PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4R0_LEIMA

TriTrypDb:

LmjF.32.3620 , LMJLV39_320044200 , LMJSD75_320044200

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4R0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.417
CLV_NRD_NRD_1	51	53	PF00675	0.543
CLV_PCSK_KEX2_1	51	53	PF00082	0.543
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DOC_CKS1_1	201	206	PF01111	0.479
DOC_PP2B_LxvP_1	180	183	PF13499	0.396
DOC_USP7_UBL2_3	190	194	PF12436	0.460
DOC_WW_Pin1_4	200	205	PF00397	0.542
DOC_WW_Pin1_4	214	219	PF00397	0.364
DOC_WW_Pin1_4	43	48	PF00397	0.708
DOC_WW_Pin1_4	72	77	PF00397	0.722
DOC_WW_Pin1_4	78	83	PF00397	0.621
DOC_WW_Pin1_4	87	92	PF00397	0.581
LIG_14-3-3_CanoR_1	22	29	PF00244	0.673
LIG_14-3-3_CanoR_1	51	61	PF00244	0.589
LIG_BRCT_BRCA1_1	113	117	PF00533	0.573
LIG_BRCT_BRCA1_1	120	124	PF00533	0.409
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.405
LIG_FHA_1	227	233	PF00498	0.382
LIG_FHA_1	37	43	PF00498	0.549
LIG_FHA_1	56	62	PF00498	0.543
LIG_FHA_2	201	207	PF00498	0.428
LIG_FHA_2	72	78	PF00498	0.704
LIG_FHA_2	99	105	PF00498	0.520
LIG_LIR_Apic_2	200	204	PF02991	0.461
LIG_LIR_Apic_2	233	238	PF02991	0.509
LIG_LIR_Gen_1	222	232	PF02991	0.394
LIG_LIR_Nem_3	195	199	PF02991	0.401
LIG_LIR_Nem_3	222	227	PF02991	0.394
LIG_LIR_Nem_3	229	234	PF02991	0.385
LIG_Pex14_1	160	164	PF04695	0.469
LIG_SH2_NCK_1	54	58	PF00017	0.593
LIG_SH2_PTP2	128	131	PF00017	0.394
LIG_SH2_PTP2	231	234	PF00017	0.467
LIG_SH2_STAP1	140	144	PF00017	0.480
LIG_SH2_STAT5	128	131	PF00017	0.394
LIG_SH2_STAT5	196	199	PF00017	0.369
LIG_SH2_STAT5	202	205	PF00017	0.439
LIG_SH2_STAT5	231	234	PF00017	0.467
LIG_SH2_STAT5	235	238	PF00017	0.558
LIG_SH3_1	147	153	PF00018	0.484
LIG_SH3_2	47	52	PF14604	0.635
LIG_SH3_3	147	153	PF00018	0.481
LIG_SH3_3	173	179	PF00018	0.370
LIG_SH3_3	44	50	PF00018	0.610
LIG_SH3_3	91	97	PF00018	0.699
LIG_SUMO_SIM_par_1	178	185	PF11976	0.399
LIG_TRAF2_1	3	6	PF00917	0.571
LIG_WRC_WIRS_1	161	166	PF05994	0.440
MOD_CDC14_SPxK_1	49	52	PF00782	0.628
MOD_CDC14_SPxK_1	75	78	PF00782	0.683
MOD_CDC14_SPxK_1	90	93	PF00782	0.454
MOD_CDK_SPK_2	46	51	PF00069	0.534
MOD_CDK_SPxK_1	46	52	PF00069	0.626
MOD_CDK_SPxK_1	72	78	PF00069	0.679
MOD_CDK_SPxK_1	87	93	PF00069	0.467
MOD_CDK_SPxxK_3	214	221	PF00069	0.454
MOD_CK1_1	166	172	PF00069	0.429
MOD_CK1_1	46	52	PF00069	0.651
MOD_CK1_1	55	61	PF00069	0.669
MOD_CK1_1	67	73	PF00069	0.791
MOD_CK2_1	139	145	PF00069	0.566
MOD_CK2_1	200	206	PF00069	0.419
MOD_CK2_1	214	220	PF00069	0.371
MOD_CK2_1	98	104	PF00069	0.548
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.643
MOD_GlcNHglycan	113	116	PF01048	0.558
MOD_GlcNHglycan	118	121	PF01048	0.551
MOD_GlcNHglycan	131	134	PF01048	0.315
MOD_GlcNHglycan	258	261	PF01048	0.637
MOD_GlcNHglycan	54	57	PF01048	0.684
MOD_GlcNHglycan	82	85	PF01048	0.754
MOD_GlcNHglycan	87	90	PF01048	0.784
MOD_GSK3_1	116	123	PF00069	0.435
MOD_GSK3_1	131	138	PF00069	0.413
MOD_GSK3_1	42	49	PF00069	0.742
MOD_GSK3_1	64	71	PF00069	0.724
MOD_N-GLC_1	192	197	PF02516	0.531
MOD_NEK2_1	116	121	PF00069	0.535
MOD_NEK2_1	15	20	PF00069	0.553
MOD_NEK2_1	213	218	PF00069	0.546
MOD_NEK2_1	256	261	PF00069	0.655
MOD_PK_1	64	70	PF00069	0.784
MOD_PKA_2	111	117	PF00069	0.578
MOD_PKA_2	166	172	PF00069	0.436
MOD_PKA_2	50	56	PF00069	0.645
MOD_Plk_1	192	198	PF00069	0.418
MOD_Plk_4	103	109	PF00069	0.435
MOD_Plk_4	192	198	PF00069	0.393
MOD_ProDKin_1	200	206	PF00069	0.545
MOD_ProDKin_1	214	220	PF00069	0.360
MOD_ProDKin_1	43	49	PF00069	0.707
MOD_ProDKin_1	72	78	PF00069	0.726
MOD_ProDKin_1	87	93	PF00069	0.584
MOD_SUMO_rev_2	184	192	PF00179	0.444
TRG_DiLeu_BaEn_1	223	228	PF01217	0.491
TRG_DiLeu_BaEn_1	6	11	PF01217	0.606
TRG_DiLeu_BaEn_4	6	12	PF01217	0.551
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.369
TRG_DiLeu_LyEn_5	6	11	PF01217	0.567
TRG_ENDOCYTIC_2	128	131	PF00928	0.394
TRG_ENDOCYTIC_2	196	199	PF00928	0.387
TRG_ENDOCYTIC_2	231	234	PF00928	0.467
TRG_ER_diArg_1	50	52	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT8	Leptomonas seymouri	56%	95%
A0A3Q8IG98	Leishmania donovani	94%	100%
A0A3R7P3C4	Trypanosoma rangeli	49%	100%
A4HL01	Leishmania braziliensis	78%	96%
A4I8I2	Leishmania infantum	94%	100%
E9B3E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%