ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4X4_LEIMA

TriTrypDb:

LmjF.32.2990 , LMJLV39_320037500 , LMJSD75_320037700

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.592
CLV_C14_Caspase3-7	169	173	PF00656	0.536
CLV_C14_Caspase3-7	177	181	PF00656	0.436
CLV_C14_Caspase3-7	286	290	PF00656	0.579
CLV_C14_Caspase3-7	431	435	PF00656	0.550
CLV_C14_Caspase3-7	463	467	PF00656	0.503
CLV_C14_Caspase3-7	73	77	PF00656	0.498
CLV_NRD_NRD_1	350	352	PF00675	0.449
CLV_NRD_NRD_1	375	377	PF00675	0.580
CLV_NRD_NRD_1	487	489	PF00675	0.607
CLV_NRD_NRD_1	682	684	PF00675	0.581
CLV_PCSK_KEX2_1	350	352	PF00082	0.449
CLV_PCSK_KEX2_1	375	377	PF00082	0.571
CLV_PCSK_KEX2_1	637	639	PF00082	0.591
CLV_PCSK_KEX2_1	684	686	PF00082	0.597
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.591
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.593
CLV_PCSK_SKI1_1	103	107	PF00082	0.549
CLV_PCSK_SKI1_1	214	218	PF00082	0.576
CLV_PCSK_SKI1_1	219	223	PF00082	0.593
CLV_PCSK_SKI1_1	350	354	PF00082	0.554
CLV_PCSK_SKI1_1	369	373	PF00082	0.276
CLV_PCSK_SKI1_1	436	440	PF00082	0.405
CLV_PCSK_SKI1_1	488	492	PF00082	0.526
CLV_PCSK_SKI1_1	678	682	PF00082	0.627
CLV_PCSK_SKI1_1	694	698	PF00082	0.553
CLV_Separin_Metazoa	294	298	PF03568	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_ODPH_VHL_1	206	217	PF01847	0.586
DEG_ODPH_VHL_1	394	407	PF01847	0.595
DOC_CKS1_1	352	357	PF01111	0.610
DOC_CKS1_1	615	620	PF01111	0.633
DOC_CYCLIN_RxL_1	132	142	PF00134	0.561
DOC_CYCLIN_RxL_1	675	682	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.506
DOC_MAPK_gen_1	245	252	PF00069	0.431
DOC_MAPK_MEF2A_6	245	252	PF00069	0.434
DOC_MAPK_MEF2A_6	273	280	PF00069	0.500
DOC_MAPK_MEF2A_6	44	53	PF00069	0.499
DOC_MAPK_MEF2A_6	445	454	PF00069	0.464
DOC_PP1_RVXF_1	159	166	PF00149	0.359
DOC_PP1_RVXF_1	434	441	PF00149	0.403
DOC_PP1_RVXF_1	475	481	PF00149	0.533
DOC_PP1_SILK_1	91	96	PF00149	0.549
DOC_PP2B_LxvP_1	205	208	PF13499	0.420
DOC_PP2B_LxvP_1	448	451	PF13499	0.460
DOC_PP4_FxxP_1	198	201	PF00568	0.546
DOC_PP4_FxxP_1	352	355	PF00568	0.609
DOC_PP4_FxxP_1	444	447	PF00568	0.547
DOC_PP4_FxxP_1	558	561	PF00568	0.675
DOC_PP4_FxxP_1	742	745	PF00568	0.499
DOC_SPAK_OSR1_1	417	421	PF12202	0.622
DOC_SPAK_OSR1_1	62	66	PF12202	0.527
DOC_USP7_MATH_1	192	196	PF00917	0.655
DOC_USP7_MATH_1	209	213	PF00917	0.470
DOC_USP7_MATH_1	301	305	PF00917	0.498
DOC_USP7_MATH_1	363	367	PF00917	0.581
DOC_USP7_MATH_1	460	464	PF00917	0.516
