ER membrane protein complex subunit 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab5-interacting protein (Rab5ip), putative

Species:

Leishmania major

UniProt:

Q4Q4X3_LEIMA

TriTrypDb:

LmjF.32.2995 , LMJLV39_320037700 , LMJSD75_320037900

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0072546	EMC complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11

Expansion

Sequence features

Q4Q4X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4X3

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	2
GO:0006996	organelle organization	4	11
GO:0007033	vacuole organization	5	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:1905037	autophagosome organization	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	44	48	PF00082	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.611
DOC_PP1_RVXF_1	42	49	PF00149	0.295
DOC_USP7_UBL2_3	71	75	PF12436	0.518
LIG_BRCT_BRCA1_1	77	81	PF00533	0.512
LIG_EH1_1	80	88	PF00400	0.527
LIG_FHA_1	75	81	PF00498	0.511
LIG_FHA_1	90	96	PF00498	0.301
LIG_FHA_2	1	7	PF00498	0.625
LIG_LIR_Gen_1	14	23	PF02991	0.616
LIG_LIR_Gen_1	56	63	PF02991	0.329
LIG_LIR_Gen_1	92	101	PF02991	0.304
LIG_LIR_Nem_3	14	20	PF02991	0.616
LIG_LIR_Nem_3	41	46	PF02991	0.296
LIG_LIR_Nem_3	92	96	PF02991	0.311
LIG_LIR_Nem_3	98	104	PF02991	0.293
LIG_PDZ_Class_2	102	107	PF00595	0.317
LIG_Pex14_1	97	101	PF04695	0.301
LIG_Pex14_2	43	47	PF04695	0.318
LIG_SH2_CRK	101	105	PF00017	0.306
LIG_SH2_NCK_1	101	105	PF00017	0.306
LIG_SH2_NCK_1	17	21	PF00017	0.615
LIG_SH2_PTP2	93	96	PF00017	0.373
LIG_SH2_STAP1	101	105	PF00017	0.306
LIG_SH2_STAP1	17	21	PF00017	0.592
LIG_SH2_STAT5	93	96	PF00017	0.284
LIG_TYR_ITIM	99	104	PF00017	0.365
LIG_WRC_WIRS_1	55	60	PF05994	0.343
MOD_GlcNHglycan	87	90	PF01048	0.412
MOD_GSK3_1	75	82	PF00069	0.512
MOD_GSK3_1	85	92	PF00069	0.320
MOD_NEK2_1	38	43	PF00069	0.285
MOD_NEK2_1	95	100	PF00069	0.295
MOD_Plk_4	16	22	PF00069	0.563
MOD_Plk_4	25	31	PF00069	0.334
MOD_Plk_4	89	95	PF00069	0.295
TRG_ENDOCYTIC_2	101	104	PF00928	0.270
TRG_ENDOCYTIC_2	17	20	PF00928	0.580
TRG_ENDOCYTIC_2	93	96	PF00928	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P905	Leptomonas seymouri	78%	100%
A0A1X0NRR3	Trypanosomatidae	53%	100%
A0A3Q8IG59	Leishmania donovani	99%	100%
A0A422NYQ7	Trypanosoma rangeli	52%	100%
A4HKU4	Leishmania braziliensis	85%	100%
A4I8C3	Leishmania infantum	99%	100%
D0AAU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B382	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O59764	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	99%
V5BVN7	Trypanosoma cruzi	52%	100%