Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4S8_LEIMA

TriTrypDb:

LmjF.32.3440 , LMJLV39_320042600 , LMJSD75_320042600

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.630
CLV_C14_Caspase3-7	574	578	PF00656	0.566
CLV_NRD_NRD_1	14	16	PF00675	0.694
CLV_NRD_NRD_1	227	229	PF00675	0.686
CLV_NRD_NRD_1	28	30	PF00675	0.616
CLV_NRD_NRD_1	411	413	PF00675	0.532
CLV_NRD_NRD_1	430	432	PF00675	0.461
CLV_NRD_NRD_1	459	461	PF00675	0.747
CLV_NRD_NRD_1	543	545	PF00675	0.532
CLV_NRD_NRD_1	622	624	PF00675	0.458
CLV_PCSK_KEX2_1	13	15	PF00082	0.702
CLV_PCSK_KEX2_1	227	229	PF00082	0.686
CLV_PCSK_KEX2_1	262	264	PF00082	0.502
CLV_PCSK_KEX2_1	27	29	PF00082	0.655
CLV_PCSK_KEX2_1	458	460	PF00082	0.744
CLV_PCSK_KEX2_1	543	545	PF00082	0.595
CLV_PCSK_KEX2_1	622	624	PF00082	0.458
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.483
CLV_PCSK_SKI1_1	270	274	PF00082	0.467
CLV_PCSK_SKI1_1	386	390	PF00082	0.627
CLV_PCSK_SKI1_1	622	626	PF00082	0.440
CLV_PCSK_SKI1_1	644	648	PF00082	0.555
DEG_APCC_DBOX_1	621	629	PF00400	0.436
DEG_Nend_UBRbox_2	1	3	PF02207	0.612
DOC_CKS1_1	161	166	PF01111	0.459
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.619
DOC_MAPK_gen_1	13	22	PF00069	0.641
DOC_MAPK_gen_1	431	438	PF00069	0.520
DOC_MAPK_gen_1	543	550	PF00069	0.464
DOC_MAPK_gen_1	622	628	PF00069	0.432
DOC_MAPK_HePTP_8	10	22	PF00069	0.625
DOC_MAPK_MEF2A_6	13	22	PF00069	0.641
DOC_MAPK_MEF2A_6	166	174	PF00069	0.550
DOC_MAPK_MEF2A_6	470	479	PF00069	0.661
DOC_PP2B_LxvP_1	20	23	PF13499	0.656
DOC_PP2B_LxvP_1	618	621	PF13499	0.486
DOC_PP4_FxxP_1	154	157	PF00568	0.454
DOC_PP4_FxxP_1	173	176	PF00568	0.667
DOC_USP7_MATH_1	183	187	PF00917	0.647
DOC_USP7_MATH_1	234	238	PF00917	0.749
DOC_USP7_MATH_1	489	493	PF00917	0.658
DOC_USP7_MATH_1	513	517	PF00917	0.569
DOC_USP7_MATH_1	700	704	PF00917	0.592
DOC_USP7_MATH_1	709	713	PF00917	0.365
DOC_WW_Pin1_4	160	165	PF00397	0.627
DOC_WW_Pin1_4	179	184	PF00397	0.475
DOC_WW_Pin1_4	197	202	PF00397	0.713
DOC_WW_Pin1_4	22	27	PF00397	0.694
DOC_WW_Pin1_4	229	234	PF00397	0.676
DOC_WW_Pin1_4	241	246	PF00397	0.626
DOC_WW_Pin1_4	318	323	PF00397	0.523
DOC_WW_Pin1_4	471	476	PF00397	0.683
DOC_WW_Pin1_4	538	543	PF00397	0.659
LIG_14-3-3_CanoR_1	118	122	PF00244	0.553
LIG_14-3-3_CanoR_1	150	155	PF00244	0.543
