LeishMANIAdb
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Transmembrane protein 144

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein 144
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4W5_LEIMA
TriTrypDb:
LmjF.32.3065 , LMJLV39_320038600 , LMJSD75_320038800 *
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q4W5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4W5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 30 32 PF00675 0.374
CLV_PCSK_FUR_1 27 31 PF00082 0.273
CLV_PCSK_KEX2_1 29 31 PF00082 0.384
CLV_PCSK_SKI1_1 31 35 PF00082 0.306
DEG_Nend_Nbox_1 1 3 PF02207 0.491
DOC_CKS1_1 78 83 PF01111 0.431
DOC_MAPK_gen_1 27 35 PF00069 0.625
DOC_PP2B_LxvP_1 83 86 PF13499 0.437
DOC_USP7_MATH_1 18 22 PF00917 0.355
DOC_USP7_MATH_1 65 69 PF00917 0.333
DOC_WW_Pin1_4 77 82 PF00397 0.429
LIG_FHA_1 34 40 PF00498 0.389
LIG_FHA_1 78 84 PF00498 0.376
LIG_PTB_Apo_2 87 94 PF02174 0.447
LIG_PTB_Phospho_1 87 93 PF10480 0.447
LIG_SH2_STAP1 112 116 PF00017 0.631
LIG_SH2_STAP1 53 57 PF00017 0.387
LIG_SH2_STAT3 103 106 PF00017 0.467
LIG_SH2_STAT5 3 6 PF00017 0.409
LIG_SH2_STAT5 73 76 PF00017 0.380
LIG_SH3_3 46 52 PF00018 0.454
MOD_GlcNHglycan 67 70 PF01048 0.543
MOD_N-GLC_2 17 19 PF02516 0.447
MOD_N-GLC_2 40 42 PF02516 0.496
MOD_NEK2_1 33 38 PF00069 0.340
MOD_Plk_4 84 90 PF00069 0.328
MOD_ProDKin_1 77 83 PF00069 0.426
TRG_ENDOCYTIC_2 3 6 PF00928 0.435
TRG_ER_diArg_1 107 110 PF00400 0.549
TRG_ER_diArg_1 26 29 PF00400 0.586
TRG_ER_diArg_1 30 32 PF00400 0.580

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N3 Leptomonas seymouri 81% 100%
A0A0S4IXI5 Bodo saltans 38% 87%
A0A1X0NRS6 Trypanosomatidae 48% 100%
A0A3S7X608 Leishmania donovani 97% 100%
A4HKV2 Leishmania braziliensis 92% 100%
A4I8D1 Leishmania infantum 97% 100%
D0AAU2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 99%
E9B390 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5B5T9 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS