LeishMANIAdb
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Septum formation initiator

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Septum formation initiator
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q4T9_LEIMA
TriTrypDb:
LmjF.32.3330 , LMJLV39_320041500 , LMJSD75_320041500
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q4T9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4T9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 24 28 PF00656 0.683
CLV_NRD_NRD_1 21 23 PF00675 0.450
CLV_PCSK_KEX2_1 20 22 PF00082 0.445
CLV_PCSK_PC7_1 17 23 PF00082 0.483
DOC_USP7_MATH_1 102 106 PF00917 0.468
DOC_USP7_UBL2_3 68 72 PF12436 0.502
LIG_14-3-3_CanoR_1 86 91 PF00244 0.423
LIG_FHA_1 75 81 PF00498 0.523
LIG_FHA_2 74 80 PF00498 0.454
LIG_LIR_Gen_1 8 16 PF02991 0.577
LIG_LIR_Nem_3 8 12 PF02991 0.549
LIG_NRP_CendR_1 112 114 PF00754 0.737
LIG_Pex14_2 47 51 PF04695 0.335
LIG_WRC_WIRS_1 93 98 PF05994 0.447
MOD_CK2_1 73 79 PF00069 0.478
MOD_CK2_1 92 98 PF00069 0.483
MOD_GlcNHglycan 39 42 PF01048 0.344
MOD_NEK2_2 15 20 PF00069 0.634
MOD_PK_1 86 92 PF00069 0.410
MOD_Plk_1 15 21 PF00069 0.671
TRG_ER_diArg_1 111 114 PF00400 0.560
TRG_ER_diArg_1 19 22 PF00400 0.680
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ08 Leptomonas seymouri 79% 100%
A0A0S4J9Y1 Bodo saltans 46% 82%
A0A1X0NTB8 Trypanosomatidae 67% 96%
A0A3Q8IDF0 Leishmania donovani 97% 100%
A0A422P2W9 Trypanosoma rangeli 65% 97%
A4HKX8 Leishmania braziliensis 89% 100%
A4I8F8 Leishmania infantum 97% 100%
E9B3B6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BR10 Trypanosoma cruzi 65% 97%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS