Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q4V4_LEIMA

TriTrypDb:

LmjF.32.3180 , LMJLV39_320040000 , LMJSD75_320040000

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4V4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.492
CLV_NRD_NRD_1	292	294	PF00675	0.571
CLV_NRD_NRD_1	396	398	PF00675	0.453
CLV_NRD_NRD_1	61	63	PF00675	0.349
CLV_NRD_NRD_1	667	669	PF00675	0.553
CLV_PCSK_KEX2_1	12	14	PF00082	0.685
CLV_PCSK_KEX2_1	222	224	PF00082	0.492
CLV_PCSK_KEX2_1	291	293	PF00082	0.577
CLV_PCSK_KEX2_1	395	397	PF00082	0.592
CLV_PCSK_KEX2_1	61	63	PF00082	0.349
CLV_PCSK_KEX2_1	667	669	PF00082	0.553
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.550
CLV_PCSK_PC7_1	288	294	PF00082	0.531
CLV_PCSK_PC7_1	57	63	PF00082	0.332
CLV_PCSK_PC7_1	663	669	PF00082	0.547
CLV_PCSK_SKI1_1	12	16	PF00082	0.537
CLV_PCSK_SKI1_1	169	173	PF00082	0.413
CLV_PCSK_SKI1_1	203	207	PF00082	0.342
CLV_PCSK_SKI1_1	222	226	PF00082	0.408
CLV_PCSK_SKI1_1	265	269	PF00082	0.538
CLV_PCSK_SKI1_1	299	303	PF00082	0.556
CLV_PCSK_SKI1_1	328	332	PF00082	0.373
CLV_PCSK_SKI1_1	336	340	PF00082	0.370
CLV_PCSK_SKI1_1	428	432	PF00082	0.546
CLV_PCSK_SKI1_1	499	503	PF00082	0.594
CLV_PCSK_SKI1_1	522	526	PF00082	0.620
CLV_PCSK_SKI1_1	536	540	PF00082	0.520
CLV_PCSK_SKI1_1	571	575	PF00082	0.608
CLV_PCSK_SKI1_1	615	619	PF00082	0.448
CLV_Separin_Metazoa	333	337	PF03568	0.361
DEG_APCC_DBOX_1	327	335	PF00400	0.404
DEG_APCC_DBOX_1	38	46	PF00400	0.506
DEG_APCC_DBOX_1	498	506	PF00400	0.584
DEG_APCC_DBOX_1	614	622	PF00400	0.454
DOC_CDC14_PxL_1	411	419	PF14671	0.499
DOC_CKS1_1	282	287	PF01111	0.577
DOC_CYCLIN_RxL_1	325	333	PF00134	0.454
DOC_CYCLIN_RxL_1	401	410	PF00134	0.448
DOC_CYCLIN_RxL_1	499	509	PF00134	0.438
DOC_CYCLIN_RxL_1	68	78	PF00134	0.546
DOC_CYCLIN_yClb5_NLxxxL_5	71	79	PF00134	0.448
DOC_MAPK_gen_1	49	56	PF00069	0.343
DOC_MAPK_MEF2A_6	169	176	PF00069	0.413
DOC_MAPK_MEF2A_6	412	419	PF00069	0.626
DOC_MAPK_MEF2A_6	495	504	PF00069	0.446
DOC_MAPK_MEF2A_6	552	561	PF00069	0.469
DOC_MAPK_NFAT4_5	169	177	PF00069	0.376
DOC_MAPK_NFAT4_5	552	560	PF00069	0.407
DOC_PP1_RVXF_1	316	323	PF00149	0.450
DOC_PP1_RVXF_1	402	409	PF00149	0.424
DOC_PP4_FxxP_1	341	344	PF00568	0.439
DOC_USP7_MATH_1	258	262	PF00917	0.503
DOC_USP7_MATH_1	364	368	PF00917	0.635
DOC_USP7_MATH_1	603	607	PF00917	0.495
DOC_WW_Pin1_4	105	110	PF00397	0.492
DOC_WW_Pin1_4	2	7	PF00397	0.589
DOC_WW_Pin1_4	226	231	PF00397	0.462
DOC_WW_Pin1_4	281	286	PF00397	0.646
DOC_WW_Pin1_4	432	437	PF00397	0.564
DOC_WW_Pin1_4	476	481	PF00397	0.447
DOC_WW_Pin1_4	545	550	PF00397	0.364
LIG_14-3-3_CanoR_1	120	124	PF00244	0.428
LIG_14-3-3_CanoR_1	395	400	PF00244	0.506
LIG_14-3-3_CanoR_1	503	512	PF00244	0.409
LIG_14-3-3_CanoR_1	61	65	PF00244	0.427
LIG_Actin_WH2_2	482	497	PF00022	0.361
LIG_Actin_WH2_2	69	84	PF00022	0.389
