Roc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras family, putative

Species:

Leishmania major

UniProt:

Q4Q4W7_LEIMA

TriTrypDb:

LmjF.32.3050 , LMJLV39_320038400 , LMJSD75_320038600

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4W7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	7
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	770	774	PF00656	0.694
CLV_NRD_NRD_1	267	269	PF00675	0.520
CLV_NRD_NRD_1	340	342	PF00675	0.492
CLV_NRD_NRD_1	444	446	PF00675	0.468
CLV_NRD_NRD_1	467	469	PF00675	0.530
CLV_NRD_NRD_1	63	65	PF00675	0.328
CLV_NRD_NRD_1	668	670	PF00675	0.473
CLV_NRD_NRD_1	79	81	PF00675	0.275
CLV_NRD_NRD_1	813	815	PF00675	0.482
CLV_PCSK_FUR_1	811	815	PF00082	0.502
CLV_PCSK_KEX2_1	267	269	PF00082	0.520
CLV_PCSK_KEX2_1	339	341	PF00082	0.424
CLV_PCSK_KEX2_1	467	469	PF00082	0.491
CLV_PCSK_KEX2_1	63	65	PF00082	0.352
CLV_PCSK_KEX2_1	668	670	PF00082	0.473
CLV_PCSK_KEX2_1	811	813	PF00082	0.482
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.424
CLV_PCSK_SKI1_1	107	111	PF00082	0.309
CLV_PCSK_SKI1_1	13	17	PF00082	0.490
CLV_PCSK_SKI1_1	139	143	PF00082	0.280
CLV_PCSK_SKI1_1	183	187	PF00082	0.283
CLV_PCSK_SKI1_1	455	459	PF00082	0.369
CLV_PCSK_SKI1_1	65	69	PF00082	0.384
CLV_PCSK_SKI1_1	813	817	PF00082	0.500
DEG_APCC_DBOX_1	449	457	PF00400	0.307
DEG_APCC_DBOX_1	610	618	PF00400	0.436
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_ODPH_VHL_1	541	554	PF01847	0.348
DEG_SPOP_SBC_1	239	243	PF00917	0.708
DEG_SPOP_SBC_1	24	28	PF00917	0.587
DEG_SPOP_SBC_1	248	252	PF00917	0.506
DEG_SPOP_SBC_1	96	100	PF00917	0.275
DOC_CKS1_1	416	421	PF01111	0.400
DOC_CKS1_1	532	537	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.318
DOC_MAPK_DCC_7	46	56	PF00069	0.605
DOC_MAPK_DCC_7	570	580	PF00069	0.271
DOC_MAPK_gen_1	339	346	PF00069	0.375
DOC_MAPK_gen_1	539	546	PF00069	0.348
DOC_MAPK_gen_1	548	556	PF00069	0.348
DOC_MAPK_gen_1	570	580	PF00069	0.451
DOC_MAPK_gen_1	609	616	PF00069	0.385
DOC_MAPK_gen_1	63	69	PF00069	0.277
DOC_MAPK_HePTP_8	346	358	PF00069	0.224
DOC_MAPK_MEF2A_6	339	348	PF00069	0.382
DOC_MAPK_MEF2A_6	349	358	PF00069	0.268
DOC_MAPK_MEF2A_6	548	556	PF00069	0.448
DOC_PP1_RVXF_1	453	459	PF00149	0.312
DOC_PP1_RVXF_1	51	57	PF00149	0.571
DOC_PP1_RVXF_1	551	557	PF00149	0.334
DOC_PP2B_LxvP_1	716	719	PF13499	0.580
DOC_PP2B_LxvP_1	749	752	PF13499	0.421
DOC_PP4_FxxP_1	458	461	PF00568	0.324
DOC_PP4_FxxP_1	574	577	PF00568	0.265
DOC_USP7_MATH_1	237	241	PF00917	0.719
DOC_USP7_MATH_1	24	28	PF00917	0.603
DOC_USP7_MATH_1	249	253	PF00917	0.549
DOC_USP7_MATH_2	490	496	PF00917	0.453
DOC_USP7_UBL2_3	208	212	PF12436	0.368
DOC_WW_Pin1_4	415	420	PF00397	0.385
DOC_WW_Pin1_4	466	471	PF00397	0.498
DOC_WW_Pin1_4	531	536	PF00397	0.363
DOC_WW_Pin1_4	754	759	PF00397	0.566
DOC_WW_Pin1_4	818	823	PF00397	0.586
LIG_14-3-3_CanoR_1	349	356	PF00244	0.340
LIG_14-3-3_CanoR_1	373	379	PF00244	0.294
LIG_14-3-3_CanoR_1	404	410	PF00244	0.428
LIG_14-3-3_CanoR_1	668	672	PF00244	0.457
LIG_14-3-3_CanoR_1	97	104	PF00244	0.353
LIG_APCC_ABBA_1	623	628	PF00400	0.307
LIG_APCC_ABBAyCdc20_2	622	628	PF00400	0.307
LIG_BIR_III_4	778	782	PF00653	0.534
LIG_BRCT_BRCA1_1	494	498	PF00533	0.484
LIG_BRCT_BRCA1_1	84	88	PF00533	0.391
LIG_deltaCOP1_diTrp_1	561	567	PF00928	0.325
LIG_EH1_1	341	349	PF00400	0.366
LIG_FHA_1	131	137	PF00498	0.279
LIG_FHA_1	278	284	PF00498	0.361
LIG_FHA_1	327	333	PF00498	0.419
LIG_FHA_1	722	728	PF00498	0.435
LIG_FHA_1	775	781	PF00498	0.653
LIG_FHA_1	97	103	PF00498	0.275
LIG_FHA_2	187	193	PF00498	0.275
LIG_FHA_2	780	786	PF00498	0.544
LIG_LIR_Apic_2	522	527	PF02991	0.331
LIG_LIR_Gen_1	140	150	PF02991	0.275
LIG_LIR_Gen_1	351	360	PF02991	0.437
LIG_LIR_Gen_1	377	384	PF02991	0.282
LIG_LIR_Gen_1	411	420	PF02991	0.368
LIG_LIR_Gen_1	495	506	PF02991	0.435
LIG_LIR_Gen_1	555	563	PF02991	0.332
LIG_LIR_Nem_3	140	145	PF02991	0.275
LIG_LIR_Nem_3	174	179	PF02991	0.293
LIG_LIR_Nem_3	351	356	PF02991	0.309
LIG_LIR_Nem_3	377	381	PF02991	0.280
LIG_LIR_Nem_3	411	415	PF02991	0.342
LIG_LIR_Nem_3	495	501	PF02991	0.420
LIG_LIR_Nem_3	555	559	PF02991	0.318
LIG_LIR_Nem_3	561	567	PF02991	0.285
LIG_LIR_Nem_3	662	666	PF02991	0.312
LIG_MYND_1	527	531	PF01753	0.335
LIG_NRBOX	655	661	PF00104	0.367
LIG_PCNA_yPIPBox_3	566	575	PF02747	0.369
LIG_Pex14_1	378	382	PF04695	0.294
LIG_Pex14_2	142	146	PF04695	0.275
LIG_REV1ctd_RIR_1	86	93	PF16727	0.336
LIG_SH2_CRK	463	467	PF00017	0.252
LIG_SH2_CRK	572	576	PF00017	0.355
LIG_SH2_CRK	663	667	PF00017	0.323
LIG_SH2_CRK	753	757	PF00017	0.546
LIG_SH2_SRC	525	528	PF00017	0.376
LIG_SH2_SRC	581	584	PF00017	0.489
LIG_SH2_SRC	71	74	PF00017	0.333
LIG_SH2_SRC	786	789	PF00017	0.392
