AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4R5_LEIMA

TriTrypDb:

LmjF.32.3560 , LMJLV39_320043700 , LMJSD75_320043700

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.642
CLV_NRD_NRD_1	143	145	PF00675	0.571
CLV_NRD_NRD_1	146	148	PF00675	0.599
CLV_NRD_NRD_1	298	300	PF00675	0.513
CLV_NRD_NRD_1	424	426	PF00675	0.386
CLV_NRD_NRD_1	453	455	PF00675	0.723
CLV_NRD_NRD_1	5	7	PF00675	0.620
CLV_NRD_NRD_1	567	569	PF00675	0.736
CLV_PCSK_KEX2_1	143	145	PF00082	0.641
CLV_PCSK_KEX2_1	151	153	PF00082	0.565
CLV_PCSK_KEX2_1	298	300	PF00082	0.513
CLV_PCSK_KEX2_1	424	426	PF00082	0.386
CLV_PCSK_KEX2_1	5	7	PF00082	0.620
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.542
CLV_PCSK_PC7_1	147	153	PF00082	0.526
CLV_PCSK_SKI1_1	143	147	PF00082	0.570
CLV_PCSK_SKI1_1	151	155	PF00082	0.520
CLV_PCSK_SKI1_1	243	247	PF00082	0.463
CLV_PCSK_SKI1_1	5	9	PF00082	0.806
CLV_Separin_Metazoa	93	97	PF03568	0.595
DEG_APCC_DBOX_1	242	250	PF00400	0.477
DEG_SPOP_SBC_1	363	367	PF00917	0.631
DOC_CYCLIN_RxL_1	422	432	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	483	489	PF00134	0.636
DOC_MAPK_gen_1	240	248	PF00069	0.582
DOC_MAPK_gen_1	424	431	PF00069	0.394
DOC_MAPK_MEF2A_6	424	431	PF00069	0.394
DOC_MAPK_NFAT4_5	424	432	PF00069	0.402
DOC_PP2B_LxvP_1	106	109	PF13499	0.543
DOC_PP2B_LxvP_1	124	127	PF13499	0.628
DOC_PP2B_LxvP_1	13	16	PF13499	0.569
DOC_PP2B_LxvP_1	483	486	PF13499	0.539
DOC_PP2B_LxvP_1	533	536	PF13499	0.658
DOC_PP4_FxxP_1	233	236	PF00568	0.562
DOC_PP4_FxxP_1	301	304	PF00568	0.479
DOC_USP7_MATH_1	135	139	PF00917	0.594
DOC_USP7_MATH_1	363	367	PF00917	0.745
DOC_USP7_MATH_1	468	472	PF00917	0.776
DOC_USP7_MATH_1	50	54	PF00917	0.704
DOC_USP7_MATH_1	522	526	PF00917	0.565
DOC_USP7_MATH_1	65	69	PF00917	0.756
DOC_WW_Pin1_4	253	258	PF00397	0.525
DOC_WW_Pin1_4	393	398	PF00397	0.686
DOC_WW_Pin1_4	46	51	PF00397	0.682
DOC_WW_Pin1_4	472	477	PF00397	0.672
DOC_WW_Pin1_4	481	486	PF00397	0.661
DOC_WW_Pin1_4	505	510	PF00397	0.566
DOC_WW_Pin1_4	61	66	PF00397	0.697
DOC_WW_Pin1_4	80	85	PF00397	0.490
LIG_14-3-3_CanoR_1	220	225	PF00244	0.539
LIG_14-3-3_CanoR_1	298	302	PF00244	0.547
LIG_14-3-3_CanoR_1	334	341	PF00244	0.575
LIG_14-3-3_CanoR_1	354	363	PF00244	0.621
LIG_14-3-3_CanoR_1	424	428	PF00244	0.415
LIG_AP2alpha_2	231	233	PF02296	0.569
LIG_BRCT_BRCA1_1	255	259	PF00533	0.496
LIG_BRCT_BRCA1_1	366	370	PF00533	0.581
LIG_FHA_1	2	8	PF00498	0.810
LIG_FHA_1	221	227	PF00498	0.400
LIG_FHA_1	29	35	PF00498	0.346
LIG_FHA_1	424	430	PF00498	0.519
LIG_FHA_1	81	87	PF00498	0.437
LIG_FHA_2	205	211	PF00498	0.476
LIG_FHA_2	346	352	PF00498	0.662
LIG_FHA_2	373	379	PF00498	0.587
LIG_FHA_2	515	521	PF00498	0.518
LIG_FHA_2	526	532	PF00498	0.418
LIG_FHA_2	74	80	PF00498	0.691
LIG_FHA_2	83	89	PF00498	0.612
LIG_GBD_Chelix_1	213	221	PF00786	0.486
LIG_LIR_Apic_2	231	236	PF02991	0.458
LIG_LIR_Apic_2	247	253	PF02991	0.478
LIG_LIR_Apic_2	300	304	PF02991	0.458
LIG_LIR_Gen_1	188	197	PF02991	0.539
LIG_LIR_Gen_1	22	33	PF02991	0.581
LIG_LIR_Gen_1	305	316	PF02991	0.431
LIG_LIR_LC3C_4	210	214	PF02991	0.508
LIG_LIR_Nem_3	138	142	PF02991	0.504
LIG_LIR_Nem_3	188	192	PF02991	0.536
LIG_LIR_Nem_3	22	28	PF02991	0.573
LIG_LIR_Nem_3	305	311	PF02991	0.369
LIG_LIR_Nem_3	336	341	PF02991	0.732
LIG_MAD2	6	14	PF02301	0.796
LIG_NRBOX	292	298	PF00104	0.569
LIG_SH2_CRK	250	254	PF00017	0.572
LIG_SH2_CRK	279	283	PF00017	0.432
LIG_SH2_SRC	413	416	PF00017	0.486
LIG_SH2_STAP1	19	23	PF00017	0.468
LIG_SH2_STAP1	308	312	PF00017	0.418
LIG_SH2_STAT5	25	28	PF00017	0.568
LIG_SH2_STAT5	33	36	PF00017	0.416
LIG_SH2_STAT5	413	416	PF00017	0.576
LIG_SH3_2	476	481	PF14604	0.741
LIG_SH3_3	251	257	PF00018	0.517
LIG_SH3_3	388	394	PF00018	0.549
LIG_SH3_3	473	479	PF00018	0.745
LIG_SH3_3	506	512	PF00018	0.586
LIG_SH3_3	555	561	PF00018	0.399
LIG_SH3_3	67	73	PF00018	0.778
LIG_SH3_3	94	100	PF00018	0.593
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.574
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.560
LIG_TRAF2_1	120	123	PF00917	0.546
LIG_UBA3_1	107	113	PF00899	0.529
LIG_UBA3_1	515	521	PF00899	0.642
LIG_WRC_WIRS_1	136	141	PF05994	0.616
LIG_WW_3	14	18	PF00397	0.598
LIG_WW_3	475	479	PF00397	0.709
MOD_CDK_SPK_2	46	51	PF00069	0.567
MOD_CDK_SPK_2	505	510	PF00069	0.668
MOD_CDK_SPxK_1	472	478	PF00069	0.703
MOD_CK1_1	396	402	PF00069	0.694
MOD_CK1_1	405	411	PF00069	0.638
MOD_CK1_1	418	424	PF00069	0.408
MOD_CK1_1	514	520	PF00069	0.542
MOD_CK1_1	525	531	PF00069	0.531
MOD_CK1_1	53	59	PF00069	0.818
MOD_CK2_1	187	193	PF00069	0.684
MOD_CK2_1	204	210	PF00069	0.398
MOD_CK2_1	396	402	PF00069	0.694
MOD_CK2_1	514	520	PF00069	0.643
MOD_CK2_1	525	531	PF00069	0.452
MOD_CK2_1	73	79	PF00069	0.630
MOD_CK2_1	82	88	PF00069	0.511
MOD_CMANNOS	307	310	PF00535	0.453
MOD_Cter_Amidation	149	152	PF01082	0.569
MOD_Cter_Amidation	452	455	PF01082	0.641
MOD_DYRK1A_RPxSP_1	481	485	PF00069	0.550
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.825
MOD_GlcNHglycan	170	174	PF01048	0.635
MOD_GlcNHglycan	195	198	PF01048	0.630
MOD_GlcNHglycan	304	307	PF01048	0.429
MOD_GlcNHglycan	335	338	PF01048	0.639
MOD_GlcNHglycan	358	361	PF01048	0.803
MOD_GlcNHglycan	387	390	PF01048	0.455
MOD_GlcNHglycan	398	401	PF01048	0.643
MOD_GlcNHglycan	470	473	PF01048	0.760
MOD_GlcNHglycan	533	536	PF01048	0.604
MOD_GSK3_1	187	194	PF00069	0.571
MOD_GSK3_1	29	36	PF00069	0.546
MOD_GSK3_1	302	309	PF00069	0.475
MOD_GSK3_1	341	348	PF00069	0.673
MOD_GSK3_1	398	405	PF00069	0.537
MOD_GSK3_1	414	421	PF00069	0.459
MOD_GSK3_1	46	53	PF00069	0.600
MOD_GSK3_1	468	475	PF00069	0.802
MOD_GSK3_1	61	68	PF00069	0.677
MOD_N-GLC_1	28	33	PF02516	0.354
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	28	33	PF00069	0.354
MOD_NEK2_1	370	375	PF00069	0.575
MOD_NEK2_1	385	390	PF00069	0.374
MOD_NEK2_1	423	428	PF00069	0.586
MOD_NEK2_1	429	434	PF00069	0.538
MOD_PIKK_1	260	266	PF00454	0.459
MOD_PIKK_1	567	573	PF00454	0.616
MOD_PKA_1	151	157	PF00069	0.625
MOD_PKA_2	151	157	PF00069	0.556
MOD_PKA_2	219	225	PF00069	0.579
MOD_PKA_2	297	303	PF00069	0.543
MOD_PKA_2	333	339	PF00069	0.523
MOD_PKA_2	342	348	PF00069	0.653
MOD_PKA_2	423	429	PF00069	0.406
MOD_PKA_2	50	56	PF00069	0.583
MOD_PKA_2	567	573	PF00069	0.616
MOD_Plk_1	330	336	PF00069	0.477
MOD_Plk_1	418	424	PF00069	0.531
MOD_Plk_2-3	204	210	PF00069	0.490
MOD_Plk_2-3	372	378	PF00069	0.597
MOD_Plk_4	135	141	PF00069	0.539
MOD_Plk_4	29	35	PF00069	0.481
MOD_Plk_4	306	312	PF00069	0.392
MOD_Plk_4	418	424	PF00069	0.531
MOD_Plk_4	511	517	PF00069	0.659
MOD_Plk_4	82	88	PF00069	0.632
MOD_ProDKin_1	253	259	PF00069	0.518
MOD_ProDKin_1	393	399	PF00069	0.690
MOD_ProDKin_1	46	52	PF00069	0.688
MOD_ProDKin_1	472	478	PF00069	0.675
MOD_ProDKin_1	481	487	PF00069	0.655
MOD_ProDKin_1	505	511	PF00069	0.571
MOD_ProDKin_1	61	67	PF00069	0.696
MOD_ProDKin_1	80	86	PF00069	0.479
MOD_SUMO_rev_2	563	570	PF00179	0.636
TRG_DiLeu_BaEn_1	208	213	PF01217	0.454
TRG_DiLeu_BaEn_1	244	249	PF01217	0.577
TRG_DiLeu_BaEn_2	254	260	PF01217	0.478
TRG_ENDOCYTIC_2	25	28	PF00928	0.568
TRG_ENDOCYTIC_2	279	282	PF00928	0.433
TRG_ENDOCYTIC_2	308	311	PF00928	0.452
TRG_ER_diArg_1	142	144	PF00400	0.644
TRG_ER_diArg_1	297	299	PF00400	0.510
TRG_ER_diArg_1	423	425	PF00400	0.385
TRG_ER_diArg_1	5	7	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.572
TRG_PTS2	1	13	PF00400	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P3	Leptomonas seymouri	38%	100%
A0A3Q8IFU0	Leishmania donovani	87%	100%
A4HKZ7	Leishmania braziliensis	70%	100%
A4I8H7	Leishmania infantum	87%	100%
E9B3D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%