Dynein axonemal assembly factor 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain/TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4Q4Z0_LEIMA

TriTrypDb:

LmjF.32.2850 , LMJLV39_320036000 , LMJSD75_320036200

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	2
GO:0042995	cell projection	2	11
GO:0043005	neuron projection	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0120293	dynein axonemal particle	5	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q4Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Z0

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007399	nervous system development	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0032502	developmental process	1	11
GO:0036158	outer dynein arm assembly	7	2
GO:0036159	inner dynein arm assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0048731	system development	3	11
GO:0048856	anatomical structure development	2	11
GO:0065003	protein-containing complex assembly	5	2
GO:0070286	axonemal dynein complex assembly	6	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.492
CLV_C14_Caspase3-7	511	515	PF00656	0.643
CLV_NRD_NRD_1	106	108	PF00675	0.424
CLV_NRD_NRD_1	134	136	PF00675	0.540
CLV_NRD_NRD_1	372	374	PF00675	0.313
CLV_NRD_NRD_1	551	553	PF00675	0.444
CLV_PCSK_FUR_1	549	553	PF00082	0.585
CLV_PCSK_KEX2_1	106	108	PF00082	0.424
CLV_PCSK_KEX2_1	133	135	PF00082	0.517
CLV_PCSK_KEX2_1	313	315	PF00082	0.368
CLV_PCSK_KEX2_1	336	338	PF00082	0.376
CLV_PCSK_KEX2_1	372	374	PF00082	0.313
CLV_PCSK_KEX2_1	551	553	PF00082	0.523
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.481
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.356
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.376
CLV_PCSK_PC7_1	129	135	PF00082	0.473
CLV_PCSK_SKI1_1	100	104	PF00082	0.507
CLV_PCSK_SKI1_1	134	138	PF00082	0.529
CLV_PCSK_SKI1_1	419	423	PF00082	0.470
DEG_SCF_FBW7_2	349	356	PF00400	0.436
DEG_SPOP_SBC_1	229	233	PF00917	0.586
DEG_SPOP_SBC_1	527	531	PF00917	0.520
DOC_CKS1_1	173	178	PF01111	0.571
DOC_CKS1_1	218	223	PF01111	0.568
DOC_CKS1_1	235	240	PF01111	0.524
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.721
DOC_MAPK_gen_1	23	32	PF00069	0.448
DOC_MAPK_gen_1	272	281	PF00069	0.538
DOC_MAPK_gen_1	477	487	PF00069	0.350
DOC_MAPK_MEF2A_6	242	251	PF00069	0.510
DOC_MAPK_MEF2A_6	26	34	PF00069	0.456
DOC_PP4_FxxP_1	258	261	PF00568	0.680
DOC_USP7_MATH_1	211	215	PF00917	0.570
DOC_USP7_MATH_1	229	233	PF00917	0.526
DOC_USP7_MATH_1	261	265	PF00917	0.591
DOC_USP7_MATH_1	527	531	PF00917	0.662
DOC_USP7_MATH_1	56	60	PF00917	0.479
DOC_USP7_UBL2_3	23	27	PF12436	0.462
DOC_USP7_UBL2_3	583	587	PF12436	0.413
DOC_WW_Pin1_4	172	177	PF00397	0.694
DOC_WW_Pin1_4	181	186	PF00397	0.710
DOC_WW_Pin1_4	192	197	PF00397	0.719
DOC_WW_Pin1_4	212	217	PF00397	0.619
DOC_WW_Pin1_4	234	239	PF00397	0.705
DOC_WW_Pin1_4	251	256	PF00397	0.449
DOC_WW_Pin1_4	281	286	PF00397	0.413
DOC_WW_Pin1_4	349	354	PF00397	0.410
DOC_WW_Pin1_4	596	601	PF00397	0.387
LIG_14-3-3_CanoR_1	419	428	PF00244	0.466
LIG_14-3-3_CanoR_1	94	99	PF00244	0.619
LIG_BRCT_BRCA1_1	62	66	PF00533	0.491
LIG_Clathr_ClatBox_1	48	52	PF01394	0.448
LIG_FHA_1	244	250	PF00498	0.483
LIG_FHA_1	27	33	PF00498	0.573
LIG_FHA_1	480	486	PF00498	0.375
LIG_FHA_2	10	16	PF00498	0.448
LIG_FHA_2	125	131	PF00498	0.609
LIG_FHA_2	398	404	PF00498	0.449
LIG_FHA_2	420	426	PF00498	0.616
LIG_FHA_2	555	561	PF00498	0.613
LIG_FHA_2	597	603	PF00498	0.385
LIG_LIR_Apic_2	170	176	PF02991	0.411
LIG_LIR_Apic_2	257	261	PF02991	0.677
LIG_LIR_Gen_1	326	335	PF02991	0.456
LIG_LIR_Gen_1	36	45	PF02991	0.486
LIG_LIR_Gen_1	451	462	PF02991	0.350
LIG_LIR_Nem_3	274	279	PF02991	0.544
LIG_LIR_Nem_3	36	41	PF02991	0.492
LIG_LIR_Nem_3	360	365	PF02991	0.401
LIG_LIR_Nem_3	451	457	PF02991	0.337
LIG_MLH1_MIPbox_1	62	66	PF16413	0.457
LIG_Pex14_1	169	173	PF04695	0.384
LIG_RPA_C_Fungi	102	114	PF08784	0.420
LIG_SH2_CRK	173	177	PF00017	0.445
LIG_SH2_CRK	276	280	PF00017	0.518
LIG_SH2_CRK	362	366	PF00017	0.376
LIG_SH2_CRK	454	458	PF00017	0.334
LIG_SH2_CRK	566	570	PF00017	0.360
LIG_SH2_GRB2like	601	604	PF00017	0.479
LIG_SH2_NCK_1	173	177	PF00017	0.445
LIG_SH2_NCK_1	447	451	PF00017	0.308
LIG_SH2_STAP1	308	312	PF00017	0.339
LIG_SH2_STAP1	454	458	PF00017	0.308
LIG_SH2_STAP1	601	605	PF00017	0.379
LIG_SH2_STAT3	118	121	PF00017	0.585
LIG_SH2_STAT3	270	273	PF00017	0.628
LIG_SH2_STAT3	296	299	PF00017	0.482
LIG_SH2_STAT5	173	176	PF00017	0.525
LIG_SH2_STAT5	329	332	PF00017	0.411
LIG_SH2_STAT5	377	380	PF00017	0.418
LIG_SH2_STAT5	47	50	PF00017	0.305
LIG_SH2_STAT5	572	575	PF00017	0.419
LIG_SH2_STAT5	591	594	PF00017	0.459
LIG_SH2_STAT5	65	68	PF00017	0.289
LIG_SH3_3	215	221	PF00018	0.564
LIG_SH3_3	223	229	PF00018	0.655
LIG_SH3_3	232	238	PF00018	0.619
LIG_SH3_3	38	44	PF00018	0.368
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.417
LIG_SUMO_SIM_par_1	277	284	PF11976	0.517
LIG_SUMO_SIM_par_1	47	52	PF11976	0.307
LIG_TRAF2_1	534	537	PF00917	0.643
LIG_UBA3_1	17	23	PF00899	0.368
LIG_UBA3_1	53	61	PF00899	0.334
LIG_WW_1	44	47	PF00397	0.368
MOD_CDK_SPK_2	251	256	PF00069	0.514
MOD_CK1_1	172	178	PF00069	0.706
MOD_CK1_1	231	237	PF00069	0.711
MOD_CK1_1	355	361	PF00069	0.432
MOD_CK1_1	530	536	PF00069	0.509
MOD_CK1_1	59	65	PF00069	0.403
MOD_CK1_1	625	631	PF00069	0.558
MOD_CK2_1	124	130	PF00069	0.535
MOD_CK2_1	512	518	PF00069	0.635
MOD_CK2_1	526	532	PF00069	0.649
MOD_CK2_1	554	560	PF00069	0.342
MOD_GlcNHglycan	181	184	PF01048	0.610
MOD_GlcNHglycan	199	202	PF01048	0.493
MOD_GlcNHglycan	325	328	PF01048	0.376
