Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4U4_LEIMA

TriTrypDb:

LmjF.32.3280 , LMJLV39_320041000 , LMJSD75_320041000

Length:

864

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	754	758	PF00656	0.590
CLV_NRD_NRD_1	314	316	PF00675	0.699
CLV_NRD_NRD_1	506	508	PF00675	0.812
CLV_NRD_NRD_1	525	527	PF00675	0.674
CLV_NRD_NRD_1	611	613	PF00675	0.715
CLV_NRD_NRD_1	686	688	PF00675	0.702
CLV_NRD_NRD_1	727	729	PF00675	0.573
CLV_PCSK_KEX2_1	314	316	PF00082	0.699
CLV_PCSK_KEX2_1	497	499	PF00082	0.700
CLV_PCSK_KEX2_1	506	508	PF00082	0.642
CLV_PCSK_KEX2_1	611	613	PF00082	0.715
CLV_PCSK_KEX2_1	686	688	PF00082	0.707
CLV_PCSK_KEX2_1	727	729	PF00082	0.573
CLV_PCSK_KEX2_1	800	802	PF00082	0.701
CLV_PCSK_KEX2_1	838	840	PF00082	0.832
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.678
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.746
CLV_PCSK_PC1ET2_1	838	840	PF00082	0.832
CLV_PCSK_PC7_1	682	688	PF00082	0.701
CLV_PCSK_SKI1_1	151	155	PF00082	0.614
CLV_PCSK_SKI1_1	162	166	PF00082	0.725
CLV_PCSK_SKI1_1	205	209	PF00082	0.636
CLV_PCSK_SKI1_1	221	225	PF00082	0.777
CLV_PCSK_SKI1_1	425	429	PF00082	0.692
CLV_PCSK_SKI1_1	472	476	PF00082	0.592
CLV_PCSK_SKI1_1	644	648	PF00082	0.747
CLV_PCSK_SKI1_1	687	691	PF00082	0.776
CLV_PCSK_SKI1_1	832	836	PF00082	0.733
DEG_APCC_DBOX_1	150	158	PF00400	0.511
DEG_COP1_1	378	390	PF00400	0.730
DEG_ODPH_VHL_1	170	181	PF01847	0.545
DEG_SPOP_SBC_1	171	175	PF00917	0.616
DEG_SPOP_SBC_1	427	431	PF00917	0.568
DEG_SPOP_SBC_1	645	649	PF00917	0.772
DEG_SPOP_SBC_1	817	821	PF00917	0.758
DOC_CKS1_1	211	216	PF01111	0.734
DOC_CKS1_1	58	63	PF01111	0.735
DOC_CYCLIN_yClb1_LxF_4	410	415	PF00134	0.682
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.672
DOC_MAPK_DCC_7	785	793	PF00069	0.715
DOC_MAPK_MEF2A_6	356	365	PF00069	0.660
DOC_MAPK_MEF2A_6	785	793	PF00069	0.715
DOC_PP1_RVXF_1	410	416	PF00149	0.683
DOC_PP2B_LxvP_1	169	172	PF13499	0.680
DOC_PP2B_LxvP_1	394	397	PF13499	0.703
DOC_PP2B_LxvP_1	567	570	PF13499	0.711
DOC_PP2B_PxIxI_1	358	364	PF00149	0.662
DOC_PP4_FxxP_1	18	21	PF00568	0.702
DOC_PP4_FxxP_1	672	675	PF00568	0.653
DOC_USP7_MATH_1	130	134	PF00917	0.650
DOC_USP7_MATH_1	172	176	PF00917	0.760
DOC_USP7_MATH_1	23	27	PF00917	0.702
DOC_USP7_MATH_1	259	263	PF00917	0.709
DOC_USP7_MATH_1	377	381	PF00917	0.735
DOC_USP7_MATH_1	388	392	PF00917	0.781
DOC_USP7_MATH_1	52	56	PF00917	0.742
DOC_USP7_MATH_1	627	631	PF00917	0.705
DOC_USP7_MATH_1	645	649	PF00917	0.600
DOC_USP7_MATH_1	654	658	PF00917	0.773
DOC_USP7_MATH_1	705	709	PF00917	0.737
DOC_USP7_MATH_1	715	719	PF00917	0.587
DOC_USP7_MATH_1	729	733	PF00917	0.660
DOC_USP7_MATH_1	751	755	PF00917	0.564
DOC_USP7_MATH_1	807	811	PF00917	0.719
DOC_USP7_MATH_1	812	816	PF00917	0.834
DOC_USP7_MATH_1	817	821	PF00917	0.774
DOC_USP7_MATH_1	823	827	PF00917	0.643
DOC_USP7_MATH_2	272	278	PF00917	0.765
DOC_USP7_UBL2_3	796	800	PF12436	0.747
DOC_USP7_UBL2_3	832	836	PF12436	0.698
DOC_WW_Pin1_4	210	215	PF00397	0.737
DOC_WW_Pin1_4	216	221	PF00397	0.635
DOC_WW_Pin1_4	229	234	PF00397	0.585
DOC_WW_Pin1_4	253	258	PF00397	0.634
DOC_WW_Pin1_4	483	488	PF00397	0.669
DOC_WW_Pin1_4	517	522	PF00397	0.710
DOC_WW_Pin1_4	552	557	PF00397	0.679
DOC_WW_Pin1_4	57	62	PF00397	0.809
DOC_WW_Pin1_4	600	605	PF00397	0.680
DOC_WW_Pin1_4	616	621	PF00397	0.702
DOC_WW_Pin1_4	648	653	PF00397	0.709
DOC_WW_Pin1_4	71	76	PF00397	0.587
DOC_WW_Pin1_4	710	715	PF00397	0.620
DOC_WW_Pin1_4	759	764	PF00397	0.800
DOC_WW_Pin1_4	801	806	PF00397	0.702
LIG_14-3-3_CanoR_1	127	134	PF00244	0.669
LIG_14-3-3_CanoR_1	144	153	PF00244	0.566
LIG_14-3-3_CanoR_1	202	208	PF00244	0.693
LIG_14-3-3_CanoR_1	221	226	PF00244	0.779
LIG_14-3-3_CanoR_1	227	233	PF00244	0.684
LIG_14-3-3_CanoR_1	314	318	PF00244	0.695
LIG_14-3-3_CanoR_1	412	418	PF00244	0.687
LIG_14-3-3_CanoR_1	56	61	PF00244	0.661
LIG_14-3-3_CanoR_1	644	654	PF00244	0.757
LIG_14-3-3_CanoR_1	781	789	PF00244	0.691
LIG_14-3-3_CanoR_1	839	845	PF00244	0.622
LIG_14-3-3_CanoR_1	84	89	PF00244	0.599
LIG_Actin_WH2_2	150	168	PF00022	0.525
LIG_Actin_WH2_2	174	192	PF00022	0.628
LIG_BIR_III_2	460	464	PF00653	0.565
LIG_BIR_III_2	560	564	PF00653	0.683
LIG_BRCT_BRCA1_1	521	525	PF00533	0.555
LIG_BRCT_BRCA1_1	62	66	PF00533	0.812
LIG_BRCT_BRCA1_1	668	672	PF00533	0.660
LIG_BRCT_BRCA1_2	521	527	PF00533	0.558
LIG_CaM_NSCaTE_8	505	512	PF13499	0.741
LIG_eIF4E_1	568	574	PF01652	0.567
LIG_FHA_1	123	129	PF00498	0.645
LIG_FHA_1	15	21	PF00498	0.699
LIG_FHA_1	171	177	PF00498	0.702
LIG_FHA_1	358	364	PF00498	0.708
LIG_FHA_1	408	414	PF00498	0.759
LIG_FHA_1	429	435	PF00498	0.737
LIG_FHA_1	484	490	PF00498	0.722
LIG_FHA_1	678	684	PF00498	0.671
LIG_FHA_2	143	149	PF00498	0.637
LIG_FHA_2	48	54	PF00498	0.768
LIG_FHA_2	92	98	PF00498	0.699
LIG_LIR_Apic_2	17	21	PF02991	0.702
LIG_LIR_Apic_2	669	675	PF02991	0.647
LIG_LIR_Gen_1	13	23	PF02991	0.716
LIG_LIR_Nem_3	13	19	PF02991	0.715
LIG_LYPXL_SIV_4	617	625	PF13949	0.657
LIG_MLH1_MIPbox_1	521	525	PF16413	0.555
LIG_PAM2_1	413	425	PF00658	0.560
LIG_REV1ctd_RIR_1	138	148	PF16727	0.660
LIG_REV1ctd_RIR_1	522	531	PF16727	0.561
LIG_SH2_CRK	16	20	PF00017	0.780
LIG_SH2_CRK	446	450	PF00017	0.600
LIG_SH2_NCK_1	618	622	PF00017	0.655
LIG_SH2_SRC	776	779	PF00017	0.650
LIG_SH2_STAP1	16	20	PF00017	0.780
LIG_SH2_STAP1	776	780	PF00017	0.650
LIG_SH2_STAT5	16	19	PF00017	0.780
LIG_SH3_1	614	620	PF00018	0.708
LIG_SH3_3	244	250	PF00018	0.668
LIG_SH3_3	275	281	PF00018	0.760
LIG_SH3_3	292	298	PF00018	0.519
LIG_SH3_3	307	313	PF00018	0.760
LIG_SH3_3	349	355	PF00018	0.727
LIG_SH3_3	418	424	PF00018	0.666
LIG_SH3_3	434	440	PF00018	0.685
LIG_SH3_3	510	516	PF00018	0.757
LIG_SH3_3	543	549	PF00018	0.810
LIG_SH3_3	566	572	PF00018	0.701
LIG_SH3_3	589	595	PF00018	0.669
LIG_SH3_3	614	620	PF00018	0.708
LIG_SH3_3	72	78	PF00018	0.785
LIG_SH3_4	796	803	PF00018	0.746
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.709
LIG_SUMO_SIM_par_1	177	183	PF11976	0.625
LIG_SUMO_SIM_par_1	297	304	PF11976	0.800
LIG_SxIP_EBH_1	633	644	PF03271	0.563
LIG_TRAF2_1	266	269	PF00917	0.619
LIG_WRC_WIRS_1	667	672	PF05994	0.660
LIG_WW_3	536	540	PF00397	0.684
LIG_WW_3	568	572	PF00397	0.679
MOD_CDK_SPK_2	216	221	PF00069	0.736
MOD_CDK_SPK_2	552	557	PF00069	0.677
MOD_CDK_SPK_2	648	653	PF00069	0.692
MOD_CDK_SPK_2	801	806	PF00069	0.710
MOD_CDK_SPxxK_3	229	236	PF00069	0.716
MOD_CDK_SPxxK_3	801	808	PF00069	0.730
MOD_CK1_1	104	110	PF00069	0.530
MOD_CK1_1	219	225	PF00069	0.825
MOD_CK1_1	33	39	PF00069	0.671
MOD_CK1_1	386	392	PF00069	0.822
MOD_CK1_1	401	407	PF00069	0.608
MOD_CK1_1	426	432	PF00069	0.642
MOD_CK1_1	520	526	PF00069	0.659
MOD_CK1_1	555	561	PF00069	0.595
MOD_CK1_1	57	63	PF00069	0.752
MOD_CK1_1	636	642	PF00069	0.712
MOD_CK1_1	648	654	PF00069	0.786
MOD_CK1_1	827	833	PF00069	0.718
MOD_CK2_1	142	148	PF00069	0.631
MOD_CK2_1	177	183	PF00069	0.603
MOD_CK2_1	192	198	PF00069	0.652
MOD_CK2_1	377	383	PF00069	0.721
MOD_CK2_1	47	53	PF00069	0.755
MOD_CK2_1	56	62	PF00069	0.656
MOD_CK2_1	582	588	PF00069	0.602
MOD_CK2_1	697	703	PF00069	0.692
MOD_CK2_1	772	778	PF00069	0.661
MOD_Cter_Amidation	495	498	PF01082	0.683
MOD_Cter_Amidation	798	801	PF01082	0.710
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.713
MOD_GlcNHglycan	103	106	PF01048	0.577
MOD_GlcNHglycan	128	131	PF01048	0.674
MOD_GlcNHglycan	154	157	PF01048	0.745
MOD_GlcNHglycan	244	247	PF01048	0.678
MOD_GlcNHglycan	25	28	PF01048	0.629
MOD_GlcNHglycan	261	264	PF01048	0.580
MOD_GlcNHglycan	310	313	PF01048	0.696
MOD_GlcNHglycan	379	382	PF01048	0.721
MOD_GlcNHglycan	391	394	PF01048	0.787
MOD_GlcNHglycan	401	404	PF01048	0.712
MOD_GlcNHglycan	431	434	PF01048	0.749
MOD_GlcNHglycan	50	53	PF01048	0.719
MOD_GlcNHglycan	584	587	PF01048	0.682
MOD_GlcNHglycan	648	651	PF01048	0.741
MOD_GlcNHglycan	656	659	PF01048	0.769
MOD_GlcNHglycan	703	706	PF01048	0.742
MOD_GlcNHglycan	717	720	PF01048	0.691
MOD_GlcNHglycan	78	81	PF01048	0.562
MOD_GlcNHglycan	782	785	PF01048	0.734
MOD_GlcNHglycan	809	812	PF01048	0.717
MOD_GlcNHglycan	814	817	PF01048	0.746
MOD_GSK3_1	122	129	PF00069	0.678
MOD_GSK3_1	219	226	PF00069	0.722
MOD_GSK3_1	35	42	PF00069	0.776
MOD_GSK3_1	373	380	PF00069	0.721
MOD_GSK3_1	399	406	PF00069	0.647
MOD_GSK3_1	423	430	PF00069	0.637
MOD_GSK3_1	44	51	PF00069	0.626
MOD_GSK3_1	473	480	PF00069	0.756
MOD_GSK3_1	52	59	PF00069	0.536
MOD_GSK3_1	578	585	PF00069	0.721
MOD_GSK3_1	62	69	PF00069	0.564
MOD_GSK3_1	627	634	PF00069	0.674
MOD_GSK3_1	644	651	PF00069	0.755
MOD_GSK3_1	654	661	PF00069	0.755
MOD_GSK3_1	692	699	PF00069	0.695
MOD_GSK3_1	701	708	PF00069	0.715
MOD_GSK3_1	74	81	PF00069	0.642
MOD_GSK3_1	742	749	PF00069	0.732
MOD_GSK3_1	812	819	PF00069	0.794
MOD_GSK3_1	823	830	PF00069	0.598
MOD_GSK3_1	84	91	PF00069	0.604
MOD_LATS_1	822	828	PF00433	0.753
MOD_N-GLC_1	407	412	PF02516	0.723
MOD_N-GLC_1	659	664	PF02516	0.712
MOD_N-GLC_1	824	829	PF02516	0.750
MOD_N-GLC_2	629	631	PF02516	0.602
MOD_NEK2_1	120	125	PF00069	0.576
MOD_NEK2_1	223	228	PF00069	0.717
MOD_NEK2_1	30	35	PF00069	0.676
MOD_NEK2_1	413	418	PF00069	0.744
MOD_NEK2_1	428	433	PF00069	0.566
MOD_NEK2_1	475	480	PF00069	0.697
MOD_NEK2_1	633	638	PF00069	0.709
MOD_NEK2_1	646	651	PF00069	0.572
MOD_NEK2_1	66	71	PF00069	0.721
MOD_NEK2_1	780	785	PF00069	0.681
MOD_NEK2_2	122	127	PF00069	0.640
MOD_OFUCOSY	626	631	PF10250	0.646
MOD_PIKK_1	33	39	PF00454	0.662
MOD_PIKK_1	633	639	PF00454	0.787
MOD_PIKK_1	840	846	PF00454	0.581
MOD_PK_1	289	295	PF00069	0.733
MOD_PK_1	84	90	PF00069	0.650
MOD_PKA_1	838	844	PF00069	0.748
MOD_PKA_2	126	132	PF00069	0.562
MOD_PKA_2	157	163	PF00069	0.647
MOD_PKA_2	228	234	PF00069	0.712
MOD_PKA_2	313	319	PF00069	0.694
MOD_PKA_2	780	786	PF00069	0.682
MOD_PKA_2	827	833	PF00069	0.667
MOD_PKA_2	83	89	PF00069	0.583
MOD_PKA_2	838	844	PF00069	0.695
MOD_Plk_1	120	126	PF00069	0.524
MOD_Plk_1	274	280	PF00069	0.780
MOD_Plk_1	659	665	PF00069	0.553
MOD_Plk_2-3	62	68	PF00069	0.687
MOD_Plk_4	14	20	PF00069	0.776
MOD_Plk_4	423	429	PF00069	0.691
MOD_Plk_4	520	526	PF00069	0.676
MOD_ProDKin_1	210	216	PF00069	0.737
MOD_ProDKin_1	229	235	PF00069	0.753
MOD_ProDKin_1	253	259	PF00069	0.635
MOD_ProDKin_1	483	489	PF00069	0.670
MOD_ProDKin_1	517	523	PF00069	0.707
MOD_ProDKin_1	552	558	PF00069	0.675
MOD_ProDKin_1	57	63	PF00069	0.805
MOD_ProDKin_1	600	606	PF00069	0.683
MOD_ProDKin_1	616	622	PF00069	0.700
MOD_ProDKin_1	648	654	PF00069	0.704
MOD_ProDKin_1	71	77	PF00069	0.581
MOD_ProDKin_1	710	716	PF00069	0.621
MOD_ProDKin_1	759	765	PF00069	0.803
MOD_ProDKin_1	801	807	PF00069	0.705
TRG_DiLeu_BaEn_1	685	690	PF01217	0.711
TRG_DiLeu_BaLyEn_6	672	677	PF01217	0.652
TRG_ENDOCYTIC_2	16	19	PF00928	0.780
TRG_ER_diArg_1	313	315	PF00400	0.695
TRG_ER_diArg_1	505	507	PF00400	0.738
TRG_ER_diArg_1	611	614	PF00400	0.719
TRG_ER_diArg_1	727	729	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC13	Leptomonas seymouri	37%	100%
A0A3S7X647	Leishmania donovani	87%	100%
A4HKX3	Leishmania braziliensis	47%	100%
A4I8F3	Leishmania infantum	87%	100%
E9B3B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%