Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase, putative

Species:

Leishmania major

UniProt:

Q4Q4S3_LEIMA

TriTrypDb:

LmjF.32.3490 , LMJLV39_320043300 , LMJSD75_320043300

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q4S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.733
CLV_C14_Caspase3-7	517	521	PF00656	0.598
CLV_C14_Caspase3-7	679	683	PF00656	0.575
CLV_NRD_NRD_1	2	4	PF00675	0.611
CLV_NRD_NRD_1	220	222	PF00675	0.297
CLV_NRD_NRD_1	233	235	PF00675	0.246
CLV_NRD_NRD_1	261	263	PF00675	0.269
CLV_NRD_NRD_1	271	273	PF00675	0.271
CLV_NRD_NRD_1	344	346	PF00675	0.438
CLV_NRD_NRD_1	501	503	PF00675	0.524
CLV_NRD_NRD_1	505	507	PF00675	0.523
CLV_NRD_NRD_1	513	515	PF00675	0.530
CLV_NRD_NRD_1	537	539	PF00675	0.669
CLV_NRD_NRD_1	588	590	PF00675	0.499
CLV_NRD_NRD_1	8	10	PF00675	0.575
CLV_PCSK_KEX2_1	14	16	PF00082	0.560
CLV_PCSK_KEX2_1	220	222	PF00082	0.297
CLV_PCSK_KEX2_1	260	262	PF00082	0.263
CLV_PCSK_KEX2_1	267	269	PF00082	0.262
CLV_PCSK_KEX2_1	271	273	PF00082	0.261
CLV_PCSK_KEX2_1	344	346	PF00082	0.438
CLV_PCSK_KEX2_1	43	45	PF00082	0.493
CLV_PCSK_KEX2_1	500	502	PF00082	0.521
CLV_PCSK_KEX2_1	537	539	PF00082	0.669
CLV_PCSK_KEX2_1	588	590	PF00082	0.545
CLV_PCSK_KEX2_1	665	667	PF00082	0.483
CLV_PCSK_KEX2_1	8	10	PF00082	0.585
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.567
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.300
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.591
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.544
CLV_PCSK_PC7_1	256	262	PF00082	0.388
CLV_PCSK_SKI1_1	172	176	PF00082	0.212
CLV_PCSK_SKI1_1	204	208	PF00082	0.269
CLV_PCSK_SKI1_1	220	224	PF00082	0.296
CLV_PCSK_SKI1_1	314	318	PF00082	0.291
CLV_PCSK_SKI1_1	345	349	PF00082	0.449
CLV_PCSK_SKI1_1	36	40	PF00082	0.632
CLV_PCSK_SKI1_1	387	391	PF00082	0.504
CLV_PCSK_SKI1_1	49	53	PF00082	0.532
CLV_PCSK_SKI1_1	644	648	PF00082	0.547
CLV_Separin_Metazoa	225	229	PF03568	0.519
DEG_APCC_DBOX_1	399	407	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.702
DEG_SIAH_1	75	83	PF03145	0.629
DEG_SPOP_SBC_1	112	116	PF00917	0.705
DEG_SPOP_SBC_1	117	121	PF00917	0.651
DOC_CKS1_1	248	253	PF01111	0.448
DOC_CYCLIN_RxL_1	311	320	PF00134	0.562
DOC_CYCLIN_RxL_1	344	356	PF00134	0.613
DOC_CYCLIN_RxL_1	8	22	PF00134	0.642
DOC_MAPK_gen_1	164	173	PF00069	0.464
DOC_MAPK_gen_1	318	328	PF00069	0.481
DOC_MAPK_gen_1	631	641	PF00069	0.445
DOC_MAPK_gen_1	662	672	PF00069	0.504
