TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4S4_LEIMA

TriTrypDb:

LmjF.32.3480 , LMJLV39_320043100 , LMJSD75_320043100

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.809
CLV_NRD_NRD_1	390	392	PF00675	0.532
CLV_NRD_NRD_1	431	433	PF00675	0.518
CLV_NRD_NRD_1	6	8	PF00675	0.731
CLV_PCSK_KEX2_1	12	14	PF00082	0.691
CLV_PCSK_KEX2_1	389	391	PF00082	0.514
CLV_PCSK_KEX2_1	431	433	PF00082	0.548
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.728
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.514
CLV_PCSK_PC7_1	427	433	PF00082	0.360
CLV_PCSK_SKI1_1	13	17	PF00082	0.734
CLV_PCSK_SKI1_1	225	229	PF00082	0.491
CLV_PCSK_SKI1_1	343	347	PF00082	0.518
CLV_PCSK_SKI1_1	362	366	PF00082	0.643
DEG_APCC_DBOX_1	12	20	PF00400	0.738
DEG_APCC_DBOX_1	257	265	PF00400	0.501
DEG_APCC_DBOX_1	442	450	PF00400	0.514
DOC_CKS1_1	24	29	PF01111	0.754
DOC_CYCLIN_yClb5_NLxxxL_5	469	478	PF00134	0.616
DOC_MAPK_MEF2A_6	243	251	PF00069	0.470
DOC_MAPK_MEF2A_6	258	265	PF00069	0.490
DOC_MAPK_MEF2A_6	270	277	PF00069	0.416
DOC_MAPK_MEF2A_6	554	563	PF00069	0.474
DOC_MAPK_NFAT4_5	270	278	PF00069	0.457
DOC_PP2B_LxvP_1	19	22	PF13499	0.741
DOC_PP2B_LxvP_1	561	564	PF13499	0.598
DOC_PP4_FxxP_1	15	18	PF00568	0.733
DOC_USP7_MATH_1	11	15	PF00917	0.769
DOC_USP7_MATH_1	168	172	PF00917	0.602
DOC_USP7_MATH_1	381	385	PF00917	0.643
DOC_USP7_MATH_1	483	487	PF00917	0.672
DOC_USP7_MATH_1	496	500	PF00917	0.701
DOC_USP7_MATH_1	528	532	PF00917	0.521
DOC_USP7_MATH_1	617	621	PF00917	0.551
DOC_USP7_UBL2_3	361	365	PF12436	0.616
DOC_USP7_UBL2_3	8	12	PF12436	0.687
DOC_WW_Pin1_4	23	28	PF00397	0.724
LIG_14-3-3_CanoR_1	184	194	PF00244	0.450
LIG_14-3-3_CanoR_1	198	206	PF00244	0.450
LIG_14-3-3_CanoR_1	343	348	PF00244	0.460
LIG_14-3-3_CanoR_1	405	414	PF00244	0.514
LIG_14-3-3_CanoR_1	431	435	PF00244	0.490
LIG_14-3-3_CanoR_1	443	447	PF00244	0.400
LIG_14-3-3_CanoR_1	506	512	PF00244	0.695
LIG_14-3-3_CanoR_1	90	98	PF00244	0.641
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BRCT_BRCA1_1	522	526	PF00533	0.526
LIG_BRCT_BRCA1_1	608	612	PF00533	0.486
LIG_eIF4E_1	272	278	PF01652	0.481
LIG_FHA_1	142	148	PF00498	0.566
LIG_FHA_1	291	297	PF00498	0.503
LIG_FHA_1	418	424	PF00498	0.528
LIG_FHA_1	43	49	PF00498	0.571
LIG_FHA_1	496	502	PF00498	0.695
LIG_FHA_1	506	512	PF00498	0.679
LIG_FHA_1	551	557	PF00498	0.476
LIG_FHA_2	200	206	PF00498	0.582
LIG_FHA_2	230	236	PF00498	0.617
LIG_FHA_2	344	350	PF00498	0.544
LIG_FHA_2	97	103	PF00498	0.687
LIG_LIR_Apic_2	14	18	PF02991	0.731
LIG_LIR_Apic_2	181	186	PF02991	0.566
LIG_LIR_Gen_1	215	223	PF02991	0.459
LIG_LIR_Gen_1	433	442	PF02991	0.412
LIG_LIR_Gen_1	49	58	PF02991	0.589
LIG_LIR_Gen_1	508	517	PF02991	0.724
LIG_LIR_Gen_1	523	534	PF02991	0.375
LIG_LIR_Nem_3	215	220	PF02991	0.455
LIG_LIR_Nem_3	271	275	PF02991	0.516
LIG_LIR_Nem_3	433	437	PF02991	0.414
LIG_LIR_Nem_3	49	53	PF02991	0.586
LIG_LIR_Nem_3	508	512	PF02991	0.731
LIG_LIR_Nem_3	523	529	PF02991	0.390
LIG_LIR_Nem_3	607	613	PF02991	0.558
LIG_NRBOX	276	282	PF00104	0.368
LIG_Pex14_2	213	217	PF04695	0.470
LIG_SH2_CRK	183	187	PF00017	0.542
LIG_SH2_CRK	272	276	PF00017	0.472
LIG_SH2_NCK_1	288	292	PF00017	0.493
LIG_SH2_NCK_1	613	617	PF00017	0.535
LIG_SH2_SRC	288	291	PF00017	0.521
LIG_SH2_STAP1	613	617	PF00017	0.524
LIG_SH2_STAT3	633	636	PF00017	0.546
LIG_SH2_STAT5	151	154	PF00017	0.516
LIG_SH2_STAT5	240	243	PF00017	0.447
