Putative RNA-binding, protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding, protein, putative

Species:

Leishmania major

UniProt:

Q4Q4S5_LEIMA

TriTrypDb:

LmjF.32.3470 , LMJLV39_320043000 , LMJSD75_320043000

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.815
CLV_C14_Caspase3-7	441	445	PF00656	0.612
CLV_NRD_NRD_1	341	343	PF00675	0.549
CLV_NRD_NRD_1	377	379	PF00675	0.591
CLV_NRD_NRD_1	386	388	PF00675	0.587
CLV_NRD_NRD_1	389	391	PF00675	0.563
CLV_NRD_NRD_1	394	396	PF00675	0.549
CLV_NRD_NRD_1	58	60	PF00675	0.672
CLV_NRD_NRD_1	74	76	PF00675	0.461
CLV_PCSK_FUR_1	377	381	PF00082	0.589
CLV_PCSK_FUR_1	382	386	PF00082	0.597
CLV_PCSK_KEX2_1	341	343	PF00082	0.549
CLV_PCSK_KEX2_1	376	378	PF00082	0.589
CLV_PCSK_KEX2_1	379	381	PF00082	0.585
CLV_PCSK_KEX2_1	384	386	PF00082	0.601
CLV_PCSK_KEX2_1	393	395	PF00082	0.575
CLV_PCSK_KEX2_1	58	60	PF00082	0.697
CLV_PCSK_KEX2_1	74	76	PF00082	0.461
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.589
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.585
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.575
CLV_PCSK_PC7_1	380	386	PF00082	0.666
CLV_PCSK_PC7_1	390	396	PF00082	0.476
CLV_PCSK_SKI1_1	130	134	PF00082	0.589
CLV_PCSK_SKI1_1	197	201	PF00082	0.682
CLV_PCSK_SKI1_1	342	346	PF00082	0.562
CLV_PCSK_SKI1_1	390	394	PF00082	0.588
CLV_PCSK_SKI1_1	395	399	PF00082	0.575
CLV_PCSK_SKI1_1	472	476	PF00082	0.316
CLV_PCSK_SKI1_1	50	54	PF00082	0.567
CLV_PCSK_SKI1_1	82	86	PF00082	0.564
DEG_APCC_DBOX_1	49	57	PF00400	0.550
DEG_APCC_DBOX_1	81	89	PF00400	0.566
DEG_COP1_1	448	457	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DOC_CDC14_PxL_1	17	25	PF14671	0.678
DOC_CKS1_1	115	120	PF01111	0.705
DOC_CYCLIN_RxL_1	194	205	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	155	158	PF00134	0.618
DOC_MAPK_gen_1	390	400	PF00069	0.685
DOC_MAPK_MEF2A_6	312	319	PF00069	0.473
DOC_MAPK_MEF2A_6	393	402	PF00069	0.472
DOC_PP1_RVXF_1	195	202	PF00149	0.690
DOC_PP2B_LxvP_1	154	157	PF13499	0.763
DOC_PP2B_PxIxI_1	454	460	PF00149	0.280
DOC_PP4_FxxP_1	201	204	PF00568	0.679
DOC_USP7_MATH_1	124	128	PF00917	0.728
DOC_USP7_MATH_1	132	136	PF00917	0.780
DOC_USP7_MATH_1	169	173	PF00917	0.749
DOC_USP7_MATH_1	355	359	PF00917	0.643
DOC_USP7_MATH_1	367	371	PF00917	0.547
DOC_USP7_MATH_1	420	424	PF00917	0.770
DOC_USP7_MATH_1	62	66	PF00917	0.554
DOC_USP7_UBL2_3	414	418	PF12436	0.575
DOC_WW_Pin1_4	114	119	PF00397	0.694
DOC_WW_Pin1_4	130	135	PF00397	0.496
DOC_WW_Pin1_4	147	152	PF00397	0.712
DOC_WW_Pin1_4	171	176	PF00397	0.693
DOC_WW_Pin1_4	249	254	PF00397	0.523
DOC_WW_Pin1_4	435	440	PF00397	0.699
