Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0564, putative

Species:

Leishmania major

UniProt:

Q4Q4S9_LEIMA

TriTrypDb:

LmjF.32.3430 , LMJLV39_320042500 , LMJSD75_320042500

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0044782	cilium organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.593
CLV_C14_Caspase3-7	468	472	PF00656	0.581
CLV_C14_Caspase3-7	734	738	PF00656	0.645
CLV_C14_Caspase3-7	802	806	PF00656	0.672
CLV_NRD_NRD_1	144	146	PF00675	0.682
CLV_NRD_NRD_1	155	157	PF00675	0.584
CLV_NRD_NRD_1	17	19	PF00675	0.524
CLV_NRD_NRD_1	185	187	PF00675	0.600
CLV_NRD_NRD_1	195	197	PF00675	0.457
CLV_NRD_NRD_1	418	420	PF00675	0.337
CLV_NRD_NRD_1	477	479	PF00675	0.381
CLV_NRD_NRD_1	490	492	PF00675	0.234
CLV_NRD_NRD_1	570	572	PF00675	0.313
CLV_NRD_NRD_1	61	63	PF00675	0.565
CLV_NRD_NRD_1	767	769	PF00675	0.729
CLV_NRD_NRD_1	790	792	PF00675	0.583
CLV_NRD_NRD_1	88	90	PF00675	0.480
CLV_PCSK_FUR_1	153	157	PF00082	0.604
CLV_PCSK_FUR_1	183	187	PF00082	0.603
CLV_PCSK_KEX2_1	143	145	PF00082	0.676
CLV_PCSK_KEX2_1	155	157	PF00082	0.640
CLV_PCSK_KEX2_1	17	19	PF00082	0.524
CLV_PCSK_KEX2_1	185	187	PF00082	0.649
CLV_PCSK_KEX2_1	418	420	PF00082	0.350
CLV_PCSK_KEX2_1	477	479	PF00082	0.381
CLV_PCSK_KEX2_1	490	492	PF00082	0.234
CLV_PCSK_KEX2_1	500	502	PF00082	0.311
CLV_PCSK_KEX2_1	572	574	PF00082	0.322
CLV_PCSK_KEX2_1	61	63	PF00082	0.521
CLV_PCSK_KEX2_1	660	662	PF00082	0.613
CLV_PCSK_KEX2_1	767	769	PF00082	0.775
CLV_PCSK_KEX2_1	790	792	PF00082	0.583
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.374
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.381
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.613
CLV_PCSK_PC7_1	139	145	PF00082	0.683
CLV_PCSK_PC7_1	568	574	PF00082	0.337
CLV_PCSK_SKI1_1	102	106	PF00082	0.596
CLV_PCSK_SKI1_1	135	139	PF00082	0.628
CLV_PCSK_SKI1_1	20	24	PF00082	0.646
CLV_PCSK_SKI1_1	403	407	PF00082	0.420
CLV_PCSK_SKI1_1	445	449	PF00082	0.315
CLV_PCSK_SKI1_1	587	591	PF00082	0.348
CLV_PCSK_SKI1_1	605	609	PF00082	0.573
CLV_PCSK_SKI1_1	643	647	PF00082	0.579
CLV_PCSK_SKI1_1	660	664	PF00082	0.585
CLV_PCSK_SKI1_1	791	795	PF00082	0.626
DEG_APCC_DBOX_1	121	129	PF00400	0.648
DEG_Nend_UBRbox_3	1	3	PF02207	0.557
DEG_SPOP_SBC_1	480	484	PF00917	0.513
DOC_ANK_TNKS_1	686	693	PF00023	0.659
DOC_CKS1_1	304	309	PF01111	0.713
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.492
DOC_MAPK_gen_1	119	128	PF00069	0.522
DOC_MAPK_gen_1	183	191	PF00069	0.607
DOC_MAPK_gen_1	418	426	PF00069	0.537
DOC_MAPK_MEF2A_6	164	172	PF00069	0.551
DOC_MAPK_MEF2A_6	418	426	PF00069	0.581
DOC_MAPK_RevD_3	777	791	PF00069	0.625
