Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4Y9_LEIMA

TriTrypDb:

LmjF.32.2860 , LMJLV39_320036100 , LMJSD75_320036300

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.705
CLV_NRD_NRD_1	323	325	PF00675	0.661
CLV_NRD_NRD_1	392	394	PF00675	0.590
CLV_NRD_NRD_1	64	66	PF00675	0.504
CLV_NRD_NRD_1	721	723	PF00675	0.574
CLV_NRD_NRD_1	744	746	PF00675	0.673
CLV_PCSK_KEX2_1	169	171	PF00082	0.648
CLV_PCSK_KEX2_1	323	325	PF00082	0.661
CLV_PCSK_KEX2_1	392	394	PF00082	0.590
CLV_PCSK_KEX2_1	420	422	PF00082	0.637
CLV_PCSK_KEX2_1	721	723	PF00082	0.573
CLV_PCSK_KEX2_1	744	746	PF00082	0.555
CLV_PCSK_KEX2_1	91	93	PF00082	0.515
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.588
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.573
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.515
CLV_PCSK_SKI1_1	323	327	PF00082	0.687
CLV_PCSK_SKI1_1	377	381	PF00082	0.619
CLV_PCSK_SKI1_1	384	388	PF00082	0.529
CLV_PCSK_SKI1_1	468	472	PF00082	0.471
CLV_PCSK_SKI1_1	477	481	PF00082	0.505
CLV_PCSK_SKI1_1	88	92	PF00082	0.604
CLV_PCSK_SKI1_1	96	100	PF00082	0.598
DEG_SCF_FBW7_1	447	454	PF00400	0.719
DEG_SPOP_SBC_1	363	367	PF00917	0.790
DEG_SPOP_SBC_1	446	450	PF00917	0.784
DOC_CKS1_1	511	516	PF01111	0.550
DOC_MAPK_gen_1	473	481	PF00069	0.465
DOC_PP1_RVXF_1	133	140	PF00149	0.622
DOC_PP2B_LxvP_1	552	555	PF13499	0.529
DOC_USP7_MATH_1	126	130	PF00917	0.649
DOC_USP7_MATH_1	195	199	PF00917	0.639
DOC_USP7_MATH_1	283	287	PF00917	0.824
DOC_USP7_MATH_1	295	299	PF00917	0.654
DOC_USP7_MATH_1	358	362	PF00917	0.693
DOC_USP7_MATH_1	439	443	PF00917	0.791
DOC_USP7_MATH_1	445	449	PF00917	0.725
DOC_USP7_MATH_1	451	455	PF00917	0.698
DOC_USP7_MATH_1	59	63	PF00917	0.579
DOC_USP7_MATH_1	734	738	PF00917	0.517
DOC_WW_Pin1_4	180	185	PF00397	0.749
DOC_WW_Pin1_4	248	253	PF00397	0.731
DOC_WW_Pin1_4	258	263	PF00397	0.606
DOC_WW_Pin1_4	429	434	PF00397	0.806
DOC_WW_Pin1_4	441	446	PF00397	0.560
DOC_WW_Pin1_4	447	452	PF00397	0.647
DOC_WW_Pin1_4	5	10	PF00397	0.770
DOC_WW_Pin1_4	510	515	PF00397	0.614
DOC_WW_Pin1_4	565	570	PF00397	0.492
DOC_WW_Pin1_4	74	79	PF00397	0.707
LIG_14-3-3_CanoR_1	218	222	PF00244	0.630
LIG_14-3-3_CanoR_1	227	236	PF00244	0.576
LIG_14-3-3_CanoR_1	287	293	PF00244	0.779
LIG_14-3-3_CanoR_1	377	383	PF00244	0.749
LIG_14-3-3_CanoR_1	412	417	PF00244	0.740
LIG_14-3-3_CanoR_1	438	447	PF00244	0.774
LIG_14-3-3_CanoR_1	556	560	PF00244	0.464
LIG_14-3-3_CanoR_1	606	610	PF00244	0.620
LIG_14-3-3_CanoR_1	683	692	PF00244	0.436
LIG_14-3-3_CanoR_1	722	730	PF00244	0.465
LIG_14-3-3_CanoR_1	92	98	PF00244	0.509
LIG_AP2alpha_2	70	72	PF02296	0.573
LIG_BIR_III_2	239	243	PF00653	0.710
LIG_BIR_III_4	279	283	PF00653	0.710
LIG_BRCT_BRCA1_1	231	235	PF00533	0.748
LIG_FHA_1	132	138	PF00498	0.688
LIG_FHA_1	189	195	PF00498	0.722
LIG_FHA_1	209	215	PF00498	0.436
LIG_FHA_1	249	255	PF00498	0.733
