Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 4, putative

Species:

Leishmania major

UniProt:

Q4Q4W8_LEIMA

TriTrypDb:

LmjF.32.3040 , LMJLV39_320038300 , LMJSD75_320038500

Length:

308

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Annotations by Jardim et al.

Phosphatase, Serine/threonine- phosphatase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 12
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q4W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4W8

Function

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Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0017018	myosin phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.333
CLV_NRD_NRD_1	107	109	PF00675	0.445
CLV_NRD_NRD_1	132	134	PF00675	0.299
CLV_NRD_NRD_1	182	184	PF00675	0.302
CLV_PCSK_KEX2_1	107	109	PF00082	0.445
CLV_PCSK_KEX2_1	182	184	PF00082	0.302
CLV_PCSK_KEX2_1	27	29	PF00082	0.497
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.497
CLV_PCSK_SKI1_1	108	112	PF00082	0.307
CLV_PCSK_SKI1_1	119	123	PF00082	0.285

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	43%	100%
A0A0N1HSR2	Leptomonas seymouri	39%	83%
A0A0N1I0V3	Leptomonas seymouri	40%	78%
A0A0N1IBK9	Leptomonas seymouri	97%	100%
A0A0N1ILH2	Leptomonas seymouri	33%	72%
A0A0N1P9X9	Leptomonas seymouri	59%	100%
A0A0N1PAV9	Leptomonas seymouri	47%	85%
A0A0N1PCC5	Leptomonas seymouri	50%	100%
A0A0N1PDK9	Leptomonas seymouri	59%	97%
A0A0S4IIW0	Bodo saltans	37%	78%

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