Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania major

UniProt:

Q4Q4V6_LEIMA

TriTrypDb:

LmjF.32.3160 , LMJLV39_320039800 , LMJSD75_320039800

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	9
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4Q4V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.584
CLV_C14_Caspase3-7	227	231	PF00656	0.624
CLV_C14_Caspase3-7	233	237	PF00656	0.586
CLV_NRD_NRD_1	15	17	PF00675	0.748
CLV_NRD_NRD_1	455	457	PF00675	0.419
CLV_NRD_NRD_1	461	463	PF00675	0.444
CLV_NRD_NRD_1	468	470	PF00675	0.464
CLV_NRD_NRD_1	647	649	PF00675	0.610
CLV_NRD_NRD_1	742	744	PF00675	0.610
CLV_PCSK_KEX2_1	15	17	PF00082	0.610
CLV_PCSK_KEX2_1	325	327	PF00082	0.584
CLV_PCSK_KEX2_1	455	457	PF00082	0.401
CLV_PCSK_KEX2_1	461	463	PF00082	0.418
CLV_PCSK_KEX2_1	555	557	PF00082	0.704
CLV_PCSK_KEX2_1	647	649	PF00082	0.509
CLV_PCSK_KEX2_1	693	695	PF00082	0.647
CLV_PCSK_KEX2_1	742	744	PF00082	0.610
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.584
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.704
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.647
CLV_PCSK_PC7_1	643	649	PF00082	0.503
CLV_PCSK_PC7_1	738	744	PF00082	0.611
CLV_PCSK_SKI1_1	462	466	PF00082	0.496
CLV_PCSK_SKI1_1	48	52	PF00082	0.642
CLV_PCSK_SKI1_1	635	639	PF00082	0.435
CLV_PCSK_SKI1_1	648	652	PF00082	0.477
CLV_PCSK_SKI1_1	91	95	PF00082	0.438
DEG_APCC_DBOX_1	386	394	PF00400	0.317
DEG_SCF_FBW7_1	669	676	PF00400	0.614
DEG_SPOP_SBC_1	549	553	PF00917	0.604
DOC_CKS1_1	219	224	PF01111	0.596
DOC_CKS1_1	708	713	PF01111	0.608
DOC_CYCLIN_RxL_1	45	54	PF00134	0.609
DOC_CYCLIN_RxL_1	643	653	PF00134	0.469
DOC_MAPK_gen_1	130	139	PF00069	0.408
DOC_MAPK_gen_1	413	423	PF00069	0.285
DOC_MAPK_MEF2A_6	130	139	PF00069	0.411
DOC_MAPK_MEF2A_6	592	601	PF00069	0.435
DOC_PP4_MxPP_1	534	537	PF00568	0.549
DOC_USP7_MATH_1	183	187	PF00917	0.583
DOC_USP7_MATH_1	263	267	PF00917	0.784
DOC_USP7_MATH_1	549	553	PF00917	0.795
DOC_USP7_MATH_1	557	561	PF00917	0.659
DOC_USP7_MATH_1	564	568	PF00917	0.589
DOC_USP7_MATH_1	578	582	PF00917	0.563
DOC_USP7_MATH_1	684	688	PF00917	0.661
DOC_USP7_MATH_1	704	708	PF00917	0.672
DOC_USP7_UBL2_3	32	36	PF12436	0.736
DOC_USP7_UBL2_3	321	325	PF12436	0.504
DOC_USP7_UBL2_3	48	52	PF12436	0.511
DOC_WW_Pin1_4	128	133	PF00397	0.512
DOC_WW_Pin1_4	148	153	PF00397	0.453
DOC_WW_Pin1_4	181	186	PF00397	0.575
DOC_WW_Pin1_4	218	223	PF00397	0.668
DOC_WW_Pin1_4	545	550	PF00397	0.825
DOC_WW_Pin1_4	63	68	PF00397	0.700
DOC_WW_Pin1_4	669	674	PF00397	0.756
DOC_WW_Pin1_4	707	712	PF00397	0.640
DOC_WW_Pin1_4	91	96	PF00397	0.499
LIG_14-3-3_CanoR_1	133	138	PF00244	0.404
LIG_14-3-3_CanoR_1	361	366	PF00244	0.425