DOC_MAPK_gen_1	8	18	PF00069	0.692
DOC_MAPK_MEF2A_6	11	20	PF00069	0.682
DOC_MAPK_MEF2A_6	153	161	PF00069	0.456
DOC_MAPK_MEF2A_6	321	330	PF00069	0.478
DOC_MAPK_MEF2A_6	631	639	PF00069	0.513
DOC_PP1_RVXF_1	202	208	PF00149	0.464
DOC_PP1_RVXF_1	34	41	PF00149	0.550
DOC_PP2B_LxvP_1	446	449	PF13499	0.463
DOC_PP2B_LxvP_1	584	587	PF13499	0.690
DOC_PP2B_LxvP_1	602	605	PF13499	0.483
DOC_PP4_FxxP_1	632	635	PF00568	0.573
DOC_USP7_MATH_1	112	116	PF00917	0.734
DOC_USP7_MATH_1	117	121	PF00917	0.684
DOC_USP7_MATH_1	208	212	PF00917	0.504
DOC_USP7_MATH_1	363	367	PF00917	0.665
DOC_USP7_MATH_1	371	375	PF00917	0.696
DOC_USP7_MATH_1	416	420	PF00917	0.711
DOC_USP7_MATH_1	552	556	PF00917	0.775
DOC_USP7_MATH_1	573	577	PF00917	0.704
DOC_USP7_MATH_1	635	639	PF00917	0.580
DOC_WW_Pin1_4	247	252	PF00397	0.464
DOC_WW_Pin1_4	530	535	PF00397	0.718
DOC_WW_Pin1_4	565	570	PF00397	0.710
DOC_WW_Pin1_4	579	584	PF00397	0.641
LIG_14-3-3_CanoR_1	274	280	PF00244	0.468
LIG_14-3-3_CanoR_1	480	486	PF00244	0.567
LIG_14-3-3_CanoR_1	53	59	PF00244	0.591
LIG_14-3-3_CanoR_1	589	599	PF00244	0.544
LIG_14-3-3_CanoR_1	634	640	PF00244	0.568
LIG_Actin_WH2_2	16	33	PF00022	0.598
LIG_BRCT_BRCA1_1	119	123	PF00533	0.657
LIG_BRCT_BRCA1_1	532	536	PF00533	0.602
LIG_CaM_IQ_9	392	407	PF13499	0.551
LIG_CaM_IQ_9	492	508	PF13499	0.460
LIG_Clathr_ClatBox_1	290	294	PF01394	0.464
LIG_CtBP_PxDLS_1	69	73	PF00389	0.484
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.527
LIG_deltaCOP1_diTrp_1	252	257	PF00928	0.478
LIG_eIF4E_1	346	352	PF01652	0.589
LIG_FHA_1	138	144	PF00498	0.525
LIG_FHA_1	152	158	PF00498	0.420
LIG_FHA_1	173	179	PF00498	0.520
LIG_FHA_1	208	214	PF00498	0.468
LIG_FHA_1	221	227	PF00498	0.464
LIG_FHA_1	231	237	PF00498	0.470
LIG_FHA_1	248	254	PF00498	0.393
LIG_FHA_1	285	291	PF00498	0.484
LIG_FHA_1	354	360	PF00498	0.527
LIG_FHA_1	480	486	PF00498	0.646
LIG_FHA_1	490	496	PF00498	0.536
LIG_FHA_1	606	612	PF00498	0.432
LIG_FHA_1	615	621	PF00498	0.442
LIG_FHA_2	247	253	PF00498	0.562
LIG_FHA_2	393	399	PF00498	0.415
LIG_FHA_2	616	622	PF00498	0.524
LIG_HCF-1_HBM_1	216	219	PF13415	0.552
LIG_LIR_Apic_2	195	200	PF02991	0.553
LIG_LIR_Apic_2	320	325	PF02991	0.525
LIG_LIR_Gen_1	25	33	PF02991	0.522
LIG_LIR_Gen_1	278	285	PF02991	0.512
LIG_LIR_Gen_1	442	449	PF02991	0.536
LIG_LIR_Nem_3	120	126	PF02991	0.557
LIG_LIR_Nem_3	216	222	PF02991	0.521
LIG_LIR_Nem_3	25	30	PF02991	0.517
LIG_LIR_Nem_3	252	258	PF02991	0.484
