Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania major

UniProt:

Q4Q4Y1_LEIMA

TriTrypDb:

LmjF.32.2930 , LMJLV39_320036900 , LMJSD75_320037100

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	2
GO:0005876	spindle microtubule	7	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Y1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004835	tubulin-tyrosine ligase activity	3	7
GO:0016874	ligase activity	2	11
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016881	acid-amino acid ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.492
CLV_NRD_NRD_1	239	241	PF00675	0.259
CLV_NRD_NRD_1	66	68	PF00675	0.543
CLV_NRD_NRD_1	84	86	PF00675	0.739
CLV_PCSK_KEX2_1	239	241	PF00082	0.267
CLV_PCSK_KEX2_1	485	487	PF00082	0.497
CLV_PCSK_KEX2_1	66	68	PF00082	0.543
CLV_PCSK_KEX2_1	71	73	PF00082	0.617
CLV_PCSK_KEX2_1	84	86	PF00082	0.739
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.331
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.525
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.658
CLV_PCSK_PC7_1	67	73	PF00082	0.638
CLV_PCSK_PC7_1	80	86	PF00082	0.695
CLV_PCSK_SKI1_1	120	124	PF00082	0.388
CLV_PCSK_SKI1_1	13	17	PF00082	0.502
CLV_PCSK_SKI1_1	207	211	PF00082	0.292
CLV_PCSK_SKI1_1	233	237	PF00082	0.301
CLV_PCSK_SKI1_1	326	330	PF00082	0.299
CLV_PCSK_SKI1_1	460	464	PF00082	0.495
DEG_APCC_DBOX_1	206	214	PF00400	0.482
DEG_APCC_DBOX_1	311	319	PF00400	0.492
DEG_APCC_DBOX_1	361	369	PF00400	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.440
DEG_SCF_FBW7_1	153	158	PF00400	0.451
DOC_ANK_TNKS_1	413	420	PF00023	0.389
DOC_CYCLIN_RxL_1	10	18	PF00134	0.529
DOC_CYCLIN_RxL_1	207	218	PF00134	0.534
DOC_CYCLIN_yClb5_NLxxxL_5	437	446	PF00134	0.327
DOC_MAPK_gen_1	483	493	PF00069	0.436
DOC_MAPK_MEF2A_6	465	472	PF00069	0.467
DOC_MAPK_MEF2A_6	91	100	PF00069	0.689
DOC_MAPK_NFAT4_5	465	473	PF00069	0.467
DOC_PP1_RVXF_1	109	116	PF00149	0.521
DOC_PP1_RVXF_1	209	216	PF00149	0.531
DOC_PP1_SILK_1	207	212	PF00149	0.482
DOC_PP2B_LxvP_1	98	101	PF13499	0.626
DOC_USP7_MATH_1	101	105	PF00917	0.460
DOC_USP7_MATH_1	155	159	PF00917	0.482
DOC_USP7_MATH_1	188	192	PF00917	0.475
DOC_USP7_MATH_1	412	416	PF00917	0.489
DOC_USP7_MATH_1	83	87	PF00917	0.577
DOC_WW_Pin1_4	151	156	PF00397	0.451
DOC_WW_Pin1_4	278	283	PF00397	0.536
DOC_WW_Pin1_4	333	338	PF00397	0.541
DOC_WW_Pin1_4	92	97	PF00397	0.616
LIG_14-3-3_CanoR_1	120	125	PF00244	0.406
LIG_14-3-3_CanoR_1	20	26	PF00244	0.505