DOC_USP7_MATH_1	482	486	PF00917	0.639
DOC_USP7_MATH_1	611	615	PF00917	0.609
DOC_USP7_MATH_1	695	699	PF00917	0.709
DOC_USP7_MATH_1	710	714	PF00917	0.567
DOC_USP7_UBL2_3	4	8	PF12436	0.564
DOC_WW_Pin1_4	197	202	PF00397	0.539
DOC_WW_Pin1_4	351	356	PF00397	0.566
DOC_WW_Pin1_4	483	488	PF00397	0.635
DOC_WW_Pin1_4	512	517	PF00397	0.624
DOC_WW_Pin1_4	614	619	PF00397	0.577
LIG_14-3-3_CanoR_1	138	142	PF00244	0.572
LIG_14-3-3_CanoR_1	231	239	PF00244	0.632
LIG_14-3-3_CanoR_1	25	32	PF00244	0.583
LIG_14-3-3_CanoR_1	383	389	PF00244	0.526
LIG_14-3-3_CanoR_1	412	417	PF00244	0.535
LIG_14-3-3_CanoR_1	445	451	PF00244	0.385
LIG_Actin_WH2_2	122	140	PF00022	0.579
LIG_Actin_WH2_2	198	216	PF00022	0.573
LIG_APCC_ABBA_1	604	609	PF00400	0.614
LIG_BRCT_BRCA1_1	110	114	PF00533	0.465
LIG_BRCT_BRCA1_1	127	131	PF00533	0.351
LIG_BRCT_BRCA1_1	194	198	PF00533	0.623
LIG_BRCT_BRCA1_1	414	418	PF00533	0.501
LIG_BRCT_BRCA1_1	697	701	PF00533	0.622
LIG_BRCT_BRCA1_1	77	81	PF00533	0.469
LIG_CtBP_PxDLS_1	583	587	PF00389	0.573
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.601
LIG_Dynein_DLC8_1	381	387	PF01221	0.436
LIG_EH1_1	80	88	PF00400	0.510
LIG_eIF4E_1	675	681	PF01652	0.701
LIG_FHA_1	29	35	PF00498	0.545
LIG_FHA_1	383	389	PF00498	0.487
LIG_FHA_1	402	408	PF00498	0.286
LIG_FHA_1	427	433	PF00498	0.629
LIG_FHA_1	45	51	PF00498	0.494
LIG_FHA_2	429	435	PF00498	0.488
LIG_FHA_2	706	712	PF00498	0.559
LIG_HP1_1	201	205	PF01393	0.524
LIG_LIR_Apic_2	195	201	PF02991	0.577
LIG_LIR_Apic_2	741	745	PF02991	0.590
LIG_LIR_Gen_1	111	120	PF02991	0.562
LIG_LIR_Gen_1	379	388	PF02991	0.450
LIG_LIR_Gen_1	564	572	PF02991	0.599
LIG_LIR_Gen_1	9	16	PF02991	0.487
LIG_LIR_Nem_3	111	117	PF02991	0.491
LIG_LIR_Nem_3	254	259	PF02991	0.557
LIG_LIR_Nem_3	319	325	PF02991	0.649
LIG_LIR_Nem_3	354	359	PF02991	0.554
LIG_LIR_Nem_3	379	384	PF02991	0.426
LIG_LIR_Nem_3	564	569	PF02991	0.638
LIG_LIR_Nem_3	585	591	PF02991	0.492
LIG_LIR_Nem_3	748	753	PF02991	0.505
LIG_LIR_Nem_3	9	13	PF02991	0.478
LIG_LYPXL_yS_3	588	591	PF13949	0.474
LIG_NRBOX	81	87	PF00104	0.463
LIG_PDZ_Class_2	754	759	PF00595	0.522
LIG_Pex14_1	440	444	PF04695	0.501
LIG_REV1ctd_RIR_1	129	139	PF16727	0.473
LIG_SH2_CRK	381	385	PF00017	0.340
LIG_SH2_CRK	472	476	PF00017	0.474
LIG_SH2_NCK_1	539	543	PF00017	0.607
LIG_SH2_NCK_1	97	101	PF00017	0.544
LIG_SH2_PTP2	10	13	PF00017	0.517
LIG_SH2_STAP1	153	157	PF00017	0.503
LIG_SH2_STAP1	225	229	PF00017	0.616
LIG_SH2_STAT5	10	13	PF00017	0.489