LIG_APCC_ABBA_1	310	315	PF00400	0.426
LIG_BIR_III_4	271	275	PF00653	0.609
LIG_BRCT_BRCA1_1	220	224	PF00533	0.401
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.436
LIG_EH1_1	300	308	PF00400	0.329
LIG_eIF4E_1	175	181	PF01652	0.438
LIG_FHA_1	109	115	PF00498	0.397
LIG_FHA_1	120	126	PF00498	0.415
LIG_FHA_1	13	19	PF00498	0.453
LIG_FHA_1	143	149	PF00498	0.384
LIG_FHA_1	180	186	PF00498	0.426
LIG_FHA_1	192	198	PF00498	0.332
LIG_FHA_1	204	210	PF00498	0.304
LIG_FHA_1	227	233	PF00498	0.476
LIG_FHA_1	238	244	PF00498	0.492
LIG_FHA_1	26	32	PF00498	0.586
LIG_FHA_1	3	9	PF00498	0.572
LIG_FHA_1	425	431	PF00498	0.551
LIG_FHA_1	461	467	PF00498	0.495
LIG_FHA_1	489	495	PF00498	0.441
LIG_FHA_1	507	513	PF00498	0.386
LIG_FHA_1	580	586	PF00498	0.434
LIG_FHA_1	587	593	PF00498	0.320
LIG_FHA_1	76	82	PF00498	0.398
LIG_FHA_2	162	168	PF00498	0.444
LIG_FHA_2	247	253	PF00498	0.438
LIG_FHA_2	282	288	PF00498	0.592
LIG_FHA_2	33	39	PF00498	0.523
LIG_FHA_2	488	494	PF00498	0.347
LIG_FHA_2	664	670	PF00498	0.614
LIG_LIR_Gen_1	111	118	PF02991	0.399
LIG_LIR_Gen_1	129	137	PF02991	0.344
LIG_LIR_Gen_1	551	562	PF02991	0.454
LIG_LIR_Nem_3	111	115	PF02991	0.560
LIG_LIR_Nem_3	126	131	PF02991	0.473
LIG_LIR_Nem_3	295	301	PF02991	0.512
LIG_LIR_Nem_3	3	7	PF02991	0.529
LIG_LIR_Nem_3	409	414	PF02991	0.509
LIG_LIR_Nem_3	551	557	PF02991	0.394
LIG_LIR_Nem_3	63	67	PF02991	0.592
LIG_NRBOX	501	507	PF00104	0.433
LIG_PCNA_TLS_4	169	176	PF02747	0.413
LIG_Pex14_2	130	134	PF04695	0.365
LIG_Pex14_2	64	68	PF04695	0.405
LIG_PTB_Apo_2	211	218	PF02174	0.386
LIG_SH2_SRC	250	253	PF00017	0.452
LIG_SH2_STAP1	10	14	PF00017	0.414
LIG_SH2_STAP1	387	391	PF00017	0.624
LIG_SH2_STAP1	587	591	PF00017	0.326
LIG_SH2_STAT5	10	13	PF00017	0.536
LIG_SH2_STAT5	102	105	PF00017	0.343
LIG_SH2_STAT5	175	178	PF00017	0.529
LIG_SH2_STAT5	250	253	PF00017	0.453
LIG_SH2_STAT5	4	7	PF00017	0.636
LIG_SH2_STAT5	554	557	PF00017	0.371
LIG_SH2_STAT5	92	95	PF00017	0.444
LIG_SH3_3	274	280	PF00018	0.776
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.440
LIG_SUMO_SIM_par_1	589	596	PF11976	0.428
LIG_TRAF2_1	136	139	PF00917	0.389
LIG_TRAF2_1	490	493	PF00917	0.415
LIG_TRAF2_1	529	532	PF00917	0.544
LIG_UBA3_1	170	177	PF00899	0.337
LIG_UBA3_1	75	82	PF00899	0.383
MOD_CDK_SPK_2	226	231	PF00069	0.451
MOD_CDK_SPxxK_3	281	288	PF00069	0.624
MOD_CDK_SPxxK_3	545	552	PF00069	0.425
MOD_CK1_1	108	114	PF00069	0.466
MOD_CK1_1	207	213	PF00069	0.456
MOD_CK1_1	365	371	PF00069	0.586
MOD_CK1_1	517	523	PF00069	0.519
MOD_CK1_1	548	554	PF00069	0.471
MOD_CK2_1	161	167	PF00069	0.394
MOD_CK2_1	246	252	PF00069	0.423
MOD_CK2_1	281	287	PF00069	0.600
MOD_CK2_1	487	493	PF00069	0.420
MOD_CK2_1	663	669	PF00069	0.691
MOD_CMANNOS	322	325	PF00535	0.467
MOD_GlcNHglycan	103	106	PF01048	0.477
MOD_GlcNHglycan	199	203	PF01048	0.470