LIG_14-3-3_CanoR_1	266	271	PF00244	0.436
LIG_14-3-3_CanoR_1	27	32	PF00244	0.563
LIG_14-3-3_CanoR_1	381	386	PF00244	0.548
LIG_14-3-3_CanoR_1	84	90	PF00244	0.594
LIG_14-3-3_CanoR_1	91	96	PF00244	0.591
LIG_Actin_WH2_2	109	127	PF00022	0.413
LIG_APCC_ABBA_1	257	262	PF00400	0.492
LIG_CaM_NSCaTE_8	445	452	PF13499	0.417
LIG_eIF4E_1	230	236	PF01652	0.436
LIG_eIF4E_1	258	264	PF01652	0.467
LIG_FHA_1	117	123	PF00498	0.494
LIG_FHA_1	128	134	PF00498	0.556
LIG_FHA_1	265	271	PF00498	0.460
LIG_FHA_1	281	287	PF00498	0.417
LIG_FHA_1	30	36	PF00498	0.619
LIG_FHA_1	389	395	PF00498	0.451
LIG_FHA_1	426	432	PF00498	0.463
LIG_FHA_1	465	471	PF00498	0.358
LIG_FHA_1	477	483	PF00498	0.519
LIG_FHA_2	140	146	PF00498	0.433
LIG_FHA_2	38	44	PF00498	0.586
LIG_Integrin_RGD_1	203	205	PF01839	0.251
LIG_Integrin_RGD_1	348	350	PF01839	0.251
LIG_Integrin_RGD_1	373	375	PF01839	0.204
LIG_IRF3_LxIS_1	31	38	PF10401	0.406
LIG_LIR_Gen_1	18	26	PF02991	0.412
LIG_LIR_Gen_1	426	437	PF02991	0.355
LIG_LIR_Gen_1	6	16	PF02991	0.424
LIG_LIR_Nem_3	18	24	PF02991	0.524
LIG_LIR_Nem_3	205	209	PF02991	0.567
LIG_LIR_Nem_3	253	258	PF02991	0.442
LIG_LIR_Nem_3	298	304	PF02991	0.434
LIG_LIR_Nem_3	333	338	PF02991	0.497
LIG_LIR_Nem_3	426	432	PF02991	0.337
LIG_Pex14_2	432	436	PF04695	0.369
LIG_SH2_CRK	206	210	PF00017	0.482
LIG_SH2_CRK	335	339	PF00017	0.451
LIG_SH2_CRK	434	438	PF00017	0.294
LIG_SH2_GRB2like	357	360	PF00017	0.451
LIG_SH2_PTP2	490	493	PF00017	0.416
LIG_SH2_SRC	304	307	PF00017	0.492
LIG_SH2_STAP1	255	259	PF00017	0.436
LIG_SH2_STAP1	434	438	PF00017	0.291
LIG_SH2_STAP1	8	12	PF00017	0.430
LIG_SH2_STAT5	146	149	PF00017	0.467
LIG_SH2_STAT5	230	233	PF00017	0.469
LIG_SH2_STAT5	258	261	PF00017	0.498
LIG_SH2_STAT5	335	338	PF00017	0.575
LIG_SH2_STAT5	475	478	PF00017	0.475
LIG_SH2_STAT5	490	493	PF00017	0.401
LIG_SH3_2	343	348	PF14604	0.451
LIG_SH3_2	453	458	PF14604	0.521
LIG_SH3_3	228	234	PF00018	0.492
LIG_SH3_3	340	346	PF00018	0.517
LIG_SH3_3	348	354	PF00018	0.517
LIG_SH3_3	415	421	PF00018	0.483
LIG_SH3_3	450	456	PF00018	0.527
LIG_SH3_3	471	477	PF00018	0.420
LIG_SUMO_SIM_par_1	390	395	PF11976	0.495
LIG_TRFH_1	151	155	PF08558	0.404
LIG_UBA3_1	166	171	PF00899	0.248
MOD_CDK_SPK_2	337	342	PF00069	0.384
MOD_CDK_SPxxK_3	278	285	PF00069	0.335
MOD_CDK_SPxxK_3	92	99	PF00069	0.622
MOD_CK1_1	127	133	PF00069	0.295
MOD_CK1_1	22	28	PF00069	0.656
MOD_CK1_1	276	282	PF00069	0.368
MOD_CK1_1	358	364	PF00069	0.403
