RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania major

UniProt:

Q4Q4Y7_LEIMA

TriTrypDb:

LmjF.32.2880 , LMJLV39_320036300 , LMJSD75_320036500

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q4Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.517
CLV_C14_Caspase3-7	423	427	PF00656	0.470
CLV_NRD_NRD_1	132	134	PF00675	0.471
CLV_NRD_NRD_1	290	292	PF00675	0.270
CLV_NRD_NRD_1	327	329	PF00675	0.270
CLV_NRD_NRD_1	330	332	PF00675	0.270
CLV_NRD_NRD_1	391	393	PF00675	0.304
CLV_NRD_NRD_1	559	561	PF00675	0.450
CLV_PCSK_FUR_1	325	329	PF00082	0.270
CLV_PCSK_KEX2_1	132	134	PF00082	0.471
CLV_PCSK_KEX2_1	290	292	PF00082	0.270
CLV_PCSK_KEX2_1	327	329	PF00082	0.270
CLV_PCSK_KEX2_1	330	332	PF00082	0.270
CLV_PCSK_KEX2_1	390	392	PF00082	0.306
CLV_PCSK_KEX2_1	559	561	PF00082	0.449
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.279
CLV_PCSK_SKI1_1	318	322	PF00082	0.270
CLV_PCSK_SKI1_1	515	519	PF00082	0.202
CLV_PCSK_SKI1_1	543	547	PF00082	0.270
CLV_PCSK_SKI1_1	589	593	PF00082	0.527
DEG_APCC_DBOX_1	222	230	PF00400	0.500
DEG_SCF_FBW7_1	46	53	PF00400	0.641
DEG_SPOP_SBC_1	107	111	PF00917	0.606
DEG_SPOP_SBC_1	230	234	PF00917	0.498
DOC_ANK_TNKS_1	444	451	PF00023	0.470
DOC_CDC14_PxL_1	114	122	PF14671	0.699
DOC_CYCLIN_RxL_1	129	140	PF00134	0.678
DOC_CYCLIN_RxL_1	538	549	PF00134	0.517
DOC_MAPK_DCC_7	313	322	PF00069	0.470
DOC_MAPK_FxFP_2	152	155	PF00069	0.608
DOC_PP1_RVXF_1	541	547	PF00149	0.470
DOC_PP1_RVXF_1	587	593	PF00149	0.320
DOC_PP2B_LxvP_1	134	137	PF13499	0.680
DOC_PP4_FxxP_1	152	155	PF00568	0.608
DOC_USP7_MATH_1	157	161	PF00917	0.547
DOC_USP7_MATH_1	174	178	PF00917	0.491
DOC_USP7_MATH_1	247	251	PF00917	0.471
DOC_USP7_MATH_1	252	256	PF00917	0.457
DOC_USP7_MATH_1	282	286	PF00917	0.480
DOC_USP7_MATH_1	409	413	PF00917	0.517
DOC_USP7_MATH_1	448	452	PF00917	0.470
DOC_USP7_MATH_1	503	507	PF00917	0.448
DOC_USP7_MATH_1	517	521	PF00917	0.433
DOC_USP7_MATH_1	527	531	PF00917	0.489
DOC_USP7_MATH_1	65	69	PF00917	0.700
DOC_USP7_MATH_1	80	84	PF00917	0.695
DOC_USP7_UBL2_3	491	495	PF12436	0.517
DOC_WW_Pin1_4	122	127	PF00397	0.684
DOC_WW_Pin1_4	258	263	PF00397	0.470
DOC_WW_Pin1_4	274	279	PF00397	0.383
DOC_WW_Pin1_4	3	8	PF00397	0.710
DOC_WW_Pin1_4	329	334	PF00397	0.517
DOC_WW_Pin1_4	367	372	PF00397	0.431
DOC_WW_Pin1_4	378	383	PF00397	0.463
DOC_WW_Pin1_4	451	456	PF00397	0.470
DOC_WW_Pin1_4	46	51	PF00397	0.657
DOC_WW_Pin1_4	489	494	PF00397	0.475
DOC_WW_Pin1_4	505	510	PF00397	0.435
DOC_WW_Pin1_4	95	100	PF00397	0.682
LIG_14-3-3_CanoR_1	22	29	PF00244	0.615
LIG_14-3-3_CanoR_1	294	302	PF00244	0.521
LIG_BIR_III_2	524	528	PF00653	0.517
LIG_BIR_III_4	401	405	PF00653	0.517
LIG_BRCT_BRCA1_1	159	163	PF00533	0.470
LIG_BRCT_BRCA1_1	276	280	PF00533	0.517
LIG_BRCT_BRCA1_1	463	467	PF00533	0.470
LIG_deltaCOP1_diTrp_1	536	546	PF00928	0.512
LIG_FHA_1	109	115	PF00498	0.647
LIG_FHA_1	230	236	PF00498	0.515
