Putative exosome-associated protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 2, putative

Species:

Leishmania major

UniProt:

Q4Q4S6_LEIMA

TriTrypDb:

LmjF.32.3460 , LMJLV39_320042900 , LMJSD75_320042900

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	2
GO:0000177	cytoplasmic exosome (RNase complex)	5	2
GO:0000178	exosome (RNase complex)	4	11
GO:0032991	protein-containing complex	1	11
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11

Expansion

Sequence features

Q4Q4S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S6

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	2
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	2
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	2
GO:0006401	RNA catabolic process	5	11
GO:0006402	mRNA catabolic process	6	2
GO:0006417	regulation of translation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009896	positive regulation of catabolic process	5	2
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	2
GO:0016072	rRNA metabolic process	7	2
GO:0016073	snRNA metabolic process	7	2
GO:0016075	rRNA catabolic process	7	2
GO:0016078	tRNA catabolic process	7	2
GO:0016180	snRNA processing	8	2
GO:0017148	negative regulation of translation	7	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	11
GO:0031123	RNA 3'-end processing	7	2
GO:0031125	rRNA 3'-end processing	9	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031331	positive regulation of cellular catabolic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034249	negative regulation of amide metabolic process	6	2
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	2
GO:0034470	ncRNA processing	7	2
GO:0034472	snRNA 3'-end processing	8	2
GO:0034473	U1 snRNA 3'-end processing	9	2
GO:0034475	U4 snRNA 3'-end processing	9	2
GO:0034476	U5 snRNA 3'-end processing	9	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034655	nucleobase-containing compound catabolic process	4	11
GO:0034660	ncRNA metabolic process	6	2
GO:0034661	ncRNA catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	11
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043628	regulatory ncRNA 3'-end processing	8	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0043633	polyadenylation-dependent RNA catabolic process	6	2
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	2
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0044270	cellular nitrogen compound catabolic process	4	11
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0046483	heterocycle metabolic process	3	11
GO:0046700	heterocycle catabolic process	4	11
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050779	RNA destabilization	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0061014	positive regulation of mRNA catabolic process	7	2
GO:0061157	mRNA destabilization	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071025	RNA surveillance	6	2
GO:0071027	nuclear RNA surveillance	7	2
GO:0071028	nuclear mRNA surveillance	8	2
GO:0071029	nuclear ncRNA surveillance	7	2
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	2
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	2
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	7	2
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	2
GO:0071047	polyadenylation-dependent mRNA catabolic process	6	2
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	11
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	2
GO:0106354	tRNA surveillance	7	2
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901361	organic cyclic compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903313	positive regulation of mRNA metabolic process	7	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.450
