RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine hydrolase (FSH1)/50S ribosome-binding GTPase/GTPase of unknown function C-terminal, putative

Species:

Leishmania major

UniProt:

Q4Q4W0_LEIMA

TriTrypDb:

LmjF.32.3110 , LMJLV39_320039100 , LMJSD75_320039300

Length:

962

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4W0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.383
CLV_C14_Caspase3-7	311	315	PF00656	0.498
CLV_C14_Caspase3-7	621	625	PF00656	0.433
CLV_C14_Caspase3-7	68	72	PF00656	0.357
CLV_MEL_PAP_1	685	691	PF00089	0.438
CLV_NRD_NRD_1	131	133	PF00675	0.357
CLV_NRD_NRD_1	422	424	PF00675	0.614
CLV_NRD_NRD_1	428	430	PF00675	0.744
CLV_NRD_NRD_1	575	577	PF00675	0.242
CLV_NRD_NRD_1	687	689	PF00675	0.448
CLV_NRD_NRD_1	766	768	PF00675	0.357
CLV_NRD_NRD_1	939	941	PF00675	0.500
CLV_PCSK_FUR_1	573	577	PF00082	0.227
CLV_PCSK_KEX2_1	131	133	PF00082	0.357
CLV_PCSK_KEX2_1	422	424	PF00082	0.626
CLV_PCSK_KEX2_1	428	430	PF00082	0.727
CLV_PCSK_KEX2_1	575	577	PF00082	0.242
CLV_PCSK_KEX2_1	687	689	PF00082	0.448
CLV_PCSK_KEX2_1	794	796	PF00082	0.391
CLV_PCSK_KEX2_1	898	900	PF00082	0.456
CLV_PCSK_KEX2_1	958	960	PF00082	0.459
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.391
CLV_PCSK_PC1ET2_1	898	900	PF00082	0.456
CLV_PCSK_PC1ET2_1	958	960	PF00082	0.459
CLV_PCSK_SKI1_1	15	19	PF00082	0.342
CLV_PCSK_SKI1_1	669	673	PF00082	0.431
CLV_Separin_Metazoa	239	243	PF03568	0.469
CLV_Separin_Metazoa	399	403	PF03568	0.469
DEG_APCC_DBOX_1	796	804	PF00400	0.378
DEG_SPOP_SBC_1	543	547	PF00917	0.393
DOC_ANK_TNKS_1	377	384	PF00023	0.572
DOC_CDC14_PxL_1	160	168	PF14671	0.297
DOC_CYCLIN_RxL_1	101	112	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	719	725	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	844	850	PF00134	0.334
DOC_MAPK_gen_1	322	332	PF00069	0.483
DOC_MAPK_gen_1	573	581	PF00069	0.445
DOC_MAPK_gen_1	718	727	PF00069	0.399
DOC_MAPK_gen_1	885	894	PF00069	0.429
DOC_MAPK_HePTP_8	715	727	PF00069	0.357
DOC_MAPK_MEF2A_6	363	370	PF00069	0.461
DOC_MAPK_MEF2A_6	718	727	PF00069	0.354
DOC_MAPK_MEF2A_6	757	765	PF00069	0.386
DOC_PP1_RVXF_1	292	298	PF00149	0.411
DOC_PP1_RVXF_1	716	722	PF00149	0.452
DOC_PP1_RVXF_1	755	761	PF00149	0.410
DOC_PP2B_LxvP_1	38	41	PF13499	0.357
DOC_PP4_FxxP_1	297	300	PF00568	0.412
DOC_USP7_MATH_1	146	150	PF00917	0.365
DOC_USP7_MATH_1	178	182	PF00917	0.342
DOC_USP7_MATH_1	272	276	PF00917	0.530
DOC_USP7_MATH_1	317	321	PF00917	0.372
DOC_USP7_MATH_1	385	389	PF00917	0.762
DOC_USP7_MATH_1	450	454	PF00917	0.699
DOC_USP7_MATH_1	474	478	PF00917	0.455
DOC_USP7_MATH_1	487	491	PF00917	0.442
DOC_USP7_MATH_1	54	58	PF00917	0.334
DOC_USP7_MATH_1	543	547	PF00917	0.509
