Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4V0_LEIMA

TriTrypDb:

LmjF.32.3220 , LMJLV39_320040400 , LMJSD75_320040400

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	623	627	PF00656	0.569
CLV_NRD_NRD_1	168	170	PF00675	0.705
CLV_NRD_NRD_1	203	205	PF00675	0.610
CLV_NRD_NRD_1	289	291	PF00675	0.445
CLV_NRD_NRD_1	361	363	PF00675	0.528
CLV_NRD_NRD_1	475	477	PF00675	0.632
CLV_NRD_NRD_1	76	78	PF00675	0.775
CLV_NRD_NRD_1	81	83	PF00675	0.740
CLV_PCSK_FUR_1	201	205	PF00082	0.614
CLV_PCSK_KEX2_1	168	170	PF00082	0.705
CLV_PCSK_KEX2_1	203	205	PF00082	0.610
CLV_PCSK_KEX2_1	361	363	PF00082	0.528
CLV_PCSK_KEX2_1	475	477	PF00082	0.632
CLV_PCSK_KEX2_1	76	78	PF00082	0.781
CLV_PCSK_KEX2_1	81	83	PF00082	0.735
CLV_PCSK_PC7_1	77	83	PF00082	0.713
CLV_PCSK_SKI1_1	222	226	PF00082	0.556
CLV_PCSK_SKI1_1	380	384	PF00082	0.638
DEG_APCC_DBOX_1	232	240	PF00400	0.420
DEG_APCC_DBOX_1	485	493	PF00400	0.612
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DEG_SCF_FBW7_1	432	439	PF00400	0.663
DEG_SPOP_SBC_1	162	166	PF00917	0.676
DEG_SPOP_SBC_1	499	503	PF00917	0.511
DOC_CDC14_PxL_1	381	389	PF14671	0.544
DOC_CKS1_1	170	175	PF01111	0.613
DOC_CKS1_1	404	409	PF01111	0.611
DOC_MAPK_DCC_7	480	489	PF00069	0.579
DOC_MAPK_gen_1	252	260	PF00069	0.449
DOC_MAPK_gen_1	290	297	PF00069	0.421
DOC_MAPK_gen_1	364	373	PF00069	0.484
DOC_MAPK_gen_1	81	88	PF00069	0.741
DOC_MAPK_MEF2A_6	252	259	PF00069	0.455
DOC_MAPK_MEF2A_6	367	375	PF00069	0.429
DOC_MAPK_MEF2A_6	480	489	PF00069	0.579
DOC_PP2B_LxvP_1	179	182	PF13499	0.642
DOC_PP4_FxxP_1	382	385	PF00568	0.546
DOC_PP4_MxPP_1	482	485	PF00568	0.628
DOC_USP7_MATH_1	162	166	PF00917	0.653
DOC_USP7_MATH_1	185	189	PF00917	0.683
DOC_USP7_MATH_1	250	254	PF00917	0.558
DOC_USP7_MATH_1	321	325	PF00917	0.462
DOC_USP7_MATH_1	423	427	PF00917	0.727
DOC_USP7_MATH_1	436	440	PF00917	0.615
DOC_USP7_MATH_1	445	449	PF00917	0.592
DOC_USP7_MATH_1	498	502	PF00917	0.559
DOC_USP7_MATH_1	559	563	PF00917	0.738
DOC_USP7_MATH_1	6	10	PF00917	0.647
DOC_USP7_MATH_1	91	95	PF00917	0.761
DOC_WW_Pin1_4	142	147	PF00397	0.642
DOC_WW_Pin1_4	154	159	PF00397	0.725
DOC_WW_Pin1_4	169	174	PF00397	0.524
DOC_WW_Pin1_4	19	24	PF00397	0.717
DOC_WW_Pin1_4	192	197	PF00397	0.573
DOC_WW_Pin1_4	403	408	PF00397	0.615