LIG_14-3-3_CanoR_1	217	222	PF00244	0.664
LIG_14-3-3_CanoR_1	312	319	PF00244	0.651
LIG_14-3-3_CanoR_1	416	426	PF00244	0.634
LIG_14-3-3_CanoR_1	42	48	PF00244	0.460
LIG_14-3-3_CanoR_1	470	475	PF00244	0.710
LIG_14-3-3_CanoR_1	488	498	PF00244	0.489
LIG_14-3-3_CanoR_1	554	560	PF00244	0.606
LIG_14-3-3_CanoR_1	623	629	PF00244	0.424
LIG_14-3-3_CanoR_1	684	690	PF00244	0.491
LIG_BIR_III_2	387	391	PF00653	0.606
LIG_BRCT_BRCA1_1	288	292	PF00533	0.607
LIG_CaM_NSCaTE_8	117	124	PF13499	0.430
LIG_CSL_BTD_1	499	502	PF09270	0.561
LIG_EVH1_2	611	615	PF00568	0.624
LIG_FHA_1	203	209	PF00498	0.724
LIG_FHA_1	299	305	PF00498	0.629
LIG_FHA_1	312	318	PF00498	0.388
LIG_FHA_1	418	424	PF00498	0.634
LIG_FHA_1	531	537	PF00498	0.697
LIG_FHA_1	638	644	PF00498	0.512
LIG_FHA_1	691	697	PF00498	0.401
LIG_FHA_2	117	123	PF00498	0.486
LIG_FHA_2	142	148	PF00498	0.538
LIG_FHA_2	361	367	PF00498	0.711
LIG_FHA_2	535	541	PF00498	0.714
LIG_FHA_2	572	578	PF00498	0.558
LIG_LIR_Apic_2	153	157	PF02991	0.442
LIG_LIR_Apic_2	503	508	PF02991	0.488
LIG_LIR_Gen_1	60	67	PF02991	0.467
LIG_LIR_Gen_1	613	621	PF02991	0.460
LIG_LIR_Nem_3	60	66	PF02991	0.465
LIG_LIR_Nem_3	613	618	PF02991	0.631
LIG_LIR_Nem_3	703	708	PF02991	0.387
LIG_LYPXL_S_1	380	384	PF13949	0.531
LIG_LYPXL_yS_3	381	384	PF13949	0.531
LIG_MAD2	29	37	PF02301	0.564
LIG_NRBOX	518	524	PF00104	0.396
LIG_PDZ_Class_2	710	715	PF00595	0.453
LIG_Pex14_1	500	504	PF04695	0.521
LIG_Pex14_2	154	158	PF04695	0.577
LIG_SH2_CRK	63	67	PF00017	0.451
LIG_SH2_CRK	708	712	PF00017	0.481
LIG_SH2_NCK_1	708	712	PF00017	0.481
LIG_SH2_STAP1	63	67	PF00017	0.451
LIG_SH2_STAT5	63	66	PF00017	0.444
LIG_SH3_1	227	233	PF00018	0.565
LIG_SH3_2	23	28	PF14604	0.679
LIG_SH3_3	20	26	PF00018	0.705
LIG_SH3_3	227	233	PF00018	0.679
LIG_SH3_3	27	33	PF00018	0.495
LIG_SH3_3	323	329	PF00018	0.537
LIG_SH3_3	445	451	PF00018	0.543
LIG_SH3_3	496	502	PF00018	0.574
LIG_SH3_3	539	545	PF00018	0.785
LIG_SH3_3	547	553	PF00018	0.437
LIG_SH3_3	606	612	PF00018	0.633
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.560
LIG_SUMO_SIM_par_1	305	311	PF11976	0.461
LIG_SUMO_SIM_par_1	339	345	PF11976	0.551
LIG_SUMO_SIM_par_1	588	594	PF11976	0.462
LIG_SUMO_SIM_par_1	624	630	PF11976	0.432
LIG_SUMO_SIM_par_1	692	699	PF11976	0.410
LIG_TRAF2_1	334	337	PF00917	0.469
LIG_TYR_ITIM	706	711	PF00017	0.480
LIG_UBA3_1	255	262	PF00899	0.632
LIG_WRC_WIRS_1	501	506	PF05994	0.495
MOD_CDC14_SPxK_1	25	28	PF00782	0.658
MOD_CDK_SPK_2	22	27	PF00069	0.694
MOD_CDK_SPK_2	538	543	PF00069	0.606
MOD_CDK_SPxK_1	160	166	PF00069	0.636
MOD_CDK_SPxK_1	22	28	PF00069	0.685
MOD_CDK_SPxK_1	538	544	PF00069	0.791
MOD_CDK_SPxxK_3	22	29	PF00069	0.681
MOD_CK1_1	106	112	PF00069	0.580
MOD_CK1_1	120	126	PF00069	0.360
MOD_CK1_1	182	188	PF00069	0.667
MOD_CK1_1	298	304	PF00069	0.602
MOD_CK1_1	463	469	PF00069	0.661
MOD_CK1_1	492	498	PF00069	0.701
MOD_CK1_1	534	540	PF00069	0.645
MOD_CK1_1	594	600	PF00069	0.540
MOD_CK1_1	616	622	PF00069	0.476
MOD_CK1_1	649	655	PF00069	0.432
MOD_CK1_1	690	696	PF00069	0.525
MOD_CK2_1	116	122	PF00069	0.542
MOD_CK2_1	150	156	PF00069	0.442
MOD_CK2_1	331	337	PF00069	0.516
MOD_CK2_1	360	366	PF00069	0.604
MOD_CK2_1	43	49	PF00069	0.464
MOD_CK2_1	611	617	PF00069	0.567
MOD_CK2_1	624	630	PF00069	0.498
MOD_Cter_Amidation	11	14	PF01082	0.605
MOD_GlcNHglycan	105	108	PF01048	0.634
MOD_GlcNHglycan	122	125	PF01048	0.350
MOD_GlcNHglycan	131	134	PF01048	0.491
MOD_GlcNHglycan	192	195	PF01048	0.647
MOD_GlcNHglycan	2	6	PF01048	0.591
MOD_GlcNHglycan	236	239	PF01048	0.651
MOD_GlcNHglycan	491	494	PF01048	0.656
MOD_GlcNHglycan	533	536	PF01048	0.675
MOD_GlcNHglycan	555	558	PF01048	0.695
MOD_GlcNHglycan	593	596	PF01048	0.562
MOD_GlcNHglycan	617	621	PF01048	0.574
MOD_GlcNHglycan	68	71	PF01048	0.538
MOD_GSK3_1	112	119	PF00069	0.541
MOD_GSK3_1	137	144	PF00069	0.596
MOD_GSK3_1	179	186	PF00069	0.632
MOD_GSK3_1	18	25	PF00069	0.685
MOD_GSK3_1	213	220	PF00069	0.636
MOD_GSK3_1	270	277	PF00069	0.475
MOD_GSK3_1	286	293	PF00069	0.562
MOD_GSK3_1	295	302	PF00069	0.624
MOD_GSK3_1	318	325	PF00069	0.666
MOD_GSK3_1	36	43	PF00069	0.602
MOD_GSK3_1	460	467	PF00069	0.732
MOD_GSK3_1	513	520	PF00069	0.421
MOD_GSK3_1	523	530	PF00069	0.562
MOD_GSK3_1	534	541	PF00069	0.677
MOD_GSK3_1	57	64	PF00069	0.512
MOD_GSK3_1	633	640	PF00069	0.516
MOD_N-GLC_2	400	402	PF02516	0.563
MOD_N-GLC_2	93	95	PF02516	0.607
MOD_NEK2_1	128	133	PF00069	0.494
MOD_NEK2_1	190	195	PF00069	0.692
MOD_NEK2_1	523	528	PF00069	0.539
MOD_NEK2_1	66	71	PF00069	0.590
MOD_NEK2_1	701	706	PF00069	0.490
MOD_NEK2_2	662	667	PF00069	0.365
MOD_NEK2_2	709	714	PF00069	0.431
MOD_PIKK_1	248	254	PF00454	0.558
MOD_PIKK_1	270	276	PF00454	0.465
MOD_PIKK_1	286	292	PF00454	0.539
MOD_PIKK_1	417	423	PF00454	0.623
MOD_PIKK_1	492	498	PF00454	0.701
MOD_PIKK_1	649	655	PF00454	0.511
MOD_PK_1	217	223	PF00069	0.618
MOD_PK_1	544	550	PF00069	0.610
MOD_PKA_2	117	123	PF00069	0.550
MOD_PKA_2	311	317	PF00069	0.579
MOD_PKA_2	367	373	PF00069	0.719
MOD_PKA_2	43	49	PF00069	0.576
MOD_PKA_2	463	469	PF00069	0.756
MOD_PKA_2	530	536	PF00069	0.702
MOD_PKA_2	553	559	PF00069	0.599
MOD_PKB_1	458	466	PF00069	0.590
MOD_Plk_1	432	438	PF00069	0.650
MOD_Plk_1	61	67	PF00069	0.579
MOD_Plk_4	150	156	PF00069	0.535
MOD_Plk_4	36	42	PF00069	0.465
MOD_Plk_4	43	49	PF00069	0.464
MOD_Plk_4	500	506	PF00069	0.508
MOD_Plk_4	513	519	PF00069	0.417
MOD_Plk_4	523	529	PF00069	0.536
MOD_Plk_4	571	577	PF00069	0.507
MOD_Plk_4	61	67	PF00069	0.334
MOD_Plk_4	701	707	PF00069	0.523
MOD_ProDKin_1	160	166	PF00069	0.636
MOD_ProDKin_1	179	185	PF00069	0.478
MOD_ProDKin_1	197	203	PF00069	0.712
MOD_ProDKin_1	22	28	PF00069	0.685
MOD_ProDKin_1	229	235	PF00069	0.677
MOD_ProDKin_1	241	247	PF00069	0.623
MOD_ProDKin_1	318	324	PF00069	0.517
MOD_ProDKin_1	471	477	PF00069	0.683
MOD_ProDKin_1	538	544	PF00069	0.654
MOD_SUMO_rev_2	257	264	PF00179	0.488
TRG_DiLeu_BaEn_1	260	265	PF01217	0.472
TRG_DiLeu_BaEn_1	336	341	PF01217	0.466
TRG_DiLeu_BaEn_1	353	358	PF01217	0.306
TRG_DiLeu_BaEn_1	410	415	PF01217	0.558
TRG_DiLeu_BaEn_1	62	67	PF01217	0.572
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.677
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.612
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.461
TRG_ENDOCYTIC_2	381	384	PF00928	0.531
TRG_ENDOCYTIC_2	63	66	PF00928	0.444
TRG_ENDOCYTIC_2	708	711	PF00928	0.375
TRG_ER_diArg_1	13	15	PF00400	0.693
TRG_ER_diArg_1	187	190	PF00400	0.723
TRG_ER_diArg_1	26	29	PF00400	0.541
TRG_ER_diArg_1	41	44	PF00400	0.442
TRG_ER_diArg_1	458	460	PF00400	0.744
TRG_ER_diArg_1	542	544	PF00400	0.549
TRG_ER_diArg_1	621	623	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC97	Leptomonas seymouri	38%	92%
A0A3Q8IGI2	Leishmania donovani	93%	100%
A4HKY7	Leishmania braziliensis	74%	100%
A4I8G8	Leishmania infantum	93%	100%
E9B3C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	83%