MOD_GlcNHglycan	206	209	PF01048	0.391
MOD_GlcNHglycan	341	344	PF01048	0.362
MOD_GlcNHglycan	348	351	PF01048	0.506
MOD_GlcNHglycan	364	367	PF01048	0.653
MOD_GlcNHglycan	371	374	PF01048	0.602
MOD_GlcNHglycan	420	423	PF01048	0.448
MOD_GlcNHglycan	521	525	PF01048	0.648
MOD_GlcNHglycan	595	598	PF01048	0.513
MOD_GlcNHglycan	605	608	PF01048	0.464
MOD_GSK3_1	101	108	PF00069	0.439
MOD_GSK3_1	179	186	PF00069	0.513
MOD_GSK3_1	203	210	PF00069	0.417
MOD_GSK3_1	23	30	PF00069	0.440
MOD_GSK3_1	365	372	PF00069	0.593
MOD_GSK3_1	506	513	PF00069	0.565
MOD_GSK3_1	587	594	PF00069	0.351
MOD_GSK3_1	8	15	PF00069	0.550
MOD_N-GLC_1	359	364	PF02516	0.518
MOD_NEK2_1	103	108	PF00069	0.380
MOD_NEK2_1	27	32	PF00069	0.612
MOD_NEK2_1	316	321	PF00069	0.396
MOD_NEK2_1	339	344	PF00069	0.405
MOD_NEK2_1	406	411	PF00069	0.565
MOD_NEK2_1	506	511	PF00069	0.434
MOD_NEK2_1	561	566	PF00069	0.609
MOD_NEK2_1	579	584	PF00069	0.420
MOD_NEK2_1	586	591	PF00069	0.488
MOD_NEK2_1	593	598	PF00069	0.427
MOD_NEK2_1	75	80	PF00069	0.582
MOD_NEK2_1	90	95	PF00069	0.246
MOD_PIKK_1	103	109	PF00454	0.384
MOD_PIKK_1	32	38	PF00454	0.589
MOD_PIKK_1	441	447	PF00454	0.500
MOD_PKA_1	12	18	PF00069	0.556
MOD_PKA_1	395	401	PF00069	0.504
MOD_PKA_2	119	125	PF00069	0.403
MOD_PKA_2	12	18	PF00069	0.556
MOD_PKA_2	236	242	PF00069	0.430
MOD_PKA_2	395	401	PF00069	0.515
MOD_PKA_2	514	520	PF00069	0.553
MOD_PKA_2	60	66	PF00069	0.388
MOD_PKA_2	662	668	PF00069	0.566
MOD_Plk_1	286	292	PF00069	0.592
MOD_Plk_1	40	46	PF00069	0.461
MOD_Plk_1	520	526	PF00069	0.548
MOD_Plk_4	119	125	PF00069	0.388
MOD_Plk_4	147	153	PF00069	0.496
MOD_Plk_4	246	252	PF00069	0.437
MOD_Plk_4	27	33	PF00069	0.442
MOD_Plk_4	587	593	PF00069	0.415
MOD_ProDKin_1	105	111	PF00069	0.487
MOD_ProDKin_1	2	8	PF00069	0.583
MOD_ProDKin_1	226	232	PF00069	0.458
MOD_ProDKin_1	281	287	PF00069	0.643
MOD_ProDKin_1	432	438	PF00069	0.562
MOD_ProDKin_1	476	482	PF00069	0.443
MOD_ProDKin_1	545	551	PF00069	0.362
MOD_SUMO_rev_2	492	497	PF00179	0.416
MOD_SUMO_rev_2	664	673	PF00179	0.556
TRG_DiLeu_BaEn_1	167	172	PF01217	0.365
TRG_DiLeu_BaEn_1	492	497	PF01217	0.405
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.355
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.451
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.447
TRG_ENDOCYTIC_2	131	134	PF00928	0.404
TRG_ENDOCYTIC_2	411	414	PF00928	0.517
TRG_ENDOCYTIC_2	554	557	PF00928	0.436
TRG_ER_diArg_1	18	21	PF00400	0.679
TRG_ER_diArg_1	222	224	PF00400	0.490
TRG_ER_diArg_1	290	293	PF00400	0.584
TRG_ER_diArg_1	394	397	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY7	Leptomonas seymouri	36%	100%
A0A3S7X637	Leishmania donovani	92%	100%
A4HKW3	Leishmania braziliensis	76%	100%
A4I8E3	Leishmania infantum	92%	100%
E9B3A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%