LIG_FHA_1	305	311	PF00498	0.553
LIG_FHA_1	341	347	PF00498	0.599
LIG_FHA_1	447	453	PF00498	0.692
LIG_FHA_1	488	494	PF00498	0.598
LIG_FHA_1	510	516	PF00498	0.497
LIG_FHA_1	530	536	PF00498	0.513
LIG_FHA_1	547	553	PF00498	0.514
LIG_FHA_1	730	736	PF00498	0.578
LIG_FHA_2	106	112	PF00498	0.593
LIG_FHA_2	274	280	PF00498	0.769
LIG_FHA_2	339	345	PF00498	0.649
LIG_FHA_2	365	371	PF00498	0.706
LIG_FHA_2	413	419	PF00498	0.763
LIG_FHA_2	420	426	PF00498	0.514
LIG_FHA_2	92	98	PF00498	0.614
LIG_LIR_Gen_1	111	120	PF02991	0.584
LIG_LIR_Gen_1	378	387	PF02991	0.567
LIG_LIR_Gen_1	549	559	PF02991	0.628
LIG_LIR_Gen_1	70	80	PF02991	0.674
LIG_LIR_Gen_1	704	714	PF02991	0.503
LIG_LIR_Nem_3	111	116	PF02991	0.695
LIG_LIR_Nem_3	378	382	PF02991	0.576
LIG_LIR_Nem_3	549	554	PF02991	0.647
LIG_LIR_Nem_3	608	614	PF02991	0.451
LIG_LIR_Nem_3	70	75	PF02991	0.702
LIG_LIR_Nem_3	702	708	PF02991	0.542
LIG_NRBOX	518	524	PF00104	0.662
LIG_REV1ctd_RIR_1	495	504	PF16727	0.481
LIG_SH2_GRB2like	115	118	PF00017	0.641
LIG_SH2_SRC	115	118	PF00017	0.704
LIG_SH2_STAT3	693	696	PF00017	0.506
LIG_SH2_STAT5	115	118	PF00017	0.768
LIG_SH2_STAT5	27	30	PF00017	0.692
LIG_SH2_STAT5	551	554	PF00017	0.680
LIG_SH2_STAT5	678	681	PF00017	0.611
LIG_SH2_STAT5	693	696	PF00017	0.355
LIG_SH3_3	239	245	PF00018	0.816
LIG_SH3_3	542	548	PF00018	0.468
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.497
LIG_SUMO_SIM_par_1	210	215	PF11976	0.611
LIG_SUMO_SIM_par_1	253	259	PF11976	0.773
LIG_SUMO_SIM_par_1	306	311	PF11976	0.545
LIG_SUMO_SIM_par_1	531	537	PF11976	0.614
LIG_TRAF2_1	256	259	PF00917	0.702
LIG_TRAF2_1	653	656	PF00917	0.697
LIG_TYR_ITSM	547	554	PF00017	0.632
LIG_WRC_WIRS_1	376	381	PF05994	0.580
LIG_WW_1	690	693	PF00397	0.548
MOD_CDK_SPK_2	429	434	PF00069	0.803
MOD_CK1_1	157	163	PF00069	0.726
MOD_CK1_1	198	204	PF00069	0.537
MOD_CK1_1	228	234	PF00069	0.803
MOD_CK1_1	261	267	PF00069	0.691
MOD_CK1_1	281	287	PF00069	0.609
MOD_CK1_1	378	384	PF00069	0.554
MOD_CK1_1	419	425	PF00069	0.801
MOD_CK1_1	5	11	PF00069	0.769
MOD_CK2_1	253	259	PF00069	0.710
MOD_CK2_1	362	368	PF00069	0.647
MOD_CK2_1	412	418	PF00069	0.716
MOD_CK2_1	419	425	PF00069	0.790
MOD_CK2_1	695	701	PF00069	0.540
MOD_CK2_1	79	85	PF00069	0.497
MOD_CK2_1	91	97	PF00069	0.610
MOD_GlcNHglycan	128	131	PF01048	0.684
MOD_GlcNHglycan	196	200	PF01048	0.504
MOD_GlcNHglycan	227	230	PF01048	0.748
MOD_GlcNHglycan	231	234	PF01048	0.731
MOD_GlcNHglycan	278	283	PF01048	0.780
MOD_GlcNHglycan	292	295	PF01048	0.777
MOD_GlcNHglycan	297	300	PF01048	0.649
MOD_GlcNHglycan	353	356	PF01048	0.761
MOD_GlcNHglycan	360	363	PF01048	0.668
MOD_GlcNHglycan	441	444	PF01048	0.741
MOD_GlcNHglycan	525	529	PF01048	0.478
MOD_GlcNHglycan	570	573	PF01048	0.524
MOD_GlcNHglycan	697	700	PF01048	0.660
MOD_GlcNHglycan	725	728	PF01048	0.523
MOD_GlcNHglycan	736	739	PF01048	0.587
MOD_GSK3_1	1	8	PF00069	0.774
MOD_GSK3_1	225	232	PF00069	0.794
MOD_GSK3_1	27	34	PF00069	0.735
MOD_GSK3_1	278	285	PF00069	0.813
MOD_GSK3_1	334	341	PF00069	0.608
MOD_GSK3_1	342	349	PF00069	0.627
MOD_GSK3_1	358	365	PF00069	0.631
MOD_GSK3_1	401	408	PF00069	0.641
MOD_GSK3_1	412	419	PF00069	0.639
MOD_GSK3_1	429	436	PF00069	0.699
MOD_GSK3_1	441	448	PF00069	0.824
MOD_GSK3_1	568	575	PF00069	0.444
MOD_GSK3_1	695	702	PF00069	0.605
MOD_GSK3_1	70	77	PF00069	0.549
MOD_N-GLC_1	154	159	PF02516	0.746
MOD_N-GLC_1	188	193	PF02516	0.566
MOD_N-GLC_1	332	337	PF02516	0.545
MOD_N-GLC_1	699	704	PF02516	0.595
MOD_NEK2_1	105	110	PF00069	0.604
MOD_NEK2_1	197	202	PF00069	0.649
MOD_NEK2_1	217	222	PF00069	0.529
MOD_NEK2_1	288	293	PF00069	0.786
MOD_NEK2_1	351	356	PF00069	0.726
MOD_NEK2_1	488	493	PF00069	0.636
MOD_NEK2_1	523	528	PF00069	0.598
MOD_NEK2_1	570	575	PF00069	0.455
MOD_NEK2_1	713	718	PF00069	0.713
MOD_NEK2_2	133	138	PF00069	0.748
MOD_NEK2_2	665	670	PF00069	0.649
MOD_PIKK_1	451	457	PF00454	0.830
MOD_PIKK_1	546	552	PF00454	0.623
MOD_PIKK_1	622	628	PF00454	0.449
MOD_PIKK_1	713	719	PF00454	0.533
MOD_PIKK_1	729	735	PF00454	0.583
MOD_PKA_1	91	97	PF00069	0.456
MOD_PKA_2	157	163	PF00069	0.630
MOD_PKA_2	173	179	PF00069	0.658
MOD_PKA_2	217	223	PF00069	0.575
MOD_PKA_2	433	439	PF00069	0.742
MOD_PKA_2	555	561	PF00069	0.462
MOD_PKA_2	605	611	PF00069	0.619
MOD_PKA_2	622	628	PF00069	0.315
MOD_PKA_2	91	97	PF00069	0.515
MOD_PKB_1	47	55	PF00069	0.618
MOD_Plk_1	105	111	PF00069	0.504
MOD_Plk_1	21	27	PF00069	0.626
MOD_Plk_1	332	338	PF00069	0.578
MOD_Plk_1	488	494	PF00069	0.598
MOD_Plk_1	524	530	PF00069	0.595
MOD_Plk_1	665	671	PF00069	0.646
MOD_Plk_1	699	705	PF00069	0.595
MOD_Plk_2-3	701	707	PF00069	0.588
MOD_Plk_4	488	494	PF00069	0.598
MOD_Plk_4	701	707	PF00069	0.614
MOD_ProDKin_1	180	186	PF00069	0.748
MOD_ProDKin_1	248	254	PF00069	0.732
MOD_ProDKin_1	258	264	PF00069	0.604
MOD_ProDKin_1	429	435	PF00069	0.806
MOD_ProDKin_1	441	447	PF00069	0.557
MOD_ProDKin_1	5	11	PF00069	0.769
MOD_ProDKin_1	510	516	PF00069	0.615
MOD_ProDKin_1	565	571	PF00069	0.492
MOD_ProDKin_1	74	80	PF00069	0.706
MOD_SUMO_for_1	600	603	PF00179	0.552
TRG_DiLeu_BaEn_1	525	530	PF01217	0.486
TRG_DiLeu_BaEn_2	466	472	PF01217	0.596
TRG_DiLeu_BaEn_4	400	406	PF01217	0.551
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.482
TRG_ENDOCYTIC_2	551	554	PF00928	0.654
TRG_ER_diArg_1	392	394	PF00400	0.590
TRG_ER_diArg_1	472	475	PF00400	0.462
TRG_ER_diArg_1	720	722	PF00400	0.576
TRG_NES_CRM1_1	97	111	PF08389	0.592
TRG_NLS_MonoExtC_3	64	70	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B7	Leptomonas seymouri	46%	100%
A0A3Q8ITJ0	Leishmania donovani	95%	100%
A4HKS7	Leishmania braziliensis	75%	100%
A4I8A7	Leishmania infantum	95%	100%
E9B365	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%