CLV_C14_Caspase3-7	74	78	PF00656	0.566
CLV_NRD_NRD_1	306	308	PF00675	0.472
CLV_PCSK_KEX2_1	31	33	PF00082	0.389
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.389
CLV_PCSK_SKI1_1	307	311	PF00082	0.435
CLV_PCSK_SKI1_1	31	35	PF00082	0.523
DOC_MAPK_DCC_7	210	218	PF00069	0.273
DOC_MAPK_MEF2A_6	184	192	PF00069	0.274
DOC_MAPK_MEF2A_6	210	218	PF00069	0.273
DOC_PP2B_LxvP_1	102	105	PF13499	0.513
DOC_PP2B_LxvP_1	211	214	PF13499	0.375
DOC_USP7_MATH_1	17	21	PF00917	0.552
DOC_USP7_MATH_1	300	304	PF00917	0.373
DOC_USP7_MATH_1	61	65	PF00917	0.630
DOC_WW_Pin1_4	57	62	PF00397	0.616
LIG_14-3-3_CanoR_1	275	280	PF00244	0.530
LIG_Actin_WH2_2	181	199	PF00022	0.326
LIG_APCC_ABBA_1	115	120	PF00400	0.479
LIG_APCC_ABBAyCdc20_2	114	120	PF00400	0.483
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BIR_III_4	88	92	PF00653	0.470
LIG_Clathr_ClatBox_1	189	193	PF01394	0.470
LIG_DLG_GKlike_1	197	205	PF00625	0.378
LIG_FHA_1	252	258	PF00498	0.477
LIG_FHA_1	265	271	PF00498	0.386
LIG_FHA_1	5	11	PF00498	0.497
LIG_FHA_1	70	76	PF00498	0.586
LIG_FHA_2	159	165	PF00498	0.414
LIG_FHA_2	253	259	PF00498	0.484
LIG_FHA_2	72	78	PF00498	0.586
LIG_LIR_Gen_1	138	144	PF02991	0.566
LIG_LIR_Gen_1	70	81	PF02991	0.401
LIG_LIR_Nem_3	133	139	PF02991	0.576
LIG_LIR_Nem_3	239	243	PF02991	0.525
LIG_LIR_Nem_3	70	76	PF02991	0.451
LIG_PCNA_yPIPBox_3	95	106	PF02747	0.478
LIG_SH2_NCK_1	86	90	PF00017	0.459
LIG_SH2_STAP1	15	19	PF00017	0.482
LIG_SH2_STAP1	86	90	PF00017	0.477
LIG_SH2_STAT5	158	161	PF00017	0.492
LIG_SH2_STAT5	73	76	PF00017	0.591
LIG_SH2_STAT5	86	89	PF00017	0.304
LIG_SH3_3	101	107	PF00018	0.414
LIG_SH3_3	116	122	PF00018	0.355
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.324
LIG_SUMO_SIM_par_1	186	191	PF11976	0.467
LIG_SUMO_SIM_par_1	266	272	PF11976	0.438
LIG_TRAF2_1	256	259	PF00917	0.428
LIG_WRC_WIRS_1	136	141	PF05994	0.584
LIG_WW_3	103	107	PF00397	0.514
MOD_CK1_1	170	176	PF00069	0.432
MOD_CK1_1	60	66	PF00069	0.713
MOD_CK1_1	67	73	PF00069	0.737
MOD_CK2_1	252	258	PF00069	0.484
MOD_GlcNHglycan	127	130	PF01048	0.628
MOD_GlcNHglycan	144	147	PF01048	0.614
MOD_GlcNHglycan	15	18	PF01048	0.493
MOD_GlcNHglycan	302	305	PF01048	0.423
MOD_GlcNHglycan	63	66	PF01048	0.738
MOD_GSK3_1	125	132	PF00069	0.622
MOD_GSK3_1	13	20	PF00069	0.528
MOD_GSK3_1	275	282	PF00069	0.511
MOD_GSK3_1	57	64	PF00069	0.694
MOD_GSK3_1	67	74	PF00069	0.635
MOD_N-GLC_1	67	72	PF02516	0.657
MOD_NEK2_1	142	147	PF00069	0.605
MOD_NEK2_1	167	172	PF00069	0.377
MOD_NEK2_1	183	188	PF00069	0.460
MOD_NEK2_1	69	74	PF00069	0.606
MOD_NEK2_2	302	307	PF00069	0.260
MOD_PIKK_1	167	173	PF00454	0.432
MOD_PK_1	275	281	PF00069	0.467
MOD_Plk_1	167	173	PF00069	0.410
MOD_Plk_1	252	258	PF00069	0.453
MOD_Plk_4	158	164	PF00069	0.340
MOD_Plk_4	17	23	PF00069	0.284
MOD_Plk_4	170	176	PF00069	0.308
MOD_Plk_4	183	189	PF00069	0.387
MOD_Plk_4	71	77	PF00069	0.503
MOD_ProDKin_1	57	63	PF00069	0.616
MOD_SUMO_rev_2	71	81	PF00179	0.578
MOD_SUMO_rev_2	9	14	PF00179	0.464
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.471
TRG_ENDOCYTIC_2	136	139	PF00928	0.531
TRG_ENDOCYTIC_2	73	76	PF00928	0.436
TRG_ER_diArg_1	214	217	PF00400	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z5	Leptomonas seymouri	68%	100%
A0A0S4J9X0	Bodo saltans	34%	100%
A0A1X0NRW1	Trypanosomatidae	40%	100%
A0A3R7N361	Trypanosoma rangeli	41%	100%
A0A3S7X628	Leishmania donovani	93%	100%
A4HKY9	Leishmania braziliensis	83%	100%
A4I8H0	Leishmania infantum	93%	100%
D0AAP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q5XJQ5	Danio rerio	26%	79%
V5B5R5	Trypanosoma cruzi	40%	100%