DOC_PP1_RVXF_1	186	192	PF00149	0.606
DOC_PP2B_LxvP_1	486	489	PF13499	0.515
DOC_PP2B_LxvP_1	517	520	PF13499	0.439
DOC_PP4_FxxP_1	625	628	PF00568	0.571
DOC_USP7_MATH_1	285	289	PF00917	0.719
DOC_USP7_MATH_1	29	33	PF00917	0.633
DOC_USP7_MATH_1	292	296	PF00917	0.610
DOC_USP7_MATH_1	320	324	PF00917	0.677
DOC_USP7_MATH_1	357	361	PF00917	0.713
DOC_USP7_MATH_1	374	378	PF00917	0.588
DOC_USP7_MATH_1	390	394	PF00917	0.685
DOC_USP7_MATH_1	399	403	PF00917	0.648
DOC_USP7_MATH_1	405	409	PF00917	0.407
DOC_USP7_MATH_1	479	483	PF00917	0.511
DOC_USP7_MATH_1	683	687	PF00917	0.682
DOC_USP7_MATH_1	761	765	PF00917	0.710
DOC_USP7_MATH_1	772	776	PF00917	0.590
DOC_WW_Pin1_4	210	215	PF00397	0.709
DOC_WW_Pin1_4	221	226	PF00397	0.549
DOC_WW_Pin1_4	258	263	PF00397	0.702
DOC_WW_Pin1_4	273	278	PF00397	0.522
DOC_WW_Pin1_4	288	293	PF00397	0.601
DOC_WW_Pin1_4	298	303	PF00397	0.777
DOC_WW_Pin1_4	377	382	PF00397	0.786
DOC_WW_Pin1_4	463	468	PF00397	0.548
DOC_WW_Pin1_4	491	496	PF00397	0.574
DOC_WW_Pin1_4	503	508	PF00397	0.482
DOC_WW_Pin1_4	65	70	PF00397	0.606
DOC_WW_Pin1_4	662	667	PF00397	0.605
DOC_WW_Pin1_4	691	696	PF00397	0.672
DOC_WW_Pin1_4	713	718	PF00397	0.702
DOC_WW_Pin1_4	756	761	PF00397	0.767
LIG_14-3-3_CanoR_1	112	118	PF00244	0.494
LIG_14-3-3_CanoR_1	196	204	PF00244	0.605
LIG_14-3-3_CanoR_1	478	488	PF00244	0.583
LIG_14-3-3_CanoR_1	571	579	PF00244	0.544
LIG_14-3-3_CanoR_1	587	596	PF00244	0.434
LIG_14-3-3_CanoR_1	661	666	PF00244	0.601
LIG_14-3-3_CanoR_1	748	756	PF00244	0.677
LIG_14-3-3_CanoR_1	767	772	PF00244	0.563
LIG_14-3-3_CanoR_1	790	796	PF00244	0.698
LIG_Actin_WH2_2	106	121	PF00022	0.605
LIG_BIR_III_4	676	680	PF00653	0.660
LIG_EVH1_1	338	342	PF00568	0.643
LIG_EVH1_2	71	75	PF00568	0.694
LIG_FHA_1	382	388	PF00498	0.677
LIG_FHA_1	481	487	PF00498	0.444
LIG_FHA_1	533	539	PF00498	0.495
LIG_FHA_1	588	594	PF00498	0.501
LIG_FHA_1	662	668	PF00498	0.534
LIG_FHA_1	673	679	PF00498	0.657
LIG_FHA_1	683	689	PF00498	0.653
LIG_FHA_1	774	780	PF00498	0.736
LIG_FHA_2	136	142	PF00498	0.664
LIG_FHA_2	407	413	PF00498	0.537
LIG_GSK3_LRP6_1	298	303	PF00069	0.569
LIG_LIR_Gen_1	107	118	PF02991	0.603
LIG_LIR_Nem_3	107	113	PF02991	0.601
LIG_LIR_Nem_3	414	420	PF02991	0.581
LIG_LIR_Nem_3	557	563	PF02991	0.548
LIG_Pex14_2	437	441	PF04695	0.495
LIG_RPA_C_Plants	40	51	PF08784	0.603
LIG_SH2_NCK_1	220	224	PF00017	0.740
LIG_SH2_NCK_1	721	725	PF00017	0.574
LIG_SH2_STAP1	539	543	PF00017	0.581
LIG_SH2_STAP1	79	83	PF00017	0.488
LIG_SH2_STAT3	420	423	PF00017	0.581
LIG_SH2_STAT5	4	7	PF00017	0.533
LIG_SH2_STAT5	577	580	PF00017	0.495
LIG_SH3_1	66	72	PF00018	0.599