LIG_14-3-3_CanoR_1	485	489	PF00244	0.546
LIG_14-3-3_CanoR_1	502	507	PF00244	0.383
LIG_14-3-3_CanoR_1	522	527	PF00244	0.671
LIG_14-3-3_CanoR_1	97	105	PF00244	0.652
LIG_BRCT_BRCA1_1	491	495	PF00533	0.546
LIG_DLG_GKlike_1	522	530	PF00625	0.660
LIG_eIF4E_1	521	527	PF01652	0.594
LIG_FHA_1	190	196	PF00498	0.521
LIG_FHA_1	219	225	PF00498	0.531
LIG_FHA_1	269	275	PF00498	0.513
LIG_FHA_1	284	290	PF00498	0.497
LIG_FHA_1	328	334	PF00498	0.590
LIG_FHA_1	494	500	PF00498	0.530
LIG_FHA_1	93	99	PF00498	0.671
LIG_FHA_2	148	154	PF00498	0.660
LIG_FHA_2	267	273	PF00498	0.543
LIG_FHA_2	464	470	PF00498	0.531
LIG_FHA_2	478	484	PF00498	0.459
LIG_FHA_2	558	564	PF00498	0.655
LIG_IBAR_NPY_1	240	242	PF08397	0.528
LIG_LIR_Nem_3	89	93	PF02991	0.609
LIG_NRBOX	470	476	PF00104	0.546
LIG_PCNA_PIPBox_1	81	90	PF02747	0.670
LIG_PDZ_Class_2	562	567	PF00595	0.537
LIG_PDZ_Wminus1_1	565	567	PF00595	0.565
LIG_PTB_Apo_2	237	244	PF02174	0.510
LIG_PTB_Apo_2	515	522	PF02174	0.619
LIG_PTB_Phospho_1	515	521	PF10480	0.619
LIG_Rb_pABgroove_1	18	26	PF01858	0.597
LIG_REV1ctd_RIR_1	198	203	PF16727	0.578
LIG_RPA_C_Fungi	373	385	PF08784	0.571
LIG_SH2_CRK	38	42	PF00017	0.707
LIG_SH2_CRK	478	482	PF00017	0.411
LIG_SH2_CRK	524	528	PF00017	0.464
LIG_SH2_NCK_1	524	528	PF00017	0.566
LIG_SH2_STAP1	24	28	PF00017	0.550
LIG_SH2_STAT5	225	228	PF00017	0.524
LIG_SH2_STAT5	242	245	PF00017	0.527
LIG_SH2_STAT5	262	265	PF00017	0.623
LIG_SH2_STAT5	288	291	PF00017	0.462
LIG_SH2_STAT5	310	313	PF00017	0.564
LIG_SH3_3	120	126	PF00018	0.782
LIG_SH3_3	176	182	PF00018	0.739
LIG_SH3_3	553	559	PF00018	0.578
LIG_SUMO_SIM_anti_2	533	539	PF11976	0.543
LIG_SUMO_SIM_par_1	291	298	PF11976	0.421
LIG_SUMO_SIM_par_1	50	55	PF11976	0.562
LIG_SUMO_SIM_par_1	536	542	PF11976	0.543
LIG_TRAF2_1	410	413	PF00917	0.773
LIG_TRAF2_1	505	508	PF00917	0.411
MOD_CDK_SPxK_1	135	141	PF00069	0.746
MOD_CDK_SPxxK_3	171	178	PF00069	0.806
MOD_CDK_SPxxK_3	249	256	PF00069	0.503
MOD_CK1_1	135	141	PF00069	0.650
MOD_CK1_1	174	180	PF00069	0.718
MOD_CK1_1	280	286	PF00069	0.553
MOD_CK1_1	358	364	PF00069	0.661
MOD_CK1_1	407	413	PF00069	0.706
MOD_CK1_1	422	428	PF00069	0.641
MOD_CK1_1	430	436	PF00069	0.713
MOD_CK1_1	438	444	PF00069	0.720
MOD_CK1_1	525	531	PF00069	0.552
MOD_CK1_1	99	105	PF00069	0.682
MOD_CK2_1	147	153	PF00069	0.806
MOD_CK2_1	266	272	PF00069	0.537
MOD_CK2_1	407	413	PF00069	0.693
MOD_CK2_1	477	483	PF00069	0.397
MOD_CK2_1	502	508	PF00069	0.387
MOD_CK2_1	557	563	PF00069	0.619
MOD_CK2_1	86	92	PF00069	0.613
MOD_GlcNHglycan	126	129	PF01048	0.734
MOD_GlcNHglycan	165	168	PF01048	0.826
MOD_GlcNHglycan	169	172	PF01048	0.796
MOD_GlcNHglycan	282	285	PF01048	0.640
MOD_GlcNHglycan	359	363	PF01048	0.694
MOD_GlcNHglycan	370	373	PF01048	0.467
MOD_GlcNHglycan	422	425	PF01048	0.794
MOD_GlcNHglycan	426	429	PF01048	0.811
MOD_GlcNHglycan	444	447	PF01048	0.615
MOD_GlcNHglycan	489	494	PF01048	0.411
MOD_GlcNHglycan	527	530	PF01048	0.422
MOD_GlcNHglycan	62	65	PF01048	0.715
MOD_GSK3_1	126	133	PF00069	0.687
MOD_GSK3_1	145	152	PF00069	0.639
MOD_GSK3_1	163	170	PF00069	0.633
MOD_GSK3_1	189	196	PF00069	0.702
MOD_GSK3_1	403	410	PF00069	0.680
MOD_GSK3_1	419	426	PF00069	0.583
MOD_GSK3_1	428	435	PF00069	0.680
MOD_GSK3_1	438	445	PF00069	0.715
MOD_GSK3_1	489	496	PF00069	0.357
MOD_GSK3_1	60	67	PF00069	0.620
MOD_GSK3_1	92	99	PF00069	0.700
MOD_N-GLC_1	60	65	PF02516	0.617
MOD_NEK2_1	218	223	PF00069	0.555
MOD_NEK2_1	266	271	PF00069	0.460
MOD_NEK2_1	37	42	PF00069	0.555
MOD_NEK2_1	510	515	PF00069	0.420
MOD_NEK2_1	60	65	PF00069	0.695
MOD_PIKK_1	26	32	PF00454	0.694
MOD_PK_1	393	399	PF00069	0.692
MOD_PK_1	502	508	PF00069	0.474
MOD_PK_1	547	553	PF00069	0.543
MOD_PKA_1	393	399	PF00069	0.692
MOD_PKA_2	167	173	PF00069	0.824
MOD_PKA_2	202	208	PF00069	0.703
MOD_PKA_2	393	399	PF00069	0.692
MOD_PKA_2	484	490	PF00069	0.411
MOD_PKA_2	96	102	PF00069	0.688
MOD_Plk_1	235	241	PF00069	0.540
MOD_Plk_1	433	439	PF00069	0.573
MOD_Plk_4	283	289	PF00069	0.475
MOD_Plk_4	522	528	PF00069	0.486
MOD_ProDKin_1	114	120	PF00069	0.696
MOD_ProDKin_1	130	136	PF00069	0.498
MOD_ProDKin_1	147	153	PF00069	0.715
MOD_ProDKin_1	171	177	PF00069	0.692
MOD_ProDKin_1	249	255	PF00069	0.522
MOD_ProDKin_1	435	441	PF00069	0.693
MOD_SUMO_rev_2	406	416	PF00179	0.558
TRG_DiLeu_BaEn_4	507	513	PF01217	0.513
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.634
TRG_ENDOCYTIC_2	225	228	PF00928	0.524
TRG_ENDOCYTIC_2	24	27	PF00928	0.580
TRG_ENDOCYTIC_2	246	249	PF00928	0.530
TRG_ENDOCYTIC_2	34	37	PF00928	0.613
TRG_ENDOCYTIC_2	38	41	PF00928	0.605
TRG_ENDOCYTIC_2	478	481	PF00928	0.411
TRG_ENDOCYTIC_2	524	527	PF00928	0.421
TRG_ER_diArg_1	340	342	PF00400	0.521
TRG_ER_diArg_1	347	350	PF00400	0.601
TRG_ER_diArg_1	377	380	PF00400	0.592
TRG_ER_diArg_1	382	385	PF00400	0.598
TRG_ER_diArg_1	58	60	PF00400	0.697
TRG_ER_diArg_1	74	76	PF00400	0.461
TRG_NLS_Bipartite_1	376	397	PF00514	0.583
TRG_NLS_MonoExtC_3	377	382	PF00514	0.599
TRG_NLS_MonoExtN_4	376	383	PF00514	0.588
TRG_NLS_MonoExtN_4	390	397	PF00514	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT8	Leptomonas seymouri	53%	100%
A0A3Q8IDF9	Leishmania donovani	93%	100%
A4HKZ0	Leishmania braziliensis	77%	100%
A4I8H1	Leishmania infantum	92%	100%
E9B3D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%