LIG_SH2_STAT5	593	596	PF00017	0.479
LIG_SH2_STAT5	613	616	PF00017	0.231
LIG_SH2_STAT5	630	633	PF00017	0.266
LIG_SH3_3	21	27	PF00018	0.725
LIG_SH3_3	38	44	PF00018	0.525
LIG_SH3_3	461	467	PF00018	0.622
LIG_SH3_3	618	624	PF00018	0.445
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.440
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.448
LIG_SUMO_SIM_par_1	274	279	PF11976	0.386
LIG_SUMO_SIM_par_1	68	77	PF11976	0.642
LIG_TRAF2_1	136	139	PF00917	0.792
LIG_TRAF2_1	333	336	PF00917	0.545
LIG_TRAF2_2	627	632	PF00917	0.437
LIG_UBA3_1	261	270	PF00899	0.577
MOD_CK1_1	123	129	PF00069	0.732
MOD_CK1_1	218	224	PF00069	0.486
MOD_CK1_1	34	40	PF00069	0.775
MOD_CK1_1	510	516	PF00069	0.614
MOD_CK1_1	89	95	PF00069	0.609
MOD_CK2_1	106	112	PF00069	0.773
MOD_CK2_1	229	235	PF00069	0.621
MOD_CK2_1	381	387	PF00069	0.556
MOD_CK2_1	43	49	PF00069	0.583
MOD_CK2_1	612	618	PF00069	0.470
MOD_CK2_1	96	102	PF00069	0.683
MOD_GlcNHglycan	1	4	PF01048	0.788
MOD_GlcNHglycan	121	125	PF01048	0.715
MOD_GlcNHglycan	131	134	PF01048	0.708
MOD_GlcNHglycan	170	173	PF01048	0.544
MOD_GlcNHglycan	34	37	PF01048	0.655
MOD_GlcNHglycan	352	355	PF01048	0.560
MOD_GlcNHglycan	384	387	PF01048	0.611
MOD_GlcNHglycan	45	48	PF01048	0.514
MOD_GlcNHglycan	498	501	PF01048	0.681
MOD_GlcNHglycan	512	515	PF01048	0.575
MOD_GlcNHglycan	564	567	PF01048	0.483
MOD_GlcNHglycan	60	63	PF01048	0.507
MOD_GlcNHglycan	614	617	PF01048	0.424
MOD_GlcNHglycan	91	94	PF01048	0.690
MOD_GSK3_1	397	404	PF00069	0.504
MOD_GSK3_1	479	486	PF00069	0.659
MOD_GSK3_1	501	508	PF00069	0.654
MOD_GSK3_1	92	99	PF00069	0.654
MOD_NEK2_1	276	281	PF00069	0.378
MOD_NEK2_1	406	411	PF00069	0.557
MOD_NEK2_1	437	442	PF00069	0.410
MOD_NEK2_1	512	517	PF00069	0.596
MOD_NEK2_1	550	555	PF00069	0.477
MOD_NEK2_1	58	63	PF00069	0.589
MOD_NEK2_1	612	617	PF00069	0.475
MOD_NEK2_2	507	512	PF00069	0.652
MOD_PIKK_1	437	443	PF00454	0.461
MOD_PKA_1	360	366	PF00069	0.616
MOD_PKA_2	229	235	PF00069	0.578
MOD_PKA_2	430	436	PF00069	0.462
MOD_PKA_2	442	448	PF00069	0.385
MOD_PKA_2	505	511	PF00069	0.738
MOD_PKA_2	89	95	PF00069	0.657
MOD_Plk_1	606	612	PF00069	0.468
MOD_Plk_1	617	623	PF00069	0.516
MOD_Plk_2-3	229	235	PF00069	0.630
MOD_Plk_4	268	274	PF00069	0.456
MOD_Plk_4	276	282	PF00069	0.350
MOD_Plk_4	442	448	PF00069	0.490
MOD_Plk_4	529	535	PF00069	0.443
MOD_Plk_4	545	551	PF00069	0.319
MOD_ProDKin_1	23	29	PF00069	0.724
MOD_SUMO_rev_2	84	89	PF00179	0.604
TRG_DiLeu_BaEn_1	545	550	PF01217	0.433
TRG_DiLeu_BaEn_1	68	73	PF01217	0.596
TRG_DiLeu_BaEn_3	68	74	PF01217	0.626
TRG_DiLeu_BaEn_3	76	82	PF01217	0.571
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.589
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.502
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.526
TRG_ENDOCYTIC_2	272	275	PF00928	0.483
TRG_ER_diArg_1	390	392	PF00400	0.532
TRG_ER_diArg_1	430	432	PF00400	0.562
TRG_ER_diArg_1	447	450	PF00400	0.330
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK53	Leptomonas seymouri	61%	99%
A0A1X0NRY3	Trypanosomatidae	27%	100%
A0A3Q8IHE5	Leishmania donovani	94%	100%
A0A422P2Z2	Trypanosoma rangeli	28%	100%
A4HKZ1	Leishmania braziliensis	72%	100%
A4I8H2	Leishmania infantum	94%	100%
D0AAP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B3D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BQY9	Trypanosoma cruzi	26%	100%