AMPK1_CBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania major

UniProt:

Q4Q4X1_LEIMA

TriTrypDb:

LmjF.32.3010 , LMJLV39_320038000 , LMJSD75_320038200

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4Q4X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4X1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.487
CLV_NRD_NRD_1	579	581	PF00675	0.356
CLV_NRD_NRD_1	677	679	PF00675	0.443
CLV_NRD_NRD_1	7	9	PF00675	0.678
CLV_NRD_NRD_1	715	717	PF00675	0.507
CLV_PCSK_KEX2_1	677	679	PF00082	0.460
CLV_PCSK_KEX2_1	681	683	PF00082	0.563
CLV_PCSK_KEX2_1	7	9	PF00082	0.677
CLV_PCSK_KEX2_1	715	717	PF00082	0.525
CLV_PCSK_KEX2_1	727	729	PF00082	0.677
CLV_PCSK_KEX2_1	795	797	PF00082	0.593
CLV_PCSK_KEX2_1	81	83	PF00082	0.462
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.622
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.575
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.612
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.462
CLV_PCSK_PC7_1	677	683	PF00082	0.555
CLV_PCSK_SKI1_1	32	36	PF00082	0.510
CLV_PCSK_SKI1_1	531	535	PF00082	0.526
CLV_PCSK_SKI1_1	546	550	PF00082	0.424
CLV_PCSK_SKI1_1	628	632	PF00082	0.456
CLV_PCSK_SKI1_1	722	726	PF00082	0.518
CLV_PCSK_SKI1_1	801	805	PF00082	0.567
DEG_APCC_DBOX_1	24	32	PF00400	0.533
DEG_SCF_FBW7_1	805	812	PF00400	0.532
DOC_ANK_TNKS_1	340	347	PF00023	0.341
DOC_CDC14_PxL_1	124	132	PF14671	0.341
DOC_CDC14_PxL_1	143	151	PF14671	0.341
DOC_CKS1_1	438	443	PF01111	0.419
DOC_CYCLIN_RxL_1	749	759	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.437
DOC_MAPK_DCC_7	839	848	PF00069	0.559
DOC_MAPK_gen_1	25	36	PF00069	0.522
DOC_MAPK_MEF2A_6	59	68	PF00069	0.415
DOC_MAPK_MEF2A_6	839	848	PF00069	0.559
DOC_PP2B_LxvP_1	331	334	PF13499	0.341
DOC_USP7_MATH_1	117	121	PF00917	0.404
DOC_USP7_MATH_1	393	397	PF00917	0.648
DOC_USP7_MATH_1	555	559	PF00917	0.511
DOC_USP7_MATH_1	638	642	PF00917	0.444
DOC_USP7_MATH_1	809	813	PF00917	0.560
DOC_USP7_UBL2_3	198	202	PF12436	0.549
DOC_USP7_UBL2_3	581	585	PF12436	0.466
DOC_USP7_UBL2_3	598	602	PF12436	0.466
DOC_WW_Pin1_4	257	262	PF00397	0.560
DOC_WW_Pin1_4	389	394	PF00397	0.561
DOC_WW_Pin1_4	406	411	PF00397	0.438
DOC_WW_Pin1_4	437	442	PF00397	0.393
DOC_WW_Pin1_4	483	488	PF00397	0.462
DOC_WW_Pin1_4	516	521	PF00397	0.404
DOC_WW_Pin1_4	539	544	PF00397	0.593
