Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4Y6_LEIMA

TriTrypDb:

LmjF.32.2885 , LMJLV39_320036400 , LMJSD75_320036600

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q4Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.719
CLV_C14_Caspase3-7	222	226	PF00656	0.729
CLV_C14_Caspase3-7	416	420	PF00656	0.739
CLV_NRD_NRD_1	331	333	PF00675	0.612
CLV_NRD_NRD_1	351	353	PF00675	0.410
CLV_NRD_NRD_1	354	356	PF00675	0.630
CLV_PCSK_FUR_1	329	333	PF00082	0.615
CLV_PCSK_FUR_1	352	356	PF00082	0.668
CLV_PCSK_KEX2_1	331	333	PF00082	0.605
CLV_PCSK_KEX2_1	353	355	PF00082	0.674
CLV_PCSK_KEX2_1	370	372	PF00082	0.466
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.674
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.466
CLV_PCSK_PC7_1	327	333	PF00082	0.624
CLV_PCSK_SKI1_1	370	374	PF00082	0.564
CLV_PCSK_SKI1_1	55	59	PF00082	0.512
DEG_APCC_DBOX_1	303	311	PF00400	0.525
DEG_SPOP_SBC_1	191	195	PF00917	0.409
DEG_SPOP_SBC_1	413	417	PF00917	0.662
DOC_PP1_RVXF_1	106	113	PF00149	0.685
DOC_PP2B_PxIxI_1	43	49	PF00149	0.559
DOC_PP4_FxxP_1	229	232	PF00568	0.519
DOC_PP4_FxxP_1	50	53	PF00568	0.507
DOC_USP7_MATH_1	161	165	PF00917	0.753
DOC_USP7_MATH_1	191	195	PF00917	0.579
DOC_USP7_MATH_1	319	323	PF00917	0.681
DOC_USP7_MATH_1	362	366	PF00917	0.657
DOC_USP7_MATH_1	439	443	PF00917	0.638
DOC_USP7_MATH_1	85	89	PF00917	0.686
DOC_USP7_MATH_2	213	219	PF00917	0.764
DOC_WW_Pin1_4	117	122	PF00397	0.576
DOC_WW_Pin1_4	163	168	PF00397	0.747
DOC_WW_Pin1_4	88	93	PF00397	0.711
LIG_14-3-3_CanoR_1	190	197	PF00244	0.489
LIG_14-3-3_CanoR_1	304	308	PF00244	0.523
LIG_14-3-3_CanoR_1	334	343	PF00244	0.612
LIG_14-3-3_CanoR_1	371	377	PF00244	0.767
LIG_14-3-3_CanoR_1	407	414	PF00244	0.698
LIG_14-3-3_CanoR_1	74	80	PF00244	0.720
LIG_APCC_ABBA_1	239	244	PF00400	0.434
LIG_BIR_III_4	84	88	PF00653	0.718
LIG_BRCT_BRCA1_1	193	197	PF00533	0.623
LIG_FHA_1	15	21	PF00498	0.557
LIG_FHA_1	372	378	PF00498	0.526
LIG_FHA_1	76	82	PF00498	0.701
LIG_FHA_1	84	90	PF00498	0.614
LIG_FHA_2	371	377	PF00498	0.526
LIG_FHA_2	414	420	PF00498	0.733
LIG_GBD_Chelix_1	178	186	PF00786	0.499
LIG_LIR_Gen_1	109	118	PF02991	0.629
LIG_LIR_Gen_1	3	9	PF02991	0.498
LIG_LIR_Nem_3	109	115	PF02991	0.632
LIG_LIR_Nem_3	3	8	PF02991	0.500
LIG_LIR_Nem_3	78	82	PF02991	0.660
LIG_LYPXL_yS_3	79	82	PF13949	0.668
LIG_NRBOX	309	315	PF00104	0.541
LIG_PDZ_Class_1	439	444	PF00595	0.606
LIG_Pex14_2	112	116	PF04695	0.616
LIG_SH2_PTP2	5	8	PF00017	0.485
LIG_SH2_STAP1	16	20	PF00017	0.535
LIG_SH2_STAP1	61	65	PF00017	0.478
LIG_SH2_STAT5	16	19	PF00017	0.472
LIG_SH2_STAT5	188	191	PF00017	0.542
LIG_SH2_STAT5	339	342	PF00017	0.501
LIG_SH2_STAT5	393	396	PF00017	0.560
LIG_SH2_STAT5	440	443	PF00017	0.529
LIG_SH2_STAT5	5	8	PF00017	0.464
LIG_SH3_2	347	352	PF14604	0.722
LIG_SH3_3	166	172	PF00018	0.541
LIG_SH3_3	337	343	PF00018	0.506
LIG_SH3_3	344	350	PF00018	0.562
