Cytoplasmic dynein 2 light intermediate chain 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light intermediate chain, putative

Species:

Leishmania major

UniProt:

Q4Q4U9_LEIMA

TriTrypDb:

LmjF.32.3230 , LMJLV39_320040500 , LMJSD75_320040500

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	5
GO:0005868	cytoplasmic dynein complex	4	11
GO:0005875	microtubule associated complex	2	11
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	11
GO:0030990	intraciliary transport particle	2	2
GO:0032991	protein-containing complex	1	11
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	11
GO:1902494	catalytic complex	2	11
GO:0005737	cytoplasm	2	9
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4Q4U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4U9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035721	intraciliary retrograde transport	4	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.467
CLV_MEL_PAP_1	202	208	PF00089	0.451
CLV_NRD_NRD_1	138	140	PF00675	0.485
CLV_NRD_NRD_1	200	202	PF00675	0.347
CLV_NRD_NRD_1	260	262	PF00675	0.312
CLV_NRD_NRD_1	29	31	PF00675	0.626
CLV_NRD_NRD_1	382	384	PF00675	0.601
CLV_NRD_NRD_1	400	402	PF00675	0.456
CLV_NRD_NRD_1	411	413	PF00675	0.453
CLV_NRD_NRD_1	7	9	PF00675	0.612
CLV_PCSK_KEX2_1	124	126	PF00082	0.642
CLV_PCSK_KEX2_1	138	140	PF00082	0.365
CLV_PCSK_KEX2_1	200	202	PF00082	0.309
CLV_PCSK_KEX2_1	240	242	PF00082	0.418
CLV_PCSK_KEX2_1	260	262	PF00082	0.252
CLV_PCSK_KEX2_1	29	31	PF00082	0.626
CLV_PCSK_KEX2_1	382	384	PF00082	0.508
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.683
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.418
CLV_PCSK_SKI1_1	124	128	PF00082	0.627
CLV_PCSK_SKI1_1	223	227	PF00082	0.449
CLV_PCSK_SKI1_1	79	83	PF00082	0.579
DEG_APCC_DBOX_1	240	248	PF00400	0.347
DOC_CKS1_1	166	171	PF01111	0.314
DOC_MAPK_DCC_7	243	252	PF00069	0.302
DOC_MAPK_gen_1	260	268	PF00069	0.544
DOC_MAPK_gen_1	294	301	PF00069	0.439
DOC_MAPK_MEF2A_6	243	252	PF00069	0.300
DOC_MAPK_MEF2A_6	319	326	PF00069	0.440
DOC_PP4_FxxP_1	304	307	PF00568	0.375
DOC_PP4_FxxP_1	392	395	PF00568	0.432
DOC_USP7_MATH_1	10	14	PF00917	0.759
DOC_USP7_MATH_1	137	141	PF00917	0.496
DOC_USP7_MATH_1	215	219	PF00917	0.401
DOC_USP7_MATH_1	317	321	PF00917	0.393
DOC_USP7_MATH_1	337	341	PF00917	0.547
DOC_USP7_MATH_1	419	423	PF00917	0.591
DOC_USP7_MATH_1	98	102	PF00917	0.416
DOC_WW_Pin1_4	1	6	PF00397	0.657
DOC_WW_Pin1_4	165	170	PF00397	0.325
DOC_WW_Pin1_4	217	222	PF00397	0.377
