trypanosomatidae	23%	100%
A0A3S5ISF7	Trypanosoma rangeli	24%	100%
A0A3S7X5V5	Leishmania donovani	93%	100%
A4HKR9	Leishmania braziliensis	78%	100%
A4I899	Leishmania infantum	92%	100%
E9B357	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%