LIG_14-3-3_CanoR_1	556	565	PF00244	0.673
LIG_14-3-3_CanoR_1	701	709	PF00244	0.757
LIG_14-3-3_CanoR_1	730	735	PF00244	0.481
LIG_14-3-3_CanoR_1	742	746	PF00244	0.581
LIG_14-3-3_CanoR_1	754	760	PF00244	0.450
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_Clathr_ClatBox_1	106	110	PF01394	0.384
LIG_FHA_1	334	340	PF00498	0.487
LIG_FHA_1	374	380	PF00498	0.406
LIG_FHA_1	429	435	PF00498	0.472
LIG_FHA_1	517	523	PF00498	0.692
LIG_FHA_1	670	676	PF00498	0.687
LIG_FHA_1	71	77	PF00498	0.599
LIG_FHA_2	231	237	PF00498	0.766
LIG_FHA_2	277	283	PF00498	0.712
LIG_FHA_2	304	310	PF00498	0.571
LIG_FHA_2	463	469	PF00498	0.503
LIG_FHA_2	622	628	PF00498	0.481
LIG_FHA_2	654	660	PF00498	0.568
LIG_FHA_2	742	748	PF00498	0.685
LIG_Integrin_RGD_1	244	246	PF01839	0.556
LIG_LIR_Apic_2	126	132	PF02991	0.504
LIG_LIR_Apic_2	290	295	PF02991	0.650
LIG_LIR_Apic_2	530	536	PF02991	0.575
LIG_LIR_Gen_1	120	129	PF02991	0.399
LIG_LIR_Gen_1	483	490	PF02991	0.381
LIG_LIR_Gen_1	633	642	PF02991	0.512
LIG_LIR_Gen_1	75	86	PF02991	0.466
LIG_LIR_Nem_3	120	124	PF02991	0.396
LIG_LIR_Nem_3	296	301	PF02991	0.495
LIG_LIR_Nem_3	351	355	PF02991	0.555
LIG_LIR_Nem_3	483	487	PF02991	0.376
LIG_LIR_Nem_3	633	639	PF02991	0.513
LIG_LIR_Nem_3	75	81	PF02991	0.488
LIG_MYND_1	673	677	PF01753	0.597
LIG_NRBOX	407	413	PF00104	0.416
LIG_PTAP_UEV_1	676	681	PF05743	0.607
LIG_SH2_CRK	121	125	PF00017	0.489
LIG_SH2_CRK	129	133	PF00017	0.521
LIG_SH2_CRK	533	537	PF00017	0.558
LIG_SH2_PTP2	636	639	PF00017	0.493
LIG_SH2_PTP2	78	81	PF00017	0.465
LIG_SH2_STAP1	484	488	PF00017	0.471
LIG_SH2_STAT3	294	297	PF00017	0.627
LIG_SH2_STAT3	493	496	PF00017	0.531
LIG_SH2_STAT5	150	153	PF00017	0.577
LIG_SH2_STAT5	292	295	PF00017	0.645
LIG_SH2_STAT5	298	301	PF00017	0.576
LIG_SH2_STAT5	458	461	PF00017	0.445
LIG_SH2_STAT5	493	496	PF00017	0.506
LIG_SH2_STAT5	636	639	PF00017	0.493
LIG_SH2_STAT5	78	81	PF00017	0.465
LIG_SH3_1	533	539	PF00018	0.573
LIG_SH3_1	98	104	PF00018	0.518
LIG_SH3_2	538	543	PF14604	0.638
LIG_SH3_3	171	177	PF00018	0.602
LIG_SH3_3	216	222	PF00018	0.527
LIG_SH3_3	499	505	PF00018	0.667
LIG_SH3_3	533	539	PF00018	0.655
LIG_SH3_3	65	71	PF00018	0.642
LIG_SH3_3	674	680	PF00018	0.603
LIG_SH3_3	713	719	PF00018	0.599
LIG_SH3_3	98	104	PF00018	0.518
LIG_SUMO_SIM_anti_2	108	113	PF11976	0.482
LIG_SUMO_SIM_anti_2	266	272	PF11976	0.511
LIG_SUMO_SIM_anti_2	624	630	PF11976	0.482
LIG_SUMO_SIM_anti_2	712	718	PF11976	0.571
LIG_SUMO_SIM_par_1	105	110	PF11976	0.384
LIG_SUMO_SIM_par_1	376	383	PF11976	0.322
LIG_SUMO_SIM_par_1	429	438	PF11976	0.331
LIG_SUMO_SIM_par_1	662	668	PF11976	0.598
LIG_SUMO_SIM_par_1	70	75	PF11976	0.462
