Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4T0_LEIMA

TriTrypDb:

LmjF.32.3420 , LMJLV39_320042400 , LMJSD75_320042400

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q4T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.498
CLV_NRD_NRD_1	378	380	PF00675	0.462
CLV_NRD_NRD_1	390	392	PF00675	0.395
CLV_NRD_NRD_1	89	91	PF00675	0.469
CLV_PCSK_FUR_1	376	380	PF00082	0.381
CLV_PCSK_KEX2_1	378	380	PF00082	0.462
CLV_PCSK_KEX2_1	389	391	PF00082	0.410
CLV_PCSK_KEX2_1	88	90	PF00082	0.488
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.361
CLV_PCSK_SKI1_1	384	388	PF00082	0.452
DEG_APCC_DBOX_1	87	95	PF00400	0.547
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DOC_CYCLIN_yCln2_LP_2	271	277	PF00134	0.350
DOC_MAPK_FxFP_2	392	395	PF00069	0.647
DOC_MAPK_gen_1	376	385	PF00069	0.685
DOC_MAPK_MEF2A_6	281	288	PF00069	0.263
DOC_MAPK_MEF2A_6	376	385	PF00069	0.605
DOC_PP1_RVXF_1	335	341	PF00149	0.452
DOC_PP4_FxxP_1	392	395	PF00568	0.647
DOC_USP7_MATH_1	313	317	PF00917	0.505
LIG_14-3-3_CanoR_1	213	220	PF00244	0.543
LIG_14-3-3_CanoR_1	390	395	PF00244	0.645
LIG_Actin_WH2_2	321	339	PF00022	0.338
LIG_BIR_III_4	149	153	PF00653	0.307
LIG_BRCT_BRCA1_1	20	24	PF00533	0.276
LIG_BRCT_BRCA1_1	214	218	PF00533	0.509
LIG_BRCT_BRCA1_1	46	50	PF00533	0.270
LIG_BRCT_BRCA1_1	97	101	PF00533	0.311
LIG_eIF4E_1	12	18	PF01652	0.338
LIG_FHA_1	116	122	PF00498	0.338
LIG_FHA_1	153	159	PF00498	0.307
LIG_FHA_1	202	208	PF00498	0.593
LIG_FHA_1	220	226	PF00498	0.195
LIG_FHA_1	342	348	PF00498	0.309
LIG_FHA_1	56	62	PF00498	0.300
LIG_FHA_2	144	150	PF00498	0.518
LIG_FHA_2	241	247	PF00498	0.394
LIG_FHA_2	30	36	PF00498	0.302
LIG_Integrin_RGD_1	138	140	PF01839	0.421
LIG_LIR_Gen_1	112	122	PF02991	0.197
LIG_LIR_Gen_1	27	34	PF02991	0.307
LIG_LIR_Gen_1	47	56	PF02991	0.299
LIG_LIR_Gen_1	96	104	PF02991	0.307
LIG_LIR_LC3C_4	221	226	PF02991	0.243
LIG_LIR_Nem_3	112	117	PF02991	0.200
LIG_LIR_Nem_3	21	26	PF02991	0.280
LIG_LIR_Nem_3	27	31	PF02991	0.262
LIG_LIR_Nem_3	47	53	PF02991	0.299
LIG_LIR_Nem_3	8	14	PF02991	0.515
LIG_LIR_Nem_3	96	100	PF02991	0.346
LIG_MLH1_MIPbox_1	20	24	PF16413	0.307
LIG_MYND_1	274	278	PF01753	0.343
LIG_NRBOX	182	188	PF00104	0.338
LIG_Pex14_2	20	24	PF04695	0.289
LIG_SH2_CRK	14	18	PF00017	0.297
LIG_SH2_CRK	28	32	PF00017	0.321
LIG_SH2_CRK	303	307	PF00017	0.532
LIG_SH2_CRK	97	101	PF00017	0.338
LIG_SH2_NCK_1	28	32	PF00017	0.211
LIG_SH2_SRC	12	15	PF00017	0.289
LIG_SH2_SRC	301	304	PF00017	0.403
LIG_SH2_SRC	309	312	PF00017	0.483
LIG_SH2_STAP1	12	16	PF00017	0.300
