START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4S1_LEIMA

TriTrypDb:

LmjF.32.3530 , LMJLV39_320043400 , LMJSD75_320043400

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4S1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.619
CLV_C14_Caspase3-7	427	431	PF00656	0.649
CLV_MEL_PAP_1	22	28	PF00089	0.520
CLV_MEL_PAP_1	7	13	PF00089	0.673
CLV_NRD_NRD_1	124	126	PF00675	0.697
CLV_NRD_NRD_1	163	165	PF00675	0.658
CLV_NRD_NRD_1	227	229	PF00675	0.627
CLV_NRD_NRD_1	258	260	PF00675	0.503
CLV_NRD_NRD_1	387	389	PF00675	0.702
CLV_NRD_NRD_1	409	411	PF00675	0.604
CLV_PCSK_KEX2_1	124	126	PF00082	0.697
CLV_PCSK_KEX2_1	163	165	PF00082	0.658
CLV_PCSK_KEX2_1	227	229	PF00082	0.607
CLV_PCSK_KEX2_1	329	331	PF00082	0.549
CLV_PCSK_KEX2_1	502	504	PF00082	0.808
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.549
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.808
CLV_PCSK_SKI1_1	181	185	PF00082	0.649
CLV_PCSK_SKI1_1	249	253	PF00082	0.486
DEG_Nend_UBRbox_2	1	3	PF02207	0.654
DOC_ANK_TNKS_1	230	237	PF00023	0.611
DOC_CDC14_PxL_1	87	95	PF14671	0.669
DOC_CKS1_1	363	368	PF01111	0.499
DOC_MAPK_FxFP_2	114	117	PF00069	0.658
DOC_MAPK_FxFP_2	182	185	PF00069	0.644
DOC_MAPK_gen_1	227	235	PF00069	0.613
DOC_MAPK_gen_1	329	337	PF00069	0.528
DOC_MAPK_gen_1	388	395	PF00069	0.531
DOC_MAPK_gen_1	461	469	PF00069	0.512
DOC_PP4_FxxP_1	114	117	PF00568	0.658
DOC_PP4_FxxP_1	182	185	PF00568	0.644
DOC_PP4_FxxP_1	192	195	PF00568	0.511
DOC_PP4_FxxP_1	348	351	PF00568	0.508
DOC_PP4_FxxP_1	491	494	PF00568	0.616
DOC_USP7_MATH_1	117	121	PF00917	0.663
DOC_USP7_MATH_1	310	314	PF00917	0.564
DOC_USP7_MATH_1	429	433	PF00917	0.536
DOC_USP7_UBL2_3	260	264	PF12436	0.517
DOC_USP7_UBL2_3	446	450	PF12436	0.582
DOC_WW_Pin1_4	115	120	PF00397	0.659
DOC_WW_Pin1_4	163	168	PF00397	0.751
DOC_WW_Pin1_4	362	367	PF00397	0.493
DOC_WW_Pin1_4	44	49	PF00397	0.736
DOC_WW_Pin1_4	92	97	PF00397	0.673
LIG_14-3-3_CanoR_1	10	19	PF00244	0.678
LIG_14-3-3_CanoR_1	124	128	PF00244	0.706
LIG_14-3-3_CanoR_1	163	167	PF00244	0.655
LIG_14-3-3_CanoR_1	168	174	PF00244	0.603
LIG_14-3-3_CanoR_1	176	181	PF00244	0.471
LIG_14-3-3_CanoR_1	283	289	PF00244	0.506
LIG_14-3-3_CanoR_1	352	358	PF00244	0.453
LIG_BRCT_BRCA1_1	151	155	PF00533	0.681
LIG_BRCT_BRCA1_1	178	182	PF00533	0.645
LIG_eIF4E_1	316	322	PF01652	0.494
LIG_EVH1_1	90	94	PF00568	0.686
LIG_FHA_1	189	195	PF00498	0.667
LIG_FHA_1	283	289	PF00498	0.506
LIG_FHA_1	291	297	PF00498	0.375
LIG_FHA_1	434	440	PF00498	0.498
LIG_FHA_2	204	210	PF00498	0.716
LIG_FHA_2	221	227	PF00498	0.611
LIG_LIR_Apic_2	179	185	PF02991	0.645
LIG_LIR_Apic_2	191	195	PF02991	0.531
LIG_LIR_Apic_2	207	213	PF02991	0.497
LIG_LIR_Apic_2	339	345	PF02991	0.483
LIG_LIR_Apic_2	371	376	PF02991	0.554
LIG_LIR_Apic_2	488	494	PF02991	0.606
LIG_LIR_Gen_1	237	248	PF02991	0.497
LIG_LIR_Gen_1	262	273	PF02991	0.507
LIG_LIR_Gen_1	356	364	PF02991	0.465
LIG_LIR_Gen_1	420	429	PF02991	0.498
LIG_LIR_Nem_3	109	114	PF02991	0.657
LIG_LIR_Nem_3	191	196	PF02991	0.740
LIG_LIR_Nem_3	237	243	PF02991	0.520
LIG_LIR_Nem_3	262	268	PF02991	0.510
LIG_LIR_Nem_3	356	360	PF02991	0.466
LIG_LIR_Nem_3	420	424	PF02991	0.490
LIG_MLH1_MIPbox_1	151	155	PF16413	0.681
LIG_NRBOX	18	24	PF00104	0.665
LIG_NRBOX	359	365	PF00104	0.473
LIG_Pex14_2	193	197	PF04695	0.774
LIG_SH2_CRK	318	322	PF00017	0.485
LIG_SH2_CRK	342	346	PF00017	0.497
LIG_SH2_CRK	421	425	PF00017	0.488
LIG_SH2_GRB2like	483	486	PF00017	0.578
LIG_SH2_PTP2	357	360	PF00017	0.470
LIG_SH2_SRC	210	213	PF00017	0.712
LIG_SH2_SRC	265	268	PF00017	0.501
LIG_SH2_STAP1	265	269	PF00017	0.496
LIG_SH2_STAP1	318	322	PF00017	0.485
LIG_SH2_STAP1	419	423	PF00017	0.500
LIG_SH2_STAT5	104	107	PF00017	0.669
LIG_SH2_STAT5	154	157	PF00017	0.691
LIG_SH2_STAT5	173	176	PF00017	0.658
LIG_SH2_STAT5	305	308	PF00017	0.544
LIG_SH2_STAT5	357	360	PF00017	0.470
LIG_SH2_STAT5	402	405	PF00017	0.551
LIG_SH3_3	137	143	PF00018	0.723
LIG_SH3_3	45	51	PF00018	0.766
LIG_SH3_3	57	63	PF00018	0.585
LIG_SH3_3	88	94	PF00018	0.798
LIG_SUMO_SIM_par_1	436	442	PF11976	0.499
LIG_TRAF2_1	218	221	PF00917	0.680
LIG_TYR_ITIM	355	360	PF00017	0.463
LIG_WW_2	91	94	PF00397	0.685
MOD_CDK_SPK_2	163	168	PF00069	0.657
MOD_CK1_1	203	209	PF00069	0.772
MOD_CK1_1	274	280	PF00069	0.552
MOD_CK1_1	356	362	PF00069	0.467
MOD_CK1_1	65	71	PF00069	0.709
MOD_CK2_1	11	17	PF00069	0.661
MOD_CK2_1	203	209	PF00069	0.714
MOD_CK2_1	452	458	PF00069	0.544
MOD_CK2_1	492	498	PF00069	0.675
MOD_Cter_Amidation	500	503	PF01082	0.752
MOD_GlcNHglycan	252	255	PF01048	0.621
MOD_GlcNHglycan	67	70	PF01048	0.733
MOD_GSK3_1	149	156	PF00069	0.682
MOD_GSK3_1	196	203	PF00069	0.790
MOD_GSK3_1	250	257	PF00069	0.597
MOD_GSK3_1	333	340	PF00069	0.497
MOD_GSK3_1	429	436	PF00069	0.600
MOD_GSK3_1	65	72	PF00069	0.714
MOD_N-GLC_1	310	315	PF02516	0.517
MOD_N-GLC_1	333	338	PF02516	0.506
MOD_NEK2_1	106	111	PF00069	0.693
MOD_NEK2_1	11	16	PF00069	0.706
MOD_NEK2_1	162	167	PF00069	0.678
MOD_NEK2_1	250	255	PF00069	0.495
MOD_NEK2_1	282	287	PF00069	0.542
MOD_NEK2_1	393	398	PF00069	0.463
MOD_NEK2_1	433	438	PF00069	0.501
MOD_NEK2_1	83	88	PF00069	0.671
MOD_NEK2_2	149	154	PF00069	0.679
MOD_NEK2_2	254	259	PF00069	0.506
MOD_NEK2_2	71	76	PF00069	0.673
MOD_NEK2_2	99	104	PF00069	0.670
MOD_OFUCOSY	242	247	PF10250	0.476
MOD_PIKK_1	271	277	PF00454	0.634
MOD_PIKK_1	393	399	PF00454	0.464
MOD_PKA_1	410	416	PF00069	0.534
MOD_PKA_2	123	129	PF00069	0.705
MOD_PKA_2	162	168	PF00069	0.659
MOD_PKA_2	175	181	PF00069	0.468
MOD_PKA_2	282	288	PF00069	0.502
MOD_PKA_2	374	380	PF00069	0.602
MOD_Plk_1	199	205	PF00069	0.693
MOD_Plk_1	310	316	PF00069	0.515
MOD_Plk_1	333	339	PF00069	0.501
MOD_Plk_2-3	220	226	PF00069	0.618
MOD_Plk_2-3	453	459	PF00069	0.536
MOD_Plk_4	117	123	PF00069	0.668
MOD_Plk_4	149	155	PF00069	0.680
MOD_Plk_4	188	194	PF00069	0.658
MOD_Plk_4	310	316	PF00069	0.515
MOD_Plk_4	419	425	PF00069	0.495
MOD_Plk_4	478	484	PF00069	0.540
MOD_ProDKin_1	115	121	PF00069	0.661
MOD_ProDKin_1	163	169	PF00069	0.749
MOD_ProDKin_1	362	368	PF00069	0.494
MOD_ProDKin_1	44	50	PF00069	0.735
MOD_ProDKin_1	92	98	PF00069	0.674
MOD_SUMO_rev_2	266	274	PF00179	0.504
MOD_SUMO_rev_2	495	504	PF00179	0.734
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.492
TRG_ENDOCYTIC_2	265	268	PF00928	0.501
TRG_ENDOCYTIC_2	318	321	PF00928	0.489
TRG_ENDOCYTIC_2	357	360	PF00928	0.470
TRG_ENDOCYTIC_2	421	424	PF00928	0.490
TRG_ER_diArg_1	108	111	PF00400	0.660
TRG_ER_diArg_1	162	164	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AEG9	Leishmania major	100%	100%