LIG_LIR_Nem_3	442	446	PF02991	0.541
LIG_LIR_Nem_3	533	539	PF02991	0.657
LIG_MYND_1	412	416	PF01753	0.632
LIG_PCNA_yPIPBox_3	310	321	PF02747	0.541
LIG_PTB_Apo_2	239	246	PF02174	0.552
LIG_PTB_Phospho_1	239	245	PF10480	0.552
LIG_RPA_C_Fungi	256	268	PF08784	0.387
LIG_RPA_C_Fungi	359	371	PF08784	0.628
LIG_SH2_CRK	219	223	PF00017	0.310
LIG_SH2_CRK	322	326	PF00017	0.334
LIG_SH2_PTP2	245	248	PF00017	0.287
LIG_SH2_PTP2	443	446	PF00017	0.435
LIG_SH2_SRC	94	97	PF00017	0.535
LIG_SH2_STAP1	277	281	PF00017	0.433
LIG_SH2_STAT3	138	141	PF00017	0.330
LIG_SH2_STAT5	184	187	PF00017	0.436
LIG_SH2_STAT5	245	248	PF00017	0.310
LIG_SH2_STAT5	319	322	PF00017	0.447
LIG_SH2_STAT5	391	394	PF00017	0.395
LIG_SH2_STAT5	443	446	PF00017	0.505
LIG_SH2_STAT5	484	487	PF00017	0.599
LIG_SH2_STAT5	94	97	PF00017	0.415
LIG_SH3_2	583	588	PF14604	0.578
LIG_SH3_3	142	148	PF00018	0.435
LIG_SH3_3	245	251	PF00018	0.287
LIG_SH3_3	458	464	PF00018	0.522
LIG_SH3_3	520	526	PF00018	0.644
LIG_SH3_3	580	586	PF00018	0.665
LIG_SH3_3	76	82	PF00018	0.550
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.433
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.314
LIG_SUMO_SIM_anti_2	442	448	PF11976	0.392
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.418
LIG_SUMO_SIM_anti_2	638	643	PF11976	0.397
LIG_SUMO_SIM_par_1	175	181	PF11976	0.433
LIG_SUMO_SIM_par_1	289	295	PF11976	0.310
LIG_SUMO_SIM_par_1	444	450	PF11976	0.364
LIG_TRFH_1	279	283	PF08558	0.330
LIG_UBA3_1	312	321	PF00899	0.310
LIG_UBA3_1	444	453	PF00899	0.452
LIG_WW_3	585	589	PF00397	0.577
MOD_CDC14_SPxK_1	582	585	PF00782	0.624
MOD_CDK_SPxK_1	579	585	PF00069	0.633
MOD_CDK_SPxxK_3	530	537	PF00069	0.469
MOD_CK1_1	105	111	PF00069	0.620
MOD_CK1_1	115	121	PF00069	0.585
MOD_CK1_1	211	217	PF00069	0.383
MOD_CK1_1	430	436	PF00069	0.775
MOD_CK1_1	564	570	PF00069	0.733
MOD_CK2_1	392	398	PF00069	0.424
MOD_CK2_1	615	621	PF00069	0.442
MOD_GlcNHglycan	115	118	PF01048	0.613
MOD_GlcNHglycan	331	334	PF01048	0.310
MOD_GlcNHglycan	365	368	PF01048	0.731
MOD_GlcNHglycan	418	421	PF01048	0.707
MOD_GlcNHglycan	433	436	PF01048	0.575
MOD_GlcNHglycan	527	530	PF01048	0.655
MOD_GlcNHglycan	644	647	PF01048	0.444
MOD_GlcNHglycan	678	681	PF01048	0.600
MOD_GSK3_1	102	109	PF00069	0.569
MOD_GSK3_1	111	118	PF00069	0.645
MOD_GSK3_1	207	214	PF00069	0.435
MOD_GSK3_1	25	32	PF00069	0.518
MOD_GSK3_1	331	338	PF00069	0.310
MOD_GSK3_1	371	378	PF00069	0.612
MOD_GSK3_1	426	433	PF00069	0.657
