T-complex protein 1 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperonin alpha subunit, putative

Species:

Leishmania major

UniProt:

Q4Q4U5_LEIMA

TriTrypDb:

LmjF.32.3270 , LMJLV39_320040900 , LMJSD75_320040900

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 1
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005832	chaperonin-containing T-complex	4	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0101031	protein folding chaperone complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2

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Expansion

Sequence features

Q4Q4U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4U5

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.528
CLV_C14_Caspase3-7	89	93	PF00656	0.407
CLV_NRD_NRD_1	195	197	PF00675	0.407
CLV_NRD_NRD_1	22	24	PF00675	0.512
CLV_NRD_NRD_1	313	315	PF00675	0.394
CLV_NRD_NRD_1	321	323	PF00675	0.391
CLV_PCSK_KEX2_1	106	108	PF00082	0.407
CLV_PCSK_KEX2_1	22	24	PF00082	0.527
CLV_PCSK_KEX2_1	313	315	PF00082	0.393
CLV_PCSK_KEX2_1	321	323	PF00082	0.393

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U4	Leptomonas seymouri	31%	100%
A0A0N1HUM6	Leptomonas seymouri	32%	100%
A0A0N1HUW6	Leptomonas seymouri	31%	99%
A0A0N1HXN1	Leptomonas seymouri	26%	100%
A0A0N1I104	Leptomonas seymouri	35%	96%
A0A0N1I2L2	Leptomonas seymouri	32%	100%
A0A0N1II94	Leptomonas seymouri	93%	100%
A0A0N1IM41	Leptomonas seymouri	29%	100%
A0A0N1PDS3	Leptomonas seymouri	22%	92%
A0A0S4IN05	Bodo saltans	22%	92%

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