DOC_WW_Pin1_4	586	591	PF00397	0.421
DOC_WW_Pin1_4	612	617	PF00397	0.313
DOC_WW_Pin1_4	687	692	PF00397	0.631
DOC_WW_Pin1_4	709	714	PF00397	0.409
DOC_WW_Pin1_4	80	85	PF00397	0.448
DOC_WW_Pin1_4	805	810	PF00397	0.443
LIG_14-3-3_CanoR_1	131	136	PF00244	0.341
LIG_14-3-3_CanoR_1	387	393	PF00244	0.421
LIG_14-3-3_CanoR_1	790	795	PF00244	0.445
LIG_Actin_WH2_2	66	83	PF00022	0.497
LIG_AP2alpha_2	498	500	PF02296	0.446
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BRCT_BRCA1_1	133	137	PF00533	0.341
LIG_BRCT_BRCA1_1	298	302	PF00533	0.412
LIG_Clathr_ClatBox_1	180	184	PF01394	0.439
LIG_Clathr_ClatBox_1	51	55	PF01394	0.528
LIG_Clathr_ClatBox_1	63	67	PF01394	0.499
LIG_FHA_1	108	114	PF00498	0.382
LIG_FHA_1	152	158	PF00498	0.341
LIG_FHA_1	276	282	PF00498	0.519
LIG_FHA_1	309	315	PF00498	0.437
LIG_FHA_1	328	334	PF00498	0.356
LIG_FHA_1	533	539	PF00498	0.459
LIG_FHA_1	545	551	PF00498	0.436
LIG_FHA_1	595	601	PF00498	0.356
LIG_FHA_1	654	660	PF00498	0.562
LIG_FHA_1	668	674	PF00498	0.572
LIG_FHA_1	718	724	PF00498	0.547
LIG_FHA_1	72	78	PF00498	0.486
LIG_FHA_1	81	87	PF00498	0.404
LIG_FHA_1	819	825	PF00498	0.571
LIG_FHA_2	139	145	PF00498	0.556
LIG_FHA_2	409	415	PF00498	0.415
LIG_FHA_2	504	510	PF00498	0.475
LIG_FHA_2	697	703	PF00498	0.454
LIG_FHA_2	762	768	PF00498	0.496
LIG_FHA_2	857	863	PF00498	0.818
LIG_Integrin_isoDGR_2	5	7	PF01839	0.663
LIG_LIR_Apic_2	284	289	PF02991	0.421
LIG_LIR_Gen_1	103	113	PF02991	0.419
LIG_LIR_Gen_1	134	143	PF02991	0.341
LIG_LIR_Gen_1	235	246	PF02991	0.559
LIG_LIR_Gen_1	394	403	PF02991	0.521
LIG_LIR_Gen_1	40	51	PF02991	0.400
LIG_LIR_Gen_1	430	441	PF02991	0.404
LIG_LIR_Gen_1	574	582	PF02991	0.358
LIG_LIR_Gen_1	693	703	PF02991	0.528
LIG_LIR_Gen_1	779	789	PF02991	0.487
LIG_LIR_Nem_3	103	108	PF02991	0.438
LIG_LIR_Nem_3	119	124	PF02991	0.397
LIG_LIR_Nem_3	134	140	PF02991	0.334
LIG_LIR_Nem_3	141	146	PF02991	0.361
LIG_LIR_Nem_3	235	241	PF02991	0.591
LIG_LIR_Nem_3	285	291	PF02991	0.445
LIG_LIR_Nem_3	337	343	PF02991	0.372
LIG_LIR_Nem_3	394	400	PF02991	0.499
LIG_LIR_Nem_3	40	46	PF02991	0.412
LIG_LIR_Nem_3	430	436	PF02991	0.408
LIG_LIR_Nem_3	469	474	PF02991	0.519
LIG_LIR_Nem_3	479	485	PF02991	0.382
LIG_LIR_Nem_3	498	503	PF02991	0.324
LIG_LIR_Nem_3	517	521	PF02991	0.486
LIG_LIR_Nem_3	574	579	PF02991	0.342
LIG_LIR_Nem_3	586	591	PF02991	0.357
LIG_LIR_Nem_3	613	617	PF02991	0.306