LIG_SH2_STAP1	265	269	PF00017	0.459
LIG_SH2_STAP1	387	391	PF00017	0.357
LIG_SH2_STAP1	412	416	PF00017	0.348
LIG_SH2_STAT3	14	17	PF00017	0.549
LIG_SH2_STAT5	134	137	PF00017	0.391
LIG_SH2_STAT5	14	17	PF00017	0.433
LIG_SH2_STAT5	304	307	PF00017	0.421
LIG_SH2_STAT5	382	385	PF00017	0.304
LIG_SH2_STAT5	431	434	PF00017	0.380
LIG_SH2_STAT5	448	451	PF00017	0.306
LIG_SH2_STAT5	525	528	PF00017	0.364
LIG_SH2_STAT5	748	751	PF00017	0.372
LIG_SH2_STAT5	786	789	PF00017	0.464
LIG_SH3_3	230	236	PF00018	0.599
LIG_SH3_3	393	399	PF00018	0.427
LIG_SH3_3	503	509	PF00018	0.448
LIG_SH3_3	577	583	PF00018	0.499
LIG_SH3_3	669	675	PF00018	0.372
LIG_SUMO_SIM_par_1	183	189	PF11976	0.391
LIG_SUMO_SIM_par_1	489	497	PF11976	0.403
LIG_SUMO_SIM_par_1	722	728	PF11976	0.435
LIG_TRAF2_1	124	127	PF00917	0.298
LIG_TRAF2_1	364	367	PF00917	0.436
LIG_TRAF2_1	603	606	PF00917	0.512
LIG_TRAF2_1	759	762	PF00917	0.585
LIG_TRFH_1	556	560	PF08558	0.299
LIG_TYR_ITIM	69	74	PF00017	0.333
LIG_UBA3_1	141	147	PF00899	0.275
LIG_UBA3_1	301	310	PF00899	0.422
LIG_UBA3_1	331	339	PF00899	0.399
LIG_WRC_WIRS_1	213	218	PF05994	0.371
MOD_CDC14_SPxK_1	757	760	PF00782	0.637
MOD_CDK_SPxK_1	754	760	PF00069	0.597
MOD_CK1_1	128	134	PF00069	0.333
MOD_CK1_1	224	230	PF00069	0.529
MOD_CK1_1	240	246	PF00069	0.690
MOD_CK1_1	26	32	PF00069	0.660
MOD_CK1_1	277	283	PF00069	0.396
MOD_CK1_1	408	414	PF00069	0.429
MOD_CK1_1	634	640	PF00069	0.438
MOD_CK1_1	642	648	PF00069	0.376
MOD_CK1_1	690	696	PF00069	0.512
MOD_CK1_1	738	744	PF00069	0.465
MOD_CK1_1	774	780	PF00069	0.770
MOD_CK2_1	146	152	PF00069	0.288
MOD_CK2_1	361	367	PF00069	0.342
MOD_CK2_1	431	437	PF00069	0.373
MOD_CK2_1	779	785	PF00069	0.560
MOD_CK2_1	89	95	PF00069	0.309
MOD_CK2_1	97	103	PF00069	0.247
MOD_GlcNHglycan	148	151	PF01048	0.295
MOD_GlcNHglycan	157	160	PF01048	0.249
MOD_GlcNHglycan	293	296	PF01048	0.348
MOD_GlcNHglycan	298	301	PF01048	0.305
MOD_GlcNHglycan	636	639	PF01048	0.471
MOD_GlcNHglycan	710	713	PF01048	0.518
MOD_GlcNHglycan	99	102	PF01048	0.428
MOD_GSK3_1	130	137	PF00069	0.275
MOD_GSK3_1	2	9	PF00069	0.679
MOD_GSK3_1	224	231	PF00069	0.523
MOD_GSK3_1	23	30	PF00069	0.561
MOD_GSK3_1	515	522	PF00069	0.493
MOD_GSK3_1	634	641	PF00069	0.465
MOD_GSK3_1	688	695	PF00069	0.473
MOD_GSK3_1	767	774	PF00069	0.742
MOD_N-GLC_1	224	229	PF02516	0.518
MOD_N-GLC_1	639	644	PF02516	0.412
MOD_NEK2_1	155	160	PF00069	0.275
MOD_NEK2_1	186	191	PF00069	0.313
MOD_NEK2_1	238	243	PF00069	0.629
MOD_NEK2_1	274	279	PF00069	0.315
MOD_NEK2_1	405	410	PF00069	0.320
MOD_NEK2_1	721	726	PF00069	0.455
MOD_NEK2_1	735	740	PF00069	0.364
MOD_NEK2_1	798	803	PF00069	0.504
MOD_NEK2_1	89	94	PF00069	0.295
MOD_NEK2_2	75	80	PF00069	0.275
MOD_OFUCOSY	736	742	PF10250	0.454
MOD_PIKK_1	515	521	PF00454	0.441
MOD_PIKK_1	719	725	PF00454	0.523
MOD_PK_1	760	766	PF00069	0.648
MOD_PKA_2	326	332	PF00069	0.270
MOD_PKA_2	348	354	PF00069	0.344
MOD_PKA_2	610	616	PF00069	0.433
MOD_PKA_2	642	648	PF00069	0.523
MOD_PKA_2	667	673	PF00069	0.478
MOD_PKA_2	96	102	PF00069	0.333
MOD_Plk_1	105	111	PF00069	0.337
MOD_Plk_1	137	143	PF00069	0.275
MOD_Plk_1	760	766	PF00069	0.699
MOD_Plk_2-3	492	498	PF00069	0.475
MOD_Plk_2-3	767	773	PF00069	0.711
MOD_Plk_4	130	136	PF00069	0.298
MOD_Plk_4	405	411	PF00069	0.461
MOD_Plk_4	576	582	PF00069	0.448
MOD_Plk_4	610	616	PF00069	0.442
MOD_Plk_4	631	637	PF00069	0.447
MOD_Plk_4	721	727	PF00069	0.437
MOD_ProDKin_1	415	421	PF00069	0.392
MOD_ProDKin_1	466	472	PF00069	0.493
MOD_ProDKin_1	531	537	PF00069	0.364
MOD_ProDKin_1	754	760	PF00069	0.579
MOD_ProDKin_1	818	824	PF00069	0.588
TRG_DiLeu_BaEn_1	483	488	PF01217	0.430
TRG_DiLeu_BaEn_1	728	733	PF01217	0.347
TRG_DiLeu_BaEn_2	137	143	PF01217	0.391
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.447
TRG_DiLeu_LyEn_5	390	395	PF01217	0.326
TRG_ENDOCYTIC_2	412	415	PF00928	0.394
TRG_ENDOCYTIC_2	463	466	PF00928	0.242
TRG_ENDOCYTIC_2	572	575	PF00928	0.301
TRG_ENDOCYTIC_2	663	666	PF00928	0.316
TRG_ENDOCYTIC_2	71	74	PF00928	0.333
TRG_ENDOCYTIC_2	748	751	PF00928	0.372
TRG_ER_diArg_1	267	269	PF00400	0.535
TRG_ER_diArg_1	466	468	PF00400	0.457
TRG_ER_diArg_1	52	55	PF00400	0.517
TRG_ER_diArg_1	550	553	PF00400	0.429
TRG_ER_diArg_1	598	601	PF00400	0.519
TRG_ER_diArg_1	811	814	PF00400	0.496
TRG_NLS_MonoExtC_3	338	343	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9V2	Leptomonas seymouri	78%	82%
A0A1X0NT83	Trypanosomatidae	51%	82%
A0A3S5H7S9	Leishmania donovani	97%	100%
A0A422NYM8	Trypanosoma rangeli	47%	84%
A4HKV0	Leishmania braziliensis	89%	100%
A4I8C9	Leishmania infantum	97%	100%
E9B388	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DM76	Trypanosoma cruzi	47%	94%