AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4T2_LEIMA

TriTrypDb:

LmjF.32.3400 , LMJLV39_320042200 , LMJSD75_320042200

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q4T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.390
CLV_PCSK_SKI1_1	104	108	PF00082	0.601
CLV_PCSK_SKI1_1	267	271	PF00082	0.605
CLV_PCSK_SKI1_1	303	307	PF00082	0.479
CLV_PCSK_SKI1_1	403	407	PF00082	0.549
CLV_PCSK_SKI1_1	86	90	PF00082	0.593
DEG_APCC_DBOX_1	302	310	PF00400	0.313
DEG_SPOP_SBC_1	154	158	PF00917	0.335
DOC_ANK_TNKS_1	180	187	PF00023	0.358
DOC_CDC14_PxL_1	312	320	PF14671	0.371
DOC_CDC14_PxL_1	325	333	PF14671	0.328
DOC_CKS1_1	480	485	PF01111	0.384
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.361
DOC_MAPK_DCC_7	8	18	PF00069	0.455
DOC_MAPK_gen_1	301	310	PF00069	0.292
DOC_MAPK_gen_1	68	74	PF00069	0.369
DOC_MAPK_MEF2A_6	108	115	PF00069	0.384
DOC_MAPK_MEF2A_6	301	310	PF00069	0.363
DOC_MAPK_MEF2A_6	560	567	PF00069	0.349
DOC_MAPK_MEF2A_6	86	93	PF00069	0.382
DOC_MAPK_NFAT4_5	303	311	PF00069	0.352
DOC_MAPK_NFAT4_5	560	568	PF00069	0.379
DOC_PP1_RVXF_1	283	289	PF00149	0.356
DOC_PP1_RVXF_1	509	515	PF00149	0.341
DOC_PP1_RVXF_1	69	75	PF00149	0.363
DOC_PP4_FxxP_1	531	534	PF00568	0.398
DOC_USP7_MATH_1	118	122	PF00917	0.346
DOC_USP7_MATH_1	131	135	PF00917	0.395
DOC_USP7_MATH_1	153	157	PF00917	0.399
DOC_USP7_MATH_1	261	265	PF00917	0.322
DOC_USP7_MATH_1	407	411	PF00917	0.408
DOC_USP7_MATH_1	41	45	PF00917	0.436
DOC_USP7_MATH_2	52	58	PF00917	0.352
DOC_WW_Pin1_4	121	126	PF00397	0.332
DOC_WW_Pin1_4	479	484	PF00397	0.411
DOC_WW_Pin1_4	48	53	PF00397	0.404
DOC_WW_Pin1_4	583	588	PF00397	0.525
LIG_14-3-3_CanoR_1	267	272	PF00244	0.366
LIG_14-3-3_CanoR_1	403	412	PF00244	0.381
LIG_14-3-3_CanoR_1	417	427	PF00244	0.413
LIG_14-3-3_CanoR_1	47	52	PF00244	0.402
LIG_14-3-3_CanoR_1	476	481	PF00244	0.285
LIG_14-3-3_CanoR_1	560	566	PF00244	0.217
LIG_14-3-3_CanoR_1	592	598	PF00244	0.665
LIG_14-3-3_CanoR_1	71	77	PF00244	0.356
LIG_Actin_WH2_2	458	473	PF00022	0.424
LIG_APCC_ABBA_1	489	494	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BRCT_BRCA1_1	593	597	PF00533	0.622
LIG_deltaCOP1_diTrp_1	527	531	PF00928	0.344
LIG_EH1_1	73	81	PF00400	0.384
LIG_FHA_1	17	23	PF00498	0.378
LIG_FHA_1	430	436	PF00498	0.351
LIG_FHA_1	440	446	PF00498	0.321
LIG_FHA_1	480	486	PF00498	0.385
LIG_FHA_1	503	509	PF00498	0.413
LIG_FHA_1	56	62	PF00498	0.418
LIG_FHA_1	562	568	PF00498	0.289
LIG_FHA_2	180	186	PF00498	0.375
LIG_FHA_2	358	364	PF00498	0.261
LIG_IBAR_NPY_1	135	137	PF08397	0.330
LIG_LIR_Apic_2	219	223	PF02991	0.331
LIG_LIR_Apic_2	530	534	PF02991	0.371
LIG_LIR_Gen_1	227	237	PF02991	0.315
LIG_LIR_Gen_1	262	272	PF02991	0.281
LIG_LIR_Gen_1	90	100	PF02991	0.387
LIG_LIR_Nem_3	227	232	PF02991	0.279
LIG_LIR_Nem_3	262	268	PF02991	0.281
LIG_LIR_Nem_3	595	601	PF02991	0.610
LIG_LYPXL_S_1	314	318	PF13949	0.534
LIG_LYPXL_yS_3	315	318	PF13949	0.361
LIG_NRBOX	240	246	PF00104	0.316
LIG_PCNA_PIPBox_1	225	234	PF02747	0.303
LIG_PCNA_yPIPBox_3	321	334	PF02747	0.334
LIG_Pex14_2	553	557	PF04695	0.466
LIG_Pex14_3	372	377	PF04695	0.295
LIG_Rb_pABgroove_1	344	352	PF01858	0.292
LIG_RPA_C_Fungi	491	503	PF08784	0.305
LIG_SH2_CRK	350	354	PF00017	0.338
LIG_SH2_CRK	590	594	PF00017	0.542
LIG_SH2_GRB2like	598	601	PF00017	0.511
LIG_SH2_NCK_1	359	363	PF00017	0.464
LIG_SH2_NCK_1	590	594	PF00017	0.595