LIG_LIR_Nem_3	693	698	PF02991	0.497
LIG_LIR_Nem_3	779	785	PF02991	0.491
LIG_LIR_Nem_3	806	810	PF02991	0.448
LIG_LYPXL_S_1	287	291	PF13949	0.484
LIG_LYPXL_yS_3	146	149	PF13949	0.375
LIG_LYPXL_yS_3	288	291	PF13949	0.484
LIG_PTB_Apo_2	425	432	PF02174	0.515
LIG_RPA_C_Fungi	228	240	PF08784	0.499
LIG_SH2_CRK	340	344	PF00017	0.341
LIG_SH2_CRK	43	47	PF00017	0.467
LIG_SH2_CRK	588	592	PF00017	0.466
LIG_SH2_CRK	614	618	PF00017	0.306
LIG_SH2_CRK	807	811	PF00017	0.450
LIG_SH2_GRB2like	426	429	PF00017	0.524
LIG_SH2_NCK_1	397	401	PF00017	0.484
LIG_SH2_NCK_1	588	592	PF00017	0.412
LIG_SH2_NCK_1	614	618	PF00017	0.356
LIG_SH2_SRC	286	289	PF00017	0.455
LIG_SH2_SRC	332	335	PF00017	0.345
LIG_SH2_SRC	426	429	PF00017	0.445
LIG_SH2_STAP1	338	342	PF00017	0.356
LIG_SH2_STAP1	39	43	PF00017	0.453
LIG_SH2_STAT5	238	241	PF00017	0.517
LIG_SH2_STAT5	286	289	PF00017	0.429
LIG_SH2_STAT5	326	329	PF00017	0.345
LIG_SH2_STAT5	332	335	PF00017	0.335
LIG_SH2_STAT5	342	345	PF00017	0.212
LIG_SH2_STAT5	385	388	PF00017	0.466
LIG_SH2_STAT5	408	411	PF00017	0.430
LIG_SH2_STAT5	426	429	PF00017	0.458
LIG_SH2_STAT5	435	438	PF00017	0.435
LIG_SH2_STAT5	45	48	PF00017	0.400
LIG_SH2_STAT5	470	473	PF00017	0.438
LIG_SH2_STAT5	588	591	PF00017	0.341
LIG_SH2_STAT5	599	602	PF00017	0.341
LIG_SH2_STAT5	609	612	PF00017	0.356
LIG_SH2_STAT5	614	617	PF00017	0.356
LIG_SH2_STAT5	663	666	PF00017	0.469
LIG_SH2_STAT5	760	763	PF00017	0.445
LIG_SH2_STAT5	792	795	PF00017	0.455
LIG_SH2_STAT5	807	810	PF00017	0.435
LIG_SH3_3	144	150	PF00018	0.352
LIG_SH3_3	155	161	PF00018	0.310
LIG_SH3_3	438	444	PF00018	0.448
LIG_SH3_3	493	499	PF00018	0.584
LIG_SH3_3	597	603	PF00018	0.417
LIG_SH3_3	731	737	PF00018	0.503
LIG_SH3_3	742	748	PF00018	0.407
LIG_SH3_3	771	777	PF00018	0.535
LIG_SH3_5	334	338	PF00018	0.375
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.417
LIG_SUMO_SIM_anti_2	643	650	PF11976	0.585
LIG_SUMO_SIM_par_1	179	184	PF11976	0.463
LIG_SUMO_SIM_par_1	260	265	PF11976	0.556
LIG_SUMO_SIM_par_1	311	317	PF11976	0.357
LIG_SUMO_SIM_par_1	61	67	PF11976	0.400
LIG_TRAF2_1	375	378	PF00917	0.687
LIG_TRAF2_1	860	863	PF00917	0.782
LIG_TYR_ITIM	612	617	PF00017	0.306
LIG_TYR_ITIM	805	810	PF00017	0.443
LIG_WRC_WIRS_1	118	123	PF05994	0.394
LIG_WRC_WIRS_1	140	145	PF05994	0.320
LIG_WRC_WIRS_1	51	56	PF05994	0.470
MOD_CDK_SPxK_1	437	443	PF00069	0.529
MOD_CDK_SPxK_1	516	522	PF00069	0.408
MOD_CDK_SPxK_1	709	715	PF00069	0.411
MOD_CDK_SPxK_1	805	811	PF00069	0.446
MOD_CDK_SPxxK_3	539	546	PF00069	0.464
MOD_CDK_SPxxK_3	709	716	PF00069	0.472
MOD_CK1_1	142	148	PF00069	0.380
MOD_CK1_1	355	361	PF00069	0.484
MOD_CK1_1	391	397	PF00069	0.564
MOD_CK1_1	439	445	PF00069	0.555
MOD_CK1_1	532	538	PF00069	0.495
MOD_CK1_1	586	592	PF00069	0.284
MOD_CK1_1	643	649	PF00069	0.449
MOD_CK1_1	683	689	PF00069	0.632
MOD_CK1_1	690	696	PF00069	0.603
MOD_CK1_1	849	855	PF00069	0.821
MOD_CK1_1	857	863	PF00069	0.642
MOD_CK1_1	864	870	PF00069	0.755
MOD_CK2_1	138	144	PF00069	0.413
MOD_CK2_1	27	33	PF00069	0.469
MOD_CK2_1	485	491	PF00069	0.516
MOD_CK2_1	66	72	PF00069	0.388
MOD_CK2_1	761	767	PF00069	0.645
MOD_CK2_1	856	862	PF00069	0.772
MOD_CK2_1	866	872	PF00069	0.688
MOD_Cter_Amidation	5	8	PF01082	0.666
MOD_GlcNHglycan	18	21	PF01048	0.545
MOD_GlcNHglycan	294	297	PF01048	0.375
MOD_GlcNHglycan	393	396	PF01048	0.629
MOD_GlcNHglycan	487	490	PF01048	0.582
MOD_GlcNHglycan	591	594	PF01048	0.528
MOD_GlcNHglycan	667	670	PF01048	0.546
MOD_GlcNHglycan	831	835	PF01048	0.780
MOD_GSK3_1	107	114	PF00069	0.407
MOD_GSK3_1	138	145	PF00069	0.466
MOD_GSK3_1	292	299	PF00069	0.406
MOD_GSK3_1	308	315	PF00069	0.484
MOD_GSK3_1	348	355	PF00069	0.484
MOD_GSK3_1	389	396	PF00069	0.483
MOD_GSK3_1	402	409	PF00069	0.470
MOD_GSK3_1	661	668	PF00069	0.661
MOD_GSK3_1	683	690	PF00069	0.562
MOD_GSK3_1	703	710	PF00069	0.292
MOD_GSK3_1	761	768	PF00069	0.494
MOD_GSK3_1	805	812	PF00069	0.460
MOD_GSK3_1	842	849	PF00069	0.733
MOD_GSK3_1	850	857	PF00069	0.699
MOD_GSK3_1	858	865	PF00069	0.597
MOD_N-GLC_1	138	143	PF02516	0.392
MOD_N-GLC_1	308	313	PF02516	0.344
MOD_N-GLC_1	476	481	PF02516	0.554
MOD_N-GLC_1	594	599	PF02516	0.356
MOD_N-GLC_2	416	418	PF02516	0.453
MOD_NEK2_1	282	287	PF00069	0.556
MOD_NEK2_1	327	332	PF00069	0.377
MOD_NEK2_1	436	441	PF00069	0.430
MOD_NEK2_1	452	457	PF00069	0.468
MOD_NEK2_1	66	71	PF00069	0.401
MOD_NEK2_1	803	808	PF00069	0.510
MOD_NEK2_1	848	853	PF00069	0.674
MOD_NEK2_1	856	861	PF00069	0.584
MOD_NEK2_1	89	94	PF00069	0.404
MOD_PIKK_1	555	561	PF00454	0.484
MOD_PIKK_1	851	857	PF00454	0.794
MOD_PKA_1	680	686	PF00069	0.555
MOD_PKA_2	276	282	PF00069	0.537
MOD_PKA_2	829	835	PF00069	0.558
MOD_Plk_1	138	144	PF00069	0.375
MOD_Plk_1	32	38	PF00069	0.502
