Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q4Z4_LEIMA

TriTrypDb:

LmjF.32.2810 , LMJLV39_320035600 , LMJSD75_320035800

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.506
CLV_NRD_NRD_1	24	26	PF00675	0.450
CLV_NRD_NRD_1	293	295	PF00675	0.401
CLV_NRD_NRD_1	325	327	PF00675	0.531
CLV_NRD_NRD_1	399	401	PF00675	0.398
CLV_NRD_NRD_1	61	63	PF00675	0.645
CLV_NRD_NRD_1	7	9	PF00675	0.575
CLV_PCSK_KEX2_1	140	142	PF00082	0.254
CLV_PCSK_KEX2_1	202	204	PF00082	0.500
CLV_PCSK_KEX2_1	249	251	PF00082	0.537
CLV_PCSK_KEX2_1	325	327	PF00082	0.531
CLV_PCSK_KEX2_1	399	401	PF00082	0.400
CLV_PCSK_KEX2_1	423	425	PF00082	0.488
CLV_PCSK_KEX2_1	63	65	PF00082	0.637
CLV_PCSK_KEX2_1	7	9	PF00082	0.574
CLV_PCSK_KEX2_1	82	84	PF00082	0.479
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.319
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.500
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.545
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.546
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.637
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.591
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.479
CLV_PCSK_SKI1_1	140	144	PF00082	0.250
CLV_PCSK_SKI1_1	325	329	PF00082	0.397
CLV_PCSK_SKI1_1	355	359	PF00082	0.250
CLV_PCSK_SKI1_1	40	44	PF00082	0.591
CLV_PCSK_SKI1_1	420	424	PF00082	0.549
CLV_PCSK_SKI1_1	8	12	PF00082	0.615
DOC_CYCLIN_RxL_1	114	125	PF00134	0.450
DOC_MAPK_gen_1	223	232	PF00069	0.530
DOC_MAPK_gen_1	399	405	PF00069	0.356
DOC_PP2B_LxvP_1	268	271	PF13499	0.431
DOC_USP7_MATH_1	10	14	PF00917	0.528
DOC_USP7_MATH_1	364	368	PF00917	0.459
DOC_USP7_MATH_1	428	432	PF00917	0.567
DOC_USP7_MATH_1	443	447	PF00917	0.547
DOC_USP7_UBL2_3	248	252	PF12436	0.561
DOC_USP7_UBL2_3	3	7	PF12436	0.674
DOC_USP7_UBL2_3	31	35	PF12436	0.534
DOC_USP7_UBL2_3	36	40	PF12436	0.553
DOC_USP7_UBL2_3	55	59	PF12436	0.498
DOC_WW_Pin1_4	8	13	PF00397	0.531
LIG_14-3-3_CanoR_1	148	154	PF00244	0.484
LIG_14-3-3_CanoR_1	209	214	PF00244	0.595
LIG_14-3-3_CanoR_1	309	313	PF00244	0.431
LIG_14-3-3_CanoR_1	317	324	PF00244	0.436
LIG_14-3-3_CanoR_1	400	406	PF00244	0.364
LIG_14-3-3_CanoR_1	435	440	PF00244	0.475
LIG_Actin_WH2_2	409	425	PF00022	0.576
LIG_AP2alpha_2	217	219	PF02296	0.418
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	300	304	PF00533	0.435
LIG_deltaCOP1_diTrp_1	69	79	PF00928	0.515
LIG_FHA_1	154	160	PF00498	0.472
LIG_FHA_1	191	197	PF00498	0.526
LIG_FHA_1	361	367	PF00498	0.536
LIG_FHA_2	121	127	PF00498	0.475
LIG_FHA_2	219	225	PF00498	0.453
LIG_FHA_2	316	322	PF00498	0.446
LIG_FHA_2	341	347	PF00498	0.566
LIG_FHA_2	46	52	PF00498	0.690
LIG_LIR_Gen_1	134	144	PF02991	0.510
LIG_LIR_Gen_1	217	227	PF02991	0.385
LIG_LIR_Nem_3	134	139	PF02991	0.452
LIG_LIR_Nem_3	217	222	PF02991	0.357
LIG_LIR_Nem_3	224	230	PF02991	0.404
LIG_LIR_Nem_3	346	351	PF02991	0.443
LIG_LIR_Nem_3	367	373	PF02991	0.450
LIG_MLH1_MIPbox_1	300	304	PF16413	0.540
LIG_Pex14_2	132	136	PF04695	0.450
LIG_PTB_Apo_2	297	304	PF02174	0.514
LIG_PTB_Phospho_1	297	303	PF10480	0.506
LIG_RPA_C_Fungi	424	436	PF08784	0.468
LIG_SH2_CRK	351	355	PF00017	0.314
LIG_SH2_STAT3	173	176	PF00017	0.538
LIG_SH2_STAT3	262	265	PF00017	0.428
LIG_SH2_STAT5	131	134	PF00017	0.392
LIG_SH2_STAT5	262	265	PF00017	0.393
LIG_SH2_STAT5	283	286	PF00017	0.410
LIG_SH2_STAT5	303	306	PF00017	0.461
LIG_SH2_STAT5	335	338	PF00017	0.512
LIG_SH2_STAT5	47	50	PF00017	0.639
LIG_SH3_4	36	43	PF00018	0.591
LIG_TRAF2_1	123	126	PF00917	0.334
LIG_WRC_WIRS_1	402	407	PF05994	0.368
MOD_CK1_1	38	44	PF00069	0.599
MOD_CK1_1	437	443	PF00069	0.670
MOD_CK2_1	120	126	PF00069	0.295
MOD_CK2_1	315	321	PF00069	0.436
MOD_GlcNHglycan	136	139	PF01048	0.451
MOD_GlcNHglycan	153	156	PF01048	0.295
MOD_GlcNHglycan	162	165	PF01048	0.376
MOD_GlcNHglycan	180	184	PF01048	0.372
MOD_GlcNHglycan	242	245	PF01048	0.523
MOD_GlcNHglycan	272	275	PF01048	0.576
MOD_GlcNHglycan	410	413	PF01048	0.499
MOD_GlcNHglycan	66	69	PF01048	0.730
MOD_GSK3_1	127	134	PF00069	0.392
MOD_GSK3_1	147	154	PF00069	0.119
MOD_GSK3_1	190	197	PF00069	0.497
MOD_GSK3_1	218	225	PF00069	0.420
MOD_GSK3_1	231	238	PF00069	0.443
MOD_GSK3_1	360	367	PF00069	0.307
MOD_GSK3_1	434	441	PF00069	0.667
MOD_GSK3_1	45	52	PF00069	0.686
MOD_N-GLC_1	408	413	PF02516	0.364
MOD_NEK2_1	153	158	PF00069	0.303
MOD_NEK2_1	298	303	PF00069	0.429
MOD_NEK2_1	360	365	PF00069	0.391
MOD_NEK2_1	401	406	PF00069	0.366
MOD_NEK2_2	2	7	PF00069	0.650
MOD_NEK2_2	218	223	PF00069	0.403
MOD_NEK2_2	381	386	PF00069	0.387
MOD_NEK2_2	50	55	PF00069	0.680
MOD_PIKK_1	109	115	PF00454	0.436
MOD_PIKK_1	235	241	PF00454	0.522
MOD_PKA_1	248	254	PF00069	0.565
MOD_PKA_1	35	41	PF00069	0.629
MOD_PKA_1	58	64	PF00069	0.684
MOD_PKA_2	147	153	PF00069	0.362
MOD_PKA_2	222	228	PF00069	0.403
MOD_PKA_2	308	314	PF00069	0.481
MOD_PKA_2	428	434	PF00069	0.561
MOD_PKB_1	62	70	PF00069	0.742
MOD_Plk_1	179	185	PF00069	0.636
MOD_Plk_1	408	414	PF00069	0.370
MOD_Plk_1	50	56	PF00069	0.517
MOD_Plk_1	75	81	PF00069	0.713
MOD_Plk_2-3	91	97	PF00069	0.597
MOD_Plk_4	127	133	PF00069	0.423
MOD_Plk_4	209	215	PF00069	0.634
MOD_Plk_4	390	396	PF00069	0.422
MOD_ProDKin_1	8	14	PF00069	0.526
MOD_SUMO_rev_2	182	191	PF00179	0.625
TRG_DiLeu_BaEn_2	110	116	PF01217	0.463
TRG_ENDOCYTIC_2	283	286	PF00928	0.404
TRG_ENDOCYTIC_2	351	354	PF00928	0.314
TRG_ENDOCYTIC_2	370	373	PF00928	0.192
TRG_ER_diArg_1	145	148	PF00400	0.327
TRG_ER_diArg_1	324	326	PF00400	0.518
TRG_ER_diArg_1	399	401	PF00400	0.384
TRG_ER_diArg_1	424	427	PF00400	0.495
TRG_ER_diLys_1	442	447	PF00400	0.700
TRG_NLS_Bipartite_1	7	21	PF00514	0.525
TRG_NLS_MonoCore_2	15	20	PF00514	0.519
TRG_NLS_MonoCore_2	246	251	PF00514	0.559
TRG_NLS_MonoExtC_3	247	252	PF00514	0.547
TRG_NLS_MonoExtC_3	61	66	PF00514	0.629
TRG_NLS_MonoExtN_4	16	21	PF00514	0.505
TRG_NLS_MonoExtN_4	247	253	PF00514	0.544
TRG_NLS_MonoExtN_4	31	38	PF00514	0.493
TRG_NLS_MonoExtN_4	420	427	PF00514	0.538
TRG_NLS_MonoExtN_4	59	66	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M4	Leptomonas seymouri	84%	100%
A0A0S4IWT2	Bodo saltans	57%	100%
A0A1X0NSA9	Trypanosomatidae	63%	100%
A0A3Q8IG48	Leishmania donovani	96%	100%
A0A3R7N0S8	Trypanosoma rangeli	63%	100%
A4HKS2	Leishmania braziliensis	88%	100%
A4I8A2	Leishmania infantum	96%	100%
D0AAH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B360	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O74400	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	66%
V5BDC2	Trypanosoma cruzi	61%	92%