DOC_WW_Pin1_4	39	44	PF00397	0.697
LIG_14-3-3_CanoR_1	109	115	PF00244	0.521
LIG_14-3-3_CanoR_1	125	134	PF00244	0.547
LIG_14-3-3_CanoR_1	138	146	PF00244	0.386
LIG_14-3-3_CanoR_1	14	18	PF00244	0.523
LIG_14-3-3_CanoR_1	205	213	PF00244	0.473
LIG_AP2alpha_2	378	380	PF02296	0.500
LIG_Clathr_ClatBox_1	323	327	PF01394	0.417
LIG_deltaCOP1_diTrp_1	354	360	PF00928	0.422
LIG_FHA_1	102	108	PF00498	0.358
LIG_FHA_1	127	133	PF00498	0.418
LIG_FHA_1	194	200	PF00498	0.358
LIG_FHA_1	247	253	PF00498	0.300
LIG_FHA_1	68	74	PF00498	0.456
LIG_FHA_1	76	82	PF00498	0.447
LIG_FHA_1	89	95	PF00498	0.398
LIG_FHA_2	128	134	PF00498	0.437
LIG_FHA_2	313	319	PF00498	0.544
LIG_FHA_2	32	38	PF00498	0.630
LIG_LIR_Apic_2	302	307	PF02991	0.412
LIG_LIR_Apic_2	354	359	PF02991	0.390
LIG_LIR_Apic_2	389	395	PF02991	0.469
LIG_LIR_Gen_1	157	167	PF02991	0.478
LIG_LIR_Gen_1	329	339	PF02991	0.379
LIG_LIR_Gen_1	72	81	PF02991	0.416
LIG_LIR_LC3C_4	90	95	PF02991	0.459
LIG_LIR_Nem_3	157	162	PF02991	0.464
LIG_LIR_Nem_3	292	298	PF02991	0.471
LIG_LIR_Nem_3	329	334	PF02991	0.333
LIG_LIR_Nem_3	72	77	PF02991	0.409
LIG_Pex14_1	356	360	PF04695	0.411
LIG_Pex14_2	304	308	PF04695	0.352
LIG_Pex14_2	360	364	PF04695	0.433
LIG_Rb_pABgroove_1	379	387	PF01858	0.450
LIG_SH2_STAT5	111	114	PF00017	0.469
LIG_SH2_STAT5	275	278	PF00017	0.344
LIG_SH2_STAT5	312	315	PF00017	0.465
LIG_SH3_2	25	30	PF14604	0.599
LIG_SH3_3	163	169	PF00018	0.319
LIG_SH3_3	22	28	PF00018	0.609
LIG_SH3_3	304	310	PF00018	0.437
LIG_SH3_3	373	379	PF00018	0.584
LIG_SH3_3	63	69	PF00018	0.489
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.407
LIG_SUMO_SIM_anti_2	89	97	PF11976	0.359
LIG_SUMO_SIM_par_1	322	327	PF11976	0.379
LIG_TRAF2_1	183	186	PF00917	0.474
LIG_TRAF2_1	288	291	PF00917	0.429
LIG_TRAF2_1	35	38	PF00917	0.676
LIG_WRC_WIRS_1	111	116	PF05994	0.549
LIG_WW_3	26	30	PF00397	0.683
MOD_CDC14_SPxK_1	42	45	PF00782	0.800
MOD_CDK_SPxK_1	217	223	PF00069	0.380
MOD_CDK_SPxK_1	39	45	PF00069	0.803
MOD_CDK_SPxxK_3	1	8	PF00069	0.690
MOD_CK1_1	101	107	PF00069	0.411
MOD_CK1_1	113	119	PF00069	0.551
MOD_CK1_1	13	19	PF00069	0.737
MOD_CK1_1	207	213	PF00069	0.410
MOD_CK1_1	345	351	PF00069	0.506
MOD_CK2_1	285	291	PF00069	0.489
MOD_CK2_1	31	37	PF00069	0.788
MOD_CK2_1	312	318	PF00069	0.510
MOD_GlcNHglycan	118	121	PF01048	0.548
MOD_GlcNHglycan	244	247	PF01048	0.325
MOD_GlcNHglycan	318	322	PF01048	0.538
MOD_GlcNHglycan	344	347	PF01048	0.514
MOD_GlcNHglycan	416	419	PF01048	0.571
MOD_GlcNHglycan	61	64	PF01048	0.659
MOD_GlcNHglycan	98	101	PF01048	0.368
MOD_GSK3_1	109	116	PF00069	0.379
MOD_GSK3_1	242	249	PF00069	0.345
MOD_GSK3_1	285	292	PF00069	0.363
MOD_GSK3_1	29	36	PF00069	0.743
MOD_GSK3_1	44	51	PF00069	0.602
MOD_GSK3_1	52	59	PF00069	0.781
MOD_GSK3_1	98	105	PF00069	0.420
MOD_N-GLC_1	116	121	PF02516	0.585
MOD_N-GLC_1	299	304	PF02516	0.383
MOD_N-GLC_1	419	424	PF02516	0.627
MOD_N-GLC_1	75	80	PF02516	0.498
MOD_NEK2_1	132	137	PF00069	0.339
MOD_NEK2_1	242	247	PF00069	0.355
MOD_NEK2_1	269	274	PF00069	0.309
MOD_NEK2_1	299	304	PF00069	0.498
MOD_NEK2_1	342	347	PF00069	0.482
MOD_PIKK_1	154	160	PF00454	0.354
MOD_PIKK_1	207	213	PF00454	0.515
MOD_PIKK_1	44	50	PF00454	0.632
MOD_PKA_1	29	35	PF00069	0.629
MOD_PKA_1	412	418	PF00069	0.516
MOD_PKA_2	13	19	PF00069	0.542
MOD_PKA_2	137	143	PF00069	0.501
MOD_PKA_2	204	210	PF00069	0.457
MOD_PKA_2	242	248	PF00069	0.332
MOD_PKA_2	29	35	PF00069	0.581
MOD_PKA_2	327	333	PF00069	0.461
MOD_PKA_2	44	50	PF00069	0.481
MOD_Plk_1	132	138	PF00069	0.392
MOD_Plk_1	299	305	PF00069	0.394
MOD_Plk_1	317	323	PF00069	0.426
MOD_Plk_1	337	343	PF00069	0.592
MOD_Plk_1	89	95	PF00069	0.469
MOD_Plk_2-3	327	333	PF00069	0.365
MOD_Plk_4	102	108	PF00069	0.296
MOD_Plk_4	193	199	PF00069	0.337
MOD_Plk_4	246	252	PF00069	0.306
MOD_Plk_4	327	333	PF00069	0.449
MOD_Plk_4	61	67	PF00069	0.495
MOD_Plk_4	89	95	PF00069	0.410
MOD_ProDKin_1	1	7	PF00069	0.658
MOD_ProDKin_1	165	171	PF00069	0.323
MOD_ProDKin_1	217	223	PF00069	0.380
MOD_ProDKin_1	39	45	PF00069	0.699
MOD_SUMO_rev_2	235	242	PF00179	0.437
MOD_SUMO_rev_2	371	376	PF00179	0.555
MOD_SUMO_rev_2	4	10	PF00179	0.691
TRG_ENDOCYTIC_2	111	114	PF00928	0.529
TRG_ER_diArg_1	199	201	PF00400	0.409
TRG_ER_diArg_1	241	244	PF00400	0.327
TRG_ER_diArg_1	259	261	PF00400	0.368
TRG_ER_diArg_1	28	30	PF00400	0.626
TRG_ER_diArg_1	381	383	PF00400	0.642
TRG_NLS_Bipartite_1	401	416	PF00514	0.445
TRG_NLS_MonoExtN_4	123	128	PF00514	0.596
TRG_NLS_MonoExtN_4	237	244	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN3	Leptomonas seymouri	82%	99%
A0A0S4JG99	Bodo saltans	54%	100%
A0A1X0NS84	Trypanosomatidae	52%	100%
A0A3R7P067	Trypanosoma rangeli	54%	100%
A0A3S5H7T0	Leishmania donovani	96%	100%
A4HKW8	Leishmania braziliensis	84%	99%
A4I8E8	Leishmania infantum	95%	100%
D0AAS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q32KV4	Bos taurus	28%	100%
Q6AY43	Rattus norvegicus	28%	100%
Q7SXY4	Danio rerio	29%	100%
Q7XA07	Chlamydomonas reinhardtii	24%	100%
Q8K0T2	Mus musculus	30%	100%
Q8TCX1	Homo sapiens	26%	100%