Exonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase III epsilon subunit-like exonuclease

Species:

Leishmania major

UniProt:

Q4Q4Z6_LEIMA

TriTrypDb:

LmjF.32.2790 , LMJLV39_320035400 , LMJSD75_320035600

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004518	nuclease activity	4	5
GO:0004527	exonuclease activity	5	5
GO:0005488	binding	1	5
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.246
CLV_NRD_NRD_1	178	180	PF00675	0.385
CLV_NRD_NRD_1	26	28	PF00675	0.248
CLV_PCSK_KEX2_1	108	110	PF00082	0.246
CLV_PCSK_KEX2_1	178	180	PF00082	0.385
CLV_PCSK_KEX2_1	26	28	PF00082	0.248
DEG_Nend_UBRbox_4	1	3	PF02207	0.527
DOC_PP4_FxxP_1	115	118	PF00568	0.446
DOC_WW_Pin1_4	44	49	PF00397	0.552
LIG_14-3-3_CanoR_1	119	128	PF00244	0.391
LIG_14-3-3_CanoR_1	26	35	PF00244	0.446
LIG_CSL_BTD_1	115	118	PF09270	0.446
LIG_deltaCOP1_diTrp_1	6	16	PF00928	0.286
LIG_FHA_1	167	173	PF00498	0.446
LIG_GBD_Chelix_1	52	60	PF00786	0.171
LIG_LIR_Gen_1	125	136	PF02991	0.558
LIG_LIR_Gen_1	39	48	PF02991	0.417
LIG_LIR_Nem_3	125	131	PF02991	0.492
LIG_LIR_Nem_3	39	43	PF02991	0.423
LIG_LIR_Nem_3	47	52	PF02991	0.458
LIG_LYPXL_yS_3	133	136	PF13949	0.446
LIG_NRBOX	167	173	PF00104	0.446
LIG_Pex14_1	116	120	PF04695	0.446
LIG_Pex14_1	180	184	PF04695	0.388
LIG_Pex14_2	98	102	PF04695	0.464
LIG_SH2_CRK	59	63	PF00017	0.496
LIG_SH2_PTP2	19	22	PF00017	0.446
LIG_SH2_STAT5	19	22	PF00017	0.526
LIG_SH2_STAT6	111	115	PF00017	0.446
LIG_SH3_1	19	25	PF00018	0.446
LIG_SH3_2	22	27	PF14604	0.446
LIG_SH3_3	115	121	PF00018	0.446
LIG_SH3_3	128	134	PF00018	0.381
LIG_SH3_3	19	25	PF00018	0.417
LIG_SH3_3	83	89	PF00018	0.446
LIG_TYR_ITIM	131	136	PF00017	0.564
LIG_TYR_ITIM	57	62	PF00017	0.496
MOD_GlcNHglycan	28	31	PF01048	0.276
MOD_GlcNHglycan	69	72	PF01048	0.264
MOD_N-GLC_1	44	49	PF02516	0.171
MOD_N-GLC_1	94	99	PF02516	0.246
MOD_NEK2_1	122	127	PF00069	0.417
MOD_PKA_1	26	32	PF00069	0.446
MOD_PKA_2	20	26	PF00069	0.417
MOD_Plk_1	164	170	PF00069	0.446
MOD_Plk_1	94	100	PF00069	0.446
MOD_ProDKin_1	44	50	PF00069	0.552
TRG_ENDOCYTIC_2	112	115	PF00928	0.547
TRG_ENDOCYTIC_2	133	136	PF00928	0.522
TRG_ENDOCYTIC_2	59	62	PF00928	0.496
TRG_ER_diArg_1	107	109	PF00400	0.446
TRG_ER_diArg_1	178	180	PF00400	0.391
TRG_ER_diArg_1	25	27	PF00400	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5Y8	Leishmania donovani	93%	100%
A4I8A0	Leishmania infantum	93%	100%
P43745	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	73%
Q9CPE0	Pasteurella multocida (strain Pm70)	29%	74%
V5BHY6	Trypanosoma cruzi	33%	69%