LIG_TRAF2_1	447	450	PF00917	0.508
LIG_TRAF2_1	465	468	PF00917	0.575
LIG_TRAF2_1	53	56	PF00917	0.637
LIG_TRAF2_1	61	64	PF00917	0.627
LIG_TYR_ITIM	76	81	PF00017	0.414
LIG_WW_2	504	507	PF00397	0.629
MOD_CDK_SPK_2	128	133	PF00069	0.512
MOD_CDK_SPxxK_3	91	98	PF00069	0.499
MOD_CK1_1	105	111	PF00069	0.382
MOD_CK1_1	117	123	PF00069	0.416
MOD_CK1_1	146	152	PF00069	0.586
MOD_CK1_1	159	165	PF00069	0.509
MOD_CK1_1	202	208	PF00069	0.619
MOD_CK1_1	237	243	PF00069	0.606
MOD_CK1_1	27	33	PF00069	0.664
MOD_CK1_1	526	532	PF00069	0.659
MOD_CK1_1	548	554	PF00069	0.684
MOD_CK1_1	559	565	PF00069	0.607
MOD_CK1_1	671	677	PF00069	0.666
MOD_CK1_1	682	688	PF00069	0.690
MOD_CK1_1	707	713	PF00069	0.687
MOD_CK2_1	276	282	PF00069	0.575
MOD_CK2_1	303	309	PF00069	0.513
MOD_CK2_1	385	391	PF00069	0.476
MOD_CK2_1	443	449	PF00069	0.513
MOD_CK2_1	462	468	PF00069	0.484
MOD_CK2_1	50	56	PF00069	0.719
MOD_CK2_1	621	627	PF00069	0.474
MOD_CK2_1	653	659	PF00069	0.581
MOD_CK2_1	683	689	PF00069	0.668
MOD_CK2_1	741	747	PF00069	0.676
MOD_Cter_Amidation	323	326	PF01082	0.507
MOD_GlcNHglycan	116	119	PF01048	0.470
MOD_GlcNHglycan	145	148	PF01048	0.625
MOD_GlcNHglycan	18	21	PF01048	0.727
MOD_GlcNHglycan	204	207	PF01048	0.678
MOD_GlcNHglycan	226	229	PF01048	0.676
MOD_GlcNHglycan	259	262	PF01048	0.649
MOD_GlcNHglycan	41	44	PF01048	0.627
MOD_GlcNHglycan	511	515	PF01048	0.615
MOD_GlcNHglycan	529	532	PF01048	0.532
MOD_GlcNHglycan	552	555	PF01048	0.664
MOD_GlcNHglycan	568	571	PF01048	0.552
MOD_GlcNHglycan	580	583	PF01048	0.668
MOD_GlcNHglycan	588	591	PF01048	0.632
MOD_GlcNHglycan	677	680	PF01048	0.695
MOD_GlcNHglycan	696	699	PF01048	0.630
MOD_GSK3_1	230	237	PF00069	0.587
MOD_GSK3_1	24	31	PF00069	0.626
MOD_GSK3_1	385	392	PF00069	0.409
MOD_GSK3_1	476	483	PF00069	0.545
MOD_GSK3_1	51	58	PF00069	0.775
MOD_GSK3_1	523	530	PF00069	0.608
MOD_GSK3_1	543	550	PF00069	0.813
MOD_GSK3_1	555	562	PF00069	0.763
MOD_GSK3_1	578	585	PF00069	0.644
MOD_GSK3_1	669	676	PF00069	0.639
MOD_GSK3_1	679	686	PF00069	0.691
MOD_GSK3_1	689	696	PF00069	0.561
MOD_GSK3_1	70	77	PF00069	0.573
MOD_GSK3_1	700	707	PF00069	0.625
MOD_GSK3_1	737	744	PF00069	0.656
MOD_GSK3_1	762	769	PF00069	0.638
MOD_LATS_1	764	770	PF00433	0.498
MOD_N-GLC_1	237	242	PF02516	0.748
MOD_N-GLC_1	398	403	PF02516	0.425
MOD_N-GLC_1	523	528	PF02516	0.625
MOD_N-GLC_1	613	618	PF02516	0.406
MOD_N-GLC_1	755	760	PF02516	0.558
MOD_NEK2_1	191	196	PF00069	0.648
MOD_NEK2_1	252	257	PF00069	0.705
MOD_NEK2_1	403	408	PF00069	0.304
MOD_NEK2_1	428	433	PF00069	0.348
MOD_NEK2_1	50	55	PF00069	0.631
MOD_NEK2_1	586	591	PF00069	0.542
MOD_NEK2_1	74	79	PF00069	0.497
MOD_NEK2_1	755	760	PF00069	0.492
