WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q4Q8_LEIMA

TriTrypDb:

LmjF.32.3640 , LMJLV39_320044400 , LMJSD75_320044400

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q4Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q4Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.537
CLV_C14_Caspase3-7	264	268	PF00656	0.376
CLV_C14_Caspase3-7	45	49	PF00656	0.333
CLV_NRD_NRD_1	228	230	PF00675	0.362
CLV_NRD_NRD_1	275	277	PF00675	0.335
CLV_NRD_NRD_1	41	43	PF00675	0.323
CLV_NRD_NRD_1	412	414	PF00675	0.635
CLV_PCSK_KEX2_1	192	194	PF00082	0.430
CLV_PCSK_KEX2_1	230	232	PF00082	0.367
CLV_PCSK_KEX2_1	241	243	PF00082	0.288
CLV_PCSK_KEX2_1	41	43	PF00082	0.330
CLV_PCSK_KEX2_1	412	414	PF00082	0.581
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.387
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.367
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.288
DEG_COP1_1	56	65	PF00400	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.480
DEG_SCF_FBW7_1	19	26	PF00400	0.524
DEG_SPOP_SBC_1	47	51	PF00917	0.376
DOC_CKS1_1	20	25	PF01111	0.522
DOC_MAPK_gen_1	382	390	PF00069	0.511
DOC_MAPK_MEF2A_6	384	392	PF00069	0.517
DOC_PP2B_LxvP_1	388	391	PF13499	0.523
DOC_PP4_FxxP_1	151	154	PF00568	0.343
DOC_USP7_MATH_1	113	117	PF00917	0.318
DOC_USP7_MATH_1	180	184	PF00917	0.469
DOC_USP7_MATH_1	23	27	PF00917	0.510
DOC_USP7_MATH_1	261	265	PF00917	0.314
DOC_USP7_MATH_1	305	309	PF00917	0.646
DOC_USP7_MATH_1	378	382	PF00917	0.469
DOC_USP7_MATH_2	335	341	PF00917	0.327
DOC_WW_Pin1_4	19	24	PF00397	0.526
DOC_WW_Pin1_4	413	418	PF00397	0.642
LIG_14-3-3_CanoR_1	130	134	PF00244	0.387
LIG_14-3-3_CanoR_1	384	389	PF00244	0.733
LIG_14-3-3_CanoR_1	41	47	PF00244	0.442
LIG_Actin_WH2_2	117	132	PF00022	0.354
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.283
LIG_FHA_1	207	213	PF00498	0.573
LIG_FHA_1	289	295	PF00498	0.418
LIG_FHA_1	323	329	PF00498	0.528
LIG_FHA_1	352	358	PF00498	0.308
LIG_FHA_1	362	368	PF00498	0.319
LIG_FHA_1	371	377	PF00498	0.482
LIG_FHA_1	385	391	PF00498	0.472
LIG_FHA_1	48	54	PF00498	0.526
LIG_FHA_2	11	17	PF00498	0.488
LIG_FHA_2	433	439	PF00498	0.713
LIG_LIR_Apic_2	217	221	PF02991	0.306
LIG_LIR_LC3C_4	211	215	PF02991	0.208
LIG_LIR_Nem_3	254	260	PF02991	0.360
LIG_LIR_Nem_3	95	101	PF02991	0.326
LIG_MYND_1	19	23	PF01753	0.466
LIG_SH2_CRK	218	222	PF00017	0.335
LIG_SH2_NCK_1	218	222	PF00017	0.335
LIG_SH2_NCK_1	44	48	PF00017	0.359
LIG_SH2_SRC	61	64	PF00017	0.288
LIG_SH2_STAT5	133	136	PF00017	0.304
LIG_SH2_STAT5	257	260	PF00017	0.334
LIG_SH2_STAT5	61	64	PF00017	0.417
LIG_SH2_STAT5	67	70	PF00017	0.466
LIG_SH3_3	25	31	PF00018	0.474
LIG_SH3_3	272	278	PF00018	0.450
