G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4Q4X0_LEIMA

TriTrypDb:

LmjF.32.3020 , LMJLV39_320038100 , LMJSD75_320038300

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4X0

PDB structure(s): 7am2_BV

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.763
CLV_C14_Caspase3-7	610	614	PF00656	0.566
CLV_NRD_NRD_1	257	259	PF00675	0.787
CLV_NRD_NRD_1	394	396	PF00675	0.542
CLV_NRD_NRD_1	500	502	PF00675	0.635
CLV_NRD_NRD_1	696	698	PF00675	0.488
CLV_NRD_NRD_1	709	711	PF00675	0.517
CLV_PCSK_FUR_1	255	259	PF00082	0.777
CLV_PCSK_KEX2_1	188	190	PF00082	0.294
CLV_PCSK_KEX2_1	257	259	PF00082	0.778
CLV_PCSK_KEX2_1	394	396	PF00082	0.538
CLV_PCSK_KEX2_1	500	502	PF00082	0.614
CLV_PCSK_KEX2_1	711	713	PF00082	0.533
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.294
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.520
CLV_PCSK_SKI1_1	22	26	PF00082	0.531
CLV_PCSK_SKI1_1	30	34	PF00082	0.570
CLV_PCSK_SKI1_1	505	509	PF00082	0.782
CLV_PCSK_SKI1_1	702	706	PF00082	0.489
CLV_PCSK_SKI1_1	755	759	PF00082	0.475
CLV_PCSK_SKI1_1	770	774	PF00082	0.516
CLV_PCSK_SKI1_1	79	83	PF00082	0.529
DEG_APCC_DBOX_1	515	523	PF00400	0.527
DEG_SPOP_SBC_1	559	563	PF00917	0.583
DOC_CKS1_1	148	153	PF01111	0.490
DOC_CYCLIN_RxL_1	174	185	PF00134	0.563
DOC_CYCLIN_RxL_1	306	317	PF00134	0.510
DOC_CYCLIN_RxL_1	500	511	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	596	602	PF00134	0.705
DOC_MAPK_DCC_7	500	509	PF00069	0.541
DOC_MAPK_gen_1	217	226	PF00069	0.542
DOC_MAPK_gen_1	500	509	PF00069	0.541
DOC_MAPK_MEF2A_6	619	626	PF00069	0.550
DOC_PP1_RVXF_1	132	139	PF00149	0.490
DOC_PP1_RVXF_1	186	193	PF00149	0.490
DOC_PP2B_LxvP_1	448	451	PF13499	0.687
DOC_PP2B_LxvP_1	596	599	PF13499	0.725
DOC_PP4_FxxP_1	251	254	PF00568	0.675
DOC_PP4_FxxP_1	362	365	PF00568	0.428
DOC_SPAK_OSR1_1	501	505	PF12202	0.631
DOC_USP7_MATH_1	305	309	PF00917	0.589
DOC_USP7_MATH_1	31	35	PF00917	0.701
DOC_USP7_MATH_1	358	362	PF00917	0.417
DOC_USP7_MATH_1	43	47	PF00917	0.618
DOC_USP7_MATH_1	444	448	PF00917	0.696
DOC_USP7_MATH_1	467	471	PF00917	0.712
DOC_USP7_MATH_1	641	645	PF00917	0.531
DOC_USP7_UBL2_3	413	417	PF12436	0.435
DOC_WW_Pin1_4	147	152	PF00397	0.490
DOC_WW_Pin1_4	197	202	PF00397	0.561
DOC_WW_Pin1_4	549	554	PF00397	0.817
DOC_WW_Pin1_4	612	617	PF00397	0.478
LIG_14-3-3_CanoR_1	219	225	PF00244	0.424
LIG_14-3-3_CanoR_1	269	273	PF00244	0.432
LIG_14-3-3_CanoR_1	30	40	PF00244	0.671
LIG_14-3-3_CanoR_1	394	401	PF00244	0.580
LIG_14-3-3_CanoR_1	430	436	PF00244	0.704
LIG_14-3-3_CanoR_1	512	519	PF00244	0.679
LIG_14-3-3_CanoR_1	619	625	PF00244	0.522
LIG_Actin_WH2_2	168	184	PF00022	0.521
LIG_Actin_WH2_2	66	84	PF00022	0.431
LIG_Actin_WH2_2	7	24	PF00022	0.462
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BRCT_BRCA1_1	172	176	PF00533	0.561
