Prefoldin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin

Gene product:

prefoldin subunit, putative

Species:

Leishmania major

UniProt:

Q4Q4Z1_LEIMA

TriTrypDb:

LmjF.32.2840 , LMJLV39_320035900 , LMJSD75_320036100

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z1

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010563	negative regulation of phosphorus metabolic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010921	regulation of phosphatase activity	5	2
GO:0010923	negative regulation of phosphatase activity	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019220	regulation of phosphate metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0035303	regulation of dephosphorylation	7	2
GO:0035305	negative regulation of dephosphorylation	8	2
GO:0043086	negative regulation of catalytic activity	4	2
GO:0044092	negative regulation of molecular function	3	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0045936	negative regulation of phosphate metabolic process	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051174	regulation of phosphorus metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051346	negative regulation of hydrolase activity	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0003712	transcription coregulator activity	2	2
GO:0003714	transcription corepressor activity	3	2
GO:0004857	enzyme inhibitor activity	3	2
GO:0005488	binding	1	2
GO:0019208	phosphatase regulator activity	3	2
GO:0019212	phosphatase inhibitor activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2
GO:0140110	transcription regulator activity	1	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.655
CLV_NRD_NRD_1	101	103	PF00675	0.292
CLV_NRD_NRD_1	107	109	PF00675	0.292
CLV_NRD_NRD_1	285	287	PF00675	0.457
CLV_NRD_NRD_1	293	295	PF00675	0.446
CLV_NRD_NRD_1	445	447	PF00675	0.664
CLV_NRD_NRD_1	473	475	PF00675	0.586
CLV_NRD_NRD_1	55	57	PF00675	0.300
CLV_NRD_NRD_1	556	558	PF00675	0.530
CLV_PCSK_FUR_1	52	56	PF00082	0.300
CLV_PCSK_KEX2_1	101	103	PF00082	0.292
CLV_PCSK_KEX2_1	107	109	PF00082	0.292
CLV_PCSK_KEX2_1	285	287	PF00082	0.444
CLV_PCSK_KEX2_1	293	295	PF00082	0.497
CLV_PCSK_KEX2_1	445	447	PF00082	0.587
CLV_PCSK_KEX2_1	473	475	PF00082	0.586
CLV_PCSK_KEX2_1	54	56	PF00082	0.300
CLV_PCSK_KEX2_1	556	558	PF00082	0.530
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.530
CLV_PCSK_PC7_1	552	558	PF00082	0.520
CLV_PCSK_SKI1_1	273	277	PF00082	0.483
CLV_PCSK_SKI1_1	418	422	PF00082	0.516
CLV_PCSK_SKI1_1	55	59	PF00082	0.300
CLV_PCSK_SKI1_1	558	562	PF00082	0.572
DEG_APCC_DBOX_1	54	62	PF00400	0.500
DEG_SCF_FBW7_1	213	220	PF00400	0.739
DEG_SPOP_SBC_1	223	227	PF00917	0.660
DEG_SPOP_SBC_1	404	408	PF00917	0.628
DEG_SPOP_SBC_1	433	437	PF00917	0.633
DOC_CKS1_1	361	366	PF01111	0.590
DOC_CYCLIN_RxL_1	552	564	PF00134	0.545
DOC_MAPK_gen_1	445	453	PF00069	0.661
DOC_PP1_RVXF_1	99	106	PF00149	0.435
DOC_PP2B_LxvP_1	375	378	PF13499	0.615
DOC_PP4_MxPP_1	542	545	PF00568	0.548
DOC_USP7_MATH_1	172	176	PF00917	0.660
DOC_USP7_MATH_1	180	184	PF00917	0.675