MOD_Plk_1	402	408	PF00069	0.472
MOD_Plk_1	429	435	PF00069	0.516
MOD_Plk_1	476	482	PF00069	0.500
MOD_Plk_1	66	72	PF00069	0.381
MOD_Plk_1	707	713	PF00069	0.472
MOD_Plk_2-3	209	215	PF00069	0.478
MOD_Plk_2-3	312	318	PF00069	0.484
MOD_Plk_2-3	50	56	PF00069	0.526
MOD_Plk_4	282	288	PF00069	0.551
MOD_Plk_4	327	333	PF00069	0.345
MOD_Plk_4	379	385	PF00069	0.499
MOD_Plk_4	476	482	PF00069	0.506
MOD_Plk_4	571	577	PF00069	0.352
MOD_Plk_4	643	649	PF00069	0.581
MOD_Plk_4	765	771	PF00069	0.545
MOD_ProDKin_1	257	263	PF00069	0.560
MOD_ProDKin_1	389	395	PF00069	0.567
MOD_ProDKin_1	406	412	PF00069	0.441
MOD_ProDKin_1	437	443	PF00069	0.401
MOD_ProDKin_1	483	489	PF00069	0.465
MOD_ProDKin_1	516	522	PF00069	0.408
MOD_ProDKin_1	539	545	PF00069	0.587
MOD_ProDKin_1	586	592	PF00069	0.421
MOD_ProDKin_1	612	618	PF00069	0.313
MOD_ProDKin_1	687	693	PF00069	0.622
MOD_ProDKin_1	709	715	PF00069	0.411
MOD_ProDKin_1	80	86	PF00069	0.439
MOD_ProDKin_1	805	811	PF00069	0.446
MOD_SUMO_for_1	58	61	PF00179	0.485
MOD_SUMO_for_1	601	604	PF00179	0.344
MOD_SUMO_for_1	770	773	PF00179	0.472
MOD_SUMO_rev_2	524	533	PF00179	0.498
MOD_SUMO_rev_2	53	60	PF00179	0.477
MOD_SUMO_rev_2	565	575	PF00179	0.272
MOD_SUMO_rev_2	733	742	PF00179	0.491
TRG_DiLeu_BaEn_3	251	257	PF01217	0.637
TRG_ENDOCYTIC_2	146	149	PF00928	0.356
TRG_ENDOCYTIC_2	168	171	PF00928	0.396
TRG_ENDOCYTIC_2	238	241	PF00928	0.517
TRG_ENDOCYTIC_2	288	291	PF00928	0.484
TRG_ENDOCYTIC_2	340	343	PF00928	0.369
TRG_ENDOCYTIC_2	397	400	PF00928	0.467
TRG_ENDOCYTIC_2	43	46	PF00928	0.397
TRG_ENDOCYTIC_2	435	438	PF00928	0.378
TRG_ENDOCYTIC_2	576	579	PF00928	0.356
TRG_ENDOCYTIC_2	588	591	PF00928	0.364
TRG_ENDOCYTIC_2	609	612	PF00928	0.402
TRG_ENDOCYTIC_2	614	617	PF00928	0.350
TRG_ENDOCYTIC_2	807	810	PF00928	0.448
TRG_ER_diArg_1	676	678	PF00400	0.430
TRG_ER_diArg_1	714	716	PF00400	0.500
TRG_NES_CRM1_1	50	61	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME5	Leptomonas seymouri	78%	90%
A0A0S4II95	Bodo saltans	53%	100%
A0A1X0NRQ9	Trypanosomatidae	62%	90%
A0A3Q8IDD1	Leishmania donovani	96%	100%
A0A422NYS0	Trypanosoma rangeli	61%	95%
A4HKU6	Leishmania braziliensis	81%	99%
A4I8C5	Leishmania infantum	96%	100%
D0AAU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	90%
E9B384	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5BQQ6	Trypanosoma cruzi	62%	96%