DOC_USP7_MATH_1	549	553	PF00917	0.591
DOC_USP7_MATH_1	568	572	PF00917	0.457
DOC_USP7_MATH_1	853	857	PF00917	0.426
DOC_WW_Pin1_4	675	680	PF00397	0.393
DOC_WW_Pin1_4	771	776	PF00397	0.306
DOC_WW_Pin1_4	810	815	PF00397	0.425
DOC_WW_Pin1_4	916	921	PF00397	0.704
LIG_14-3-3_CanoR_1	131	135	PF00244	0.281
LIG_14-3-3_CanoR_1	298	304	PF00244	0.399
LIG_14-3-3_CanoR_1	544	550	PF00244	0.519
LIG_14-3-3_CanoR_1	655	665	PF00244	0.524
LIG_14-3-3_CanoR_1	808	814	PF00244	0.411
LIG_14-3-3_CanoR_1	816	822	PF00244	0.410
LIG_14-3-3_CanoR_1	823	832	PF00244	0.409
LIG_14-3-3_CanoR_1	946	954	PF00244	0.447
LIG_Actin_WH2_2	712	730	PF00022	0.333
LIG_APCC_ABBA_1	22	27	PF00400	0.355
LIG_APCC_ABBA_1	261	266	PF00400	0.487
LIG_APCC_ABBA_1	368	373	PF00400	0.405
LIG_APCC_ABBAyCdc20_2	260	266	PF00400	0.429
LIG_BRCT_BRCA1_1	180	184	PF00533	0.297
LIG_BRCT_BRCA1_1	476	480	PF00533	0.452
LIG_BRCT_BRCA1_1	570	574	PF00533	0.496
LIG_Clathr_ClatBox_1	35	39	PF01394	0.355
LIG_FHA_1	12	18	PF00498	0.297
LIG_FHA_1	217	223	PF00498	0.403
LIG_FHA_1	344	350	PF00498	0.463
LIG_FHA_1	429	435	PF00498	0.724
LIG_FHA_1	459	465	PF00498	0.446
LIG_FHA_1	564	570	PF00498	0.559
LIG_FHA_1	657	663	PF00498	0.515
LIG_FHA_1	696	702	PF00498	0.491
LIG_FHA_1	753	759	PF00498	0.421
LIG_FHA_1	824	830	PF00498	0.337
LIG_FHA_1	860	866	PF00498	0.504
LIG_FHA_1	88	94	PF00498	0.306
LIG_FHA_1	940	946	PF00498	0.493
LIG_FHA_2	263	269	PF00498	0.453
LIG_FHA_2	46	52	PF00498	0.386
LIG_FHA_2	499	505	PF00498	0.517
LIG_FHA_2	619	625	PF00498	0.421
LIG_FHA_2	633	639	PF00498	0.379
LIG_FHA_2	678	684	PF00498	0.537
LIG_FHA_2	732	738	PF00498	0.425
LIG_GBD_Chelix_1	857	865	PF00786	0.412
LIG_LIR_Apic_2	703	707	PF02991	0.274
LIG_LIR_Gen_1	181	191	PF02991	0.391
LIG_LIR_Gen_1	477	488	PF02991	0.442
LIG_LIR_Gen_1	648	656	PF02991	0.349
LIG_LIR_Gen_1	749	758	PF02991	0.426
LIG_LIR_Gen_1	759	765	PF02991	0.399
LIG_LIR_Gen_1	86	95	PF02991	0.421
LIG_LIR_Gen_1	870	881	PF02991	0.385
LIG_LIR_Nem_3	158	163	PF02991	0.391
LIG_LIR_Nem_3	181	187	PF02991	0.410
LIG_LIR_Nem_3	477	483	PF02991	0.442
LIG_LIR_Nem_3	648	654	PF02991	0.354
LIG_LIR_Nem_3	670	675	PF02991	0.434
LIG_LIR_Nem_3	759	763	PF02991	0.410
LIG_LIR_Nem_3	870	876	PF02991	0.343
LIG_MLH1_MIPbox_1	476	480	PF16413	0.455
LIG_Pex14_2	297	301	PF04695	0.419
LIG_REV1ctd_RIR_1	804	812	PF16727	0.355
LIG_RPA_C_Fungi	948	960	PF08784	0.404
LIG_SH2_CRK	651	655	PF00017	0.356
LIG_SH2_GRB2like	651	654	PF00017	0.350
LIG_SH2_PTP2	716	719	PF00017	0.453
LIG_SH2_SRC	245	248	PF00017	0.361
LIG_SH2_SRC	353	356	PF00017	0.457
LIG_SH2_STAP1	323	327	PF00017	0.431
LIG_SH2_STAT5	105	108	PF00017	0.322
LIG_SH2_STAT5	337	340	PF00017	0.469
LIG_SH2_STAT5	353	356	PF00017	0.476
