Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4T8_LEIMA

TriTrypDb:

LmjF.32.3340 , LMJLV39_320041600 , LMJSD75_320041600

Length:

1112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1104	1108	PF00656	0.567
CLV_C14_Caspase3-7	317	321	PF00656	0.642
CLV_C14_Caspase3-7	448	452	PF00656	0.545
CLV_C14_Caspase3-7	464	468	PF00656	0.699
CLV_C14_Caspase3-7	545	549	PF00656	0.438
CLV_NRD_NRD_1	1087	1089	PF00675	0.658
CLV_NRD_NRD_1	1099	1101	PF00675	0.540
CLV_NRD_NRD_1	13	15	PF00675	0.524
CLV_NRD_NRD_1	374	376	PF00675	0.498
CLV_NRD_NRD_1	398	400	PF00675	0.637
CLV_NRD_NRD_1	429	431	PF00675	0.598
CLV_NRD_NRD_1	529	531	PF00675	0.566
CLV_NRD_NRD_1	686	688	PF00675	0.578
CLV_NRD_NRD_1	901	903	PF00675	0.636
CLV_NRD_NRD_1	990	992	PF00675	0.605
CLV_PCSK_KEX2_1	1087	1089	PF00082	0.708
CLV_PCSK_KEX2_1	1095	1097	PF00082	0.585
CLV_PCSK_KEX2_1	13	15	PF00082	0.411
CLV_PCSK_KEX2_1	374	376	PF00082	0.501
CLV_PCSK_KEX2_1	398	400	PF00082	0.637
CLV_PCSK_KEX2_1	429	431	PF00082	0.602
CLV_PCSK_KEX2_1	529	531	PF00082	0.566
CLV_PCSK_KEX2_1	610	612	PF00082	0.512
CLV_PCSK_KEX2_1	686	688	PF00082	0.578
CLV_PCSK_KEX2_1	901	903	PF00082	0.636
CLV_PCSK_KEX2_1	990	992	PF00082	0.621
CLV_PCSK_PC1ET2_1	1095	1097	PF00082	0.646
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.512
CLV_PCSK_SKI1_1	1049	1053	PF00082	0.589
CLV_PCSK_SKI1_1	1103	1107	PF00082	0.646
CLV_PCSK_SKI1_1	151	155	PF00082	0.602
CLV_PCSK_SKI1_1	254	258	PF00082	0.497
CLV_PCSK_SKI1_1	337	341	PF00082	0.684
CLV_PCSK_SKI1_1	375	379	PF00082	0.455
CLV_PCSK_SKI1_1	470	474	PF00082	0.517
CLV_PCSK_SKI1_1	505	509	PF00082	0.503
CLV_PCSK_SKI1_1	614	618	PF00082	0.454
CLV_PCSK_SKI1_1	957	961	PF00082	0.609
DEG_APCC_DBOX_1	1059	1067	PF00400	0.635
DEG_APCC_DBOX_1	504	512	PF00400	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.446
DEG_SCF_FBW7_1	573	580	PF00400	0.480
DEG_SPOP_SBC_1	312	316	PF00917	0.507
DEG_SPOP_SBC_1	709	713	PF00917	0.595
DEG_SPOP_SBC_1	862	866	PF00917	0.604
DOC_CKS1_1	574	579	PF01111	0.492
DOC_CYCLIN_RxL_1	28	36	PF00134	0.527
DOC_CYCLIN_RxL_1	385	396	PF00134	0.450
DOC_CYCLIN_RxL_1	820	834	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	870	873	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	948	954	PF00134	0.517
DOC_MAPK_gen_1	1103	1111	PF00069	0.620
DOC_MAPK_gen_1	29	37	PF00069	0.486
DOC_MAPK_gen_1	429	436	PF00069	0.575
DOC_MAPK_gen_1	822	830	PF00069	0.573
DOC_MAPK_MEF2A_6	1060	1068	PF00069	0.574
DOC_MAPK_MEF2A_6	29	37	PF00069	0.481
DOC_PP1_RVXF_1	670	677	PF00149	0.521
DOC_PP2B_LxvP_1	116	119	PF13499	0.558
DOC_PP2B_LxvP_1	511	514	PF13499	0.518
DOC_PP2B_LxvP_1	870	873	PF13499	0.645
