LeishMANIAdb
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CNNM transmembrane domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CNNM transmembrane domain-containing protein
Gene product:
Domain of unknown function DUF21, putative
Species:
Leishmania major
UniProt:
Q4Q4X2_LEIMA
TriTrypDb:
LmjF.32.3000 , LMJLV39_320037900 * , LMJSD75_320038100
Length:
403

Annotations

LeishMANIAdb annotations

Homologous to plant metal transporters (likely Mg2+ transporters)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4Q4X2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4X2

Function

Biological processes
Term Name Level Count
GO:0010960 magnesium ion homeostasis 8 12
GO:0042592 homeostatic process 3 12
GO:0048878 chemical homeostasis 4 12
GO:0050801 monoatomic ion homeostasis 5 12
GO:0055065 obsolete metal ion homeostasis 7 12
GO:0055080 monoatomic cation homeostasis 6 12
GO:0065007 biological regulation 1 12
GO:0065008 regulation of biological quality 2 12
GO:0072507 obsolete divalent inorganic cation homeostasis 7 12
GO:0098771 inorganic ion homeostasis 6 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 337 341 PF00656 0.373
CLV_NRD_NRD_1 61 63 PF00675 0.265
CLV_NRD_NRD_1 64 66 PF00675 0.269
CLV_PCSK_FUR_1 62 66 PF00082 0.311
CLV_PCSK_KEX2_1 170 172 PF00082 0.489
CLV_PCSK_KEX2_1 253 255 PF00082 0.659
CLV_PCSK_KEX2_1 61 63 PF00082 0.255
CLV_PCSK_KEX2_1 64 66 PF00082 0.256
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.527
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.659
CLV_PCSK_SKI1_1 286 290 PF00082 0.576
CLV_PCSK_SKI1_1 64 68 PF00082 0.289
DEG_APCC_DBOX_1 170 178 PF00400 0.262
DEG_APCC_DBOX_1 63 71 PF00400 0.536
DOC_CDC14_PxL_1 302 310 PF14671 0.392
DOC_CYCLIN_yCln2_LP_2 8 14 PF00134 0.456
DOC_CYCLIN_yCln2_LP_2 98 104 PF00134 0.423
DOC_MAPK_DCC_7 301 310 PF00069 0.391
DOC_MAPK_gen_1 301 310 PF00069 0.365
DOC_MAPK_gen_1 61 70 PF00069 0.463
DOC_MAPK_HePTP_8 58 70 PF00069 0.522
DOC_MAPK_MEF2A_6 301 310 PF00069 0.401
DOC_MAPK_MEF2A_6 61 70 PF00069 0.520
DOC_PP1_RVXF_1 153 160 PF00149 0.283
DOC_PP1_RVXF_1 284 291 PF00149 0.408
DOC_PP2B_LxvP_1 308 311 PF13499 0.400
DOC_PP2B_LxvP_1 8 11 PF13499 0.467
DOC_USP7_MATH_1 130 134 PF00917 0.388
DOC_USP7_MATH_1 199 203 PF00917 0.575
DOC_USP7_MATH_1 249 253 PF00917 0.432
DOC_USP7_MATH_1 52 56 PF00917 0.555
DOC_USP7_UBL2_3 45 49 PF12436 0.500
DOC_WW_Pin1_4 314 319 PF00397 0.371
DOC_WW_Pin1_4 326 331 PF00397 0.346
DOC_WW_Pin1_4 335 340 PF00397 0.366
DOC_WW_Pin1_4 97 102 PF00397 0.450
LIG_14-3-3_CanoR_1 240 246 PF00244 0.379
LIG_14-3-3_CanoR_1 254 260 PF00244 0.377
LIG_14-3-3_CanoR_1 312 318 PF00244 0.362
LIG_14-3-3_CanoR_1 360 364 PF00244 0.390