LIG_FHA_1	274	280	PF00498	0.521
LIG_FHA_1	307	313	PF00498	0.470
LIG_FHA_1	361	367	PF00498	0.410
LIG_FHA_1	384	390	PF00498	0.504
LIG_FHA_1	438	444	PF00498	0.470
LIG_FHA_1	70	76	PF00498	0.717
LIG_FHA_2	107	113	PF00498	0.626
LIG_FHA_2	138	144	PF00498	0.686
LIG_LIR_Apic_2	160	164	PF02991	0.470
LIG_LIR_Gen_1	420	430	PF02991	0.472
LIG_LIR_Gen_1	463	472	PF02991	0.470
LIG_LIR_Gen_1	574	585	PF02991	0.371
LIG_LIR_Nem_3	160	166	PF02991	0.452
LIG_LIR_Nem_3	420	425	PF02991	0.472
LIG_LIR_Nem_3	463	468	PF02991	0.470
LIG_LIR_Nem_3	574	580	PF02991	0.371
LIG_NRBOX	351	357	PF00104	0.470
LIG_PDZ_Class_2	588	593	PF00595	0.438
LIG_Pex14_2	154	158	PF04695	0.517
LIG_Pex14_2	588	592	PF04695	0.398
LIG_SH2_STAP1	393	397	PF00017	0.479
LIG_SH2_STAT5	180	183	PF00017	0.517
LIG_SH2_STAT5	187	190	PF00017	0.491
LIG_SH2_STAT5	587	590	PF00017	0.374
LIG_SH3_1	272	278	PF00018	0.402
LIG_SH3_2	490	495	PF14604	0.517
LIG_SH3_3	123	129	PF00018	0.711
LIG_SH3_3	241	247	PF00018	0.521
LIG_SH3_3	256	262	PF00018	0.421
LIG_SH3_3	272	278	PF00018	0.383
LIG_SH3_3	379	385	PF00018	0.479
LIG_SH3_3	4	10	PF00018	0.646
LIG_SH3_3	484	490	PF00018	0.517
LIG_SUMO_SIM_par_1	190	198	PF11976	0.517
LIG_SUMO_SIM_par_1	96	103	PF11976	0.617
LIG_TRAF2_1	414	417	PF00917	0.517
LIG_WRC_WIRS_1	179	184	PF05994	0.305
LIG_WW_3	287	291	PF00397	0.280
MOD_CDC14_SPxK_1	492	495	PF00782	0.317
MOD_CDK_SPxK_1	46	52	PF00069	0.544
MOD_CDK_SPxK_1	489	495	PF00069	0.336
MOD_CDK_SPxxK_3	125	132	PF00069	0.604
MOD_CK1_1	16	22	PF00069	0.636
MOD_CK1_1	234	240	PF00069	0.399
MOD_CK1_1	25	31	PF00069	0.603
MOD_CK1_1	250	256	PF00069	0.231
MOD_CK1_1	263	269	PF00069	0.386
MOD_CK1_1	362	368	PF00069	0.363
MOD_CK1_1	451	457	PF00069	0.305
MOD_CK1_1	463	469	PF00069	0.305
MOD_CK1_1	48	54	PF00069	0.660
MOD_CK1_1	485	491	PF00069	0.309
MOD_CK1_1	530	536	PF00069	0.373
MOD_CK1_1	569	575	PF00069	0.305
MOD_CK1_1	6	12	PF00069	0.695
MOD_CK1_1	68	74	PF00069	0.763
MOD_CK1_1	94	100	PF00069	0.719
MOD_CK2_1	106	112	PF00069	0.500
MOD_CK2_1	137	143	PF00069	0.616
MOD_CK2_1	169	175	PF00069	0.305
MOD_CK2_1	25	31	PF00069	0.615
MOD_CK2_1	410	416	PF00069	0.312
MOD_CK2_1	530	536	PF00069	0.340
MOD_Cter_Amidation	325	328	PF01082	0.305
MOD_DYRK1A_RPxSP_1	274	278	PF00069	0.236
MOD_GlcNHglycan	122	125	PF01048	0.689
MOD_GlcNHglycan	225	229	PF01048	0.317
MOD_GlcNHglycan	251	255	PF01048	0.317
MOD_GlcNHglycan	264	268	PF01048	0.419
MOD_GlcNHglycan	284	287	PF01048	0.222
MOD_GlcNHglycan	296	299	PF01048	0.306
MOD_GlcNHglycan	303	306	PF01048	0.311
MOD_GlcNHglycan	35	38	PF01048	0.646
MOD_GlcNHglycan	406	409	PF01048	0.291
MOD_GlcNHglycan	413	416	PF01048	0.282
MOD_GlcNHglycan	446	449	PF01048	0.305
MOD_GlcNHglycan	484	487	PF01048	0.300
MOD_GlcNHglycan	501	504	PF01048	0.386
MOD_GlcNHglycan	505	508	PF01048	0.241
MOD_GlcNHglycan	519	522	PF01048	0.221
MOD_GlcNHglycan	571	574	PF01048	0.305
MOD_GlcNHglycan	67	70	PF01048	0.626
MOD_GlcNHglycan	93	96	PF01048	0.681
MOD_GSK3_1	102	109	PF00069	0.580
MOD_GSK3_1	174	181	PF00069	0.326
MOD_GSK3_1	21	28	PF00069	0.676
MOD_GSK3_1	224	231	PF00069	0.301
MOD_GSK3_1	234	241	PF00069	0.267
MOD_GSK3_1	250	257	PF00069	0.339
MOD_GSK3_1	356	363	PF00069	0.305
MOD_GSK3_1	374	381	PF00069	0.305
MOD_GSK3_1	392	399	PF00069	0.451
MOD_GSK3_1	40	47	PF00069	0.660
MOD_GSK3_1	444	451	PF00069	0.305
MOD_GSK3_1	481	488	PF00069	0.317
MOD_GSK3_1	499	506	PF00069	0.207
MOD_GSK3_1	515	522	PF00069	0.269
MOD_GSK3_1	65	72	PF00069	0.698
MOD_GSK3_1	80	87	PF00069	0.613
MOD_GSK3_1	91	98	PF00069	0.552
MOD_N-GLC_1	437	442	PF02516	0.305
MOD_N-GLC_1	91	96	PF02516	0.674
MOD_NEK2_1	106	111	PF00069	0.539
MOD_NEK2_1	120	125	PF00069	0.695
MOD_NEK2_1	182	187	PF00069	0.316
MOD_NEK2_1	235	240	PF00069	0.290
MOD_NEK2_1	321	326	PF00069	0.305
MOD_NEK2_1	33	38	PF00069	0.658
MOD_NEK2_1	437	442	PF00069	0.305
MOD_NEK2_1	546	551	PF00069	0.371
MOD_NEK2_2	385	390	PF00069	0.290
MOD_PIKK_1	174	180	PF00454	0.297
MOD_PIKK_1	238	244	PF00454	0.331
MOD_PIKK_1	306	312	PF00454	0.371
MOD_PIKK_1	335	341	PF00454	0.371
MOD_PIKK_1	476	482	PF00454	0.305
MOD_PK_1	192	198	PF00069	0.371
MOD_PKA_2	21	27	PF00069	0.546
MOD_PKA_2	273	279	PF00069	0.381
MOD_PKA_2	326	332	PF00069	0.371
MOD_PKA_2	444	450	PF00069	0.305
MOD_PKB_1	133	141	PF00069	0.558
MOD_Plk_1	182	188	PF00069	0.305
MOD_Plk_1	224	230	PF00069	0.344
MOD_Plk_1	437	443	PF00069	0.305
MOD_Plk_2-3	396	402	PF00069	0.317
MOD_Plk_4	157	163	PF00069	0.371
MOD_Plk_4	182	188	PF00069	0.316
MOD_Plk_4	209	215	PF00069	0.344
MOD_Plk_4	546	552	PF00069	0.371
MOD_Plk_4	571	577	PF00069	0.371
MOD_Plk_4	71	77	PF00069	0.648
MOD_ProDKin_1	122	128	PF00069	0.602
MOD_ProDKin_1	258	264	PF00069	0.305
MOD_ProDKin_1	274	280	PF00069	0.183
MOD_ProDKin_1	3	9	PF00069	0.643
MOD_ProDKin_1	329	335	PF00069	0.371
MOD_ProDKin_1	367	373	PF00069	0.250
MOD_ProDKin_1	378	384	PF00069	0.294
MOD_ProDKin_1	451	457	PF00069	0.305
MOD_ProDKin_1	46	52	PF00069	0.571
MOD_ProDKin_1	489	495	PF00069	0.312
MOD_ProDKin_1	505	511	PF00069	0.255
MOD_ProDKin_1	95	101	PF00069	0.602
MOD_SUMO_rev_2	184	194	PF00179	0.305
TRG_DiLeu_BaEn_1	420	425	PF01217	0.317
TRG_DiLeu_BaEn_4	420	426	PF01217	0.317
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.305
TRG_ENDOCYTIC_2	422	425	PF00928	0.305
TRG_ENDOCYTIC_2	585	588	PF00928	0.449
TRG_ER_diArg_1	132	135	PF00400	0.589
TRG_ER_diArg_1	271	274	PF00400	0.493
TRG_ER_diArg_1	289	291	PF00400	0.234
TRG_ER_diArg_1	325	328	PF00400	0.305
TRG_ER_diArg_1	391	393	PF00400	0.349
TRG_ER_diArg_1	559	561	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M3	Leptomonas seymouri	54%	77%
A0A3S7X5W7	Leishmania donovani	93%	100%
A4HKS9	Leishmania braziliensis	72%	76%
A4I8A8	Leishmania infantum	93%	100%
E9B367	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%