DOC_PP2B_LxvP_1	948	951	PF13499	0.512
DOC_PP2B_PxIxI_1	566	572	PF00149	0.513
DOC_USP7_MATH_1	1090	1094	PF00917	0.720
DOC_USP7_MATH_1	119	123	PF00917	0.519
DOC_USP7_MATH_1	153	157	PF00917	0.536
DOC_USP7_MATH_1	160	164	PF00917	0.609
DOC_USP7_MATH_1	169	173	PF00917	0.575
DOC_USP7_MATH_1	174	178	PF00917	0.709
DOC_USP7_MATH_1	282	286	PF00917	0.423
DOC_USP7_MATH_1	312	316	PF00917	0.602
DOC_USP7_MATH_1	355	359	PF00917	0.568
DOC_USP7_MATH_1	51	55	PF00917	0.634
DOC_USP7_MATH_1	512	516	PF00917	0.620
DOC_USP7_MATH_1	65	69	PF00917	0.666
DOC_USP7_MATH_1	688	692	PF00917	0.638
DOC_USP7_MATH_1	709	713	PF00917	0.750
DOC_USP7_MATH_1	894	898	PF00917	0.764
DOC_WW_Pin1_4	1073	1078	PF00397	0.580
DOC_WW_Pin1_4	262	267	PF00397	0.518
DOC_WW_Pin1_4	290	295	PF00397	0.592
DOC_WW_Pin1_4	573	578	PF00397	0.480
DOC_WW_Pin1_4	77	82	PF00397	0.630
LIG_14-3-3_CanoR_1	1039	1045	PF00244	0.581
LIG_14-3-3_CanoR_1	1096	1100	PF00244	0.714
LIG_14-3-3_CanoR_1	254	260	PF00244	0.474
LIG_14-3-3_CanoR_1	302	311	PF00244	0.577
LIG_14-3-3_CanoR_1	337	342	PF00244	0.586
LIG_14-3-3_CanoR_1	34	38	PF00244	0.543
LIG_14-3-3_CanoR_1	374	382	PF00244	0.529
LIG_14-3-3_CanoR_1	578	584	PF00244	0.515
LIG_14-3-3_CanoR_1	614	623	PF00244	0.443
LIG_14-3-3_CanoR_1	747	753	PF00244	0.469
LIG_14-3-3_CanoR_1	793	799	PF00244	0.488
LIG_14-3-3_CanoR_1	824	829	PF00244	0.598
LIG_Actin_WH2_2	21	36	PF00022	0.431
LIG_Actin_WH2_2	382	400	PF00022	0.584
LIG_Actin_WH2_2	621	637	PF00022	0.463
LIG_Actin_WH2_2	727	745	PF00022	0.373
LIG_Actin_WH2_2	765	781	PF00022	0.442
LIG_BIR_III_4	360	364	PF00653	0.535
LIG_Clathr_ClatBox_1	194	198	PF01394	0.478
LIG_EH1_1	497	505	PF00400	0.409
LIG_FHA_1	1002	1008	PF00498	0.675
LIG_FHA_1	333	339	PF00498	0.672
LIG_FHA_1	414	420	PF00498	0.629
LIG_FHA_1	469	475	PF00498	0.792
LIG_FHA_1	480	486	PF00498	0.479
LIG_FHA_1	568	574	PF00498	0.537
LIG_FHA_1	583	589	PF00498	0.505
LIG_FHA_1	737	743	PF00498	0.389
LIG_FHA_1	747	753	PF00498	0.370
LIG_FHA_1	785	791	PF00498	0.495
LIG_FHA_1	825	831	PF00498	0.515
LIG_FHA_1	833	839	PF00498	0.564
LIG_FHA_1	969	975	PF00498	0.654
LIG_FHA_1	978	984	PF00498	0.496
LIG_FHA_2	1057	1063	PF00498	0.428
LIG_FHA_2	578	584	PF00498	0.598
LIG_FHA_2	613	619	PF00498	0.475
LIG_FHA_2	725	731	PF00498	0.365
LIG_FHA_2	795	801	PF00498	0.520
LIG_FHA_2	958	964	PF00498	0.644
LIG_FHA_2	971	977	PF00498	0.719
LIG_GBD_Chelix_1	192	200	PF00786	0.429
LIG_HP1_1	282	286	PF01393	0.417
LIG_LIR_Apic_2	156	160	PF02991	0.610
LIG_LIR_Apic_2	261	266	PF02991	0.522
LIG_LIR_Gen_1	519	528	PF02991	0.342
LIG_LIR_Gen_1	737	746	PF02991	0.518
LIG_LIR_Gen_1	774	781	PF02991	0.467
LIG_LIR_Gen_1	808	816	PF02991	0.538
