SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania major

UniProt:

Q4Q4W4_LEIMA

TriTrypDb:

LmjF.32.3070 , LMJLV39_320038700 , LMJSD75_320038900

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4W4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016925	protein sumoylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0019789	SUMO transferase activity	4	2
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0061665	SUMO ligase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.570
CLV_C14_Caspase3-7	158	162	PF00656	0.642
CLV_C14_Caspase3-7	174	178	PF00656	0.493
CLV_C14_Caspase3-7	404	408	PF00656	0.543
CLV_NRD_NRD_1	13	15	PF00675	0.757
CLV_NRD_NRD_1	135	137	PF00675	0.603
CLV_NRD_NRD_1	192	194	PF00675	0.747
CLV_NRD_NRD_1	265	267	PF00675	0.481
CLV_NRD_NRD_1	316	318	PF00675	0.430
CLV_NRD_NRD_1	424	426	PF00675	0.596
CLV_NRD_NRD_1	91	93	PF00675	0.541
CLV_PCSK_FUR_1	133	137	PF00082	0.643
CLV_PCSK_FUR_1	422	426	PF00082	0.660
CLV_PCSK_KEX2_1	13	15	PF00082	0.757
CLV_PCSK_KEX2_1	135	137	PF00082	0.549
CLV_PCSK_KEX2_1	192	194	PF00082	0.747
CLV_PCSK_KEX2_1	265	267	PF00082	0.481
CLV_PCSK_KEX2_1	316	318	PF00082	0.427
CLV_PCSK_KEX2_1	422	424	PF00082	0.575
CLV_PCSK_KEX2_1	91	93	PF00082	0.456
CLV_PCSK_PC7_1	419	425	PF00082	0.554
CLV_PCSK_SKI1_1	353	357	PF00082	0.503
CLV_PCSK_SKI1_1	91	95	PF00082	0.529
DEG_APCC_DBOX_1	265	273	PF00400	0.355
DEG_COP1_1	407	417	PF00400	0.462
DEG_SPOP_SBC_1	378	382	PF00917	0.499
DEG_SPOP_SBC_1	93	97	PF00917	0.534
DOC_CYCLIN_RxL_1	348	360	PF00134	0.574
DOC_MAPK_gen_1	135	144	PF00069	0.591
DOC_PP4_FxxP_1	418	421	PF00568	0.472
DOC_SPAK_OSR1_1	387	391	PF12202	0.501
DOC_USP7_MATH_1	12	16	PF00917	0.806
DOC_USP7_MATH_1	178	182	PF00917	0.652
DOC_USP7_MATH_1	188	192	PF00917	0.711
DOC_USP7_MATH_1	271	275	PF00917	0.553
DOC_USP7_MATH_1	320	324	PF00917	0.484
DOC_USP7_MATH_1	426	430	PF00917	0.713
DOC_USP7_MATH_1	450	454	PF00917	0.727
DOC_USP7_MATH_1	52	56	PF00917	0.469
DOC_WW_Pin1_4	195	200	PF00397	0.742
DOC_WW_Pin1_4	216	221	PF00397	0.783
DOC_WW_Pin1_4	241	246	PF00397	0.657
DOC_WW_Pin1_4	5	10	PF00397	0.787
LIG_14-3-3_CanoR_1	13	21	PF00244	0.802
LIG_14-3-3_CanoR_1	91	100	PF00244	0.432
LIG_BIR_III_4	307	311	PF00653	0.517
LIG_BRCT_BRCA1_1	182	186	PF00533	0.514
LIG_BRCT_BRCA1_1	34	38	PF00533	0.562
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.405
LIG_deltaCOP1_diTrp_1	377	383	PF00928	0.525
LIG_FHA_1	113	119	PF00498	0.477
LIG_FHA_1	331	337	PF00498	0.399
LIG_FHA_2	129	135	PF00498	0.667
LIG_FHA_2	146	152	PF00498	0.481
LIG_FHA_2	172	178	PF00498	0.694
LIG_Integrin_RGDW_4	309	312	PF00362	0.509
LIG_LIR_Apic_2	416	421	PF02991	0.548
LIG_LIR_Gen_1	311	320	PF02991	0.396
LIG_LIR_Gen_1	35	44	PF02991	0.374
LIG_LIR_Gen_1	354	364	PF02991	0.617
LIG_LIR_Gen_1	67	73	PF02991	0.458
LIG_LIR_Nem_3	151	155	PF02991	0.660
LIG_LIR_Nem_3	183	189	PF02991	0.713
LIG_LIR_Nem_3	311	315	PF02991	0.377
LIG_LIR_Nem_3	35	41	PF02991	0.448
LIG_LIR_Nem_3	360	364	PF02991	0.623
LIG_LIR_Nem_3	432	437	PF02991	0.580
LIG_LIR_Nem_3	441	447	PF02991	0.623
LIG_Pex14_1	379	383	PF04695	0.480
LIG_Pex14_2	314	318	PF04695	0.483
LIG_Pex14_2	388	392	PF04695	0.484
LIG_SH2_CRK	352	356	PF00017	0.606
LIG_SH2_CRK	361	365	PF00017	0.582
LIG_SH2_CRK	372	376	PF00017	0.565
LIG_SH2_CRK	44	48	PF00017	0.506
LIG_SH2_CRK	444	448	PF00017	0.515
LIG_SH2_GRB2like	152	155	PF00017	0.645
LIG_SH2_NCK_1	361	365	PF00017	0.617
LIG_SH2_STAP1	152	156	PF00017	0.665
LIG_SH2_STAP1	361	365	PF00017	0.614
LIG_SH2_STAT5	155	158	PF00017	0.671
LIG_SH2_STAT5	345	348	PF00017	0.413
LIG_SH3_3	116	122	PF00018	0.445
LIG_SH3_3	196	202	PF00018	0.778
LIG_SH3_3	214	220	PF00018	0.501
LIG_SH3_3	79	85	PF00018	0.471
LIG_SUMO_SIM_par_1	115	121	PF11976	0.458
MOD_CK1_1	176	182	PF00069	0.596
MOD_CK1_1	322	328	PF00069	0.431
MOD_CK1_1	408	414	PF00069	0.544
MOD_CK1_1	429	435	PF00069	0.628
MOD_CK2_1	128	134	PF00069	0.608
MOD_CK2_1	351	357	PF00069	0.536
MOD_CK2_1	360	366	PF00069	0.589
MOD_Cter_Amidation	263	266	PF01082	0.411
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.677
MOD_GlcNHglycan	177	181	PF01048	0.587
MOD_GlcNHglycan	182	185	PF01048	0.645
MOD_GlcNHglycan	428	431	PF01048	0.701
MOD_GlcNHglycan	440	443	PF01048	0.460
MOD_GlcNHglycan	448	451	PF01048	0.618
MOD_GSK3_1	172	179	PF00069	0.669
MOD_GSK3_1	203	210	PF00069	0.766
MOD_GSK3_1	241	248	PF00069	0.631
MOD_GSK3_1	318	325	PF00069	0.512
MOD_GSK3_1	32	39	PF00069	0.465
MOD_GSK3_1	426	433	PF00069	0.735
MOD_GSK3_1	446	453	PF00069	0.775
MOD_N-GLC_2	56	58	PF02516	0.292
MOD_N-GLC_2	74	76	PF02516	0.159
MOD_NEK2_1	281	286	PF00069	0.533
MOD_NEK2_1	318	323	PF00069	0.523
MOD_NEK2_1	351	356	PF00069	0.573
MOD_NEK2_2	122	127	PF00069	0.470
MOD_PIKK_1	14	20	PF00454	0.751
MOD_PIKK_1	145	151	PF00454	0.483
MOD_PIKK_1	247	253	PF00454	0.708
MOD_PIKK_1	271	277	PF00454	0.441
MOD_PIKK_1	432	438	PF00454	0.656
MOD_PIKK_1	450	456	PF00454	0.717
MOD_PKA_1	91	97	PF00069	0.460
MOD_PKA_2	12	18	PF00069	0.803
MOD_PKA_2	171	177	PF00069	0.644
MOD_PKA_2	91	97	PF00069	0.460
MOD_PKB_1	170	178	PF00069	0.488
MOD_Plk_1	36	42	PF00069	0.338
MOD_Plk_2-3	360	366	PF00069	0.621
MOD_Plk_4	330	336	PF00069	0.383
MOD_Plk_4	408	414	PF00069	0.551
MOD_Plk_4	65	71	PF00069	0.458
MOD_ProDKin_1	195	201	PF00069	0.743
MOD_ProDKin_1	216	222	PF00069	0.782
MOD_ProDKin_1	241	247	PF00069	0.659
MOD_ProDKin_1	5	11	PF00069	0.786
MOD_SUMO_for_1	225	228	PF00179	0.592
MOD_SUMO_for_1	291	294	PF00179	0.572
TRG_DiLeu_BaEn_1	27	32	PF01217	0.705
TRG_ENDOCYTIC_2	352	355	PF00928	0.587
TRG_ENDOCYTIC_2	361	364	PF00928	0.574
TRG_ENDOCYTIC_2	44	47	PF00928	0.461
TRG_ENDOCYTIC_2	444	447	PF00928	0.608
TRG_ER_diArg_1	170	173	PF00400	0.503
TRG_ER_diArg_1	192	195	PF00400	0.748
TRG_ER_diArg_1	315	317	PF00400	0.437
TRG_ER_diArg_1	421	424	PF00400	0.577
TRG_ER_diArg_1	91	93	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P907	Leptomonas seymouri	67%	73%
A0A0S4IQ84	Bodo saltans	31%	77%
A0A1X0NSE9	Trypanosomatidae	40%	99%
A0A3R7NRN3	Trypanosoma rangeli	41%	100%
A0A3S7X626	Leishmania donovani	94%	100%
A4HKV3	Leishmania braziliensis	84%	69%
A4I8D2	Leishmania infantum	94%	100%
D0AAU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B391	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B5L3	Trypanosoma cruzi	42%	100%