LIG_SH3_3	433	439	PF00018	0.660
LIG_SH3_3	86	92	PF00018	0.711
LIG_TRAF2_1	131	134	PF00917	0.587
LIG_TRAF2_1	373	376	PF00917	0.528
LIG_TRAF2_1	91	94	PF00917	0.571
LIG_WW_3	231	235	PF00397	0.675
MOD_CK1_1	218	224	PF00069	0.743
MOD_CK1_1	235	241	PF00069	0.461
MOD_CK1_1	34	40	PF00069	0.495
MOD_CK1_1	83	89	PF00069	0.729
MOD_CK2_1	147	153	PF00069	0.689
MOD_CK2_1	370	376	PF00069	0.769
MOD_CK2_1	417	423	PF00069	0.783
MOD_CK2_1	88	94	PF00069	0.699
MOD_GlcNHglycan	161	164	PF01048	0.726
MOD_GlcNHglycan	194	197	PF01048	0.659
MOD_GlcNHglycan	217	220	PF01048	0.785
MOD_GlcNHglycan	234	237	PF01048	0.504
MOD_GlcNHglycan	253	256	PF01048	0.424
MOD_GlcNHglycan	317	320	PF01048	0.624
MOD_GlcNHglycan	427	430	PF01048	0.759
MOD_GlcNHglycan	62	65	PF01048	0.650
MOD_GSK3_1	134	141	PF00069	0.615
MOD_GSK3_1	155	162	PF00069	0.788
MOD_GSK3_1	215	222	PF00069	0.690
MOD_GSK3_1	315	322	PF00069	0.580
MOD_GSK3_1	413	420	PF00069	0.739
MOD_GSK3_1	98	105	PF00069	0.671
MOD_N-GLC_1	135	140	PF02516	0.614
MOD_NEK2_1	154	159	PF00069	0.806
MOD_NEK2_1	174	179	PF00069	0.404
MOD_NEK2_1	182	187	PF00069	0.420
MOD_NEK2_1	269	274	PF00069	0.450
MOD_NEK2_1	293	298	PF00069	0.413
MOD_NEK2_1	31	36	PF00069	0.444
MOD_NEK2_1	323	328	PF00069	0.609
MOD_NEK2_1	75	80	PF00069	0.640
MOD_NEK2_1	9	14	PF00069	0.401
MOD_NEK2_2	303	308	PF00069	0.577
MOD_NEK2_2	85	90	PF00069	0.683
MOD_PIKK_1	334	340	PF00454	0.581
MOD_PKA_1	370	376	PF00069	0.565
MOD_PKA_2	154	160	PF00069	0.557
MOD_PKA_2	303	309	PF00069	0.517
MOD_PKA_2	370	376	PF00069	0.767
MOD_PKA_2	406	412	PF00069	0.699
MOD_PKB_1	332	340	PF00069	0.606
MOD_Plk_1	106	112	PF00069	0.657
MOD_Plk_1	135	141	PF00069	0.661
MOD_Plk_1	146	152	PF00069	0.743
MOD_Plk_1	362	368	PF00069	0.691
MOD_Plk_2-3	147	153	PF00069	0.539
MOD_Plk_2-3	363	369	PF00069	0.694
MOD_Plk_2-3	419	425	PF00069	0.681
MOD_Plk_4	1	7	PF00069	0.524
MOD_Plk_4	235	241	PF00069	0.566
MOD_Plk_4	319	325	PF00069	0.700
MOD_Plk_4	341	347	PF00069	0.622
MOD_Plk_4	389	395	PF00069	0.602
MOD_Plk_4	85	91	PF00069	0.731
MOD_ProDKin_1	117	123	PF00069	0.574
MOD_ProDKin_1	163	169	PF00069	0.745
MOD_ProDKin_1	88	94	PF00069	0.716
MOD_SUMO_rev_2	238	248	PF00179	0.488
MOD_SUMO_rev_2	363	372	PF00179	0.630
TRG_ENDOCYTIC_2	5	8	PF00928	0.485
TRG_ENDOCYTIC_2	79	82	PF00928	0.684
TRG_ER_diArg_1	116	119	PF00400	0.574
TRG_ER_diArg_1	329	332	PF00400	0.652
TRG_ER_diArg_1	351	354	PF00400	0.666
TRG_NLS_MonoCore_2	351	356	PF00514	0.666
TRG_NLS_MonoExtN_4	350	357	PF00514	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME3	Leptomonas seymouri	52%	100%
A0A1X0NTD1	Trypanosomatidae	28%	100%
A0A3S7X601	Leishmania donovani	89%	100%
A0A422NZX0	Trypanosoma rangeli	31%	100%
A4HKT0	Leishmania braziliensis	79%	100%
A4I8A9	Leishmania infantum	89%	100%
D0AAI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B368	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DE70	Trypanosoma cruzi	29%	100%