MOD_GlcNHglycan	384	387	PF01048	0.440
MOD_GlcNHglycan	454	457	PF01048	0.364
MOD_GlcNHglycan	532	535	PF01048	0.672
MOD_GlcNHglycan	560	564	PF01048	0.407
MOD_GlcNHglycan	574	577	PF01048	0.289
MOD_GlcNHglycan	624	627	PF01048	0.495
MOD_GSK3_1	124	131	PF00069	0.531
MOD_GSK3_1	177	184	PF00069	0.742
MOD_GSK3_1	188	195	PF00069	0.631
MOD_GSK3_1	230	237	PF00069	0.745
MOD_GSK3_1	243	250	PF00069	0.616
MOD_GSK3_1	277	284	PF00069	0.566
MOD_GSK3_1	340	347	PF00069	0.359
MOD_GSK3_1	5	12	PF00069	0.356
MOD_GSK3_1	526	533	PF00069	0.735
MOD_GSK3_1	539	546	PF00069	0.660
MOD_GSK3_1	56	63	PF00069	0.405
MOD_GSK3_1	89	96	PF00069	0.578
MOD_N-GLC_1	247	252	PF02516	0.604
MOD_N-GLC_1	323	328	PF02516	0.383
MOD_NEK2_1	18	23	PF00069	0.308
MOD_NEK2_1	188	193	PF00069	0.698
MOD_NEK2_1	323	328	PF00069	0.448
MOD_NEK2_1	344	349	PF00069	0.371
MOD_NEK2_1	471	476	PF00069	0.268
MOD_NEK2_2	308	313	PF00069	0.348
MOD_PIKK_1	124	130	PF00454	0.599
MOD_PIKK_1	295	301	PF00454	0.404
MOD_PIKK_1	355	361	PF00454	0.432
MOD_PIKK_1	479	485	PF00454	0.427
MOD_PIKK_1	60	66	PF00454	0.362
MOD_PIKK_1	628	634	PF00454	0.592
MOD_PK_1	277	283	PF00069	0.524
MOD_PK_1	94	100	PF00069	0.556
MOD_PKA_1	26	32	PF00069	0.323
MOD_PKA_2	124	130	PF00069	0.544
MOD_PKA_2	271	277	PF00069	0.449
MOD_PKA_2	93	99	PF00069	0.592
MOD_Plk_1	169	175	PF00069	0.398
MOD_Plk_1	247	253	PF00069	0.625
MOD_Plk_1	340	346	PF00069	0.352
MOD_Plk_1	450	456	PF00069	0.349
MOD_Plk_2-3	398	404	PF00069	0.565
MOD_Plk_4	344	350	PF00069	0.379
MOD_Plk_4	471	477	PF00069	0.329
MOD_Plk_4	543	549	PF00069	0.415
MOD_Plk_4	617	623	PF00069	0.418
MOD_ProDKin_1	172	178	PF00069	0.699
MOD_ProDKin_1	181	187	PF00069	0.708
MOD_ProDKin_1	192	198	PF00069	0.711
MOD_ProDKin_1	212	218	PF00069	0.615
MOD_ProDKin_1	234	240	PF00069	0.701
MOD_ProDKin_1	251	257	PF00069	0.452
MOD_ProDKin_1	281	287	PF00069	0.411
MOD_ProDKin_1	349	355	PF00069	0.418
MOD_ProDKin_1	596	602	PF00069	0.384
MOD_SUMO_for_1	155	158	PF00179	0.463
MOD_SUMO_rev_2	381	385	PF00179	0.430
TRG_ENDOCYTIC_2	276	279	PF00928	0.525
TRG_ENDOCYTIC_2	329	332	PF00928	0.411
TRG_ENDOCYTIC_2	362	365	PF00928	0.385
TRG_ENDOCYTIC_2	454	457	PF00928	0.274
TRG_ENDOCYTIC_2	566	569	PF00928	0.343
TRG_ER_diArg_1	134	136	PF00400	0.551
TRG_ER_diArg_1	548	551	PF00400	0.454
TRG_ER_FFAT_2	170	179	PF00635	0.432
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE30	Leptomonas seymouri	70%	100%
A0A0S4IMJ5	Bodo saltans	46%	100%
A0A1X0NRQ0	Trypanosomatidae	51%	100%
A0A3R7LBE5	Trypanosoma rangeli	48%	100%
A0A3S7X5V3	Leishmania donovani	93%	100%
A4HKS6	Leishmania braziliensis	83%	100%
A4I8A6	Leishmania infantum	93%	100%
D0AAH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	96%
E9B364	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BMH6	Trypanosoma cruzi	50%	100%