Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4R2_LEIMA

TriTrypDb:

LmjF.32.3600 , LMJLV39_320044000 , LMJSD75_320044000

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.549
CLV_NRD_NRD_1	59	61	PF00675	0.716
CLV_NRD_NRD_1	7	9	PF00675	0.688
CLV_PCSK_KEX2_1	109	111	PF00082	0.549
CLV_PCSK_KEX2_1	59	61	PF00082	0.716
CLV_PCSK_KEX2_1	7	9	PF00082	0.688
CLV_PCSK_SKI1_1	170	174	PF00082	0.634
CLV_PCSK_SKI1_1	196	200	PF00082	0.561
CLV_PCSK_SKI1_1	67	71	PF00082	0.616
CLV_Separin_Metazoa	106	110	PF03568	0.658
CLV_Separin_Metazoa	68	72	PF03568	0.654
DEG_APCC_DBOX_1	169	177	PF00400	0.716
DEG_APCC_DBOX_1	66	74	PF00400	0.664
DOC_MAPK_gen_1	32	41	PF00069	0.688
DOC_MAPK_MEF2A_6	71	78	PF00069	0.592
DOC_MAPK_NFAT4_5	71	79	PF00069	0.591
DOC_PP2B_LxvP_1	144	147	PF13499	0.697
DOC_USP7_MATH_1	152	156	PF00917	0.697
DOC_USP7_MATH_1	88	92	PF00917	0.741
LIG_14-3-3_CanoR_1	7	15	PF00244	0.585
LIG_Actin_WH2_2	154	172	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_FHA_1	141	147	PF00498	0.688
LIG_FHA_1	32	38	PF00498	0.668
LIG_FHA_1	98	104	PF00498	0.587
LIG_FHA_2	162	168	PF00498	0.624
LIG_FHA_2	63	69	PF00498	0.645
LIG_NRBOX	69	75	PF00104	0.662
LIG_PDZ_Class_2	195	200	PF00595	0.604
LIG_SH2_STAT5	22	25	PF00017	0.706
LIG_TRAF2_1	40	43	PF00917	0.601
MOD_CK1_1	168	174	PF00069	0.620
MOD_CK1_1	2	8	PF00069	0.775
MOD_CK1_1	9	15	PF00069	0.682
MOD_CK2_1	125	131	PF00069	0.574
MOD_CK2_1	156	162	PF00069	0.746
MOD_CK2_1	168	174	PF00069	0.716
MOD_CK2_1	62	68	PF00069	0.656
MOD_GlcNHglycan	10	14	PF01048	0.692
MOD_GlcNHglycan	154	157	PF01048	0.766
MOD_GlcNHglycan	170	173	PF01048	0.461
MOD_GlcNHglycan	90	93	PF01048	0.707
MOD_GlcNHglycan	98	103	PF01048	0.547
MOD_GSK3_1	152	159	PF00069	0.700
MOD_GSK3_1	161	168	PF00069	0.552
MOD_GSK3_1	190	197	PF00069	0.659
MOD_GSK3_1	2	9	PF00069	0.774
MOD_PIKK_1	116	122	PF00454	0.597
MOD_PK_1	125	131	PF00069	0.613
MOD_PKA_2	31	37	PF00069	0.592
MOD_PKA_2	6	12	PF00069	0.683
MOD_Plk_1	187	193	PF00069	0.571
MOD_Plk_1	98	104	PF00069	0.424
MOD_Plk_4	156	162	PF00069	0.719
MOD_Plk_4	187	193	PF00069	0.571
TRG_ER_diArg_1	108	110	PF00400	0.553
TRG_ER_diArg_1	58	60	PF00400	0.653
TRG_ER_diArg_1	6	8	PF00400	0.803
TRG_NES_CRM1_1	68	82	PF08389	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVP8	Leptomonas seymouri	33%	97%
A0A3Q8ILP4	Leishmania donovani	90%	100%
A4HKZ9	Leishmania braziliensis	64%	100%
A4I8I0	Leishmania infantum	90%	100%
E9B3E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%