MOD_CK1_1	92	98	PF00069	0.758
MOD_CK2_1	156	162	PF00069	0.449
MOD_CK2_1	299	305	PF00069	0.297
MOD_CK2_1	3	9	PF00069	0.478
MOD_CK2_1	37	43	PF00069	0.574
MOD_GlcNHglycan	103	106	PF01048	0.507
MOD_GlcNHglycan	190	193	PF01048	0.293
MOD_GlcNHglycan	275	278	PF01048	0.366
MOD_GlcNHglycan	85	88	PF01048	0.620
MOD_GSK3_1	116	123	PF00069	0.358
MOD_GSK3_1	147	154	PF00069	0.326
MOD_GSK3_1	15	22	PF00069	0.562
MOD_GSK3_1	215	222	PF00069	0.317
MOD_GSK3_1	276	283	PF00069	0.398
MOD_GSK3_1	295	302	PF00069	0.298
MOD_GSK3_1	333	340	PF00069	0.483
MOD_N-GLC_1	358	363	PF02516	0.302
MOD_N-GLC_2	291	293	PF02516	0.271
MOD_NEK2_1	124	129	PF00069	0.309
MOD_NEK2_1	15	20	PF00069	0.482
MOD_NEK2_1	166	171	PF00069	0.314
MOD_NEK2_1	215	220	PF00069	0.358
MOD_NEK2_1	265	270	PF00069	0.303
MOD_NEK2_1	44	49	PF00069	0.532
MOD_NEK2_2	321	326	PF00069	0.335
MOD_PIKK_1	215	221	PF00454	0.349
MOD_PIKK_1	37	43	PF00454	0.615
MOD_PK_1	266	272	PF00069	0.271
MOD_PK_1	27	33	PF00069	0.544
MOD_PK_1	381	387	PF00069	0.270
MOD_PKA_2	19	25	PF00069	0.522
MOD_PKA_2	265	271	PF00069	0.271
MOD_PKA_2	273	279	PF00069	0.283
MOD_PKA_2	355	361	PF00069	0.425
MOD_PKA_2	406	412	PF00069	0.384
MOD_PKA_2	83	89	PF00069	0.652
MOD_Plk_4	124	130	PF00069	0.358
MOD_Plk_4	299	305	PF00069	0.356
MOD_Plk_4	3	9	PF00069	0.507
MOD_Plk_4	361	367	PF00069	0.270
MOD_Plk_4	406	412	PF00069	0.417
MOD_ProDKin_1	151	157	PF00069	0.292
MOD_ProDKin_1	278	284	PF00069	0.411
MOD_ProDKin_1	333	339	PF00069	0.417
MOD_ProDKin_1	92	98	PF00069	0.619
MOD_SUMO_for_1	330	333	PF00179	0.422
TRG_DiLeu_BaEn_1	162	167	PF01217	0.349
TRG_DiLeu_BaEn_4	305	311	PF01217	0.314
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.271
TRG_ENDOCYTIC_2	146	149	PF00928	0.349
TRG_ENDOCYTIC_2	206	209	PF00928	0.464
TRG_ENDOCYTIC_2	335	338	PF00928	0.341
TRG_ENDOCYTIC_2	434	437	PF00928	0.302
TRG_ENDOCYTIC_2	490	493	PF00928	0.381
TRG_ENDOCYTIC_2	8	11	PF00928	0.438
TRG_ER_diArg_1	173	176	PF00400	0.363
TRG_ER_diArg_1	66	68	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.204

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M9	Leptomonas seymouri	68%	77%
A0A1X0NRN8	Trypanosomatidae	41%	100%
A0A3Q8IH06	Leishmania donovani	96%	78%
A0A422NE52	Trypanosoma rangeli	29%	100%
A0A422NZN7	Trypanosoma rangeli	40%	96%
A4HKT5	Leishmania braziliensis	83%	100%
A4I8B4	Leishmania infantum	96%	100%
E9B373	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D711	Trypanosoma cruzi	32%	100%