LIG_Actin_WH2_2 223 238 PF00022 0.412
LIG_APCC_ABBA_1 243 248 PF00400 0.393
LIG_APCC_ABBA_1 267 272 PF00400 0.326
LIG_BIR_II_1 1 5 PF00653 0.470
LIG_Clathr_ClatBox_1 80 84 PF01394 0.337
LIG_EH1_1 136 144 PF00400 0.450
LIG_eIF4E_1 137 143 PF01652 0.450
LIG_FHA_1 144 150 PF00498 0.313
LIG_FHA_1 22 28 PF00498 0.431
LIG_FHA_1 240 246 PF00498 0.366
LIG_FHA_1 259 265 PF00498 0.246
LIG_FHA_1 278 284 PF00498 0.171
LIG_FHA_1 363 369 PF00498 0.519
LIG_FHA_1 77 83 PF00498 0.329
LIG_FHA_1 86 92 PF00498 0.305
LIG_FHA_2 335 341 PF00498 0.361
LIG_FHA_2 359 365 PF00498 0.425
LIG_IRF3_LxIS_1 32 39 PF10401 0.415
LIG_LIR_Gen_1 15 25 PF02991 0.447
LIG_LIR_LC3C_4 24 28 PF02991 0.450
LIG_LIR_LC3C_4 79 82 PF02991 0.396
LIG_NRBOX 284 290 PF00104 0.408
LIG_RPA_C_Fungi 242 254 PF08784 0.506
LIG_SH2_CRK 5 9 PF00017 0.597
LIG_SH2_NCK_1 270 274 PF00017 0.479
LIG_SH2_SRC 186 189 PF00017 0.468
LIG_SH2_SRC 367 370 PF00017 0.681
LIG_SH2_STAT5 137 140 PF00017 0.388
LIG_SH2_STAT5 229 232 PF00017 0.465
LIG_SH2_STAT5 293 296 PF00017 0.530
LIG_SH2_STAT5 325 328 PF00017 0.511
LIG_SH2_STAT5 367 370 PF00017 0.620
LIG_SH3_1 303 309 PF00018 0.528
LIG_SH3_3 142 148 PF00018 0.432
LIG_SH3_3 270 276 PF00018 0.476
LIG_SH3_3 303 309 PF00018 0.448
LIG_Sin3_3 136 143 PF02671 0.411
LIG_SUMO_SIM_anti_2 108 114 PF11976 0.388
LIG_SUMO_SIM_anti_2 24 30 PF11976 0.428
LIG_SUMO_SIM_anti_2 352 359 PF11976 0.529
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.360
LIG_SUMO_SIM_par_1 10 15 PF11976 0.544
LIG_SUMO_SIM_par_1 222 228 PF11976 0.461
LIG_SUMO_SIM_par_1 332 338 PF11976 0.288
LIG_SUMO_SIM_par_1 36 42 PF11976 0.339
LIG_SUMO_SIM_par_1 78 85 PF11976 0.320
LIG_TYR_ITIM 135 140 PF00017 0.388
LIG_WRC_WIRS_1 379 384 PF05994 0.664
LIG_WW_3 197 201 PF00397 0.678
MOD_CK1_1 15 21 PF00069 0.450
MOD_CK1_1 203 209 PF00069 0.637
MOD_CK1_1 258 264 PF00069 0.545
MOD_CK1_1 277 283 PF00069 0.342
MOD_CK1_1 314 320 PF00069 0.456
MOD_CK1_1 362 368 PF00069 0.585
MOD_CK1_1 39 45 PF00069 0.349
MOD_CK1_1 85 91 PF00069 0.423
MOD_CK2_1 222 228 PF00069 0.452
MOD_CK2_1 97 103 PF00069 0.450
MOD_Cter_Amidation 59 62 PF01082 0.403
MOD_GlcNHglycan 132 135 PF01048 0.340
MOD_GlcNHglycan 164 167 PF01048 0.450
MOD_GlcNHglycan 313 316 PF01048 0.494
MOD_GlcNHglycan 349 352 PF01048 0.515
MOD_GlcNHglycan 84 87 PF01048 0.423
MOD_GSK3_1 143 150 PF00069 0.346
MOD_GSK3_1 199 206 PF00069 0.750
MOD_GSK3_1 235 242 PF00069 0.469
MOD_GSK3_1 358 365 PF00069 0.592
MOD_GSK3_1 374 381 PF00069 0.617
MOD_N-GLC_1 277 282 PF02516 0.422
MOD_N-GLC_1 385 390 PF02516 0.649
MOD_NEK2_1 129 134 PF00069 0.281
MOD_NEK2_1 143 148 PF00069 0.320
MOD_NEK2_1 21 26 PF00069 0.343