DOC_WW_Pin1_4	419	424	PF00397	0.583
DOC_WW_Pin1_4	426	431	PF00397	0.615
DOC_WW_Pin1_4	432	437	PF00397	0.599
DOC_WW_Pin1_4	441	446	PF00397	0.567
DOC_WW_Pin1_4	453	458	PF00397	0.591
DOC_WW_Pin1_4	541	546	PF00397	0.637
LIG_14-3-3_CanoR_1	15	25	PF00244	0.714
LIG_14-3-3_CanoR_1	222	229	PF00244	0.622
LIG_14-3-3_CanoR_1	270	276	PF00244	0.523
LIG_14-3-3_CanoR_1	29	39	PF00244	0.693
LIG_14-3-3_CanoR_1	560	568	PF00244	0.677
LIG_14-3-3_CanoR_1	621	625	PF00244	0.613
LIG_14-3-3_CanoR_1	81	86	PF00244	0.724
LIG_Clathr_ClatBox_1	372	376	PF01394	0.581
LIG_Clathr_ClatBox_1	602	606	PF01394	0.580
LIG_DLG_GKlike_1	174	181	PF00625	0.642
LIG_eIF4E_1	234	240	PF01652	0.496
LIG_FHA_1	147	153	PF00498	0.570
LIG_FHA_1	170	176	PF00498	0.689
LIG_FHA_1	20	26	PF00498	0.777
LIG_FHA_1	32	38	PF00498	0.724
LIG_FHA_1	572	578	PF00498	0.648
LIG_FHA_1	590	596	PF00498	0.457
LIG_FHA_2	109	115	PF00498	0.639
LIG_FHA_2	314	320	PF00498	0.452
LIG_FHA_2	404	410	PF00498	0.682
LIG_FHA_2	433	439	PF00498	0.678
LIG_FHA_2	535	541	PF00498	0.718
LIG_FHA_2	621	627	PF00498	0.559
LIG_FHA_2	88	94	PF00498	0.788
LIG_LIR_Apic_2	413	417	PF02991	0.663
LIG_LIR_Gen_1	415	425	PF02991	0.597
LIG_LIR_Nem_3	299	305	PF02991	0.412
LIG_LIR_Nem_3	415	421	PF02991	0.593
LIG_LIR_Nem_3	575	581	PF02991	0.608
LIG_NRBOX	308	314	PF00104	0.454
LIG_PAM2_1	419	431	PF00658	0.566
LIG_SH2_PTP2	294	297	PF00017	0.409
LIG_SH2_PTP2	514	517	PF00017	0.664
LIG_SH2_SRC	294	297	PF00017	0.340
LIG_SH2_STAP1	127	131	PF00017	0.538
LIG_SH2_STAP1	333	337	PF00017	0.475
LIG_SH2_STAP1	388	392	PF00017	0.557
LIG_SH2_STAP1	589	593	PF00017	0.583
LIG_SH2_STAT3	215	218	PF00017	0.510
LIG_SH2_STAT5	137	140	PF00017	0.607
LIG_SH2_STAT5	294	297	PF00017	0.409
LIG_SH2_STAT5	414	417	PF00017	0.660
LIG_SH2_STAT5	514	517	PF00017	0.588
LIG_SH3_1	514	520	PF00018	0.579
LIG_SH3_3	118	124	PF00018	0.628
LIG_SH3_3	140	146	PF00018	0.573
LIG_SH3_3	167	173	PF00018	0.626
LIG_SH3_3	190	196	PF00018	0.554
LIG_SH3_3	389	395	PF00018	0.560
LIG_SH3_3	401	407	PF00018	0.591
LIG_SH3_3	48	54	PF00018	0.652
LIG_SH3_3	482	488	PF00018	0.579
LIG_SH3_3	507	513	PF00018	0.610
LIG_SH3_3	514	520	PF00018	0.555
LIG_SH3_3	535	541	PF00018	0.609
LIG_SUMO_SIM_anti_2	599	604	PF11976	0.551
LIG_SUMO_SIM_par_1	177	184	PF11976	0.665
LIG_SUMO_SIM_par_1	371	377	PF11976	0.412
LIG_SUMO_SIM_par_1	55	61	PF11976	0.546
LIG_SUMO_SIM_par_1	599	604	PF11976	0.551
LIG_SUMO_SIM_par_1	84	90	PF11976	0.557
LIG_TRAF2_1	112	115	PF00917	0.626
LIG_TRAF2_1	304	307	PF00917	0.502
LIG_TRAF2_1	38	41	PF00917	0.605
LIG_TRAF2_1	71	74	PF00917	0.683
LIG_WRC_WIRS_1	602	607	PF05994	0.655
LIG_WW_3	483	487	PF00397	0.655
MOD_CDK_SPK_2	169	174	PF00069	0.645
MOD_CDK_SPxxK_3	403	410	PF00069	0.609
MOD_CK1_1	135	141	PF00069	0.584
MOD_CK1_1	145	151	PF00069	0.751
MOD_CK1_1	177	183	PF00069	0.747
MOD_CK1_1	19	25	PF00069	0.813
MOD_CK1_1	283	289	PF00069	0.476
MOD_CK1_1	31	37	PF00069	0.656
MOD_CK1_1	339	345	PF00069	0.487
MOD_CK1_1	403	409	PF00069	0.756
MOD_CK1_1	426	432	PF00069	0.620
MOD_CK1_1	444	450	PF00069	0.662
MOD_CK1_1	465	471	PF00069	0.693
MOD_CK1_1	558	564	PF00069	0.787
MOD_CK1_1	65	71	PF00069	0.750
MOD_CK1_1	84	90	PF00069	0.566
MOD_CK2_1	108	114	PF00069	0.628
MOD_CK2_1	126	132	PF00069	0.562
MOD_CK2_1	2	8	PF00069	0.637
MOD_CK2_1	313	319	PF00069	0.456
MOD_CK2_1	35	41	PF00069	0.631
MOD_CK2_1	403	409	PF00069	0.659
MOD_CK2_1	432	438	PF00069	0.616
MOD_CK2_1	577	583	PF00069	0.566
MOD_CK2_1	68	74	PF00069	0.689
MOD_CK2_1	87	93	PF00069	0.580
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.617
MOD_GlcNHglycan	140	143	PF01048	0.507
MOD_GlcNHglycan	183	186	PF01048	0.740
MOD_GlcNHglycan	282	285	PF01048	0.469
MOD_GlcNHglycan	319	322	PF01048	0.528
MOD_GlcNHglycan	4	7	PF01048	0.692
MOD_GlcNHglycan	447	450	PF01048	0.675
MOD_GlcNHglycan	451	454	PF01048	0.745
MOD_GlcNHglycan	547	550	PF01048	0.699
MOD_GlcNHglycan	557	560	PF01048	0.614
MOD_GlcNHglycan	8	11	PF01048	0.653
MOD_GSK3_1	138	145	PF00069	0.626
MOD_GSK3_1	15	22	PF00069	0.635
MOD_GSK3_1	177	184	PF00069	0.682
MOD_GSK3_1	2	9	PF00069	0.670
MOD_GSK3_1	264	271	PF00069	0.553
MOD_GSK3_1	28	35	PF00069	0.510
MOD_GSK3_1	280	287	PF00069	0.386
MOD_GSK3_1	313	320	PF00069	0.470
MOD_GSK3_1	323	330	PF00069	0.454
MOD_GSK3_1	419	426	PF00069	0.682
MOD_GSK3_1	428	435	PF00069	0.613
MOD_GSK3_1	441	448	PF00069	0.561
MOD_GSK3_1	449	456	PF00069	0.741
MOD_GSK3_1	458	465	PF00069	0.775
MOD_GSK3_1	541	548	PF00069	0.776
MOD_GSK3_1	554	561	PF00069	0.711
MOD_GSK3_1	65	72	PF00069	0.685
