Zinc-finger of a C2HC-type family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania major

UniProt:

Q4Q4S7_LEIMA

TriTrypDb:

LmjF.32.3450 , LMJLV39_320042800 , LMJSD75_320042800

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.709
CLV_NRD_NRD_1	16	18	PF00675	0.548
CLV_NRD_NRD_1	192	194	PF00675	0.631
CLV_NRD_NRD_1	218	220	PF00675	0.626
CLV_NRD_NRD_1	472	474	PF00675	0.340
CLV_NRD_NRD_1	496	498	PF00675	0.553
CLV_PCSK_KEX2_1	16	18	PF00082	0.552
CLV_PCSK_KEX2_1	192	194	PF00082	0.631
CLV_PCSK_KEX2_1	50	52	PF00082	0.486
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.486
CLV_PCSK_SKI1_1	140	144	PF00082	0.312
CLV_PCSK_SKI1_1	158	162	PF00082	0.465
CLV_PCSK_SKI1_1	328	332	PF00082	0.650
CLV_PCSK_SKI1_1	473	477	PF00082	0.357
CLV_PCSK_SKI1_1	492	496	PF00082	0.397
CLV_PCSK_SKI1_1	514	518	PF00082	0.597
CLV_PCSK_SKI1_1	75	79	PF00082	0.610
CLV_PCSK_SKI1_1	89	93	PF00082	0.497
DEG_SPOP_SBC_1	179	183	PF00917	0.633
DOC_CKS1_1	174	179	PF01111	0.703
DOC_MAPK_MEF2A_6	281	290	PF00069	0.636
DOC_PP1_RVXF_1	305	311	PF00149	0.660
DOC_PP1_RVXF_1	49	56	PF00149	0.415
DOC_USP7_MATH_1	175	179	PF00917	0.726
DOC_USP7_MATH_1	180	184	PF00917	0.823
DOC_USP7_MATH_1	215	219	PF00917	0.686
DOC_USP7_MATH_1	246	250	PF00917	0.646
DOC_USP7_MATH_1	351	355	PF00917	0.778
DOC_USP7_MATH_1	373	377	PF00917	0.698
DOC_USP7_MATH_1	504	508	PF00917	0.552
DOC_USP7_MATH_1	524	528	PF00917	0.601
DOC_USP7_UBL2_3	71	75	PF12436	0.489
DOC_USP7_UBL2_3	9	13	PF12436	0.676
DOC_WW_Pin1_4	130	135	PF00397	0.340
DOC_WW_Pin1_4	173	178	PF00397	0.695
DOC_WW_Pin1_4	182	187	PF00397	0.624
DOC_WW_Pin1_4	296	301	PF00397	0.620
DOC_WW_Pin1_4	336	341	PF00397	0.701
DOC_WW_Pin1_4	509	514	PF00397	0.694
DOC_WW_Pin1_4	516	521	PF00397	0.602
DOC_WW_Pin1_4	66	71	PF00397	0.473
LIG_14-3-3_CanoR_1	16	20	PF00244	0.521
LIG_14-3-3_CanoR_1	307	311	PF00244	0.613
LIG_14-3-3_CanoR_1	458	467	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BIR_III_4	391	395	PF00653	0.663
LIG_FHA_1	259	265	PF00498	0.773
LIG_FHA_1	35	41	PF00498	0.345
LIG_FHA_1	510	516	PF00498	0.595
LIG_FHA_2	312	318	PF00498	0.641
LIG_FHA_2	366	372	PF00498	0.678
LIG_FHA_2	413	419	PF00498	0.749
LIG_FHA_2	459	465	PF00498	0.514
LIG_Integrin_RGD_1	57	59	PF01839	0.444
LIG_LIR_Apic_2	197	203	PF02991	0.612
LIG_LIR_Apic_2	228	232	PF02991	0.601
LIG_LIR_Gen_1	117	127	PF02991	0.414
LIG_LIR_Gen_1	309	318	PF02991	0.647
LIG_LIR_Nem_3	117	122	PF02991	0.443
LIG_LIR_Nem_3	445	450	PF02991	0.553
LIG_SH2_CRK	119	123	PF00017	0.413
LIG_SH2_CRK	200	204	PF00017	0.659
LIG_SH2_CRK	229	233	PF00017	0.604
LIG_SH2_NCK_1	229	233	PF00017	0.604
LIG_SH2_NCK_1	411	415	PF00017	0.588
LIG_SH2_NCK_1	96	100	PF00017	0.531
LIG_SH2_STAT5	29	32	PF00017	0.312
LIG_SH2_STAT5	470	473	PF00017	0.312
LIG_SH2_STAT5	48	51	PF00017	0.482
LIG_SH3_1	517	523	PF00018	0.605
LIG_SH3_2	276	281	PF14604	0.603