MOD_GSK3_1	560	567	PF00069	0.732
MOD_GSK3_1	573	580	PF00069	0.670
MOD_GSK3_1	59	66	PF00069	0.594
MOD_N-GLC_1	102	107	PF02516	0.655
MOD_N-GLC_1	211	216	PF02516	0.433
MOD_N-GLC_1	543	548	PF02516	0.609
MOD_NEK2_1	106	111	PF00069	0.712
MOD_NEK2_1	173	178	PF00069	0.392
MOD_NEK2_1	207	212	PF00069	0.336
MOD_NEK2_1	317	322	PF00069	0.378
MOD_NEK2_1	335	340	PF00069	0.190
MOD_NEK2_1	407	412	PF00069	0.477
MOD_NEK2_1	489	494	PF00069	0.649
MOD_NEK2_1	577	582	PF00069	0.736
MOD_NEK2_1	59	64	PF00069	0.568
MOD_NEK2_1	642	647	PF00069	0.473
MOD_NEK2_1	653	658	PF00069	0.480
MOD_NEK2_1	99	104	PF00069	0.619
MOD_PIKK_1	137	143	PF00454	0.377
MOD_PIKK_1	228	234	PF00454	0.237
MOD_PIKK_1	300	306	PF00454	0.417
MOD_PIKK_1	392	398	PF00454	0.585
MOD_PIKK_1	472	478	PF00454	0.715
MOD_PIKK_1	554	560	PF00454	0.760
MOD_PKA_1	220	226	PF00069	0.355
MOD_PKA_2	220	226	PF00069	0.310
MOD_PKA_2	317	323	PF00069	0.433
MOD_PKA_2	363	369	PF00069	0.599
MOD_PKA_2	479	485	PF00069	0.579
MOD_PKA_2	52	58	PF00069	0.522
MOD_PKB_1	500	508	PF00069	0.619
MOD_Plk_1	102	108	PF00069	0.577
MOD_Plk_1	489	495	PF00069	0.606
MOD_Plk_1	49	55	PF00069	0.532
MOD_Plk_1	59	65	PF00069	0.558
MOD_Plk_4	173	179	PF00069	0.387
MOD_Plk_4	637	643	PF00069	0.440
MOD_ProDKin_1	247	253	PF00069	0.310
MOD_ProDKin_1	530	536	PF00069	0.710
MOD_ProDKin_1	565	571	PF00069	0.707
MOD_ProDKin_1	579	585	PF00069	0.633
MOD_SUMO_for_1	452	455	PF00179	0.488
TRG_DiLeu_BaEn_2	503	509	PF01217	0.613
TRG_DiLeu_BaEn_4	25	31	PF01217	0.648
TRG_ENDOCYTIC_2	219	222	PF00928	0.310
TRG_ENDOCYTIC_2	245	248	PF00928	0.287
TRG_ENDOCYTIC_2	443	446	PF00928	0.536
TRG_ER_diArg_1	219	221	PF00400	0.355
TRG_ER_diArg_1	260	262	PF00400	0.346
TRG_ER_diArg_1	271	274	PF00400	0.308
TRG_ER_diArg_1	343	345	PF00400	0.433
TRG_ER_diArg_1	500	502	PF00400	0.580
TRG_ER_diArg_1	536	538	PF00400	0.662
TRG_ER_diArg_1	587	589	PF00400	0.502
TRG_ER_diArg_1	7	9	PF00400	0.544
TRG_NES_CRM1_1	483	499	PF08389	0.484
TRG_NES_CRM1_1	603	615	PF08389	0.475
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	471	476	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I401	Leptomonas seymouri	68%	99%
A0A1X0NSB4	Trypanosomatidae	45%	100%
A0A3R7NUR2	Trypanosoma rangeli	52%	100%
A0A3S7X625	Leishmania donovani	95%	100%
A4HKZ2	Leishmania braziliensis	85%	100%
A4I8H3	Leishmania infantum	95%	100%
D0AAP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BVL4	Trypanosoma cruzi	54%	100%