MOD_GSK3_1	87	94	PF00069	0.598
MOD_N-GLC_1	205	210	PF02516	0.614
MOD_NEK2_1	160	165	PF00069	0.617
MOD_NEK2_1	2	7	PF00069	0.769
MOD_NEK2_1	275	280	PF00069	0.482
MOD_NEK2_1	458	463	PF00069	0.608
MOD_NEK2_1	471	476	PF00069	0.544
MOD_NEK2_1	492	497	PF00069	0.686
MOD_NEK2_1	577	582	PF00069	0.594
MOD_NEK2_2	423	428	PF00069	0.603
MOD_NEK2_2	589	594	PF00069	0.581
MOD_OFUCOSY	450	455	PF10250	0.582
MOD_PIKK_1	132	138	PF00454	0.641
MOD_PIKK_1	374	380	PF00454	0.472
MOD_PIKK_1	458	464	PF00454	0.626
MOD_PIKK_1	531	537	PF00454	0.590
MOD_PK_1	81	87	PF00069	0.613
MOD_PKA_1	81	87	PF00069	0.694
MOD_PKA_2	271	277	PF00069	0.500
MOD_PKA_2	28	34	PF00069	0.721
MOD_PKA_2	559	565	PF00069	0.650
MOD_PKA_2	620	626	PF00069	0.658
MOD_PKA_2	81	87	PF00069	0.715
MOD_Plk_1	119	125	PF00069	0.786
MOD_Plk_1	132	138	PF00069	0.557
MOD_Plk_1	423	429	PF00069	0.606
MOD_Plk_1	436	442	PF00069	0.605
MOD_Plk_2-3	126	132	PF00069	0.542
MOD_Plk_4	174	180	PF00069	0.690
MOD_Plk_4	336	342	PF00069	0.469
MOD_Plk_4	383	389	PF00069	0.556
MOD_Plk_4	400	406	PF00069	0.678
MOD_Plk_4	423	429	PF00069	0.606
MOD_Plk_4	500	506	PF00069	0.545
MOD_Plk_4	577	583	PF00069	0.668
MOD_Plk_4	65	71	PF00069	0.620
MOD_Plk_4	81	87	PF00069	0.517
MOD_ProDKin_1	142	148	PF00069	0.640
MOD_ProDKin_1	154	160	PF00069	0.728
MOD_ProDKin_1	169	175	PF00069	0.524
MOD_ProDKin_1	19	25	PF00069	0.720
MOD_ProDKin_1	192	198	PF00069	0.573
MOD_ProDKin_1	403	409	PF00069	0.611
MOD_ProDKin_1	419	425	PF00069	0.586
MOD_ProDKin_1	426	432	PF00069	0.613
MOD_ProDKin_1	441	447	PF00069	0.565
MOD_ProDKin_1	453	459	PF00069	0.593
MOD_ProDKin_1	541	547	PF00069	0.640
TRG_DiLeu_BaEn_1	368	373	PF01217	0.531
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.612
TRG_ENDOCYTIC_2	294	297	PF00928	0.409
TRG_ER_diArg_1	168	170	PF00400	0.703
TRG_ER_diArg_1	201	204	PF00400	0.618
TRG_ER_diArg_1	27	30	PF00400	0.647
TRG_ER_diArg_1	361	364	PF00400	0.527
TRG_ER_diArg_1	75	77	PF00400	0.775
TRG_ER_diArg_1	80	82	PF00400	0.747
TRG_NES_CRM1_1	346	359	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM2	Leptomonas seymouri	54%	100%
A0A3S7X620	Leishmania donovani	94%	100%
A4HKW7	Leishmania braziliensis	72%	100%
A4I8E7	Leishmania infantum	93%	100%
E9B3A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%