LIG_BRCT_BRCA1_1	498	502	PF00533	0.598
LIG_Clathr_ClatBox_1	145	149	PF01394	0.561
LIG_eIF4E_1	321	327	PF01652	0.478
LIG_FHA_1	130	136	PF00498	0.490
LIG_FHA_1	288	294	PF00498	0.514
LIG_FHA_1	321	327	PF00498	0.446
LIG_FHA_1	466	472	PF00498	0.724
LIG_FHA_1	6	12	PF00498	0.397
LIG_FHA_1	668	674	PF00498	0.600
LIG_FHA_1	703	709	PF00498	0.482
LIG_FHA_2	225	231	PF00498	0.561
LIG_FHA_2	512	518	PF00498	0.769
LIG_FHA_2	608	614	PF00498	0.522
LIG_FHA_2	680	686	PF00498	0.578
LIG_IRF3_LxIS_1	21	28	PF10401	0.560
LIG_LIR_Apic_2	249	254	PF02991	0.673
LIG_LIR_Apic_2	341	345	PF02991	0.438
LIG_LIR_Apic_2	360	365	PF02991	0.427
LIG_LIR_Apic_2	722	727	PF02991	0.463
LIG_LIR_Gen_1	283	293	PF02991	0.430
LIG_LIR_Nem_3	173	179	PF02991	0.514
LIG_LIR_Nem_3	230	236	PF02991	0.542
LIG_LIR_Nem_3	28	32	PF02991	0.603
LIG_LIR_Nem_3	283	288	PF02991	0.393
LIG_LIR_Nem_3	96	100	PF02991	0.366
LIG_NRBOX	16	22	PF00104	0.655
LIG_PCNA_PIPBox_1	281	290	PF02747	0.477
LIG_PCNA_yPIPBox_3	369	383	PF02747	0.491
LIG_Pex14_2	172	176	PF04695	0.490
LIG_PTB_Apo_2	245	252	PF02174	0.510
LIG_PTB_Apo_2	68	75	PF02174	0.526
LIG_REV1ctd_RIR_1	264	272	PF16727	0.618
LIG_SH2_CRK	29	33	PF00017	0.639
LIG_SH2_CRK	342	346	PF00017	0.463
LIG_SH2_NCK_1	342	346	PF00017	0.444
LIG_SH2_SRC	342	345	PF00017	0.461
LIG_SH2_STAP1	649	653	PF00017	0.535
LIG_SH2_STAT3	13	16	PF00017	0.399
LIG_SH2_STAT3	236	239	PF00017	0.566
LIG_SH2_STAT3	321	324	PF00017	0.429
LIG_SH2_STAT5	178	181	PF00017	0.490
LIG_SH2_STAT5	321	324	PF00017	0.405
LIG_SH2_STAT5	435	438	PF00017	0.686
LIG_SH2_STAT5	608	611	PF00017	0.560
LIG_SH2_STAT5	707	710	PF00017	0.470
LIG_SH3_3	145	151	PF00018	0.490
LIG_SH3_3	574	580	PF00018	0.697
LIG_SUMO_SIM_anti_2	143	150	PF11976	0.531
LIG_SUMO_SIM_par_1	143	150	PF11976	0.490
LIG_SUMO_SIM_par_1	505	511	PF11976	0.548
LIG_SUMO_SIM_par_1	620	625	PF11976	0.553
LIG_TRAF2_1	648	651	PF00917	0.612
LIG_TRAF2_1	655	658	PF00917	0.604
LIG_TYR_ITIM	27	32	PF00017	0.630
LIG_WRC_WIRS_1	211	216	PF05994	0.591
LIG_WRC_WIRS_1	359	364	PF05994	0.424
MOD_CDK_SPxxK_3	612	619	PF00069	0.474
MOD_CK1_1	112	118	PF00069	0.490
MOD_CK1_1	197	203	PF00069	0.567
MOD_CK1_1	2	8	PF00069	0.421
MOD_CK1_1	46	52	PF00069	0.620
MOD_CK1_1	515	521	PF00069	0.709
MOD_CK1_1	564	570	PF00069	0.705
MOD_CK1_1	620	626	PF00069	0.450
MOD_CK1_1	744	750	PF00069	0.621
MOD_CK1_1	768	774	PF00069	0.483
MOD_CK2_1	679	685	PF00069	0.619
MOD_CK2_1	93	99	PF00069	0.370
MOD_GlcNHglycan	195	199	PF01048	0.391
MOD_GlcNHglycan	298	301	PF01048	0.539
MOD_GlcNHglycan	33	36	PF01048	0.660
MOD_GlcNHglycan	396	399	PF01048	0.509
MOD_GlcNHglycan	45	48	PF01048	0.607
MOD_GlcNHglycan	643	646	PF01048	0.503
MOD_GlcNHglycan	693	696	PF01048	0.510
MOD_GlcNHglycan	767	770	PF01048	0.526
MOD_GSK3_1	108	115	PF00069	0.490
MOD_GSK3_1	126	133	PF00069	0.490
MOD_GSK3_1	193	200	PF00069	0.591
MOD_GSK3_1	220	227	PF00069	0.561
MOD_GSK3_1	326	333	PF00069	0.539
MOD_GSK3_1	43	50	PF00069	0.634
MOD_GSK3_1	463	470	PF00069	0.736
MOD_GSK3_1	511	518	PF00069	0.651
MOD_GSK3_1	558	565	PF00069	0.787
MOD_GSK3_1	729	736	PF00069	0.634
MOD_LATS_1	256	262	PF00433	0.576
MOD_N-GLC_1	182	187	PF02516	0.363
MOD_N-GLC_1	305	310	PF02516	0.583
MOD_N-GLC_1	368	373	PF02516	0.492
MOD_N-GLC_1	67	72	PF02516	0.497
MOD_N-GLC_2	390	392	PF02516	0.370
MOD_NEK2_1	15	20	PF00069	0.614
MOD_NEK2_1	193	198	PF00069	0.591
MOD_NEK2_1	25	30	PF00069	0.550
MOD_NEK2_1	267	272	PF00069	0.518
MOD_NEK2_1	296	301	PF00069	0.494
MOD_NEK2_1	3	8	PF00069	0.511
MOD_NEK2_1	436	441	PF00069	0.760
MOD_NEK2_1	536	541	PF00069	0.572
MOD_NEK2_1	691	696	PF00069	0.533
MOD_NEK2_1	741	746	PF00069	0.616
MOD_PIKK_1	320	326	PF00454	0.470
MOD_PIKK_1	679	685	PF00454	0.483
MOD_PK_1	713	719	PF00069	0.581
MOD_PKA_1	394	400	PF00069	0.584
MOD_PKA_2	268	274	PF00069	0.441
MOD_PKA_2	394	400	PF00069	0.584
MOD_PKA_2	429	435	PF00069	0.685
MOD_PKA_2	458	464	PF00069	0.791
MOD_PKA_2	511	517	PF00069	0.690
MOD_PKA_2	689	695	PF00069	0.566
MOD_PKA_2	776	782	PF00069	0.487
MOD_Plk_1	330	336	PF00069	0.519
MOD_Plk_1	368	374	PF00069	0.475
MOD_Plk_1	437	443	PF00069	0.525
MOD_Plk_1	713	719	PF00069	0.581
MOD_Plk_4	109	115	PF00069	0.490
MOD_Plk_4	15	21	PF00069	0.648
MOD_Plk_4	210	216	PF00069	0.591
MOD_Plk_4	358	364	PF00069	0.424
MOD_Plk_4	431	437	PF00069	0.729
MOD_Plk_4	536	542	PF00069	0.752
MOD_ProDKin_1	147	153	PF00069	0.490
MOD_ProDKin_1	197	203	PF00069	0.561
MOD_ProDKin_1	549	555	PF00069	0.819
MOD_ProDKin_1	612	618	PF00069	0.473
MOD_SUMO_rev_2	377	384	PF00179	0.476
TRG_DiLeu_BaEn_2	282	288	PF01217	0.534
TRG_DiLeu_BaEn_3	209	215	PF01217	0.490
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.531
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.699
TRG_ENDOCYTIC_2	178	181	PF00928	0.490
TRG_ENDOCYTIC_2	191	194	PF00928	0.490
TRG_ENDOCYTIC_2	285	288	PF00928	0.579
TRG_ENDOCYTIC_2	29	32	PF00928	0.669
TRG_ENDOCYTIC_2	649	652	PF00928	0.517
TRG_ER_diArg_1	156	159	PF00400	0.531
TRG_ER_diArg_1	254	257	PF00400	0.772
TRG_ER_diArg_1	394	396	PF00400	0.540
TRG_ER_diArg_1	500	502	PF00400	0.625
TRG_ER_diArg_1	503	506	PF00400	0.635
TRG_NES_CRM1_1	354	366	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	755	759	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF47	Leptomonas seymouri	60%	100%
A0A1X0NRQ7	Trypanosomatidae	42%	100%
A0A3R7LAS2	Trypanosoma rangeli	42%	100%
A0A3S7X600	Leishmania donovani	91%	100%
A4HKU7	Leishmania braziliensis	78%	100%
A4I8C6	Leishmania infantum	91%	100%
E9B385	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BVC8	Trypanosoma cruzi	42%	100%