DOC_USP7_MATH_1	185	189	PF00917	0.592
DOC_USP7_MATH_1	224	228	PF00917	0.766
DOC_USP7_MATH_1	341	345	PF00917	0.733
DOC_USP7_MATH_1	371	375	PF00917	0.667
DOC_USP7_MATH_1	390	394	PF00917	0.497
DOC_USP7_MATH_1	405	409	PF00917	0.465
DOC_USP7_MATH_1	413	417	PF00917	0.594
DOC_USP7_MATH_1	419	423	PF00917	0.583
DOC_USP7_MATH_1	433	437	PF00917	0.566
DOC_USP7_MATH_1	441	445	PF00917	0.642
DOC_USP7_MATH_1	88	92	PF00917	0.457
DOC_USP7_UBL2_3	554	558	PF12436	0.644
DOC_WW_Pin1_4	151	156	PF00397	0.743
DOC_WW_Pin1_4	187	192	PF00397	0.740
DOC_WW_Pin1_4	196	201	PF00397	0.721
DOC_WW_Pin1_4	213	218	PF00397	0.593
DOC_WW_Pin1_4	219	224	PF00397	0.579
DOC_WW_Pin1_4	360	365	PF00397	0.602
DOC_WW_Pin1_4	497	502	PF00397	0.511
LIG_14-3-3_CanoR_1	201	209	PF00244	0.584
LIG_14-3-3_CanoR_1	273	280	PF00244	0.484
LIG_14-3-3_CanoR_1	304	314	PF00244	0.491
LIG_14-3-3_CanoR_1	317	326	PF00244	0.518
LIG_14-3-3_CanoR_1	418	428	PF00244	0.523
LIG_14-3-3_CanoR_1	490	497	PF00244	0.575
LIG_14-3-3_CanoR_1	505	513	PF00244	0.585
LIG_14-3-3_CanoR_1	557	561	PF00244	0.536
LIG_BIR_III_2	383	387	PF00653	0.605
LIG_BRCT_BRCA1_1	198	202	PF00533	0.589
LIG_Clathr_ClatBox_1	254	258	PF01394	0.438
LIG_FHA_1	404	410	PF00498	0.749
LIG_FHA_1	43	49	PF00498	0.513
LIG_FHA_1	498	504	PF00498	0.605
LIG_FHA_1	505	511	PF00498	0.560
LIG_FHA_1	73	79	PF00498	0.457
LIG_FHA_2	11	17	PF00498	0.472
LIG_FHA_2	239	245	PF00498	0.588
LIG_FHA_2	248	254	PF00498	0.420
LIG_FHA_2	361	367	PF00498	0.618
LIG_FHA_2	39	45	PF00498	0.504
LIG_LIR_Apic_2	360	364	PF02991	0.571
LIG_LIR_Gen_1	16	22	PF02991	0.418
LIG_LIR_Gen_1	232	240	PF02991	0.557
LIG_LIR_Gen_1	38	46	PF02991	0.470
LIG_LIR_Nem_3	16	21	PF02991	0.365
LIG_LIR_Nem_3	232	236	PF02991	0.558
LIG_LIR_Nem_3	38	42	PF02991	0.470
LIG_MYND_1	209	213	PF01753	0.547
LIG_MYND_1	314	318	PF01753	0.534
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.516
LIG_PDZ_Class_3	565	570	PF00595	0.608
LIG_SH2_CRK	361	365	PF00017	0.648
LIG_SH2_CRK	39	43	PF00017	0.500
LIG_SH2_NCK_1	233	237	PF00017	0.497
LIG_SH2_STAP1	68	72	PF00017	0.505
LIG_SH2_STAT5	18	21	PF00017	0.396
LIG_SH3_3	162	168	PF00018	0.623
LIG_SH3_3	375	381	PF00018	0.613
LIG_SH3_3	397	403	PF00018	0.598
LIG_SH3_3	475	481	PF00018	0.592
LIG_SH3_3	538	544	PF00018	0.598
LIG_SH3_3	54	60	PF00018	0.492
LIG_SH3_4	554	561	PF00018	0.584
LIG_SH3_CIN85_PxpxPR_1	196	201	PF14604	0.519
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.500
LIG_SUMO_SIM_par_1	250	258	PF11976	0.477
LIG_SUMO_SIM_par_1	544	549	PF11976	0.498
LIG_SUMO_SIM_par_1	77	84	PF11976	0.465
LIG_TRAF2_1	122	125	PF00917	0.488
LIG_TRAF2_1	168	171	PF00917	0.625
LIG_TRAF2_1	354	357	PF00917	0.537
LIG_TYR_ITIM	231	236	PF00017	0.527
LIG_WRC_WIRS_1	240	245	PF05994	0.566
MOD_CDK_SPK_2	196	201	PF00069	0.584
MOD_CK1_1	156	162	PF00069	0.758
MOD_CK1_1	175	181	PF00069	0.690
MOD_CK1_1	204	210	PF00069	0.736
MOD_CK1_1	305	311	PF00069	0.503
MOD_CK1_1	348	354	PF00069	0.773
MOD_CK1_1	407	413	PF00069	0.671
MOD_CK1_1	432	438	PF00069	0.647
MOD_CK1_1	461	467	PF00069	0.531
MOD_CK2_1	10	16	PF00069	0.426