LIG_SH2_PTP2	220	223	PF00017	0.432
LIG_SH2_SRC	220	223	PF00017	0.450
LIG_SH2_STAT3	137	140	PF00017	0.472
LIG_SH2_STAT3	333	336	PF00017	0.316
LIG_SH2_STAT5	220	223	PF00017	0.328
LIG_SH2_STAT5	231	234	PF00017	0.321
LIG_SH2_STAT5	352	355	PF00017	0.394
LIG_SH2_STAT5	359	362	PF00017	0.419
LIG_SH2_STAT5	576	579	PF00017	0.323
LIG_SH3_3	310	316	PF00018	0.395
LIG_SH3_3	394	400	PF00018	0.426
LIG_SH3_3	477	483	PF00018	0.526
LIG_SUMO_SIM_anti_2	564	569	PF11976	0.273
LIG_SUMO_SIM_par_1	14	19	PF11976	0.429
LIG_SUMO_SIM_par_1	214	219	PF11976	0.404
LIG_UBA3_1	268	276	PF00899	0.465
LIG_WRC_WIRS_1	385	390	PF05994	0.477
MOD_CK1_1	121	127	PF00069	0.511
MOD_CK1_1	156	162	PF00069	0.525
MOD_CK1_1	165	171	PF00069	0.421
MOD_CK1_1	236	242	PF00069	0.535
MOD_CK1_1	281	287	PF00069	0.475
MOD_CK1_1	387	393	PF00069	0.491
MOD_CK1_1	421	427	PF00069	0.588
MOD_CK1_1	536	542	PF00069	0.771
MOD_CK1_1	591	597	PF00069	0.592
MOD_CK2_1	357	363	PF00069	0.328
MOD_CK2_1	48	54	PF00069	0.482
MOD_GlcNHglycan	167	170	PF01048	0.454
MOD_GlcNHglycan	27	30	PF01048	0.661
MOD_GlcNHglycan	353	356	PF01048	0.512
MOD_GlcNHglycan	409	412	PF01048	0.438
MOD_GlcNHglycan	420	423	PF01048	0.578
MOD_GlcNHglycan	82	86	PF01048	0.574
MOD_GSK3_1	126	133	PF00069	0.479
MOD_GSK3_1	154	161	PF00069	0.433
MOD_GSK3_1	25	32	PF00069	0.587
MOD_GSK3_1	357	364	PF00069	0.474
MOD_GSK3_1	403	410	PF00069	0.393
MOD_GSK3_1	41	48	PF00069	0.339
MOD_GSK3_1	475	482	PF00069	0.506
MOD_N-GLC_1	131	136	PF02516	0.494
MOD_N-GLC_1	162	167	PF02516	0.490
MOD_N-GLC_1	429	434	PF02516	0.489
MOD_NEK2_1	16	21	PF00069	0.338
MOD_NEK2_1	162	167	PF00069	0.436
MOD_NEK2_1	317	322	PF00069	0.464
MOD_NEK2_1	4	9	PF00069	0.563
MOD_NEK2_1	429	434	PF00069	0.360
MOD_NEK2_1	461	466	PF00069	0.439
MOD_NEK2_1	577	582	PF00069	0.415
MOD_NEK2_1	588	593	PF00069	0.690
MOD_PIKK_1	429	435	PF00454	0.467
MOD_PIKK_1	449	455	PF00454	0.269
MOD_PKA_2	118	124	PF00069	0.379
MOD_PKA_2	416	422	PF00069	0.557
MOD_PKA_2	475	481	PF00069	0.419
MOD_PKA_2	591	597	PF00069	0.578
MOD_PKA_2	70	76	PF00069	0.443
MOD_Plk_1	162	168	PF00069	0.415
MOD_Plk_4	123	129	PF00069	0.504
MOD_Plk_4	16	22	PF00069	0.375
MOD_Plk_4	195	201	PF00069	0.346
MOD_Plk_4	267	273	PF00069	0.438
MOD_Plk_4	327	333	PF00069	0.329
MOD_Plk_4	476	482	PF00069	0.332
MOD_Plk_4	87	93	PF00069	0.375
MOD_ProDKin_1	121	127	PF00069	0.408
MOD_ProDKin_1	479	485	PF00069	0.509
MOD_ProDKin_1	48	54	PF00069	0.501
MOD_ProDKin_1	583	589	PF00069	0.403
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.298
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.392
TRG_ENDOCYTIC_2	229	232	PF00928	0.342
TRG_ENDOCYTIC_2	315	318	PF00928	0.393
TRG_ENDOCYTIC_2	350	353	PF00928	0.327
TRG_ENDOCYTIC_2	576	579	PF00928	0.377
TRG_ENDOCYTIC_2	590	593	PF00928	0.479
TRG_ENDOCYTIC_2	598	601	PF00928	0.470
TRG_ER_diArg_1	116	119	PF00400	0.461
TRG_ER_diArg_1	5	8	PF00400	0.614
TRG_ER_FFAT_2	121	133	PF00635	0.479
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I361	Leptomonas seymouri	51%	100%
A0A0S4JGY4	Bodo saltans	25%	98%
A0A1X0NRX3	Trypanosomatidae	31%	100%
A0A3Q8IFS8	Leishmania donovani	91%	100%
A0A422P343	Trypanosoma rangeli	35%	100%
A4HKY5	Leishmania braziliensis	75%	100%
A4I8G4	Leishmania infantum	91%	100%
E9B3C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DMC3	Trypanosoma cruzi	30%	100%