Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania major

UniProt:

Q4Q4T6_LEIMA

TriTrypDb:

LmjF.32.3360 , LMJLV39_320041800 , LMJSD75_320041800

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4T6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	2
GO:0016042	lipid catabolic process	4	2
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	468	472	PF00656	0.435
CLV_NRD_NRD_1	124	126	PF00675	0.474
CLV_NRD_NRD_1	204	206	PF00675	0.623
CLV_NRD_NRD_1	219	221	PF00675	0.416
CLV_NRD_NRD_1	374	376	PF00675	0.667
CLV_NRD_NRD_1	430	432	PF00675	0.482
CLV_NRD_NRD_1	526	528	PF00675	0.521
CLV_NRD_NRD_1	567	569	PF00675	0.561
CLV_NRD_NRD_1	92	94	PF00675	0.573
CLV_PCSK_KEX2_1	124	126	PF00082	0.476
CLV_PCSK_KEX2_1	204	206	PF00082	0.623
CLV_PCSK_KEX2_1	219	221	PF00082	0.416
CLV_PCSK_KEX2_1	374	376	PF00082	0.667
CLV_PCSK_KEX2_1	430	432	PF00082	0.496
CLV_PCSK_KEX2_1	525	527	PF00082	0.566
CLV_PCSK_KEX2_1	567	569	PF00082	0.561
CLV_PCSK_KEX2_1	77	79	PF00082	0.488
CLV_PCSK_KEX2_1	94	96	PF00082	0.532
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.609
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.489
CLV_PCSK_PC7_1	120	126	PF00082	0.468
CLV_PCSK_SKI1_1	219	223	PF00082	0.424
CLV_PCSK_SKI1_1	257	261	PF00082	0.412
CLV_PCSK_SKI1_1	363	367	PF00082	0.474
CLV_PCSK_SKI1_1	374	378	PF00082	0.511
CLV_PCSK_SKI1_1	416	420	PF00082	0.441
CLV_PCSK_SKI1_1	430	434	PF00082	0.481
CLV_PCSK_SKI1_1	527	531	PF00082	0.494
CLV_Separin_Metazoa	564	568	PF03568	0.418
DEG_APCC_DBOX_1	462	470	PF00400	0.520
DEG_APCC_DBOX_1	525	533	PF00400	0.519
DEG_SPOP_SBC_1	3	7	PF00917	0.676
DOC_CDC14_PxL_1	551	559	PF14671	0.459
DOC_CYCLIN_yCln2_LP_2	530	536	PF00134	0.413
DOC_MAPK_gen_1	525	534	PF00069	0.519
DOC_MAPK_MEF2A_6	303	312	PF00069	0.368
DOC_MAPK_MEF2A_6	506	513	PF00069	0.465
DOC_MAPK_MEF2A_6	525	534	PF00069	0.468
DOC_PP1_RVXF_1	448	455	PF00149	0.456
DOC_PP2B_LxvP_1	511	514	PF13499	0.348
DOC_PP2B_LxvP_1	530	533	PF13499	0.391
DOC_PP4_FxxP_1	67	70	PF00568	0.641
DOC_USP7_MATH_1	105	109	PF00917	0.420
DOC_USP7_MATH_1	27	31	PF00917	0.653
DOC_USP7_MATH_1	3	7	PF00917	0.778
DOC_USP7_MATH_1	365	369	PF00917	0.571
DOC_USP7_MATH_1	395	399	PF00917	0.734
DOC_USP7_MATH_1	501	505	PF00917	0.702
DOC_WW_Pin1_4	132	137	PF00397	0.618
DOC_WW_Pin1_4	139	144	PF00397	0.620
DOC_WW_Pin1_4	23	28	PF00397	0.789
DOC_WW_Pin1_4	264	269	PF00397	0.353
DOC_WW_Pin1_4	430	435	PF00397	0.314
DOC_WW_Pin1_4	580	585	PF00397	0.643
LIG_14-3-3_CanoR_1	112	116	PF00244	0.490
LIG_14-3-3_CanoR_1	237	241	PF00244	0.375
LIG_14-3-3_CanoR_1	257	263	PF00244	0.326
LIG_14-3-3_CanoR_1	303	312	PF00244	0.377
LIG_14-3-3_CanoR_1	328	337	PF00244	0.451
LIG_14-3-3_CanoR_1	374	380	PF00244	0.688
LIG_14-3-3_CanoR_1	69	79	PF00244	0.555
LIG_Actin_WH2_2	227	243	PF00022	0.502
LIG_ActinCP_TwfCPI_2	67	77	PF01115	0.546
LIG_AP2alpha_2	60	62	PF02296	0.641
LIG_BIR_III_4	138	142	PF00653	0.511
LIG_FHA_1	112	118	PF00498	0.579
LIG_FHA_1	17	23	PF00498	0.691
LIG_FHA_1	253	259	PF00498	0.370
LIG_FHA_1	319	325	PF00498	0.329
LIG_FHA_1	334	340	PF00498	0.433
LIG_FHA_1	368	374	PF00498	0.596
LIG_FHA_1	413	419	PF00498	0.480
LIG_FHA_1	431	437	PF00498	0.300
LIG_FHA_1	74	80	PF00498	0.638
LIG_FHA_2	133	139	PF00498	0.609
LIG_FHA_2	265	271	PF00498	0.409
LIG_FHA_2	294	300	PF00498	0.461
LIG_FHA_2	44	50	PF00498	0.702
LIG_LIR_Apic_2	65	70	PF02991	0.634
LIG_LIR_Gen_1	245	254	PF02991	0.384
LIG_LIR_Gen_1	276	287	PF02991	0.375
LIG_LIR_Gen_1	352	361	PF02991	0.446
LIG_LIR_Gen_1	71	80	PF02991	0.499
LIG_LIR_Nem_3	245	250	PF02991	0.495
LIG_LIR_Nem_3	276	282	PF02991	0.375
LIG_LIR_Nem_3	332	337	PF02991	0.384
LIG_LIR_Nem_3	352	357	PF02991	0.418
LIG_LIR_Nem_3	71	75	PF02991	0.563
LIG_LYPXL_yS_3	554	557	PF13949	0.459
LIG_NRBOX	352	358	PF00104	0.358
LIG_NRBOX	561	567	PF00104	0.468
LIG_PCNA_yPIPBox_3	350	363	PF02747	0.443
LIG_PTAP_UEV_1	385	390	PF05743	0.591
LIG_SH2_CRK	180	184	PF00017	0.347
LIG_SH2_CRK	279	283	PF00017	0.299
LIG_SH2_CRK	477	481	PF00017	0.592
LIG_SH2_GRB2like	208	211	PF00017	0.356
LIG_SH2_GRB2like	279	282	PF00017	0.358
LIG_SH2_NCK_1	175	179	PF00017	0.331
LIG_SH2_NCK_1	477	481	PF00017	0.592
LIG_SH2_SRC	206	209	PF00017	0.350
LIG_SH2_SRC	279	282	PF00017	0.412
LIG_SH2_STAP1	100	104	PF00017	0.456
LIG_SH2_STAP1	175	179	PF00017	0.373
LIG_SH2_STAP1	238	242	PF00017	0.376
LIG_SH2_STAP1	279	283	PF00017	0.412
LIG_SH2_STAP1	313	317	PF00017	0.323
LIG_SH2_STAT3	100	103	PF00017	0.533
LIG_SH2_STAT5	171	174	PF00017	0.419
LIG_SH2_STAT5	188	191	PF00017	0.261
LIG_SH2_STAT5	206	209	PF00017	0.442
LIG_SH2_STAT5	358	361	PF00017	0.478
LIG_SH2_STAT5	37	40	PF00017	0.716
LIG_SH2_STAT5	558	561	PF00017	0.422
LIG_SH3_3	383	389	PF00018	0.593
LIG_SH3_3	541	547	PF00018	0.434
LIG_SUMO_SIM_anti_2	541	548	PF11976	0.483
LIG_SUMO_SIM_par_1	541	548	PF11976	0.497
LIG_TRAF2_1	480	483	PF00917	0.601
LIG_WRC_WIRS_1	259	264	PF05994	0.358
MOD_CK1_1	108	114	PF00069	0.392
MOD_CK1_1	144	150	PF00069	0.759
MOD_CK1_1	236	242	PF00069	0.481
MOD_CK1_1	26	32	PF00069	0.771
MOD_CK1_1	332	338	PF00069	0.433
MOD_CK1_1	368	374	PF00069	0.590
MOD_CK1_1	384	390	PF00069	0.440
MOD_CK1_1	398	404	PF00069	0.514
MOD_CK1_1	484	490	PF00069	0.608
MOD_CK1_1	504	510	PF00069	0.583
MOD_CK1_1	73	79	PF00069	0.493
MOD_CK2_1	188	194	PF00069	0.498
MOD_CK2_1	27	33	PF00069	0.705
MOD_CK2_1	293	299	PF00069	0.488
MOD_CK2_1	3	9	PF00069	0.746
MOD_CK2_1	312	318	PF00069	0.386
MOD_CK2_1	43	49	PF00069	0.679
MOD_CK2_1	558	564	PF00069	0.455
MOD_GlcNHglycan	28	32	PF01048	0.674
MOD_GlcNHglycan	386	389	PF01048	0.722
MOD_GlcNHglycan	392	395	PF01048	0.754
MOD_GlcNHglycan	397	400	PF01048	0.775
MOD_GlcNHglycan	521	524	PF01048	0.537
MOD_GlcNHglycan	6	9	PF01048	0.792
MOD_GlcNHglycan	72	75	PF01048	0.539
MOD_GSK3_1	137	144	PF00069	0.639
MOD_GSK3_1	147	154	PF00069	0.705
MOD_GSK3_1	23	30	PF00069	0.728
MOD_GSK3_1	258	265	PF00069	0.329
MOD_GSK3_1	329	336	PF00069	0.380
MOD_GSK3_1	377	384	PF00069	0.710
MOD_GSK3_1	398	405	PF00069	0.788
MOD_GSK3_1	412	419	PF00069	0.449
MOD_GSK3_1	578	585	PF00069	0.594
MOD_N-GLC_1	504	509	PF02516	0.557
MOD_N-GLC_1	518	523	PF02516	0.435
MOD_NEK2_1	1	6	PF00069	0.764
MOD_NEK2_1	131	136	PF00069	0.505
MOD_NEK2_1	262	267	PF00069	0.302
MOD_NEK2_1	312	317	PF00069	0.410
MOD_NEK2_1	326	331	PF00069	0.478
MOD_NEK2_1	339	344	PF00069	0.384
MOD_NEK2_1	366	371	PF00069	0.592
MOD_NEK2_1	414	419	PF00069	0.459
MOD_NEK2_1	534	539	PF00069	0.552
MOD_NEK2_1	601	606	PF00069	0.667
MOD_NEK2_2	188	193	PF00069	0.485
MOD_PIKK_1	144	150	PF00454	0.713
MOD_PIKK_1	298	304	PF00454	0.422
MOD_PIKK_1	318	324	PF00454	0.368
MOD_PIKK_1	329	335	PF00454	0.401
MOD_PK_1	572	578	PF00069	0.460
MOD_PKA_2	111	117	PF00069	0.462
MOD_PKA_2	236	242	PF00069	0.376
MOD_PKA_2	262	268	PF00069	0.303
MOD_PKA_2	478	484	PF00069	0.656
MOD_PKA_2	601	607	PF00069	0.786
MOD_PKA_2	68	74	PF00069	0.683
MOD_PKB_1	93	101	PF00069	0.542
MOD_Plk_1	481	487	PF00069	0.618
MOD_Plk_1	504	510	PF00069	0.532
MOD_Plk_1	95	101	PF00069	0.536
MOD_Plk_4	312	318	PF00069	0.375
MOD_Plk_4	349	355	PF00069	0.393
MOD_Plk_4	368	374	PF00069	0.643
MOD_Plk_4	513	519	PF00069	0.422
MOD_Plk_4	553	559	PF00069	0.413
MOD_ProDKin_1	132	138	PF00069	0.624
MOD_ProDKin_1	139	145	PF00069	0.618
MOD_ProDKin_1	23	29	PF00069	0.786
MOD_ProDKin_1	264	270	PF00069	0.353
MOD_ProDKin_1	430	436	PF00069	0.309
MOD_ProDKin_1	580	586	PF00069	0.647
TRG_DiLeu_BaEn_1	194	199	PF01217	0.505
TRG_DiLeu_BaEn_1	226	231	PF01217	0.546
TRG_DiLeu_BaEn_1	541	546	PF01217	0.471
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.353
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.558
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.478
TRG_ENDOCYTIC_2	279	282	PF00928	0.299
TRG_ENDOCYTIC_2	313	316	PF00928	0.321
TRG_ENDOCYTIC_2	554	557	PF00928	0.532
TRG_ER_diArg_1	124	127	PF00400	0.490
TRG_ER_diArg_1	204	206	PF00400	0.573
TRG_ER_diArg_1	218	220	PF00400	0.403
TRG_ER_diArg_1	373	375	PF00400	0.665
TRG_ER_diArg_1	430	432	PF00400	0.482
TRG_ER_diArg_1	525	527	PF00400	0.569
TRG_ER_diArg_1	566	568	PF00400	0.485
TRG_ER_diArg_1	92	95	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	560	564	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U7	Leptomonas seymouri	61%	74%
A0A1X0NRV4	Trypanosomatidae	31%	100%
A0A3R7RSN6	Trypanosoma rangeli	30%	100%
A0A3S7X618	Leishmania donovani	93%	75%
A4HKY1	Leishmania braziliensis	82%	82%
A4I8G1	Leishmania infantum	93%	75%
E9B3B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	75%
V5BQX7	Trypanosoma cruzi	30%	100%