LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4U3_LEIMA
TriTrypDb:
LmjF.32.3290 , LMJLV39_320041100 , LMJSD75_320041100
Length:
240

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005739 mitochondrion 5 2
GO:0016020 membrane 2 4
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

Q4Q4U3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4U3

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 87 93 PF00089 0.376
CLV_NRD_NRD_1 159 161 PF00675 0.380
CLV_PCSK_KEX2_1 159 161 PF00082 0.369
CLV_PCSK_KEX2_1 172 174 PF00082 0.467
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.487
CLV_PCSK_SKI1_1 121 125 PF00082 0.366
CLV_PCSK_SKI1_1 160 164 PF00082 0.421
CLV_PCSK_SKI1_1 173 177 PF00082 0.408
DOC_CKS1_1 223 228 PF01111 0.684
DOC_CYCLIN_RxL_1 140 151 PF00134 0.595
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IIX5 Leptomonas seymouri 86% 100%
A0A0S4J8L9 Bodo saltans 54% 100%
A0A1X0NRU5 Trypanosomatidae 66% 100%
A0A3Q8IGH3 Leishmania donovani 98% 100%
A0A422P2X7 Trypanosoma rangeli 64% 100%
A4HKX4 Leishmania braziliensis 90% 100%
A4I8F4 Leishmania infantum 98% 100%
D0AAR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9B3B2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BVM8 Trypanosoma cruzi 67% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS