Robl_LC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Roadblock/LC7 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q4R6_LEIMA

TriTrypDb:

LmjF.32.3555 , LMJLV39_320043600 , LMJSD75_320043600

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4Q4R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4R6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	139	143	PF00082	0.287
CLV_PCSK_SKI1_1	225	229	PF00082	0.404
DEG_APCC_DBOX_1	224	232	PF00400	0.353
DEG_SPOP_SBC_1	194	198	PF00917	0.483
DEG_SPOP_SBC_1	20	24	PF00917	0.473
DOC_CKS1_1	209	214	PF01111	0.487
DOC_CKS1_1	6	11	PF01111	0.460
DOC_CYCLIN_RxL_1	222	230	PF00134	0.405
DOC_MAPK_FxFP_2	34	37	PF00069	0.454
DOC_MAPK_MEF2A_6	139	146	PF00069	0.287
DOC_MAPK_MEF2A_6	90	97	PF00069	0.439
DOC_PP2B_LxvP_1	183	186	PF13499	0.334
DOC_PP4_FxxP_1	34	37	PF00568	0.501
DOC_USP7_MATH_1	186	190	PF00917	0.573
DOC_USP7_MATH_1	193	197	PF00917	0.528
DOC_USP7_MATH_1	20	24	PF00917	0.498
DOC_USP7_UBL2_3	199	203	PF12436	0.524
DOC_WW_Pin1_4	1	6	PF00397	0.498
DOC_WW_Pin1_4	205	210	PF00397	0.583
LIG_14-3-3_CanoR_1	134	138	PF00244	0.287
LIG_14-3-3_CanoR_1	223	228	PF00244	0.468
LIG_14-3-3_CanoR_1	234	241	PF00244	0.314
LIG_BRCT_BRCA1_1	235	239	PF00533	0.376
LIG_BRCT_BRCA1_1	3	7	PF00533	0.440
LIG_BRCT_BRCA1_1	49	53	PF00533	0.444
LIG_FHA_1	102	108	PF00498	0.503
LIG_FHA_1	136	142	PF00498	0.287
LIG_FHA_1	209	215	PF00498	0.651
LIG_FHA_1	6	12	PF00498	0.562
LIG_FHA_1	74	80	PF00498	0.493
LIG_LIR_Gen_1	156	166	PF02991	0.287
LIG_LIR_Gen_1	168	177	PF02991	0.235
LIG_LIR_Nem_3	156	161	PF02991	0.287
LIG_SH2_STAP1	169	173	PF00017	0.287
LIG_SH2_STAT5	137	140	PF00017	0.287
LIG_SH2_STAT5	85	88	PF00017	0.464
LIG_SH3_3	206	212	PF00018	0.571
LIG_SH3_3	241	247	PF00018	0.444
LIG_SH3_3	6	12	PF00018	0.579
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.404
LIG_TRAF2_1	213	216	PF00917	0.529
MOD_CK1_1	72	78	PF00069	0.724
MOD_CK1_1	88	94	PF00069	0.450
MOD_CK2_1	214	220	PF00069	0.511
MOD_GlcNHglycan	123	126	PF01048	0.464
MOD_GlcNHglycan	87	90	PF01048	0.539
MOD_GSK3_1	1	8	PF00069	0.541
MOD_GSK3_1	161	168	PF00069	0.310
MOD_GSK3_1	20	27	PF00069	0.435
MOD_GSK3_1	204	211	PF00069	0.516
MOD_GSK3_1	32	39	PF00069	0.471
MOD_GSK3_1	44	51	PF00069	0.488
MOD_GSK3_1	69	76	PF00069	0.521
MOD_N-GLC_1	72	77	PF02516	0.525
MOD_NEK2_1	161	166	PF00069	0.287
MOD_OFUCOSY	58	63	PF10250	0.400
MOD_PKA_1	203	209	PF00069	0.524
MOD_PKA_2	133	139	PF00069	0.287
MOD_PKA_2	154	160	PF00069	0.287
MOD_PKA_2	233	239	PF00069	0.364
MOD_Plk_1	161	167	PF00069	0.287
MOD_Plk_1	215	221	PF00069	0.438
MOD_Plk_1	72	78	PF00069	0.496
MOD_ProDKin_1	1	7	PF00069	0.500
MOD_ProDKin_1	205	211	PF00069	0.580
TRG_ENDOCYTIC_2	169	172	PF00928	0.287
TRG_ER_diArg_1	222	225	PF00400	0.374
TRG_ER_diArg_1	25	28	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X636	Leishmania donovani	87%	99%
A4I8H6	Leishmania infantum	86%	99%