MOD_CK2_1	239	245	PF00069	0.522
MOD_CK2_1	247	253	PF00069	0.422
MOD_CK2_1	351	357	PF00069	0.596
MOD_CK2_1	392	398	PF00069	0.715
MOD_Cter_Amidation	99	102	PF01082	0.257
MOD_DYRK1A_RPxSP_1	187	191	PF00069	0.513
MOD_GlcNHglycan	175	178	PF01048	0.691
MOD_GlcNHglycan	182	185	PF01048	0.707
MOD_GlcNHglycan	186	190	PF01048	0.693
MOD_GlcNHglycan	204	207	PF01048	0.513
MOD_GlcNHglycan	226	229	PF01048	0.652
MOD_GlcNHglycan	294	297	PF01048	0.563
MOD_GlcNHglycan	319	322	PF01048	0.650
MOD_GlcNHglycan	338	341	PF01048	0.710
MOD_GlcNHglycan	343	346	PF01048	0.675
MOD_GlcNHglycan	415	418	PF01048	0.627
MOD_GlcNHglycan	421	424	PF01048	0.571
MOD_GlcNHglycan	431	434	PF01048	0.542
MOD_GlcNHglycan	436	439	PF01048	0.634
MOD_GlcNHglycan	491	494	PF01048	0.619
MOD_GlcNHglycan	525	528	PF01048	0.670
MOD_GlcNHglycan	548	551	PF01048	0.628
MOD_GlcNHglycan	89	93	PF01048	0.257
MOD_GSK3_1	212	219	PF00069	0.704
MOD_GSK3_1	341	348	PF00069	0.693
MOD_GSK3_1	38	45	PF00069	0.504
MOD_GSK3_1	388	395	PF00069	0.684
MOD_GSK3_1	403	410	PF00069	0.607
MOD_GSK3_1	428	435	PF00069	0.630
MOD_GSK3_1	457	464	PF00069	0.630
MOD_GSK3_1	499	506	PF00069	0.761
MOD_N-GLC_1	302	307	PF02516	0.518
MOD_N-GLC_1	348	353	PF02516	0.661
MOD_N-GLC_1	72	77	PF02516	0.300
MOD_NEK2_1	202	207	PF00069	0.620
MOD_NEK2_1	231	236	PF00069	0.527
MOD_NEK2_1	42	47	PF00069	0.481
MOD_NEK2_1	503	508	PF00069	0.613
MOD_NEK2_1	546	551	PF00069	0.591
MOD_NEK2_1	72	77	PF00069	0.457
MOD_PIKK_1	153	159	PF00454	0.638
MOD_PIKK_1	166	172	PF00454	0.697
MOD_PKA_1	556	562	PF00069	0.536
MOD_PKA_2	144	150	PF00069	0.528
MOD_PKA_2	292	298	PF00069	0.527
MOD_PKA_2	316	322	PF00069	0.519
MOD_PKA_2	489	495	PF00069	0.582
MOD_PKA_2	504	510	PF00069	0.584
MOD_PKA_2	556	562	PF00069	0.536
MOD_Plk_1	231	237	PF00069	0.684
MOD_Plk_1	88	94	PF00069	0.492
MOD_Plk_2-3	232	238	PF00069	0.522
MOD_Plk_2-3	247	253	PF00069	0.415
MOD_Plk_2-3	38	44	PF00069	0.504
MOD_Plk_4	461	467	PF00069	0.539
MOD_Plk_4	499	505	PF00069	0.644
MOD_Plk_4	537	543	PF00069	0.536
MOD_Plk_4	556	562	PF00069	0.568
MOD_Plk_4	74	80	PF00069	0.500
MOD_ProDKin_1	151	157	PF00069	0.745
MOD_ProDKin_1	187	193	PF00069	0.740
MOD_ProDKin_1	196	202	PF00069	0.723
MOD_ProDKin_1	213	219	PF00069	0.594
MOD_ProDKin_1	360	366	PF00069	0.602
MOD_ProDKin_1	497	503	PF00069	0.510
MOD_SUMO_for_1	122	125	PF00179	0.488
MOD_SUMO_for_1	281	284	PF00179	0.474
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.540
TRG_ENDOCYTIC_2	18	21	PF00928	0.419
TRG_ENDOCYTIC_2	233	236	PF00928	0.518
TRG_ENDOCYTIC_2	39	42	PF00928	0.457
TRG_ER_diArg_1	101	103	PF00400	0.460
TRG_ER_diArg_1	106	108	PF00400	0.475
TRG_ER_diArg_1	285	288	PF00400	0.504
TRG_ER_diArg_1	473	475	PF00400	0.564
TRG_ER_diArg_1	52	55	PF00400	0.457
TRG_NLS_MonoExtN_4	554	560	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M6	Leptomonas seymouri	45%	100%
A0A3S7X5Y7	Leishmania donovani	89%	100%
A4HKS5	Leishmania braziliensis	68%	100%
A4I8A5	Leishmania infantum	89%	100%
E9B363	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BHZ0	Trypanosoma cruzi	38%	100%