LIG_SH3_3	126	132	PF00018	0.610
LIG_SH3_3	277	283	PF00018	0.725
LIG_SH3_3	293	299	PF00018	0.540
LIG_SH3_3	301	307	PF00018	0.670
LIG_SH3_3	314	320	PF00018	0.580
LIG_SH3_3	325	331	PF00018	0.588
LIG_SH3_3	33	39	PF00018	0.636
LIG_SH3_3	333	339	PF00018	0.593
LIG_SH3_3	351	357	PF00018	0.626
LIG_SH3_3	359	365	PF00018	0.800
LIG_SH3_3	367	373	PF00018	0.603
LIG_SH3_3	384	390	PF00018	0.670
LIG_SH3_3	429	435	PF00018	0.581
LIG_SH3_3	456	462	PF00018	0.581
LIG_SH3_3	504	510	PF00018	0.550
LIG_SH3_3	66	72	PF00018	0.599
LIG_SH3_3	776	782	PF00018	0.717
LIG_TRAF2_1	698	701	PF00917	0.717
LIG_TRFH_1	463	467	PF08558	0.548
LIG_WW_2	339	342	PF00397	0.684
LIG_WW_3	37	41	PF00397	0.616
LIG_WW_3	487	491	PF00397	0.505
LIG_WW_3	518	522	PF00397	0.472
MOD_CDC14_SPxK_1	215	218	PF00782	0.735
MOD_CDK_SPxK_1	212	218	PF00069	0.723
MOD_CDK_SPxxK_3	463	470	PF00069	0.526
MOD_CDK_SPxxK_3	713	720	PF00069	0.667
MOD_CK1_1	114	120	PF00069	0.568
MOD_CK1_1	258	264	PF00069	0.695
MOD_CK1_1	276	282	PF00069	0.476
MOD_CK1_1	288	294	PF00069	0.634
MOD_CK1_1	377	383	PF00069	0.805
MOD_CK1_1	392	398	PF00069	0.609
MOD_CK1_1	716	722	PF00069	0.730
MOD_CK1_1	729	735	PF00069	0.581
MOD_CK1_1	740	746	PF00069	0.645
MOD_CK1_1	749	755	PF00069	0.659
MOD_CK1_1	763	769	PF00069	0.559
MOD_CK1_1	770	776	PF00069	0.553
MOD_CK1_1	797	803	PF00069	0.757
MOD_CK2_1	117	123	PF00069	0.617
MOD_CK2_1	135	141	PF00069	0.445
MOD_CK2_1	176	182	PF00069	0.665
MOD_CK2_1	645	651	PF00069	0.511
MOD_CK2_1	683	689	PF00069	0.699
MOD_CK2_1	789	795	PF00069	0.672
MOD_Cter_Amidation	475	478	PF01082	0.381
MOD_Cter_Amidation	497	500	PF01082	0.337
MOD_GlcNHglycan	113	116	PF01048	0.612
MOD_GlcNHglycan	147	150	PF01048	0.578
MOD_GlcNHglycan	287	290	PF01048	0.774
MOD_GlcNHglycan	332	335	PF01048	0.592
MOD_GlcNHglycan	359	362	PF01048	0.822
MOD_GlcNHglycan	366	369	PF01048	0.741
MOD_GlcNHglycan	376	379	PF01048	0.586
MOD_GlcNHglycan	392	395	PF01048	0.640
MOD_GlcNHglycan	467	470	PF01048	0.384
MOD_GlcNHglycan	483	486	PF01048	0.323
MOD_GlcNHglycan	495	498	PF01048	0.252
MOD_GlcNHglycan	521	524	PF01048	0.387
MOD_GlcNHglycan	574	577	PF01048	0.381
MOD_GlcNHglycan	710	713	PF01048	0.705
MOD_GlcNHglycan	729	732	PF01048	0.541
MOD_GlcNHglycan	751	754	PF01048	0.697
MOD_GlcNHglycan	772	775	PF01048	0.686
MOD_GlcNHglycan	791	794	PF01048	0.694
MOD_GSK3_1	114	121	PF00069	0.475
MOD_GSK3_1	145	152	PF00069	0.586
MOD_GSK3_1	191	198	PF00069	0.634
MOD_GSK3_1	254	261	PF00069	0.717
MOD_GSK3_1	288	295	PF00069	0.703
MOD_GSK3_1	377	384	PF00069	0.741
MOD_GSK3_1	543	550	PF00069	0.515
MOD_GSK3_1	668	675	PF00069	0.648
MOD_GSK3_1	722	729	PF00069	0.642
MOD_GSK3_1	731	738	PF00069	0.649
MOD_GSK3_1	742	749	PF00069	0.659
MOD_GSK3_1	752	759	PF00069	0.721
MOD_GSK3_1	763	770	PF00069	0.816
MOD_GSK3_1	797	804	PF00069	0.642
MOD_LATS_1	585	591	PF00433	0.548
MOD_N-GLC_1	471	476	PF02516	0.290
MOD_N-GLC_1	512	517	PF02516	0.407
MOD_NEK2_1	191	196	PF00069	0.597
MOD_NEK2_2	422	427	PF00069	0.581
MOD_PIKK_1	406	412	PF00454	0.517
MOD_PIKK_1	532	538	PF00454	0.495
MOD_PKA_1	156	162	PF00069	0.591
MOD_PKA_1	572	578	PF00069	0.581
MOD_PKA_1	767	773	PF00069	0.690
MOD_PKA_2	111	117	PF00069	0.524
MOD_PKA_2	118	124	PF00069	0.468
MOD_PKA_2	195	201	PF00069	0.593
MOD_PKA_2	480	486	PF00069	0.518
MOD_PKA_2	525	531	PF00069	0.624
MOD_PKA_2	572	578	PF00069	0.581
MOD_PKA_2	600	606	PF00069	0.516
MOD_PKA_2	749	755	PF00069	0.642
MOD_PKA_2	766	772	PF00069	0.556
MOD_PKA_2	789	795	PF00069	0.696
MOD_PKB_1	143	151	PF00069	0.700
MOD_Plk_1	413	419	PF00069	0.456
MOD_Plk_1	471	477	PF00069	0.449
MOD_Plk_1	512	518	PF00069	0.515
MOD_Plk_1	547	553	PF00069	0.574
MOD_Plk_1	683	689	PF00069	0.653
MOD_Plk_1	797	803	PF00069	0.711
MOD_Plk_2-3	737	743	PF00069	0.581
MOD_Plk_4	71	77	PF00069	0.565
MOD_ProDKin_1	210	216	PF00069	0.712
MOD_ProDKin_1	221	227	PF00069	0.547
MOD_ProDKin_1	258	264	PF00069	0.695
MOD_ProDKin_1	273	279	PF00069	0.523
MOD_ProDKin_1	288	294	PF00069	0.599
MOD_ProDKin_1	298	304	PF00069	0.779
MOD_ProDKin_1	377	383	PF00069	0.781
MOD_ProDKin_1	463	469	PF00069	0.548
MOD_ProDKin_1	491	497	PF00069	0.574
MOD_ProDKin_1	503	509	PF00069	0.482
MOD_ProDKin_1	65	71	PF00069	0.602
MOD_ProDKin_1	662	668	PF00069	0.610
MOD_ProDKin_1	691	697	PF00069	0.673
MOD_ProDKin_1	713	719	PF00069	0.701
MOD_ProDKin_1	756	762	PF00069	0.769
MOD_SUMO_rev_2	468	475	PF00179	0.559
TRG_DiLeu_BaEn_1	31	36	PF01217	0.694
TRG_DiLeu_BaEn_2	186	192	PF01217	0.606
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.683
TRG_ENDOCYTIC_2	79	82	PF00928	0.491
TRG_ER_diArg_1	100	103	PF00400	0.574
TRG_ER_diArg_1	142	145	PF00400	0.673
TRG_ER_diArg_1	153	156	PF00400	0.621
TRG_ER_diArg_1	183	186	PF00400	0.607
TRG_ER_diArg_1	39	42	PF00400	0.715
TRG_ER_diArg_1	417	419	PF00400	0.537
TRG_ER_diArg_1	477	479	PF00400	0.505
TRG_ER_diArg_1	489	491	PF00400	0.538
TRG_ER_diArg_1	570	573	PF00400	0.517
TRG_NLS_MonoExtN_4	568	575	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTK5	Trypanosomatidae	34%	98%
A0A3Q8IJN1	Leishmania donovani	91%	100%
A4HKY6	Leishmania braziliensis	71%	100%
A4I8G7	Leishmania infantum	91%	100%
E9B3C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B3C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%