LIG_SH3_3	167	173	PF00018	0.718
LIG_SH3_3	263	269	PF00018	0.660
LIG_SH3_3	273	279	PF00018	0.796
LIG_SH3_3	294	300	PF00018	0.625
LIG_SH3_3	323	329	PF00018	0.609
LIG_SH3_3	500	506	PF00018	0.773
LIG_SH3_3	517	523	PF00018	0.544
LIG_SH3_3	64	70	PF00018	0.474
LIG_SH3_4	9	16	PF00018	0.597
LIG_SUMO_SIM_anti_2	282	289	PF11976	0.637
LIG_SUMO_SIM_par_1	285	291	PF11976	0.717
LIG_TRAF2_1	232	235	PF00917	0.668
MOD_CDK_SPK_2	296	301	PF00069	0.597
MOD_CDK_SPK_2	509	514	PF00069	0.694
MOD_CDK_SPK_2	66	71	PF00069	0.501
MOD_CK1_1	178	184	PF00069	0.650
MOD_CK1_1	185	191	PF00069	0.642
MOD_CK1_1	222	228	PF00069	0.694
MOD_CK1_1	339	345	PF00069	0.707
MOD_CK1_1	365	371	PF00069	0.759
MOD_CK1_1	527	533	PF00069	0.627
MOD_CK2_1	111	117	PF00069	0.506
MOD_CK2_1	66	72	PF00069	0.454
MOD_Cter_Amidation	471	474	PF01082	0.340
MOD_GlcNHglycan	1	4	PF01048	0.535
MOD_GlcNHglycan	177	180	PF01048	0.802
MOD_GlcNHglycan	182	185	PF01048	0.660
MOD_GlcNHglycan	187	190	PF01048	0.636
MOD_GlcNHglycan	323	326	PF01048	0.747
MOD_GlcNHglycan	371	374	PF01048	0.777
MOD_GlcNHglycan	434	437	PF01048	0.608
MOD_GlcNHglycan	526	529	PF01048	0.681
MOD_GSK3_1	175	182	PF00069	0.602
MOD_GSK3_1	215	222	PF00069	0.708
MOD_GSK3_1	241	248	PF00069	0.816
MOD_GSK3_1	254	261	PF00069	0.514
MOD_GSK3_1	292	299	PF00069	0.700
MOD_GSK3_1	332	339	PF00069	0.585
MOD_GSK3_1	340	347	PF00069	0.759
MOD_GSK3_1	365	372	PF00069	0.662
MOD_GSK3_1	488	495	PF00069	0.455
MOD_GSK3_1	505	512	PF00069	0.693
MOD_N-GLC_1	127	132	PF02516	0.477
MOD_N-GLC_1	351	356	PF02516	0.685
MOD_N-GLC_1	442	447	PF02516	0.566
MOD_NEK2_1	127	132	PF00069	0.480
MOD_NEK2_1	320	325	PF00069	0.628
MOD_NEK2_1	364	369	PF00069	0.762
MOD_PIKK_1	362	368	PF00454	0.654
MOD_PIKK_1	373	379	PF00454	0.582
MOD_PKA_1	219	225	PF00069	0.595
MOD_PKA_2	15	21	PF00069	0.537
MOD_PKA_2	194	200	PF00069	0.548
MOD_PKA_2	306	312	PF00069	0.609
MOD_PKA_2	369	375	PF00069	0.650
MOD_PKA_2	457	463	PF00069	0.530
MOD_PKA_2	504	510	PF00069	0.613
MOD_Plk_1	127	133	PF00069	0.452
MOD_Plk_1	442	448	PF00069	0.562
MOD_Plk_4	306	312	PF00069	0.672
MOD_ProDKin_1	130	136	PF00069	0.340
MOD_ProDKin_1	173	179	PF00069	0.697
MOD_ProDKin_1	182	188	PF00069	0.624
MOD_ProDKin_1	296	302	PF00069	0.621
MOD_ProDKin_1	336	342	PF00069	0.703
MOD_ProDKin_1	509	515	PF00069	0.697
MOD_ProDKin_1	516	522	PF00069	0.602
MOD_ProDKin_1	66	72	PF00069	0.475
MOD_SUMO_rev_2	391	401	PF00179	0.695
MOD_SUMO_rev_2	544	550	PF00179	0.520
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.479
TRG_ENDOCYTIC_2	119	122	PF00928	0.419
TRG_ER_diArg_1	192	195	PF00400	0.637
TRG_NES_CRM1_1	282	294	PF08389	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN9	Leptomonas seymouri	43%	82%
A0A3Q8ITN7	Leishmania donovani	89%	100%
A4HKY8	Leishmania braziliensis	61%	92%
A4I8G9	Leishmania infantum	89%	100%
E9B3C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%