LIG_LIR_Gen_1	915	926	PF02991	0.595
LIG_LIR_Gen_1	953	962	PF02991	0.475
LIG_LIR_Nem_3	243	248	PF02991	0.452
LIG_LIR_Nem_3	519	524	PF02991	0.404
LIG_LIR_Nem_3	737	741	PF02991	0.482
LIG_LIR_Nem_3	76	82	PF02991	0.721
LIG_LIR_Nem_3	774	778	PF02991	0.441
LIG_LIR_Nem_3	808	813	PF02991	0.517
LIG_LIR_Nem_3	915	921	PF02991	0.603
LIG_LIR_Nem_3	95	101	PF02991	0.289
LIG_LYPXL_yS_3	394	397	PF13949	0.545
LIG_NRBOX	385	391	PF00104	0.434
LIG_NRBOX	583	589	PF00104	0.440
LIG_NRBOX	730	736	PF00104	0.435
LIG_NRBOX	88	94	PF00104	0.378
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.398
LIG_Pex14_1	1031	1035	PF04695	0.718
LIG_Pex14_2	736	740	PF04695	0.421
LIG_Pex14_2	914	918	PF04695	0.588
LIG_PTAP_UEV_1	895	900	PF05743	0.581
LIG_SH2_CRK	1035	1039	PF00017	0.659
LIG_SH2_CRK	157	161	PF00017	0.621
LIG_SH2_CRK	521	525	PF00017	0.434
LIG_SH2_CRK	773	777	PF00017	0.362
LIG_SH2_SRC	221	224	PF00017	0.541
LIG_SH2_STAP1	506	510	PF00017	0.466
LIG_SH2_STAT3	662	665	PF00017	0.433
LIG_SH2_STAT5	1035	1038	PF00017	0.648
LIG_SH2_STAT5	157	160	PF00017	0.671
LIG_SH2_STAT5	221	224	PF00017	0.520
LIG_SH2_STAT5	263	266	PF00017	0.444
LIG_SH2_STAT5	521	524	PF00017	0.380
LIG_SH2_STAT5	646	649	PF00017	0.457
LIG_SH2_STAT5	662	665	PF00017	0.294
LIG_SH2_STAT5	82	85	PF00017	0.562
LIG_SH2_STAT5	935	938	PF00017	0.579
LIG_SH2_STAT5	98	101	PF00017	0.301
LIG_SH3_2	1034	1039	PF14604	0.601
LIG_SH3_2	896	901	PF14604	0.581
LIG_SH3_3	1031	1037	PF00018	0.655
LIG_SH3_3	472	478	PF00018	0.732
LIG_SH3_3	511	517	PF00018	0.560
LIG_SH3_3	866	872	PF00018	0.760
LIG_SH3_3	893	899	PF00018	0.682
LIG_SH3_3	905	911	PF00018	0.571
LIG_SH3_3	993	999	PF00018	0.691
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.564
LIG_SUMO_SIM_anti_2	827	835	PF11976	0.593
LIG_SUMO_SIM_par_1	192	198	PF11976	0.532
LIG_SUMO_SIM_par_1	949	956	PF11976	0.684
LIG_SUMO_SIM_par_1	998	1004	PF11976	0.529
LIG_TRAF2_1	40	43	PF00917	0.481
LIG_TRAF2_1	594	597	PF00917	0.524
LIG_TRAF2_1	617	620	PF00917	0.526
LIG_TYR_ITIM	392	397	PF00017	0.534
LIG_TYR_ITIM	96	101	PF00017	0.397
LIG_TYR_ITSM	517	524	PF00017	0.432
LIG_UBA3_1	587	595	PF00899	0.403
LIG_UBA3_1	752	757	PF00899	0.500
LIG_WRC_WIRS_1	222	227	PF05994	0.433
LIG_WRC_WIRS_1	735	740	PF05994	0.397
LIG_WRC_WIRS_1	772	777	PF05994	0.435
LIG_WW_3	1036	1040	PF00397	0.574
MOD_CDK_SPK_2	573	578	PF00069	0.480
MOD_CK1_1	1013	1019	PF00069	0.646
MOD_CK1_1	117	123	PF00069	0.540
MOD_CK1_1	177	183	PF00069	0.761
MOD_CK1_1	258	264	PF00069	0.546
MOD_CK1_1	314	320	PF00069	0.638
MOD_CK1_1	330	336	PF00069	0.607
MOD_CK1_1	63	69	PF00069	0.690
MOD_CK1_1	691	697	PF00069	0.648
MOD_CK1_1	708	714	PF00069	0.774
MOD_CK1_1	80	86	PF00069	0.577
MOD_CK1_1	808	814	PF00069	0.465
MOD_CK1_1	851	857	PF00069	0.485
MOD_CK1_1	968	974	PF00069	0.682
MOD_CK2_1	37	43	PF00069	0.587
MOD_CK2_1	51	57	PF00069	0.469
MOD_CK2_1	532	538	PF00069	0.619
MOD_CK2_1	577	583	PF00069	0.608
MOD_CK2_1	612	618	PF00069	0.471
MOD_CK2_1	794	800	PF00069	0.526
MOD_CK2_1	961	967	PF00069	0.634
MOD_CK2_1	970	976	PF00069	0.665
MOD_Cter_Amidation	1085	1088	PF01082	0.748
MOD_GlcNHglycan	1015	1018	PF01048	0.640
MOD_GlcNHglycan	103	106	PF01048	0.486
MOD_GlcNHglycan	1053	1056	PF01048	0.720
MOD_GlcNHglycan	1088	1091	PF01048	0.694
MOD_GlcNHglycan	1092	1095	PF01048	0.626
MOD_GlcNHglycan	116	119	PF01048	0.498
MOD_GlcNHglycan	162	165	PF01048	0.637
MOD_GlcNHglycan	172	175	PF01048	0.733
MOD_GlcNHglycan	304	307	PF01048	0.489
MOD_GlcNHglycan	316	319	PF01048	0.542
MOD_GlcNHglycan	329	332	PF01048	0.628
MOD_GlcNHglycan	357	360	PF01048	0.584
MOD_GlcNHglycan	411	414	PF01048	0.748
MOD_GlcNHglycan	53	56	PF01048	0.640
MOD_GlcNHglycan	630	633	PF01048	0.578
MOD_GlcNHglycan	65	68	PF01048	0.688
MOD_GlcNHglycan	690	693	PF01048	0.606
MOD_GlcNHglycan	707	710	PF01048	0.764
MOD_GlcNHglycan	761	764	PF01048	0.416
MOD_GlcNHglycan	853	856	PF01048	0.532
MOD_GlcNHglycan	86	89	PF01048	0.480
MOD_GlcNHglycan	896	899	PF01048	0.647
MOD_GlcNHglycan	941	944	PF01048	0.551
MOD_GSK3_1	1086	1093	PF00069	0.669
MOD_GSK3_1	149	156	PF00069	0.568
MOD_GSK3_1	170	177	PF00069	0.746
MOD_GSK3_1	254	261	PF00069	0.461
MOD_GSK3_1	323	330	PF00069	0.659
MOD_GSK3_1	33	40	PF00069	0.423
MOD_GSK3_1	337	344	PF00069	0.625
MOD_GSK3_1	351	358	PF00069	0.419
MOD_GSK3_1	407	414	PF00069	0.699
MOD_GSK3_1	458	465	PF00069	0.629
MOD_GSK3_1	512	519	PF00069	0.485
MOD_GSK3_1	528	535	PF00069	0.470
MOD_GSK3_1	573	580	PF00069	0.599
MOD_GSK3_1	705	712	PF00069	0.688
MOD_GSK3_1	73	80	PF00069	0.698
MOD_GSK3_1	742	749	PF00069	0.471
MOD_GSK3_1	805	812	PF00069	0.378
MOD_GSK3_1	939	946	PF00069	0.565
MOD_GSK3_1	957	964	PF00069	0.580
MOD_N-GLC_1	290	295	PF02516	0.573
MOD_N-GLC_2	847	849	PF02516	0.531
MOD_NEK2_1	101	106	PF00069	0.518
MOD_NEK2_1	1040	1045	PF00069	0.522
MOD_NEK2_1	1051	1056	PF00069	0.503
MOD_NEK2_1	126	131	PF00069	0.439
MOD_NEK2_1	149	154	PF00069	0.541
MOD_NEK2_1	185	190	PF00069	0.557
MOD_NEK2_1	24	29	PF00069	0.497
MOD_NEK2_1	313	318	PF00069	0.615
MOD_NEK2_1	327	332	PF00069	0.688
MOD_NEK2_1	33	38	PF00069	0.495
MOD_NEK2_1	582	587	PF00069	0.498
MOD_NEK2_1	628	633	PF00069	0.421
MOD_NEK2_1	634	639	PF00069	0.414
MOD_NEK2_1	734	739	PF00069	0.452
MOD_NEK2_1	742	747	PF00069	0.487
MOD_NEK2_1	758	763	PF00069	0.321
MOD_NEK2_1	809	814	PF00069	0.575
MOD_NEK2_1	830	835	PF00069	0.621
MOD_NEK2_1	92	97	PF00069	0.562
MOD_NEK2_1	977	982	PF00069	0.512
MOD_PIKK_1	185	191	PF00454	0.605
MOD_PIKK_1	255	261	PF00454	0.511
MOD_PIKK_1	437	443	PF00454	0.588
MOD_PIKK_1	512	518	PF00454	0.489
MOD_PIKK_1	577	583	PF00454	0.548
MOD_PIKK_1	605	611	PF00454	0.466
MOD_PIKK_1	634	640	PF00454	0.521
MOD_PIKK_1	675	681	PF00454	0.513
MOD_PIKK_1	711	717	PF00454	0.712
MOD_PIKK_1	746	752	PF00454	0.514
MOD_PK_1	1101	1107	PF00069	0.575
MOD_PKA_1	1095	1101	PF00069	0.650
MOD_PKA_2	1013	1019	PF00069	0.665
MOD_PKA_2	1086	1092	PF00069	0.664
MOD_PKA_2	1095	1101	PF00069	0.618
MOD_PKA_2	33	39	PF00069	0.546
MOD_PKA_2	528	534	PF00069	0.586
MOD_PKA_2	577	583	PF00069	0.524
MOD_PKA_2	634	640	PF00069	0.508
MOD_PKA_2	742	748	PF00069	0.538
MOD_Plk_1	300	306	PF00069	0.524
MOD_Plk_1	490	496	PF00069	0.608
MOD_Plk_1	582	588	PF00069	0.496
MOD_Plk_1	766	772	PF00069	0.319
MOD_Plk_4	282	288	PF00069	0.428
MOD_Plk_4	516	522	PF00069	0.509
MOD_Plk_4	771	777	PF00069	0.418
MOD_Plk_4	805	811	PF00069	0.442
MOD_ProDKin_1	1073	1079	PF00069	0.583
MOD_ProDKin_1	262	268	PF00069	0.511
MOD_ProDKin_1	290	296	PF00069	0.598
MOD_ProDKin_1	573	579	PF00069	0.483
MOD_ProDKin_1	77	83	PF00069	0.618
MOD_SUMO_for_1	594	597	PF00179	0.482
MOD_SUMO_rev_2	1076	1085	PF00179	0.746
TRG_DiLeu_BaEn_1	109	114	PF01217	0.524
TRG_DiLeu_BaEn_1	583	588	PF01217	0.441
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.467
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.657
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.433
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.520
TRG_DiLeu_BaLyEn_6	921	926	PF01217	0.587
TRG_ENDOCYTIC_2	245	248	PF00928	0.424
TRG_ENDOCYTIC_2	276	279	PF00928	0.537
TRG_ENDOCYTIC_2	394	397	PF00928	0.545
TRG_ENDOCYTIC_2	521	524	PF00928	0.469
TRG_ENDOCYTIC_2	773	776	PF00928	0.352
TRG_ENDOCYTIC_2	935	938	PF00928	0.579
TRG_ENDOCYTIC_2	98	101	PF00928	0.404
TRG_ER_diArg_1	12	14	PF00400	0.521
TRG_ER_diArg_1	374	376	PF00400	0.484
TRG_ER_diArg_1	397	399	PF00400	0.625
TRG_ER_diArg_1	528	530	PF00400	0.549
TRG_ER_diArg_1	685	687	PF00400	0.561
TRG_ER_diArg_1	823	826	PF00400	0.598
TRG_ER_diArg_1	989	991	PF00400	0.631
TRG_NES_CRM1_1	26	38	PF08389	0.454
TRG_NES_CRM1_1	661	675	PF08389	0.452
TRG_NLS_Bipartite_1	1087	1104	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB94	Leptomonas seymouri	57%	100%
A0A0S4JFQ5	Bodo saltans	24%	100%
A0A1X0NTJ4	Trypanosomatidae	32%	100%
A0A3S7X650	Leishmania donovani	94%	100%
A4HKX9	Leishmania braziliensis	82%	100%
A4I8F9	Leishmania infantum	95%	100%
D0AAR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B3B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B5Q4	Trypanosoma cruzi	32%	100%