LIG_SH2_STAP1	236	240	PF00017	0.322
LIG_SH2_STAP1	301	305	PF00017	0.409
LIG_SH2_STAP1	97	101	PF00017	0.338
LIG_SH2_STAT5	309	312	PF00017	0.493
LIG_SH2_STAT5	33	36	PF00017	0.476
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.338
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.281
LIG_SUMO_SIM_par_1	120	126	PF11976	0.301
LIG_SUMO_SIM_par_1	15	21	PF11976	0.318
LIG_SUMO_SIM_par_1	285	291	PF11976	0.211
LIG_TRAF2_1	75	78	PF00917	0.598
LIG_TYR_ITIM	26	31	PF00017	0.307
LIG_WRC_WIRS_1	19	24	PF05994	0.243
MOD_CK1_1	27	33	PF00069	0.442
MOD_CK2_1	240	246	PF00069	0.390
MOD_CK2_1	29	35	PF00069	0.281
MOD_CK2_1	72	78	PF00069	0.653
MOD_GlcNHglycan	102	105	PF01048	0.418
MOD_GlcNHglycan	195	198	PF01048	0.338
MOD_GlcNHglycan	248	251	PF01048	0.639
MOD_GlcNHglycan	266	269	PF01048	0.579
MOD_GlcNHglycan	290	293	PF01048	0.213
MOD_GlcNHglycan	315	318	PF01048	0.475
MOD_GlcNHglycan	325	328	PF01048	0.300
MOD_GlcNHglycan	372	375	PF01048	0.253
MOD_GSK3_1	109	116	PF00069	0.391
MOD_GSK3_1	171	178	PF00069	0.360
MOD_GSK3_1	189	196	PF00069	0.386
MOD_GSK3_1	208	215	PF00069	0.480
MOD_GSK3_1	241	248	PF00069	0.422
MOD_N-GLC_1	238	243	PF02516	0.485
MOD_NEK2_1	100	105	PF00069	0.306
MOD_NEK2_1	123	128	PF00069	0.300
MOD_NEK2_1	218	223	PF00069	0.289
MOD_NEK2_1	24	29	PF00069	0.318
MOD_NEK2_1	288	293	PF00069	0.211
MOD_NEK2_1	349	354	PF00069	0.399
MOD_NEK2_1	55	60	PF00069	0.261
MOD_PIKK_1	208	214	PF00454	0.542
MOD_PKA_1	390	396	PF00069	0.560
MOD_PKA_2	212	218	PF00069	0.560
MOD_PKA_2	390	396	PF00069	0.652
MOD_PKB_1	88	96	PF00069	0.569
MOD_Plk_1	238	244	PF00069	0.288
MOD_Plk_2-3	143	149	PF00069	0.468
MOD_Plk_2-3	77	83	PF00069	0.633
MOD_Plk_4	182	188	PF00069	0.330
MOD_Plk_4	189	195	PF00069	0.262
MOD_Plk_4	220	226	PF00069	0.289
MOD_Plk_4	29	35	PF00069	0.552
MOD_Plk_4	293	299	PF00069	0.355
MOD_Plk_4	304	310	PF00069	0.467
MOD_Plk_4	343	349	PF00069	0.270
MOD_Plk_4	77	83	PF00069	0.633
MOD_Plk_4	90	96	PF00069	0.440
TRG_DiLeu_BaEn_3	76	82	PF01217	0.630
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.338
TRG_ENDOCYTIC_2	14	17	PF00928	0.315
TRG_ENDOCYTIC_2	28	31	PF00928	0.438
TRG_ENDOCYTIC_2	303	306	PF00928	0.534
TRG_ENDOCYTIC_2	97	100	PF00928	0.390
TRG_ER_diArg_1	377	379	PF00400	0.643
TRG_ER_diArg_1	390	392	PF00400	0.584
TRG_ER_diArg_1	88	90	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDQ8	Bodo saltans	26%	73%
A0A3Q8IG89	Leishmania donovani	90%	100%
A4I8G6	Leishmania infantum	90%	100%
E9B3C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%