MOD_NEK2_1 235 240 PF00069 0.510
MOD_NEK2_1 255 260 PF00069 0.524
MOD_NEK2_1 36 41 PF00069 0.412
MOD_NEK2_2 241 246 PF00069 0.475
MOD_PIKK_1 214 220 PF00454 0.545
MOD_PIKK_1 277 283 PF00454 0.445
MOD_PKA_2 199 205 PF00069 0.725
MOD_PKA_2 239 245 PF00069 0.501
MOD_PKA_2 311 317 PF00069 0.495
MOD_PKA_2 359 365 PF00069 0.502
MOD_Plk_1 12 18 PF00069 0.349
MOD_Plk_1 200 206 PF00069 0.676
MOD_Plk_1 277 283 PF00069 0.372
MOD_Plk_1 385 391 PF00069 0.620
MOD_Plk_4 105 111 PF00069 0.391
MOD_Plk_4 12 18 PF00069 0.307
MOD_Plk_4 230 236 PF00069 0.437
MOD_Plk_4 255 261 PF00069 0.495
MOD_Plk_4 3 9 PF00069 0.476
MOD_Plk_4 374 380 PF00069 0.699
MOD_Plk_4 76 82 PF00069 0.319
MOD_ProDKin_1 314 320 PF00069 0.475
MOD_ProDKin_1 326 332 PF00069 0.440
MOD_ProDKin_1 335 341 PF00069 0.470
MOD_ProDKin_1 97 103 PF00069 0.450
TRG_DiLeu_BaEn_1 284 289 PF01217 0.428
TRG_DiLeu_BaLyEn_6 283 288 PF01217 0.494
TRG_DiLeu_BaLyEn_6 303 308 PF01217 0.494
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.423
TRG_DiLeu_LyEn_5 89 94 PF01217 0.423
TRG_ENDOCYTIC_2 137 140 PF00928 0.360
TRG_ENDOCYTIC_2 270 273 PF00928 0.478
TRG_ENDOCYTIC_2 5 8 PF00928 0.569
TRG_ER_diArg_1 300 303 PF00400 0.471
TRG_ER_diArg_1 61 64 PF00400 0.363
TRG_NES_CRM1_1 89 103 PF08389 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N1 Leptomonas seymouri 70% 100%
A0A0N1I1M9 Leptomonas seymouri 35% 95%
A0A0N1PDI6 Leptomonas seymouri 22% 67%
A0A0S4IPA6 Bodo saltans 25% 100%
A0A0S4IPI7 Bodo saltans 35% 81%
A0A0S4JSF9 Bodo saltans 24% 75%
A0A1X0NRR8 Trypanosomatidae 39% 92%
A0A1X0P1F1 Trypanosomatidae 23% 100%
A0A1X0PAL3 Trypanosomatidae 22% 71%
A0A3Q8IL77 Leishmania donovani 22% 66%
A0A3Q8ITK0 Leishmania donovani 96% 100%
A0A3R7LBY6 Trypanosoma rangeli 27% 100%
A0A422NS01 Trypanosoma rangeli 23% 71%
A0A422NYJ0 Trypanosoma rangeli 38% 86%
A4HAY2 Leishmania braziliensis 21% 68%
A4HIN7 Leishmania braziliensis 24% 89%
A4HKU5 Leishmania braziliensis 87% 100%
A4I8C4 Leishmania infantum 97% 100%
A4IA41 Leishmania infantum 22% 66%
C9ZM59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 72%
E9B177 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 80%
E9B383 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B555 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 66%
Q4Q2T0 Leishmania major 22% 66%
Q4V3C7 Arabidopsis thaliana 30% 81%
Q67XQ0 Arabidopsis thaliana 29% 82%
Q8RY60 Arabidopsis thaliana 28% 76%
Q8VZI2 Arabidopsis thaliana 31% 95%
Q9LTD8 Arabidopsis thaliana 26% 81%
Q9ZQR4 Arabidopsis thaliana 29% 95%
Q9ZVS8 Arabidopsis thaliana 30% 81%
V5BKR5 Trypanosoma cruzi 23% 70%
V5DM70 Trypanosoma cruzi 37% 89%
V5DNW3 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS