Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4U3_LEIMA

TriTrypDb:

LmjF.32.3290 , LMJLV39_320041100 , LMJSD75_320041100

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4

Expansion

Sequence features

Q4Q4U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	87	93	PF00089	0.376
CLV_NRD_NRD_1	159	161	PF00675	0.380
CLV_PCSK_KEX2_1	159	161	PF00082	0.369
CLV_PCSK_KEX2_1	172	174	PF00082	0.467
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.487
CLV_PCSK_SKI1_1	121	125	PF00082	0.366
CLV_PCSK_SKI1_1	160	164	PF00082	0.421
CLV_PCSK_SKI1_1	173	177	PF00082	0.408
DOC_CKS1_1	223	228	PF01111	0.684
DOC_CYCLIN_RxL_1	140	151	PF00134	0.595
DOC_CYCLIN_RxL_1	156	167	PF00134	0.607
DOC_WW_Pin1_4	222	227	PF00397	0.669
DOC_WW_Pin1_4	5	10	PF00397	0.571
LIG_14-3-3_CanoR_1	160	170	PF00244	0.601
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BRCT_BRCA1_1	87	91	PF00533	0.445
LIG_EH1_1	155	163	PF00400	0.583
LIG_eIF4E_1	42	48	PF01652	0.460
LIG_FHA_1	174	180	PF00498	0.652
LIG_FHA_1	208	214	PF00498	0.721
LIG_FHA_2	178	184	PF00498	0.642
LIG_FHA_2	41	47	PF00498	0.382
LIG_GLEBS_BUB3_1	57	65	PF00400	0.445
LIG_LIR_Gen_1	130	141	PF02991	0.540
LIG_LIR_Nem_3	130	136	PF02991	0.536
LIG_SH2_CRK	133	137	PF00017	0.571
LIG_SH2_STAT5	42	45	PF00017	0.384
LIG_SH2_STAT5	85	88	PF00017	0.418
LIG_SH3_3	220	226	PF00018	0.664
LIG_SH3_3	96	102	PF00018	0.652
LIG_SUMO_SIM_par_1	142	149	PF11976	0.590
LIG_TRAF2_1	180	183	PF00917	0.637
LIG_TYR_ITIM	131	136	PF00017	0.552
LIG_WRC_WIRS_1	71	76	PF05994	0.363
MOD_CK1_1	152	158	PF00069	0.589
MOD_CK1_1	164	170	PF00069	0.640
MOD_CK1_1	3	9	PF00069	0.551
MOD_CK2_1	177	183	PF00069	0.644
MOD_GlcNHglycan	166	169	PF01048	0.430
MOD_GlcNHglycan	199	202	PF01048	0.488
MOD_GlcNHglycan	27	30	PF01048	0.715
MOD_GlcNHglycan	3	6	PF01048	0.704
MOD_GlcNHglycan	87	90	PF01048	0.508
MOD_GSK3_1	1	8	PF00069	0.549
MOD_GSK3_1	107	114	PF00069	0.687
MOD_GSK3_1	173	180	PF00069	0.655
MOD_GSK3_1	36	43	PF00069	0.417
MOD_N-GLC_1	152	157	PF02516	0.390
MOD_N-GLC_1	197	202	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	124	129	PF00069	0.537
MOD_NEK2_1	161	166	PF00069	0.590
MOD_NEK2_1	171	176	PF00069	0.656
MOD_PIKK_1	161	167	PF00454	0.588
MOD_PIKK_1	202	208	PF00454	0.736
MOD_PIKK_1	234	240	PF00454	0.802
MOD_PKA_2	107	113	PF00069	0.701
MOD_PKA_2	149	155	PF00069	0.660
MOD_PKA_2	202	208	PF00069	0.700
MOD_Plk_1	152	158	PF00069	0.589
MOD_Plk_4	107	113	PF00069	0.607
MOD_ProDKin_1	222	228	PF00069	0.669
MOD_ProDKin_1	5	11	PF00069	0.573
TRG_DiLeu_BaEn_1	61	66	PF01217	0.437
TRG_DiLeu_BaEn_3	182	188	PF01217	0.574
TRG_ENDOCYTIC_2	133	136	PF00928	0.556
TRG_ENDOCYTIC_2	232	235	PF00928	0.686
TRG_ER_diArg_1	158	160	PF00400	0.582
TRG_NES_CRM1_1	22	36	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX5	Leptomonas seymouri	86%	100%
A0A0S4J8L9	Bodo saltans	54%	100%
A0A1X0NRU5	Trypanosomatidae	66%	100%
A0A3Q8IGH3	Leishmania donovani	98%	100%
A0A422P2X7	Trypanosoma rangeli	64%	100%
A4HKX4	Leishmania braziliensis	90%	100%
A4I8F4	Leishmania infantum	98%	100%
D0AAR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B3B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BVM8	Trypanosoma cruzi	67%	100%