LIG_SH2_STAT5	405	408	PF00017	0.456
LIG_SH2_STAT5	515	518	PF00017	0.355
LIG_SH2_STAT5	716	719	PF00017	0.365
LIG_SH2_STAT5	770	773	PF00017	0.357
LIG_SH3_3	172	178	PF00018	0.375
LIG_SH3_3	256	262	PF00018	0.349
LIG_SH3_3	480	486	PF00018	0.297
LIG_SH3_3	659	665	PF00018	0.514
LIG_SH3_3	77	83	PF00018	0.410
LIG_SH3_3	927	933	PF00018	0.639
LIG_Sin3_3	414	421	PF02671	0.456
LIG_TRAF2_1	177	180	PF00917	0.355
LIG_UBA3_1	723	729	PF00899	0.457
LIG_UBA3_1	891	898	PF00899	0.374
LIG_WRC_WIRS_1	803	808	PF05994	0.355
MOD_CDC14_SPxK_1	813	816	PF00782	0.306
MOD_CDK_SPxK_1	810	816	PF00069	0.306
MOD_CK1_1	149	155	PF00069	0.430
MOD_CK1_1	189	195	PF00069	0.371
MOD_CK1_1	302	308	PF00069	0.579
MOD_CK1_1	542	548	PF00069	0.401
MOD_CK1_1	57	63	PF00069	0.369
MOD_CK1_1	677	683	PF00069	0.355
MOD_CK1_1	908	914	PF00069	0.659
MOD_CK1_1	935	941	PF00069	0.428
MOD_CK2_1	240	246	PF00069	0.530
MOD_CK2_1	262	268	PF00069	0.445
MOD_CK2_1	498	504	PF00069	0.318
MOD_CK2_1	631	637	PF00069	0.518
MOD_CK2_1	809	815	PF00069	0.379
MOD_CK2_1	864	870	PF00069	0.447
MOD_Cter_Amidation	169	172	PF01082	0.322
MOD_GlcNHglycan	144	147	PF01048	0.422
MOD_GlcNHglycan	148	151	PF01048	0.435
MOD_GlcNHglycan	152	155	PF01048	0.458
MOD_GlcNHglycan	179	183	PF01048	0.360
MOD_GlcNHglycan	189	192	PF01048	0.306
MOD_GlcNHglycan	223	226	PF01048	0.579
MOD_GlcNHglycan	283	287	PF01048	0.488
MOD_GlcNHglycan	334	337	PF01048	0.489
MOD_GlcNHglycan	448	451	PF01048	0.604
MOD_GlcNHglycan	452	455	PF01048	0.619
MOD_GlcNHglycan	472	475	PF01048	0.324
MOD_GlcNHglycan	541	544	PF01048	0.372
MOD_GlcNHglycan	546	549	PF01048	0.453
MOD_GlcNHglycan	551	554	PF01048	0.489
MOD_GlcNHglycan	65	70	PF01048	0.353
MOD_GlcNHglycan	672	675	PF01048	0.458
MOD_GlcNHglycan	867	870	PF01048	0.415
MOD_GlcNHglycan	947	950	PF01048	0.453
MOD_GSK3_1	138	145	PF00069	0.341
MOD_GSK3_1	146	153	PF00069	0.376
MOD_GSK3_1	187	194	PF00069	0.286
MOD_GSK3_1	216	223	PF00069	0.466
MOD_GSK3_1	262	269	PF00069	0.493
MOD_GSK3_1	278	285	PF00069	0.524
MOD_GSK3_1	299	306	PF00069	0.512
MOD_GSK3_1	446	453	PF00069	0.620
MOD_GSK3_1	458	465	PF00069	0.463
MOD_GSK3_1	470	477	PF00069	0.268
MOD_GSK3_1	539	546	PF00069	0.445
MOD_GSK3_1	54	61	PF00069	0.322
MOD_GSK3_1	559	566	PF00069	0.423
MOD_GSK3_1	637	644	PF00069	0.443
MOD_GSK3_1	663	670	PF00069	0.443
MOD_GSK3_1	802	809	PF00069	0.384
MOD_GSK3_1	911	918	PF00069	0.655
MOD_GSK3_1	931	938	PF00069	0.521
MOD_N-GLC_1	254	259	PF02516	0.433
MOD_NEK2_1	142	147	PF00069	0.295
MOD_NEK2_1	221	226	PF00069	0.582
MOD_NEK2_1	240	245	PF00069	0.405
MOD_NEK2_1	270	275	PF00069	0.498
MOD_NEK2_1	282	287	PF00069	0.443
MOD_NEK2_1	700	705	PF00069	0.485
MOD_NEK2_1	73	78	PF00069	0.467
MOD_NEK2_1	763	768	PF00069	0.417
MOD_NEK2_1	806	811	PF00069	0.486
MOD_NEK2_1	817	822	PF00069	0.384
MOD_NEK2_1	824	829	PF00069	0.228
MOD_NEK2_1	87	92	PF00069	0.215
MOD_NEK2_1	905	910	PF00069	0.560
MOD_NEK2_1	93	98	PF00069	0.150
MOD_NEK2_2	138	143	PF00069	0.492
MOD_NEK2_2	191	196	PF00069	0.210
MOD_NEK2_2	317	322	PF00069	0.370
MOD_NEK2_2	475	480	PF00069	0.279
MOD_NEK2_2	517	522	PF00069	0.330
MOD_NEK2_2	778	783	PF00069	0.343
MOD_PIKK_1	385	391	PF00454	0.770
MOD_PIKK_1	93	99	PF00454	0.279
MOD_PKA_1	428	434	PF00069	0.634
MOD_PKA_2	130	136	PF00069	0.257
MOD_PKA_2	332	338	PF00069	0.491
MOD_PKA_2	428	434	PF00069	0.634
MOD_PKA_2	543	549	PF00069	0.326
MOD_PKA_2	807	813	PF00069	0.326
MOD_PKA_2	815	821	PF00069	0.301
MOD_PKA_2	822	828	PF00069	0.219
MOD_PKA_2	939	945	PF00069	0.499
MOD_Plk_1	138	144	PF00069	0.403
MOD_Plk_1	254	260	PF00069	0.502
MOD_Plk_1	282	288	PF00069	0.490
MOD_Plk_1	559	565	PF00069	0.380
MOD_Plk_1	637	643	PF00069	0.357
MOD_Plk_1	801	807	PF00069	0.260
MOD_Plk_2-3	441	447	PF00069	0.605
MOD_Plk_4	138	144	PF00069	0.339
MOD_Plk_4	191	197	PF00069	0.409
MOD_Plk_4	20	26	PF00069	0.355
MOD_Plk_4	254	260	PF00069	0.468
MOD_Plk_4	266	272	PF00069	0.521
MOD_Plk_4	475	481	PF00069	0.279
MOD_Plk_4	645	651	PF00069	0.318
MOD_Plk_4	657	663	PF00069	0.378
MOD_Plk_4	677	683	PF00069	0.226
MOD_Plk_4	802	808	PF00069	0.432
MOD_Plk_4	817	823	PF00069	0.317
MOD_ProDKin_1	675	681	PF00069	0.390
MOD_ProDKin_1	771	777	PF00069	0.306
MOD_ProDKin_1	810	816	PF00069	0.425
MOD_ProDKin_1	916	922	PF00069	0.702
MOD_SUMO_for_1	321	324	PF00179	0.516
MOD_SUMO_rev_2	408	414	PF00179	0.466
TRG_DiLeu_BaEn_1	345	350	PF01217	0.413
TRG_DiLeu_BaEn_1	749	754	PF01217	0.210
TRG_DiLeu_BaEn_2	707	713	PF01217	0.418
TRG_DiLeu_BaEn_4	246	252	PF01217	0.484
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.391
TRG_ENDOCYTIC_2	103	106	PF00928	0.362
TRG_ENDOCYTIC_2	651	654	PF00928	0.350
TRG_ENDOCYTIC_2	716	719	PF00928	0.365
TRG_ER_diArg_1	130	132	PF00400	0.357
TRG_ER_diArg_1	422	425	PF00400	0.645
TRG_ER_diArg_1	428	430	PF00400	0.743
TRG_ER_diArg_1	574	576	PF00400	0.321
TRG_ER_diArg_1	686	688	PF00400	0.430
TRG_ER_diArg_1	717	720	PF00400	0.371
TRG_NES_CRM1_1	27	39	PF08389	0.355
TRG_NES_CRM1_1	880	893	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	899	903	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP4	Leptomonas seymouri	64%	100%
A0A0S4IRQ8	Bodo saltans	34%	96%
A0A1X0NRU1	Trypanosomatidae	39%	100%
A0A3Q8IJK7	Leishmania donovani	93%	100%
A4HKV6	Leishmania braziliensis	80%	99%
A4I8D6	Leishmania infantum	93%	100%
D0AAT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B395	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BL49	Trypanosoma cruzi	42%	100%