LIG_SH2_STAT5	472	475	PF00017	0.345
LIG_SH2_STAT5	511	514	PF00017	0.627
LIG_SH2_STAT5	566	569	PF00017	0.558
LIG_SH2_STAT5	672	675	PF00017	0.642
LIG_SH2_STAT5	753	756	PF00017	0.417
LIG_SH3_3	205	211	PF00018	0.575
LIG_SH3_3	352	358	PF00018	0.601
LIG_SH3_3	390	396	PF00018	0.624
LIG_SH3_3	516	522	PF00018	0.651
LIG_SH3_3	612	618	PF00018	0.544
LIG_SH3_3	658	664	PF00018	0.671
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.418
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.559
LIG_SUMO_SIM_par_1	26	36	PF11976	0.582
LIG_SUMO_SIM_par_1	298	304	PF11976	0.492
LIG_SUMO_SIM_par_1	403	408	PF11976	0.547
LIG_SUMO_SIM_par_1	428	434	PF11976	0.567
LIG_TRAF2_1	290	293	PF00917	0.546
LIG_TRAF2_1	714	717	PF00917	0.553
LIG_TRFH_1	558	562	PF08558	0.601
LIG_TYR_ITIM	586	591	PF00017	0.481
LIG_UBA3_1	721	729	PF00899	0.623
MOD_CDK_SPK_2	483	488	PF00069	0.635
MOD_CDK_SPxK_1	483	489	PF00069	0.631
MOD_CDK_SPxxK_3	354	361	PF00069	0.591
MOD_CK1_1	197	203	PF00069	0.457
MOD_CK1_1	224	230	PF00069	0.474
MOD_CK1_1	23	29	PF00069	0.546
MOD_CK1_1	330	336	PF00069	0.559
MOD_CK1_1	357	363	PF00069	0.575
MOD_CK1_1	614	620	PF00069	0.635
MOD_CK1_1	656	662	PF00069	0.575
MOD_CK1_1	75	81	PF00069	0.485
MOD_CK2_1	231	237	PF00069	0.544
MOD_CK2_1	287	293	PF00069	0.544
MOD_CK2_1	705	711	PF00069	0.509
MOD_CK2_1	738	744	PF00069	0.578
MOD_CK2_1	9	15	PF00069	0.543
MOD_Cter_Amidation	735	738	PF01082	0.583
MOD_GlcNHglycan	194	197	PF01048	0.630
MOD_GlcNHglycan	289	292	PF01048	0.485
MOD_GlcNHglycan	5	8	PF01048	0.599
MOD_GlcNHglycan	56	59	PF01048	0.511
MOD_GlcNHglycan	563	566	PF01048	0.691
MOD_GlcNHglycan	625	628	PF01048	0.580
MOD_GlcNHglycan	656	659	PF01048	0.681
MOD_GlcNHglycan	711	715	PF01048	0.571
MOD_GSK3_1	108	115	PF00069	0.504
MOD_GSK3_1	116	123	PF00069	0.467
MOD_GSK3_1	137	144	PF00069	0.500
MOD_GSK3_1	20	27	PF00069	0.594
MOD_GSK3_1	401	408	PF00069	0.577
MOD_GSK3_1	426	433	PF00069	0.561
MOD_GSK3_1	52	59	PF00069	0.585
MOD_GSK3_1	526	533	PF00069	0.627
MOD_GSK3_1	607	614	PF00069	0.615
MOD_GSK3_1	623	630	PF00069	0.413
MOD_GSK3_1	653	660	PF00069	0.587
MOD_GSK3_1	701	708	PF00069	0.610
MOD_N-GLC_2	471	473	PF02516	0.523
MOD_N-GLC_2	54	56	PF02516	0.579
MOD_N-GLC_2	603	605	PF02516	0.578
MOD_NEK2_1	106	111	PF00069	0.558
MOD_NEK2_1	137	142	PF00069	0.487
MOD_NEK2_1	156	161	PF00069	0.387
MOD_NEK2_1	20	25	PF00069	0.527
MOD_NEK2_1	251	256	PF00069	0.488
MOD_NEK2_1	3	8	PF00069	0.592
MOD_NEK2_1	384	389	PF00069	0.442
MOD_NEK2_1	52	57	PF00069	0.467
MOD_NEK2_1	584	589	PF00069	0.525
MOD_NEK2_1	597	602	PF00069	0.476
MOD_NEK2_1	623	628	PF00069	0.583
MOD_NEK2_1	654	659	PF00069	0.598
MOD_NEK2_1	701	706	PF00069	0.646
MOD_NEK2_1	721	726	PF00069	0.285
MOD_NEK2_1	81	86	PF00069	0.365
MOD_OFUCOSY	298	305	PF10250	0.492
MOD_OFUCOSY	72	79	PF10250	0.483
MOD_PIKK_1	382	388	PF00454	0.536
MOD_PKA_2	137	143	PF00069	0.571
MOD_PKA_2	24	30	PF00069	0.642
MOD_PKA_2	382	388	PF00069	0.561
MOD_PKA_2	701	707	PF00069	0.641
MOD_Plk_1	112	118	PF00069	0.546
MOD_Plk_1	405	411	PF00069	0.518
MOD_Plk_1	584	590	PF00069	0.538
MOD_Plk_1	710	716	PF00069	0.545
MOD_Plk_2-3	28	34	PF00069	0.562
MOD_Plk_2-3	428	434	PF00069	0.568
MOD_Plk_2-3	9	15	PF00069	0.565
MOD_Plk_4	194	200	PF00069	0.572
MOD_Plk_4	252	258	PF00069	0.441
MOD_Plk_4	318	324	PF00069	0.596
MOD_Plk_4	405	411	PF00069	0.502
MOD_Plk_4	460	466	PF00069	0.445
MOD_Plk_4	592	598	PF00069	0.512
MOD_Plk_4	611	617	PF00069	0.430
MOD_Plk_4	628	634	PF00069	0.293
MOD_Plk_4	657	663	PF00069	0.547
MOD_Plk_4	81	87	PF00069	0.358
MOD_Plk_4	89	95	PF00069	0.363
MOD_ProDKin_1	197	203	PF00069	0.530
MOD_ProDKin_1	351	357	PF00069	0.561
MOD_ProDKin_1	483	489	PF00069	0.631
MOD_ProDKin_1	512	518	PF00069	0.623
MOD_ProDKin_1	614	620	PF00069	0.575
MOD_SUMO_for_1	696	699	PF00179	0.493
MOD_SUMO_rev_2	428	438	PF00179	0.449
TRG_DiLeu_BaEn_1	717	722	PF01217	0.546
TRG_DiLeu_BaEn_2	47	53	PF01217	0.461
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.505
TRG_ENDOCYTIC_2	10	13	PF00928	0.474
TRG_ENDOCYTIC_2	153	156	PF00928	0.548
TRG_ENDOCYTIC_2	256	259	PF00928	0.550
TRG_ENDOCYTIC_2	322	325	PF00928	0.636
TRG_ENDOCYTIC_2	356	359	PF00928	0.617
TRG_ENDOCYTIC_2	381	384	PF00928	0.342
TRG_ENDOCYTIC_2	472	475	PF00928	0.470
TRG_ENDOCYTIC_2	566	569	PF00928	0.590
TRG_ENDOCYTIC_2	588	591	PF00928	0.474
TRG_ENDOCYTIC_2	97	100	PF00928	0.541
TRG_ER_diArg_1	349	351	PF00400	0.443
TRG_ER_diArg_1	683	686	PF00400	0.596
TRG_NES_CRM1_1	104	120	PF08389	0.565
TRG_NLS_MonoExtC_3	682	687	PF00514	0.615
TRG_NLS_MonoExtN_4	683	688	PF00514	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N0	Leptomonas seymouri	55%	89%
A0A1X0NTF1	Trypanosomatidae	30%	88%
A0A3Q8ILH1	Leishmania donovani	95%	100%
A0A422NYN9	Trypanosoma rangeli	31%	88%
A4HKU3	Leishmania braziliensis	82%	100%
A4I8C2	Leishmania infantum	95%	100%
D0AAV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9B381	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%