LIG_SH3_3	356	362	PF00018	0.327
LIG_SH3_3	403	409	PF00018	0.665
LIG_SH3_3	84	90	PF00018	0.348
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.306
LIG_SUMO_SIM_anti_2	354	361	PF11976	0.383
LIG_SUMO_SIM_anti_2	440	446	PF11976	0.465
LIG_SUMO_SIM_par_1	211	217	PF11976	0.270
LIG_SUMO_SIM_par_1	363	369	PF11976	0.329
LIG_SUMO_SIM_par_1	443	448	PF11976	0.344
LIG_TRAF2_1	422	425	PF00917	0.585
LIG_TRAF2_2	118	123	PF00917	0.281
LIG_WRC_WIRS_1	30	35	PF05994	0.478
MOD_CK1_1	313	319	PF00069	0.531
MOD_CK1_1	321	327	PF00069	0.518
MOD_CK1_1	340	346	PF00069	0.531
MOD_CK1_1	368	374	PF00069	0.490
MOD_CK1_1	70	76	PF00069	0.443
MOD_CK2_1	419	425	PF00069	0.572
MOD_CK2_1	432	438	PF00069	0.698
MOD_CK2_1	46	52	PF00069	0.466
MOD_GlcNHglycan	198	201	PF01048	0.298
MOD_GlcNHglycan	248	251	PF01048	0.369
MOD_GlcNHglycan	25	28	PF01048	0.605
MOD_GlcNHglycan	312	315	PF01048	0.520
MOD_GlcNHglycan	354	357	PF01048	0.403
MOD_GlcNHglycan	427	430	PF01048	0.589
MOD_GlcNHglycan	44	47	PF01048	0.500
MOD_GlcNHglycan	72	75	PF01048	0.463
MOD_GSK3_1	109	116	PF00069	0.298
MOD_GSK3_1	129	136	PF00069	0.223
MOD_GSK3_1	19	26	PF00069	0.453
MOD_GSK3_1	261	268	PF00069	0.503
MOD_GSK3_1	318	325	PF00069	0.355
MOD_GSK3_1	347	354	PF00069	0.373
MOD_GSK3_1	361	368	PF00069	0.298
MOD_GSK3_1	4	11	PF00069	0.644
MOD_GSK3_1	419	426	PF00069	0.609
MOD_GSK3_1	42	49	PF00069	0.578
MOD_GSK3_1	433	440	PF00069	0.469
MOD_GSK3_1	61	68	PF00069	0.454
MOD_N-GLC_1	136	141	PF02516	0.474
MOD_NEK2_1	129	134	PF00069	0.347
MOD_NEK2_1	283	288	PF00069	0.371
MOD_NEK2_1	319	324	PF00069	0.440
MOD_NEK2_1	65	70	PF00069	0.409
MOD_PIKK_1	113	119	PF00454	0.331
MOD_PIKK_1	168	174	PF00454	0.453
MOD_PIKK_1	180	186	PF00454	0.363
MOD_PIKK_1	261	267	PF00454	0.416
MOD_PKA_1	102	108	PF00069	0.366
MOD_PKA_2	129	135	PF00069	0.389
MOD_Plk_1	168	174	PF00069	0.383
MOD_Plk_1	400	406	PF00069	0.719
MOD_Plk_1	423	429	PF00069	0.511
MOD_Plk_1	94	100	PF00069	0.351
MOD_Plk_4	208	214	PF00069	0.336
MOD_Plk_4	29	35	PF00069	0.497
MOD_Plk_4	361	367	PF00069	0.341
MOD_ProDKin_1	19	25	PF00069	0.523
MOD_ProDKin_1	413	419	PF00069	0.642
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.482
TRG_ENDOCYTIC_2	164	167	PF00928	0.322
TRG_ER_diArg_1	40	42	PF00400	0.329
TRG_ER_diArg_1	412	415	PF00400	0.610
TRG_NLS_MonoExtC_3	228	233	PF00514	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I9	Leptomonas seymouri	54%	100%
A0A1X0NRZ3	Trypanosomatidae	33%	100%
A0A3Q8IGJ4	Leishmania donovani	95%	100%
A0A422P320	Trypanosoma rangeli	39%	100%
A4HL03	Leishmania braziliensis	78%	100%
A4I8I3	Leishmania infantum	95%	100%
D0AAN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DMD9	Trypanosoma cruzi	35%	100%