MOD_PIKK_1	205	211	PF00454	0.590
MOD_PIKK_1	293	299	PF00454	0.619
MOD_PIKK_1	303	309	PF00454	0.573
MOD_PIKK_1	385	391	PF00454	0.476
MOD_PIKK_1	491	497	PF00454	0.514
MOD_PIKK_1	51	57	PF00454	0.620
MOD_PIKK_1	517	523	PF00454	0.715
MOD_PIKK_1	704	710	PF00454	0.619
MOD_PK_1	133	139	PF00069	0.399
MOD_PKA_1	555	561	PF00069	0.674
MOD_PKA_1	693	699	PF00069	0.648
MOD_PKA_2	252	258	PF00069	0.657
MOD_PKA_2	27	33	PF00069	0.735
MOD_PKA_2	333	339	PF00069	0.596
MOD_PKA_2	555	561	PF00069	0.674
MOD_PKA_2	595	601	PF00069	0.468
MOD_PKA_2	693	699	PF00069	0.765
MOD_PKA_2	700	706	PF00069	0.540
MOD_PKA_2	737	743	PF00069	0.614
MOD_PKB_1	728	736	PF00069	0.426
MOD_Plk_1	191	197	PF00069	0.605
MOD_Plk_1	263	269	PF00069	0.568
MOD_Plk_1	523	529	PF00069	0.624
MOD_Plk_1	543	549	PF00069	0.490
MOD_Plk_1	613	619	PF00069	0.465
MOD_Plk_1	755	761	PF00069	0.566
MOD_Plk_2-3	480	486	PF00069	0.465
MOD_Plk_2-3	659	665	PF00069	0.579
MOD_Plk_2-3	741	747	PF00069	0.645
MOD_Plk_4	102	108	PF00069	0.407
MOD_Plk_4	117	123	PF00069	0.416
MOD_Plk_4	159	165	PF00069	0.579
MOD_Plk_4	175	181	PF00069	0.456
MOD_Plk_4	247	253	PF00069	0.527
MOD_Plk_4	265	271	PF00069	0.570
MOD_Plk_4	595	601	PF00069	0.367
MOD_Plk_4	621	627	PF00069	0.443
MOD_Plk_4	635	641	PF00069	0.470
MOD_Plk_4	659	665	PF00069	0.579
MOD_Plk_4	712	718	PF00069	0.666
MOD_ProDKin_1	128	134	PF00069	0.504
MOD_ProDKin_1	148	154	PF00069	0.455
MOD_ProDKin_1	181	187	PF00069	0.577
MOD_ProDKin_1	218	224	PF00069	0.671
MOD_ProDKin_1	545	551	PF00069	0.823
MOD_ProDKin_1	63	69	PF00069	0.696
MOD_ProDKin_1	669	675	PF00069	0.760
MOD_ProDKin_1	707	713	PF00069	0.638
MOD_ProDKin_1	91	97	PF00069	0.494
MOD_SUMO_rev_2	240	250	PF00179	0.634
MOD_SUMO_rev_2	317	327	PF00179	0.593
MOD_SUMO_rev_2	466	472	PF00179	0.532
TRG_DiLeu_BaEn_2	168	174	PF01217	0.580
TRG_DiLeu_BaEn_4	449	455	PF01217	0.371
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.610
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.516
TRG_ENDOCYTIC_2	121	124	PF00928	0.396
TRG_ENDOCYTIC_2	298	301	PF00928	0.451
TRG_ENDOCYTIC_2	484	487	PF00928	0.377
TRG_ENDOCYTIC_2	636	639	PF00928	0.493
TRG_ENDOCYTIC_2	78	81	PF00928	0.517
TRG_ENDOCYTIC_2	83	86	PF00928	0.515
TRG_ER_diArg_1	15	17	PF00400	0.610
TRG_ER_diArg_1	454	456	PF00400	0.398
TRG_ER_diArg_1	647	649	PF00400	0.509
TRG_ER_diArg_1	727	730	PF00400	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C3	Leptomonas seymouri	49%	92%
A0A1X0NTH1	Trypanosomatidae	32%	100%
A0A3Q8IHB8	Leishmania donovani	91%	94%
A0A422NYL4	Trypanosoma rangeli	34%	100%
A4HKW1	Leishmania braziliensis	74%	94%
A4I8E1	Leishmania infantum	91%	94%
E9B399	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%